Dr Val Mann
Associate Professor in Molecular Cell Biology
School of Biomedical Sciences (Faculty of Medicine and Dentistry)
My teaching interests cover molecular and cell biology; biology of disease – age related degenerative conditions; clinical applications of stem cells and regenerative medicine.
I contribute to teaching on a number of modules across both the undergraduate and postgraduate programmes in the School including:
BHCS1001 Biomedical Investigation and Experimentation
BHCS3004 Specialist Biochemistry and Screening
BHCS3008 Current Developments in Biomedcial Sciences
BHCS3022 Contemporary Issues in Biosciences
BIOM5001 Molecular Biology: Genomics, Transcriptomics and Proteomics
BIOM5002 Contemporary Applications of Cell Biology
BIOM5010 Medical Genomics and Personalised Medicine
My research is focused on understanding the molecular response of bone to mechanical stimulation (exercise) and the role of osteocyte apoptosis in the control of bone remodelling. I am also involved in research in the use of cell therapies for use in regenerative medicine and have experience in the production of clinical grade autologous and allogeneic sourced stem cells and in vivo models of bone and cartilage repair. I am currently undertaking research into the use of assistive technologies for weight management and the design of smart exercise regimens for frail elderly - falls prevention and cognitve decline in dementia syndrome.
Grants & contracts
Helping Health Change - Development of novel assistive technologies for weight management. Funders: SimplyHealth. Dec 2013 - Jan 2015 (Lead academic, awarded £100,000.00)
UCS PhD Studentship Role of phytochemicals in the prevention of age related bone loss. Funders: UCS PGR. Sept 2013 - Aug 2016 (PI, awarded £37,500.00).
PROGRESS – Healthy Ageing in the Workplace. Funders: European Union Programme for Employment and Social Solidarity. Sept 2012 - Jan 2014 (Lead academic, awarded £370,000.00).
VIEW project (Virtual Education in the Workplace). Funders: Strategic Health Authority. Sept 2012 - Aug 2013 (Co-PI, awarded £54, 000.00).
Establishing a UCS presence on Second Life Island. Funders: Implementing Learning and Teaching Strategies (ILTS) Fellowship, UCS. Sept 2011 - Aug 2012 (Lead academic, awarded £5,500.00).
The use of stem cell therapies for cartilage regeneration. Funders: Geron Corporation. Oct 2010 - Sept 2012 (co-PI, awarded £774,000.00).
EPSRC CASE Studentship Award. Funders: Engineering and Physical Sciences Research Council (EPSRC). Oct 2008 - Sept 2011(Co-PI, awarded £62,000.00).
Musculoskeletal Stem Cell Research Programme. Funders: UK Stem Cell Foundation. Oct 2008 - Feb 2010 (Co-PI, awarded £3.4 million).
Genetic Basis of the Response to Exercise and Inactivity – Design of Novel Genetic Markers of Disease Risk. Funders: Chief Scientist Office. Aug 2005 - July 2006 (PI, awarded £14,500.00).
Equipment Grant. Funders: Arthritis Research UK (ARUK) Aug 2006 (PI, awarded £13,000.00).
Personal Research Fellowship Molecular and Genetic Basis of ageing and Disease Related Changes in the Functional Adaptation of Bone. Funders: Royal Society of Edinburgh Lloyds TSB Foundation for Scotland. Sept 2003 - Sept 2006 (PI, awarded £150,000.00).
Tremoleda JT, Mann V, Racey SN, Khan NS, Wojtacha D, Martin AJ, McWhir J, Simpson AHWR, Noble BS. Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation. J Musculoskelet Neuronal Interact. 2012 Dec;12(4):241-53.
Greig CA, Gray C, Rankin D, Young A, Mann V, Noble BS, Atherton PJ Blunting of adaptive responses to reistance training in women aged over 75 years. Exp Gerontol. 2011 Nov 46(11):884-90
Kogianni G*, Mann V* and Noble BS. Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localised bone destruction. Journal of Bone Mineral Research. June 2008 Jun;23(6):915-27. *joint first authorship.
David V, Guignandon A, Martin A, Malaval L, Lafage-Proust MH, Rattner A, Mann V, Noble B, Jones DB, Vico L. Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Tissue Eng Part A. 2008 Jan;14(1):117-26.
Mann V, Huber C, Kogianni G, and Noble B. The Anti-Oxidant Effect of Estrogen and Selective Estrogen Receptor Modulators in the Protection of Osteocytes from Oxidative Stress Induced Cell Death in vitro. Bone. 2007 Mar;40(3):674-84.
Mann V, Huber C, Kogianni G, Jones D, Noble B. The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone. J Musculoskeletal Neuronal Interact. 2006 Oct-Dec;6(4):408-17.
