Professor Tom Hutchinson

GeissC., Ruppert K., Askem C., Barroso C., Faber D., Ducrot V., Holbech H., Hutchinson T.H ., Kajankari P., Kinnberg K.L., LagadicL., Matthiessen P., Morris S., Neiman M., Penttinen O.P., Sanchez-Marin P.,Teigler M., Weltje L., Oehlmann J., 2017. Validation of the OECD reproductiontest guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz. Ecotoxicology26: 370-382

RuppertK., Geiss C., Askem C., Benstead R., Brown R., Coke M., DucrotV., Egeler P., Holbech H., Hutchinson T.H., Kinnberg K.L., Lagadic L.,Le Page G., Macken A., Matthiessen P., Ostermann S., Schimera A., Schmitt C.,Seeland-Fremer A., Smith A.J., Weltje L., Oehlmann J., 2017.  Development and validation of an OECDreproductive toxicity test guideline with the mudsnail Potamopyrgusantipodarum (Mollusca, Gastropoda). Chemosphere 181: 589-599

CharlesS., Ducrot V., Azam D., Benstead R., Brettschneider D., De Schamphelaere K.,Goncalves S.F., Green J.W., Holbech H., Hutchinson T.H., Faber D.,Laranjeiro D., Matthiessen P., Norrgren L., Oehlmann J., Reategui-Zirena E.,Seeland-Fremer A., Teigeler M., Thome J.P., Tobor Kaplon M., Weltje L., LagadicL., 2016.  Optimizing the design of areproduction toxicity test with the pond snail Lymnaea stagnalis. RegulatoryToxicology and Pharmacology 81: 47-56

RowettC., Comber S., Hutchinson T.H. 2016.The impact of natural and anthropogenic DOC and pH on the toxicity of triclosanto the crustacean Gammarus pulex. Science of the Total Environment 565: 222-231

HutchinsonT.H., Wheeler J.R., Gourmelon A., Burden N., 2016.  Promoting the 3Rs to enhance the OECD fishtoxicity testing framework.  RegulatoryToxicology & Pharmacology 76: 231-233

Kumar A.,Batley G., Nidumolu B., Hutchinson T.H .,2016.  Derivation of water qualityguidelines for priority pharmaceuticals. Environmental Toxicology & Chemistry 35: 1815-1824 

Hallett, K.,Atfield, A., Comber, S., Hutchinson T.H. , 2016.  Developmental toxicity of metaldehyde in theembryos of Lymnaea stagnalis (Gastropoda: Pulmonata) co-exposed to thesynergist piperonyl butoxide.  Scienceof the Total Environment 543: 37-43

Burden, N., BensteadR., Clook, M., Doyle, I., Edwards, P., Maynard, S.K., Ryder K., Sheahan, D.,Whale, G., van Egmond, R., Wheeler, J. Hutchinson, T.H. , 2015.  Advancing the 3Rs in regulatory ecotoxicology:a pragmatic cross-sector approach. Integrated Environmental Assessment &Management 12:417-421

HutchinsonT.H., Burden N.,2015.   In response: Benefits of theARRIVE guidelines for improving scientific reporting in ecotoxicology – anacademic perspective.  EnvironmentalToxicology & Chemistry 34: 2446-2448

Burden, N.,Sewell, F., Andersen, M.E., Boobis, A., Chipman, J.K., Cronin, M.T.D., Hutchinson,T.H. , Kimber I., Whelan, M. 2015. Adverse outcome pathways can drive non-animals approaches for safetyassessment. Journal of Applied Toxicology 35: 971-975

Ellis, R.P, Widdicombe,S., Parry H., Hutchinson T.H., Spicer J.I., 2015.  Pathogenic challenge reveals immunetrade-off in mussels exposed to reduced seawater pH and increasedtemperature.  Journal of ExperimentalMarine Biology & Ecology 462: 83-89 .

