MPhil/PhD studentship available full-time or part-time
Project title: Identification of novel biomarkers and drug targets in genetically stratified meningiomas: PUPSMD-16-17-017
Start date: 1 January 2018
Director of Studies: Professor Oliver Hanemann
2nd Supervisor: Dr Sara Ferluga
3rd Supervisor: Dr Claire Adams
Plymouth University Peninsula Schools of Medicine and Dentistry are seeking to attract PhD candidates of outstanding ability to join their exciting and rapidly expanding programme of internationally-rated research. The Plymouth University Peninsula Schools of Medicine and Dentistry are committed to research excellence with a recent £25 million investment in staff and facilities. Medical research at PUPSMD was ranked first for outputs in REF2014.
Applications are invited from highly motivated qualified graduates, 2:1 or above, and preferably a relevant MSc or MRes qualification. International students must also have an IELTS score of 7.0 or above (with no less than 6.5 in any element).
the most common brain tumours affecting brain and spinal cord. The
heterogeneity of these tumours and the profound lack of knowledge about
specific markers contribute to make the development of new therapeutics
challenging. However, the genetic background of meningioma is well
characterized with the loss/mutation of the gene NF2 (Merlin) being the most
common together with other sporadic mutations identified in NF2+/+ meningiomas.
Sporadic mutations includes TRAF7,
KLF4, SMO and AKT1.
the molecular signature of meningiomas we use an unbiased proteomic approach
that involves the analysis of the proteome and the phosphoproteome of primary
meningioma cells and tissue. The student will carry out proteome analysis of
stratified meningiomas with TRAF7/KLF4 and AKT1/TRAF7 mutations, comparing the total
and phosphoproteome of these to our existing datasets. To verify potential drug
targets within these meningioma subgroups, we will use our well-established in
vitro model and functional assays.