Dr Xinpeng Dun
Profiles

Xinpeng Dun

Senior Research Fellow

Peninsula Medical School (Faculty of Health)

Leader of peripheral nerve regeneration research group

Qualifications

Education

  • March 2002--June 2005: PhD in biomedical engineering, Huazhong University of Science and Technology, College of Life Science and Technology, Wuhan, 430074, China.
  • September 1997--June 2000: Masters Degree in life science, Huazhong Nongye University, College of Life Sciences, Wuhan, 430070, China
  • September 1993--June 1997: Bachelor Degree in life science, Huazhong Nongye University, College of Life Sciences, Wuhan, 430070, China.
Work Experiences 
  • August 2017--present: Senior Research Fellow, Institute of Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, University of Plymouth, John Bull Building, Plymouth Science Park, Research Way, Plymouth, PL6 8BU, UK.
  • May 2014--July 2017: Research Fellow, Institute of Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, University of Plymouth, John Bull Building, Plymouth Science Park, Research Way, Plymouth, PL6 8BU, UK.
  • May 2010--April 2014: MRC Post-Doctoral Fellow, Institute of Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, University of Plymouth, John Bull Building, Plymouth Science Park, Research Way, Plymouth, PL6 8BU, UK.
  • Jun 2007--April 2010: Wellcome Trust Post-Doctoral Fellow, Clinical Neurobiology Research Group, Institute of Biomedical and Clinical Sciences, Peninsula Medical School and Dentistry, University of Plymouth and Exeter, John Bull Building, Plymouth Science Park, Research Way, Plymouth, PL6 8BU, UK.
  • July 2005--May 2007: The Swedish Foundation for International Cooperation in Research and Higher Education Post-Doctoral Fellow, Department of Neuroscience, Karolinska Institutet, Retzius, väg 8, Stockholm, S-17177, Sweden.
  • July 2000--February 2002: Natural Active Peptides Health Care Products development, Wuhan Tallyho Biological Product Co. Ltd., Wuhan, 430023, China.

Professional membership

  • Member of European Society for the Study of Peripheral Nerve Repair and Regeneration
  • Member of the United Kingdom-Ireland Controlled Release Society 
  • Member of British Neuroscience Association
  • Member of International Society for Developmental Neuroscience

Teaching interests

  • Current Issues in Neurobiology
  • Biomedical Science
  • Problem Based Learning 

Staff serving as external examiners

  • UCL PhD


Research interests

  • Expression pattern of classic axon guidance molecules in injured peripheral nerves.
  • Roles of classic axon guidance molecules in peripheral nerve regeneration.
  • Roles of regeneration associated neuropeptides in creating a distal micro-environment for successful peripheral nerve regeneration. 
  • Schwann cell biology.
  • Peripheral nerve tissue engineering.