Ducrot V., AskemC., Azam D., Brettschneider D., Brown R., Charles S., Coke M., Collinet M.,Delignette-Muller M., Forfait-Dubuc C., Holbech H., Hutchinson T.H. , Jach A., Kinnberg KL., Lacoste C.,le Page G., Matthiessen P., Oehlmann J., Rice L., Roberts E., Ruppert K.,Elphinstone Davis J., Veauvy C., Weltje L., Wortham R., Lagadic L. 2014. Developmentand validation of an OECD reproductive toxicity test guideline with the pondsnail Lymnaea stagnalis (Mollusca: Gastropoda).  Regulatory Toxicology & Pharmacology70: 605-614

Villeneuve D., Crump D., Garcia-ReyeroN., Hecker M., Hutchinson T.H., LaLone C.A., Landesmann B., Lettieri T., Munn S., Nepalska M., OttingerMA., Vergauen L., Whelan M., 2014.  Adverse Outcome Pathway (AOP) DevelopmentI:  Strategies and Principles.  Toxicological Sciences, 142:  312-320. 

Villeneuve D., Crump D., Garcia-ReyeroN., Hecker M., Hutchinson T.H., LaLone C.A., Landesmann B., Lettieri T., Munn S., Nepalska M., OttingerMA., Vergauen L., Whelan M., 2014.Adverse Outcome Pathway (AOP) Development II: Best Practices. Toxicological Sciences, 142: 321-330. 

HutchinsonT.H., Naidoo, V.,Madden, J.C., Walker, C.H., 2014. Evaluating human and veterinary pharmaceutical impacts on wildlife:comparative metabolism and pharmacokinetics as a driver of species sensitivity. Phil. Trans. R. Soc. B 2014 369: 20130583

Gaw, S., Thomas, K.V., Hutchinson T.H., 2014.  Sources, impacts and trends of pharmaceuticalsin the marine and coastal environment.  Phil. Trans. R. Soc. B 2014 369:20130572

HutchinsonT.H. , Lyons B.P.,Thain J., Law R.J., 2013. Evaluating legacy contaminants and emerging chemicalsin marine environments using adverse outcome pathways and biologicaleffects-directed analysis. MarinePollution Bulletin 74: 517-525

Sanders M.B., Bean T.P., Hutchinson T.H., Le Quesne W.J.F.,2013.  Juvenile king scallop, Pecten maximus, to potentially tolerantto low levels of ocean acidification when food is unrestricted. PLoS ONE 8(9): e74118 doi:10.1371/journal.pone.0074118

Arnold K.E., BoxallA.B.A., Brown A.R., Cuthbert R.J., Gaw S., HutchinsonT.H., Jobling S., Madden J.C., Metcalfe C.D., Naidoo V., Shore R.F., SmitsJ.E., Taggart M.A., Thompson H.M. 2013 Assessing the exposure risk and impactsof pharmaceuticals in the environment on individuals and ecosystems. Biology Letters 9: 20130492

Jones H.S., Trollope H.T., Hutchinson T.H., Panter G.H., ChipmanK.J., 2012. Metabolism of ibuprofen in zebrafishlarvae. Xenobiotica42: 1069-1075

Bartram A.E., Winter M.J., Huggett D.B., McCormack P., Constantine L.A.,Hetheridge M.J., Hutchinson T.H., Kinter L.B., Ericson J.F., Sumpter J.P.,Owen S.F., 2012. Invivo and in vitro liver and gill EROD activity in rainbow trout exposed tothe beta-blocker propranolol. Environmental Toxicology & Chemistry 27: 573-582

Malham S.K., Hutchinson T.H., Longshaw M., 2012.  A review of the biology of European cockles (Cerastodermaspp). Journal of the MarineBiological Association of the UK 92(7): 1563-1577

David R.M., Jones, H.S., Panter G.H., Winter M.J., Hutchinson T.H.,Chipman K.J., 2012.  Interference with xenobioticmetabolic activity by the commonly used vehicle solvents dimethylsulfoxide andmethanol in zebrafish larvae but not Daphnia magna. Chemosphere 88: p.912-917

Ellis R.P., Parry H., Spicer J.I., Hutchinson T.H., Pipe, R.K.,Widdicombe, S., 2011. Immunological function in marine invertebrates: Responses toenvironmental perturbation Fish & Shellfish Immunology30: 1209-1222

