Targeting macrophages in schwannoma and meningioma tumours

Project title: Targeting macrophages in schwannoma and meningioma tumours

Reference:  PUPSMD-17-18-003

Director of studies: Professor David Parkinson

2nd supervisor: Professor Oliver Hanemann

3rd supervisor: Professor Ji-liang Li

Applications are invited for a three-year PhD studentship. The studentship will begin on 1 January 2018.

The Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD) are seeking to attract PhD candidates of outstanding ability to join their exciting and rapidly expanding programme of internationally-rated research. The Plymouth University Peninsula Schools of Medicine and Dentistry are committed to research excellence with a recent £25 million investment in staff and facilities. Medical research at PUPSMD was ranked first for outputs in REF2014.

Applications are invited from suitably qualified graduates, 2:1 or above, and a relevant MSc or MRes qualification would be desirable but not essential. International students must also have an IELTS score of 7.0 or above (with no less than 6.5 in any element).

This PhD position is to join a research group working on the biology of schwannoma and meningioma tumours of the nervous system; these are relatively common tumour types associated with the loss of the Merlin tumour suppressor. This project involves the use of several transgenic mouse models to determine the genetic signalling in these tumours as well as potential therapies involving the modulation of the inflammatory environment within the tumour. This work will involve the use of a wide range of in vivo and in vitro methodology including molecular biology, protein analysis, confocal microscopy as well as the use of transgenic in vivo systems. For further details on this and other ongoing projects in the lab, please see Mindos et al (J. Cell Biol. 216: 495-510 (2017)); Schulz et al (Acta Neuropath. 132: 289-307 (2016) and Roberts et al (Development 144: 3114-3125 (2017)).

For further information regarding the project, please contact Professor David Parkinson (david.parkinson@plymouth.ac.uk). However, applications must be made in accordance with the details shown below.

Funding notes:

The studentship is supported for three years and includes full home/EU tuition fees plus a stipend of £14,553 per annum. The studentship will only fully fund those applicants who are eligible for home/EU fees with relevant qualifications. Applicants normally required to cover overseas fees will have to cover the difference between the home/EU and the overseas tuition fee rates For the 17/18 academic year the difference in fee is £10,350. If you are selected you will be required to provide financial assurances. 

To apply: 

Follow the link https://www.plymouth.ac.uk/student-life/your-studies/doctoral-college/applicants-and-enquirers and click ‘Apply’ to access the application form. Please mark the application with ref: PUPSMD-17-18-003. 

Please note: you do not need to submit a project proposal with your application.

Further information on the application process. If you have any questions on the admissions process contact pupsmd-researchdegreesadmissions@plymouth.ac.uk.  

The closing date for applications is 12 noon on 31 October 2017. Shortlisted candidates will be invited for interview. We regret that we may not be able to respond to all applications. Applicants who have not received an offer of a place by 5 December 2017 should consider their application has been unsuccessful on this occasion.