Other research

  • Brain tumor

Research degrees awarded to supervised students

  • PhD
  • Master

Grants & contracts

  • Title of the project: Gene therapy using a modified Netrin-1 gene to enhance peripheral nerve repair. Awarding Organisation: Peninsula Schools of Medicine & Dentistry (PhD studentship). Role: Principal Investigator. Amount awarded: £63,727.00. Duration: 01/10/2018-30/09/2021
  • Title of the project: Gene therapy singing a modified Netrin-1 protein to enhance peripheral nerve repair. Awaring Organisation: Northcott Devon medical Foundation. Role: Principal Investigator. Amount awarded: £9,528.00. Duration: 01/10/2017-30/09/2019.
  • Title of the project: Vasoactive intestinal peptide controls the inflammatory response after peripheral nerve injury. Awarding Organisation: Peninsula Schools of Medicine & Dentistry (PhD studentship). Role: Principal Investigator. Amount awarded: £63,727.00. Duration: 01/10/2017-30/09/2020.
  • Title of the project: Examining the role of Galanin in Schwann cell dedifferentiation and proliferation after peripheral nerve injury. Awarding Organisation: University of Plymouth (international collaborative projects). Role: Principal Investigator. Amount awarded: £18,000.00. Duration: 01/01/2013-31/12/2014.
  • Title of the project: Improvement of peripheral nerve regeneration by use of axon guidance molecules delivered nerve guidance conduit. Awarding Organisation: University of Plymouth (international collaborative projects). Role: Principal Investigator. Amount awarded: £16,150.00. Duration: 01/01/2013-31/12/2014.
  • Title of the project: Examining the role of Slit-Robo signaling in peripheral nerve regeneration and plasticity. Awarding Organisation: Peninsula Schools of Medicine & Dentistry (PhD studentship). Role: Principal Investigator. Amount awarded: £61,060.00. Duration: 01/10/2013-31/09/2016
  • Title of the project: Axon guidance molecules expression pattern after peripheral nerve injury. Awarding Organisation: National Natural Science Foundation of China. Role: Principal Investigator. Amount awarded: ¥700,000.00. Duration: 01/01/2014-31/12/2017.
  • Title of the project: Identifying targets to boost repair in the peripheral nervous system. Awarding Organisation: Northcott Devon medical Foundation (Reference: TB/MG/N5002). Role: Co-applicant. Amount awarded: £8,344.00. Duration: 01/01/2014-31/12/2014.
  • Title of the project: Therapeutic effect of macrophage factor Daintain/AIF-1 on diabetes. Awarding Organisation: National Natural Science Foundation of China (30370674). Role: Co-applicant. Amount awarded: ¥200,000.00. Duration: 01/01/2005-31/12/2007.
  • Title of the project: Examining the molecular Mechanism of Novel Bioactive Peptide-Aglycin Lowing Hyperglycemia for . Awarding Organisation: National Natural Science Foundation of China (30470823). Role: Co-applicant. Amount awarded: ¥300,000.00. Duration: 01/01/2004-31/12/2006.