Pope N.D., O'Hara S.C.M.,Imamura M., Hutchinson T.H., Langston W.J., 2011. Influence of a collapsed coastallandfill on metal levels in sediments and biota - a portent for the future? Journal of Environmental Monitoring 13:1961-1974

Celander M., Goldstone J.,Denslow N., Iguchi T., Kille P., Meyerhoff R., Smith B., Hutchinson T.H., Wheeler J.R., 2011. Species extrapolation for the21st century.  Environmental Toxicology and Chemistry 30: 52-63

Creton S., Douglas M.,Wheeler J.R., Hutchinson T.H., 2010.  Challenging the requirement for chronic fishtoxicity studies on formulated plant protection products.  ToxicologyLetters 199: 111-114

Panter G.H., Hutchinson T.H., Hurd K.S., Bamforth J.,Stanley R.D., Wheeler J.R., Tyler C.R., 2010. Effects of a weak oestrogenic active chemical(4-tert-pentylphenol) on pair-breeding and F1 development in the fatheadminnow. Aquatic Toxicology97: 314-323

Craft J.A., Gilbert J.A.,Temperton B., Dempsey K.E., Ashelford K., Tiwari B., Hutchinson T.H., Chipman J.K., 2010.  Pyrosequencing of Mytilus galloprovincialis cDNAs:tissue-specific expression patterns. PLoS One 5(1):e8875

Kádár E., Dashfield S., Hutchinson T.H., 2010. Developmental toxicity of benzotriazole in theprotochordate Ciona intestinalis(Chordata, Ascidiae). AnalyticalBioanalytical Chemistry 396: 641-647

Kádár E., Lowe D.M., SoléM., Fisher A.S., Jha A.N., Readman J.W., HutchinsonT.H. 2010. Uptake and biological responses tonano-Fe versus soluble FeCl3 in excised mussel gills.  AnalyticalBioanalytical Chemistry 396: 657-666

Solé M., Shaw J.P.,Frickers P.E., Readman J.W., HutchinsonT.H. 2010.  Effects on feeding rate and biomarker responses of marinemussels experimentally exposed to propranolol and acetaminophen.  AnalyticalBioanalytical Chemistry 396: 649-656

Küster A., Alder A.,Escher B., Duis K., Fenner K., Garric J., HutchinsonT.H., Lapen D., Duprey A., Römbke J., Snape J., Ternes T., Topp E., WehrmanA., Knacker T. 2010. Environmental risk assessment of human pharmaceuticals inthe European Union - a case study with the b -blocker atenolol. Integrated Environmental Assessment andManagement 6: 514-523

Schmitt H., Boucard T.,Garric J., Jensen J., Parrott J., Péry A., Römbke J., Straub J.O., Hutchinson T.H., Sánchez-Argüello P.,Wennmalm A., Duis K. 2010. Recommendations onthe environmental risk assessment of pharmaceuticals: Effect characterization.  IntegratedEnvironmental Assessment and Management 6: 588-602

Jones H.S., Panter G.H., Hutchinson T.H., Chipman J.K. 2010.  Oxidative andconjugative xenobiotic metabolism in zebrafish larvae in vivo. Zebrafish7: 23-30

Matthiessen P., Babut M., Batley G., Douglas M., Fawell J., Hommen U., HutchinsonT.H., Janssen M., Maycock D., Reiley M., Schneider U., Weltje L. 2009.Water and Sediment EQS Derivation and Application. In: Crane M., Matthiessen P.,Maycock D.S., Merrington G., Whitehouse P. (eds). Derivation and Use ofEnvironmental Quality and Human Health Standards for Chemical Substances inWater and Soil. CRC Press, Boca Raton. FL., USA. p. 47-103

Canty M.N., Hutchinson T.H., Brown R.J., Jones M.B.,Jha A.N. 2009. Linking genotoxic responses with cytotoxic and behavioural orphysiological consequences: differential sensitivity of echinoderms (Asteriasrubens) and marine molluscs (Mytilus edulis).  AquaticToxicology 94: 68–76