Stewart TL, Roschger P, Misof BM, Mann V, Fratzl P, Klaushofer K, Aspden R, Ralston SH. Association of COLIA1 Sp1 Alleles with Defective Bone Nodule Formation In Vitro and Abnormal Bone Mineralization In Vivo. Calcif Tissue Int. 2005 May 19.
Kogianni G, Mann V, Ebetino F, Nuttall M,Nijweide P,Simpson H, Noble B. Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis. Life Sci. 2004 Oct 29;75(24):2879-95.
Mann V and Ralston S.H. Meta-analysis of COL1A1 Sp1 polymorphism in relation to Bone Mineral Density and Osteoporotic Fracture Bone. 2003 Jun;32(6):711-7
Mann V, Hobson EE, Li B, Stewart TL, Grant SF, Robins SP, Aspden RM, Ralston SH. A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. Journal of Clinical Investigation 2001 Apr;107(7):899-907.
Noble BS, Mann V, Loveridge N, Thomson BM. Dextran sulfate promotes the rapid aggregation of porcine bone-marrow stromal cells. Bone. 1995 Oct;17(4):375-82.
Thomson BM, Bennett J, Mann V, Triffitt J, Meikle MC, Loveridge N. Preliminary characterization of porcine bone marrow stromal cells: skeletogenic potential, colony-forming activity, and response to dexamethasone, transforming growth factor beta, and basic fibroblast growth factor. J Bone Miner Res. 1993 Oct;8(10):1173-83.
Thomson BM, Mann V, Farquharson C, Noble BS. Visualisation and selective elimination of a subpopulation of mitogen-responsive bone marrow stromal cells using bromodeoxyuridine and photo-induced cell killing. Bone. 1993 Sep-Oct;14(5):779-86.
Loveridge N, Mann V, Goltzman D, Hendy GN. Bioactivity of parathyroid hormone and parathyroid hormone-like peptide: agonist and antagonist activities of amino-terminal fragments as assessed by the cytochemical bioassay and in situ biochemistry. Endocrinology. 1991 Apr;128(4):1938-46.
Rucklidge GJ, Mann V, Robins SP, Mella O, Bjerkvig R. Immunolocalization of extracellular matrix proteins during brain tumor invasion in BD IX rats. Cancer Res. 1989 Oct 1;49(19):5419-23.
Reports & invited lectures
Active Wellbeing (Dementia Syndrome) - Mann V, Teitjen A and Noble BS. 2015.
PROGRESS Towards Healthy Ageing App Development Report – Ranson T, Mann V and
Noble BS. 2014.
PROGRESS Towards Healthy Ageing Report – Housden S, Mann V and Noble BS. 2014.
Royal Society of Edinburgh response document to the House of Lords Science and Technology Sub-Committee Inquiry into the Scientific Aspects of Ageing. 2006
Hughes A, Stewart TL and MannV. Extraction of nucleic acids from bone.
Methods Mol Biol. 2012; 816: 249-59
Sun H, O’Connell MA, Mann V ,Noble BS and Keegan LP. Laser micro dissection and pressure catapulting of human motor neurons for RNA editinganalysis.
Methods Mol Biol. 2011; 718: 75-87.
Stewart TL and Mann V . Extraction of nucleic acids from bone.
Methods in Molecular Medicine. 2003; 80: 425-32.
Spring Symposium, Suffolk and District Network of U3As “Shaken not Stirred: The effects of Mechanical Stimulation (Exercise) on Bone” 17th May 2014, Ipswich.
National Osteoporosis Society, Falls & Bone Health Conference, “Exercise and Bone Health Research” 24th April 2014 and 11th September 2014, Ipswich.
British Nutrition Society “Role of Phytoestrogens in Bone Health” 25th July 2014, Newcastle.
8th International Workshop for Musculoskeletal and Neuronal Interactions
4th-7thMay 2012, Ipswich, UK. “Osteocytes and Mechanical Stimulation”
Geron Corporation, Menlo Park, USA. "Cell therapies for cartilage repair". September 2011.
Lloyds TSB Foundation for Scotland and Royal Society of Edinburgh
Ageing Population, 26th May 2006, Edinburgh, UK.
Royal Society of Edinburgh Christmas Lecture “What does your Granny have in common with a Spaceman?” James Watt College of Further Education, December 2004 and 2007.
British Orthopaedic Association, Instructional Course,
January 2004 Birmingham “GeneticAspects of Bone Disease”
EMBO Workshop – Genetics of Osteoporosis from Basic toClinical Research, Italy March 2001
“Collagen Genes and Osteoporosis”
European Federation of Endocrine Societies October 2001 Romania “The Genetics of Osteoporosis”
International Osteoporosis FoundationTraining Course, May 2000 Slovakia “The Genetics of Osteoporosis”
Washington University, December 1998 Seattle “COL1A1 Alleles, Gene Transcription, Collagen Production and Bone Strength”