Key publications

Key publications are highlighted

Journals
Articles
Chen B, Hu R, Min Q, Li Y, Parkinson DB & Dun X-P 2020 'FGF5 Regulates Schwann Cell Migration and Adhesion' Frontiers in Cellular Neuroscience 14, , DOI PEARL
Min Q, Parkinson DB & Dun X 2020 'Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge' Glia , DOI PEARL
Dun X 2019 'Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration' Frontiers in Neuroscience , DOI PEARL
Chen B, Chen Q, Parkinson DB & Dun X-P 2019 'Analysis of Schwann Cell Migration and Axon Regeneration Following Nerve Injury in the Sciatic Nerve Bridge' Frontiers in Molecular Neuroscience 12, , DOI PEARL
Chen B, Carr L & Dun X-P 2019 'Dynamic expression of Slit1–3 and Robo1–2 in the mouse peripheral nervous system after injury' Neural Regeneration Research 15, (5) 948-948 , DOI PEARL
Dun X-P & Parkinson D 2019 'Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration' Neural Regeneration Research 15, (1) 6-6 , DOI PEARL
Dun X, Carr L, Woodley P, Barry R, Drake L, Mindos T, Robert S, Lloyd A & Parkinson D 2019 'Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge' Cell Reports 26, (6) , DOI PEARL
Dun X-P & Parkinson DB 2018 'Transection and Crush Models of Nerve Injury to Measure Repair and Remyelination in Peripheral Nerve' 251-262 , DOI PEARL
Dun X-P & Parkinson DB 2018 'Whole Mount Immunostaining on Mouse Sciatic Nerves to Visualize Events of Peripheral Nerve Regeneration' 339-348 , DOI PEARL
Roberts SL, Dun X-P, Doddrell RDS, Mindos T, Drake LK, Onaitis MW, Florio F, Quattrini A, D'Antonio M & Parkinson DB 2017 'Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve' Development Author Site , DOI PEARL
Carr L, Parkinson DB & Dun X-P 2017 'Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system' PLoS One 12, (2) e0172736-e0172736 Author Site , DOI PEARL
Dun X-P & Parkinson D 2017 'Role of Netrin-1 Signaling in Nerve Regeneration' International Journal of Molecular Sciences 18, (3) 491-491 , DOI PEARL
Mindos T, Dun X-P, North K, Doddrell RDS, Schulz A, Edwards P, Russell J, Gray B, Roberts SL & Shivane A 2017 'Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity' The Journal of Cell Biology 495-510 , DOI PEARL
Mindos T, Dun X-P, North K, Schulz A, Gray B, Pan D, Edwards P, Shivane A, Morrison H & Parkinson D 2017 'The Merlin tumour suppressor controls the repair capacity of Schwann cells following injury by regulating Hippo pathway signalling' Journal of Cell Biology 65, E40-E41 , DOI PEARL
Roberts SL, Dun X-P, Dee G, Gray B, Mindos T & Parkinson DB 2017 'The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair' Journal of Neurochemistry , DOI PEARL
Ketschek A, Spillane M, Dun X, Hardy H, Chilton J & Gallo G 2016 'Drebrin coordinates the actin and microtubule cytoskeleton during the initiation of axon collateral branches' Developmental Neurobiology 76, (10) 1092-1110 , DOI
Dun X-P & Parkinson DB 2015 'Visualizing peripheral nerve regeneration by whole mount staining' PLoS One 10, (3) Author Site , DOI PEARL
Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C & Mautner V-F 2013 'Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy' NATURE NEUROSCIENCE 16, (4) 426-U86 Author Site , DOI
Doddrell RDS, Dun X-P, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO & Parkinson DB 2013 'Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells' Brain 136, (Pt 2) 549-563 Author Site , DOI PEARL
Doddrell RDS, Dun X-P, Moate RM, Jessen KR, Mirsky R & Parkinson DB 2012 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' GLIA 60, (9) 1269-1278 Author Site , DOI
Dun X-P 2012 'Origin of climbing fiber neurons and the definition of rhombic lip' INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 30, (5) 391-395 Author Site , DOI
Dun X-P, Bandeira de Lima T, Allen J, Geraldo S, Gordon-Weeks P & Chilton JK 2012 'Drebrin controls neuronal migration through the formation and alignment of the leading process' Mol Cell Neurosci 49, (3) 341-350 Author Site , DOI
Ketschek A, Spillane M, Dun X-P, Chilton J & Gallo G 2012 'Regulation of axonal filopodia and collateral branches by the actin filament binding protein drebrin' MOLECULAR BIOLOGY OF THE CELL 23, Author Site PEARL
Le Maître TW, Xia S, Le Maitre E, Dun X-P, Lu J, Theodorsson E, Ogren SO, Hökfelt T & Xu Z-QD 2011 'Galanin receptor 2 overexpressing mice display an antidepressive-like phenotype: possible involvement of the subiculum' Neuroscience 190, 270-288 Author Site , DOI
Dun X-P & Chilton JK 2010 'Control of cell shape and plasticity during development and disease by the actin-binding protein Drebrin' Histol Histopathol 25, (4) 533-540 Author Site , DOI
Dun X-P, Li F-F, Wang J-H & Chen Z-W 2008 'The effect of pea albumin 1F on glucose metabolism in mice' PEPTIDES 29, (6) 891-897 Author Site , DOI
Xia S, Dun X-P, Hu P-S, Kjaer S, Zheng K, Qian Y, Solén C, Xu T, Fredholm B & Hökfelt T 2008 'Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus' Proc Natl Acad Sci U S A 105, (14) 5609-5613 Author Site , DOI
Hu Z, Dun X, Zhang M, Zhu H, Xie L, Wu Z, Chen Z & Xu T 2007 'PA1b, a plant peptide, induces intracellular [Ca2+] increase via Ca2+ influx through the L-type Ca2+ channel and triggers secretion in pancreatic beta cells' Sci China C Life Sci 50, (3) 285-291 Author Site , DOI
Dun X-P, Wang J-H, Chen L, Lu J, Li F-F, Zhao Y-Y, Cederlund E, Bryzgalova G, Efendic S & Jörnvall H 2007 'Activity of the plant peptide aglycin in mammalian systems' FEBS J 274, (3) 751-759 Author Site , DOI
Dun X-P, Wang J-H, Chen L, Lu J, Li F-F, Zhao Y-Y, Cederlund E, Bryzgalova G, Efendic S & Jornvall H 2007 'Activity of the plant peptide aglycin in mammalian systems' FEBS JOURNAL 274, (3) 751-759 Author Site , DOI
Wang J-H, Dun X-P, Qu L-N, Zhao Y-Y, Yang T-B & Chen Z-W 2005 'Preparation and identification of monoclonal antibodies against pea albumin 1b (PA 1b)' Hybridoma (Larchmt) 24, (4) 197-200 Author Site , DOI
Dun X-P, Li F-F & Chen Z-W 2005 '[Diazepam-binding inhibitor]' Sheng Li Ke Xue Jin Zhan 36, (3) 230-232 Author Site
Conference Papers
Mindos T, Roberts S, Dun X-P, Edwards P, Doddrell R, Shivane A & Parkinson D 2015 'The Merlin tumour suppressor is critical for peripheral nerve regeneration and repair' 1-/-0/19001-/-0/1900E423-E424
North K, Mindos T, Dun X-P & Parkinson D 2015 'The role of Hippo/YAP signalling in Schwann cell development and peripheral nerve repair' 1-/-0/19001-/-0/1900E437-E437
Mindos T, Roberts S, Doddrell R, Mortimer G, Dun XP, Edwards P, Shivane A & Parkinson D 2015 'The role of the Merlin tumour suppressor in the developing and injured adult peripheral nerve' 1-/-0/19001-/-0/190054-54
Mortimer G, Dun X, Doddrell RDS, Wrabetz L, Feltri ML & Parkinson DB 2013 'EXAMINING THE ROLE OF THE MERLIN TUMOUR SUPPRESSOR IN PERIPHERAL NERVE DEVELOPMENT AND REPAIR' 1-/-0/19001-/-0/190075-75
Dun X & Chilton JK 2010 'The timing and direction of neuronal migration are regulated by the interaction of drebrin with Nck2' 1-/-0/19001-/-0/1900688-689 , DOI
Other Publications
Ketschek A, Spillane M, Dun X, Hardy H, Chilton J & Gallo G 0 Cover Image. Wiley 01/01/190001/01/1900i-i , DOI