Jones H.S., Trollope H.T.,Hutchinson T.H., Panter G.H.,Chipman J.K. 2009. Assessment of anibuprofen metabolism by zebrafish larvae, using liquid chromatography-massspectrometry (LC-MS). Toxicology262: 14-15

Boxall A.B., Hardy A.,Beulke S., Boucard T., Burgin L., Falloon P.D., Haygarth P.M., Hutchinson T.H., Kovats R.S., LeonardiG., Levy L.S., Nichols G., Parsons S.A., Potts L., Stone D., Topp E., Turley D.B.,Walsh K., Wellington E.M., Williams R.J. 2009. Impacts of climate change on indirect human exposureto pathogens and chemicals from agriculture.  EnvironmentalHealth Perspectives 117: 508-514

Owen S.F., Huggett D.B., HutchinsonT.H., Hetheridge M.J., Kinter L.B., Ericson J.F., Sumpter J.P., 2009.  Uptakeof propranolol, a cardiovascular pharmaceutical, from water into fish plasma andits effects on growth and organ biometry.  Aquatic Toxicology 93: 217-224

Giltrow E., Eccles P.D.,Winter M.J., McCormack P.J., Rand-Weaver M., Hutchinson T.H., Sumpter J.P. 2009. Chronic effects assessment and plasma concentrationsof the beta-blocker propranolol in fathead minnows. Aquatic Toxicology 95:195-202

Hutchinson T.H. , Bögi C., Winter M.J., OwensJ.W. 2009.  Benefits of the MaximumTolerated Dose (MTD) and MaximumTolerated Concentration (MTC) concept in aquatic toxicology.  AquaticToxicology 91: 197–202

Hutchinson T.H. , Beesle y A., Frickers P.E., Readman J.W., S haw J.P., Straub J.O. 2009.  Extendingthe environmental risk assessment for oseltamivir (Tamiflu®) under pandemic useconditions to the coastal marine compartment.  Environment International 35: 931-936

Jones H.S., Panter G.H., Hutchinson T.H., Chipman K.J. 2008. Cytochrome P450sand glucuronosyl transferase in zebrafish larvae.  Toxicology253: 12-13

Hutchinson T.H. , Björklund C., Jönsson R.,Mahshid Y., Kenne K. 2008. Proteomic biomarkers for early stagephospholipidosis in human U937 cell lines. Toxicologyin Vitro 22: 1198–1204

Richards F.M., Alderton W.K.,Kimber G.M., Liu Z., Strang I., Redfern W.S., Valentin J.-P., Winter M.J., Hutchinson T.H. 2008. Validation of theuse of zebrafish larvae in visual safety assessment. J ournal of Pharmacological andToxicological Methods 58: 50-58

WinterM.J., Redfern W.S., Hayfield A.J., Owen S.F., Valentin J.-P., Hutchinson T.H.2008.  Validation of a larval zebrafish locomotor assay forassessing the seizure liability of early-stage development drugs.  Journal of Pharmacological and Toxicological Methods 57:176-187

Caldwell D., Mastrocco F.,Hutchinson T.H., Länge R., HeijerickD., Janssen C., Anderson P., Sumpter J. 2008. Derivation of an aquatic Predicted No-Effect-Concentration for thesynthetic hormone, 17 a -ethinylestradiol.  EnvironmentalScience & Technology  42:7046-7054

Pounds N.A., Maclean S.,Webley M., Pascoe D., Hutchinson T.H. 2008.  Acute and chronic effects of ibuprofen inthe freshwater mollusc Planorbis carinatus (Gastropoda: Planorbidae).  Ecotoxicology & Environmental Safety 70(1): 47-52

Hooper H.L., Connon R., Callaghan A., Fryer G., Yarwood-Buchanan S.,Biggs J., Maund S.J., Hutchinson T.H.,Sibly R.M. 2008.  The ecological niche of Daphnia magna characterized usingpopulation growth rate.  Ecology 89(4): 1015–1022

Winter M.J., Lillicrap A.D.,Caunter J.E., Schaffner C., Alder A.C., Ramil M., Ternes T.A., Giltrow E.,Sumpter J.P., Hutchinson T.H.  2008.  Assessment of development and reproduction infathead minnows exposed to atenolol. Aquatic Toxicology 86(3): 361-369