Reports & invited lectures

  • Lecture title: Role of EphrinA-EphA5 signalling in peripheral nerve regeneration. South Central University for Nationalities. 18th April, 2019, Wuhan, China.
  • Lecture title: Role of Netrin1-CD146 signalling in peripheral nerve regeneration. 11th April, 2019, Nantong University, Nantong, China.
  • Lecture title: Role of Netrin1-DCC signalling in peripheral nerve regeneration. 8th April, 2019, JiangSu University, Zhenjiang, China.
  • Lecture title: Role of Sema4f-PlexinB signalling in peripheral nerve regeneration. 5th April, 2019, HuBei University of Science and Technology, Xianning, China.
  • Lecture title: Expression pattern of classic axon guidance molecules in the injured mouse peripheral nervous system. Suzhou University of Science and Technology, China, 8th June, 2016.
  • Lecture title: Axon guidance molecules in peripheral nerve regeneration. HuBei University of Science and Technology, China, 19th June, 2016.
  • Lecture title: Fabrication and characterization of a microporous PLGA nerve guidance conduit for protein delivery. HuBei University of Science and Technology, China, 16th May, 2015.
  • Lecture title: Evidence of axonal guidance molecules regulating peripheral nerve regeneration. South Central University for Nationalities, China, 11th May, 2015.
  • Lecture title: The role of transcription factor Sox2 in Schwann cell development and plasticity. Huazhong University of Science and Technology, China, 28th April, 2015.
  • Lecture title: The role of transcription factor Sox2 in Schwann cell development and plasticity. School of Medical Sciences, University of Bristol, 14th may, 2012.
  • Lecture title: Drebrin controls tangential neuronal migration by regulating the generation and alignment of the leading processes. MRC Centre for Biomedical Sciences, King’s College London, 16th January, 2008.

Other academic activities

International and UK conferences 

  • UKJiangSu 20+20 World Class Consortium AGM 2019. 8-9th, April, 2019, Zhenjiang, China. Chair of the Healthcare panel.
  • UK Nerve Engineering Network Meeting. 5th November, 2018, University College London, London, UK.
  • The Joint Symposium of the 2018 International Neural Regeneration Symposium. 26-29th July, 2018, Guangzhou, China.
  • The European Conference on 'Molecular and Cellular Mechanisms of Neural Circuit Assembly', AXON2017, 11-14th Septermber, 2017, Klosterneuburg, Austria.
  • 4rd International Symposium on Peripheral Nerve Regeneration. 6-8th July, 2017, Barcelona, Spain. 
  • Axon guidance, Synapse formation and Regeneration. 20-24th September, 2016. Cold spring harbour, USA.
  • British Society for Cell Biology and British Society for Developmental Biology spring meeting. 10th-16th April, 2016, Warwick, UK.
  • 3rd International Symposium on Peripheral Nerve Regeneration. 24-25th, September, 2015, Hannover, Germany. 
  • The Controlled Release Society 2015 Annual Meeting. 26-29th July, 2015, Edinburgh, Scotland.
  • British Neuroscience Association Event: ‘Bioengineering and Neuronal Remodeling' July 2012, University Place, Manchester, UK.
  • Annual Academic Research Event of Peninsula College of Medicine and Dentistry, 8th November 2011, Plymouth, UK.
  • 10th Biennial ISN Satellite Meeting on Myelin Biology. 24-28th August 2011; Kolymvari, Crete, Greece.
  • Annual Academic Research Event of Peninsula College of Medicine and Dentistry. 29th June 2010, Plymouth, UK.
  • 20th Head Group Meeting. 17-18th January 2008, University College London, London.
  • G-protein-coupled receptors (GPCRs): from molecular aspects to novel therapy. 17–18th August 2006, Nobel Forum, Karolinska Institutet, Stockholm, Sweden.
  • The Active Dendrite. 18-19th May 2006, Nobel Forum, Karolinska Institutet, Stockholm, Sweden.
  • 2006 Nobel Prize Lectures in Physiology or Medicine. Nobel Lecture by Andrew Z. Fire: 'Gene Silencing by Double Stranded RNA'. Nobel Lecture by Craig C. Mello: 'Return to the RNAi World: Rethinking Gene Expression and Evolution'. 
  • 2005 Nobel Prize Lectures in Physiology or Medicine. Nobel Lecture by Barry J. Marshall: 'Helicobacter Connections'. Nobel Lecture by J. Robin Warren: 'Helicobacter–The Ease and Difficulty of a New Discovery'.
  • 8th Chinese International Peptide Symposium, 3rd-6th July 2004, Kunming city, Yunnan, China.

Additional information

Conferences lectures

  • Lecture title: Opportunities and challenges for developing partnerships in healthcare between UK and Jiangsu universities. UKJiangSu 20+20 World Class Consortium AGM 2019. 8-9th, April, 2019, Zhenjiang, China. Chair of the Healthcare panel.
  • Lecture title: Role of classic axon guidance molecules in peripheral nerve regeneration. UK Nerve Engineering Network Meeting. 5th November, 2018, University College London, London, UK.
  • Lecture title: Macrophage derived Slit3 controls the trajectories of cell migration and axon pathfinding in the peripheral nerve bridge. The Joint Symposium of the 2018 International Neural Regeneration Symposium (INRS2018). July 26-29th, 2018, Guangzhou, China.
  • Lecture title: Macrophage derived Slit3 controls the trajectories of cell migration and axon pathfinding in the peripheral nerve bridge. The 4th International Symposium on Peripheral Nerve Regeneration. 6-8th July, 2017, Barcelona, Spain.
  • Lecture title: Macrophage derived Slit3 directs peripheral regenerating axons to their original trajectory. Cold spring harbour, USA. Axon guidance, Synapse formation & Regeneration, 20th–24th, September, 2016.
  • Lecture title: The role of Slit-Robo signalling in Schwann cell migration and peripheral nerve repair. The 3rd International Symposium on Peripheral Nerve Regeneration. 24th-25th September, 2015, Hannover, Germany.