Heckmann L.H., Sibly R.M.,Connon R., Hooper H.L., Hutchinson T.H.,Maund S.J., Hill C.J., Bouetard A., Callaghan A. 2008.  Systems biology meets stress ecology: linkingmolecular and organismal stressresponses in Daphnia magna.  GenomeBiology 9:R40 (available from http://genomebiology.com/2008/9/2/R40)

Montforts M., Brandt I., HutchinsonT.H. 2007.  Summary of the DIA workshopon environmental assessment of human medicines: development and use of aquatictoxicity data.  Drug Information Journal 41: 203-209

Heckmann L.H., Callaghan A.,Hooper H.L., Connon R., Hutchinson T.H., Maund S.J., Sibly R.M. 2007. Chronictoxicity of ibuprofen to Daphnia magna: effects on life historytraits and population dynamics.  Toxicology Letters 172: 137-145

Winter M.J., Ellis L.C.J.,Hutchinson T.H. 2007.  Formationof micronuclei in erythrocytes of the fathead minnow after acute treatment withmitomycin C or cyclophosphamide. Mutation Research 629: 89-99

Owen S., Giltrow E.,Huggett D., Hutchinson T.H., Kinter L., Winter M.J., Sumpter J.P. 2007.Comparative physiology, pharmacology and toxicology of b -blockers: mammals versusfish.  Aquatic Toxicology 82:145-162

Williams T.D., Caunter J.E.,Lillicrap A.D., Hutchinson T.H., Gillings E.G., Duffell S. 2007.  Evaluation of the reproductive effects oftamoxifen citrate in partial and full life-cycle studies using fatheadminnows.  Environmental Toxicology andChemistry 26: 695-707

Hutchinson T.H. 2007.  Small is useful in endocrine disrupterassessment – four key recommendations for aquatic invertebrate research.  Ecotoxicology16: 231-238

Thorpe K.L., Benstead R., HutchinsonT.H., Tyler C.R. 2007.  Associations between altered vitellogeninconcentrations and adverse health effects in fathead minnow. Aquatic Toxicology 85: 176-183

Thorpe K.L., Benstead R., HutchinsonT.H., Tyler C.R. 2007. An optimised experimental test procedure formeasuring chemical effects on reproduction in the fathead minnow, Pimephales promelas. AquaticToxicology 81: 90-98

Hutchinson T.H. , Ankley G.T., Segner H.,Tyler C.R. 2006.  Screening and testingfor endocrine disruption in fish - biomarkers as “signposts not traffic lights”in risk assessment.  Environmental Health Perspectives 114 (Suppl 1): 106–114

Iguchi T., Irie F.,Urushitani H., Tooi O., Kawashima Y., Roberts M., Norrgren L., Hutchinson T.H.2006.   Availability of in vitro vitellogenin assay forscreening of estrogenic and anti-estrogenic activities of environmentalchemicals.  Environmental Sciences 13: 161-183

Crane H.M., Pickford D.B.,Hutchinson T.H., Brown J.A. 2006. The effects of methimazole on development of the fathead minnow fromembryo to adult.  Toxicological Sciences93: 278-285

Cunningham V.L., Buzby M.,Hutchinson T.H., Mastrocco F., Parke N., Roden N. 2006.  Effects of human pharmaceuticals on aquaticlife: next steps. Environmental Science andTechnology  40:  3456–3462

Heckmann L.H., Connon R., HutchinsonT.H., Maund S.J., Sibly R.M., Callaghan A. 2006.  Expression of target and reference genes in Daphnia magna exposed to ibuprofen.  BMC Genomics 2006, 7:175(article number #175)

Eidem J.K., Kleivdal H.,Kroll K., Denslow N., van Aerle R., Tyler C.R., Panter G.H., Hutchinson T.H.,Goksøyr A. 2006.  Development andvalidation of a direct homologous quantitative sandwich ELISA for fatheadminnow vitellogenin. Aquatic Toxicology 78:202–206

Noël H., Hopkin S., HutchinsonT.H., Williams T.D., Sibly R. 2006. Population growth rate and carryingcapacity for springtails Folsomia candidaexposed to ivermectin. EcologicalApplications 16: 656–665

Noël H., Hopkin S., HutchinsonT.H., Williams T.D., Sibly R. 2006.  Towardsa population ecology of stressed environments: the effects of zinc on thespringtail Folsomia candida. Journal of Applied Ecology 43: 325–332

Hooper H.L., Connon R.,Callaghan A., Maund S.J., Liess M., Duquesne S., Hutchinson T.H., Moggs J., Sibly R., 2006.  The use of image analysis to estimatepopulation growth rate in Daphnia magna.  Journalof Applied Ecology 43: 828-834

Hutchinson T.H. , Shillabeer N., Winter M.J.,Pickford D.B. 2006. Acute and chronic effects of carrier solvents in aquaticorganisms: a critical review.  Aquatic Toxicology 76(1): 69-92

Jeram S., Riego Sintes J.M.,Halder M., Baraibar Fentanes J., Sokull-Klüttgen B.,  Hutchinson T.H. 2005.  Astrategy to reduce the use of fish in acute ecotoxicity testing of new chemicalsubstances notified in the European Union.  RegulatoryToxicology and Pharmacology 42: 218-224

Brown R.J., Rundle S.D., HutchinsonT.H., Williams T.D., Jones M.B. 2005. A microplate freshwater copepod bioassay for evaluating acute andchronic effects of chemicals.  Environmental Toxicology and Chemistry24: 1528–1531

Crane H., Pickford D.B., HutchinsonT.H., Brown J.A. 2005.  Effects ofammonium perchlorate on thyroid function in developing fathead minnows. Environmental Health Perspectives 113:396–401

Hooper H.L., Sibly R.M., HutchinsonT.H., Maund S.J. 2005. Joint effects of density and a growth inhibitor onthe life history and population growth rate of the midge Chironomus riparius.  Environmental Toxicology and Chemistry 24:1140-1145

Knacker T., Duis K.,Ternes T., Fenner K., Escher B., Schmitt H., Römbke J., Garric J., HutchinsonT.H., Boxall A.B.A. 2005.  TheEU-project ERAPharm: incentives for the further development of guidancedocuments? Environmental Science &Pollution Research 12: 62 – 65

Snape J.R., Maund S.J.,Pickford D.B., Hutchinson T.H.  2004.  Ecotoxicogenomics:the challenge of integrating genomics into aquatic and terrestrialecotoxicology.  Aquatic Toxicology 67: 143-154

PanterG.H., Hutchinson T.H. , HurdK.S., Sherren A., Stanley R.D., Tyler C.R. 2004. Successful detection of(anti-)androgenic and aromatase inhibitors in pre-spawning adult fatheadminnows using easily measured endpoints of sexual development.   Aquatic Toxicology 70(1):11-21

Thomas-Jones E., Thorpe K.L.,Harrison N., Thomas G., Morris C., Hutchinson T.H., Woodhead S., Tyler C.R.2003.  Dynamics of estrogen biomarkerresponses in rainbow trout exposed to 17 b -oestradiol and 17 a -ethinylestradiol.  Environmental Toxicology and Chemistry 22: 3001-3008

WallisN.T., Smith F.M., Panter G.H., HutchinsonT.H. 2003.  Laboratory fish gonadalsex differentiation: a comparison of fathead minnow, sheepshead minnow andzebrafish. Toxicology Sciences 72:192-193

HooperH.L., Sibly R.M., Hutchinson T.H., Maund S.J. 2003.  The influence of larval density, foodavailability and habitat longevity on the life history and population growthrate of the midge, Chironomus riparius.  Oikos 102: 515-524

HooperH.L., Sibly R.M., Maund S.J., Hutchinson T.H. 2003.  The joint effects of larval density and 14C-cypermethrinon the life history and population growth rate of the midge, Chironomus riparius.  Journalof Applied Ecology 40: 1049-1059

ThorpeK.L., Cummings R.I., Hutchinson T.H., Scholze M., Brighty G., Sumpter J.P.,Tyler C.R. 2003.  Relative potencies andcombination effects of steroidal oestrogens in fish.  EnvironmentalScience & Technology 37: 1142-1149

ThorpeK.L., Benstead R., Hutchinson T.H., Cummings R.I., Tyler C.R. 2003.Reproductive effects of exposure to oestrone in the fathead minnow.  FishPhysiology & Biochemistry 28: 451-452

Hutchinson T.H. , Barrett S., Busby M.,Constable D., Hartmann A., Hayes E., Huggett D., Länge R., Lillicrap A.D., Straub J.O., Thompson R.S. 2003.  Astrategy to reduce the numbers of fish used in acute ecotoxicity testing ofpharmaceuticals.  Environmental Toxicology andChemistry 22: 3031-3036

Pickford D.B., HetheridgeM.J., Caunter J.E., Tilghman Hall A., Hutchinson T.H. 2003.  Assessing chronic toxicity of bisphenol A tolarvae of the African clawed frog (Xenopuslaevis) in a flow-through exposure system. Chemosphere 53: 223-235

Brown R.J., Rundle S.D., HutchinsonT.H., Williams T.D., Jones M.B. 2003. Small-scale detritus-invertebrate interactions: influence of detritalbiofilm composition on development and reproduction in a meiofaunalcopepod.  Archives of Hydrobiology 157: 117-129

Brown A.R., Riddle A.M.,Cunningham N.L., Kedwards T.J., Shillabeer N., Hutchinson T.H. 2003.  Predicting the effects of endocrinedisrupting chemicals on fish populations. Human & Ecological RiskAssessment 9: 761-788

HutchinsonT.H. , Field M.D.R., Manning M.J. 2003.  E valuation of non-specific immune functions in dab, Limanda limanda (L.), following short-term exposure to sediments contaminated withpolyaromatic hydrocarbons and/or polychlorinated biphenyls.  Marine Environmental Research 55:193-202

BrownR.J., Rundle S., Hutchinson T.H., Williams T.D., Jones M.B. 2003.  A copepod life-cycle test and growth model for interpreting theeffects of lindane.  Aquatic Toxicology 63: 1–11

Hutchinson T.H. , Pickford D.B. 2003.  Ecological risk assessment and testing forendocrine disruption in the aquatic environment.  Toxicology181-182C: 383-387

van Aerle R., Pounds N., HutchinsonT.H., Maddix S., Tyler C.R. 2002.  Windowsof sensitivity for the oestrogenic effects of ethynylestradiol in early life stagesof the fathead minnow.  Ecotoxicology11: 423-434

Pounds N.A., HutchinsonT.H., Williams T.D., Whiting P., Dinan L. 2002. Assessment of putativeendocrine disrupters in an in vivo crustaceanassay and an in vitro insectassay.  Marine Environmental Research 54: 709-713

Dinan L., Bourne P., CaryF., Whiting P., Harmatha J., Lafont R., Marion-Poll F., Dhadialla T.S., HormannR.E., Hutchinson T.H. 2002. Structure-activity studies on natural andnon-natural ligands for ecdysteroid receptors. Journal of Insect Science 2.16: 5-6

Matthiessen P., Allen Y.,Bamber S., Craft J., Hurst M., Hutchinson T.H., Feist S., Katsiadaki I.,Kirby M., Robinson C., Scott A.P., Thain J.E., Thomas K. 2002.  The impact ofoestrogenic and androgenic contamination on marine organisms in the UK –summary of the EDMAR programme.  Marine Environmental Research 54:645-649

Hutchinson T.H. 2002.  Impacts of endocrine disrupters on fishdevelopment: opportunities for adapting OECD Test Guideline 210.  EnvironmentalSciences 9: 439-450

Hutchinson T.H. 2002. Reproductive anddevelopmental effects of endocrine disrupters in invertebrates: in vitro and in vivo approaches.  ToxicologyLetters 131:75-81

Zerulla M., Länge R.,Steger-Hartmann T., Panter G.H., Hutchinson T.H., Dietrich D.R. 2002.  Morphological sex reversal upon short-termexposure to endocrine modulators in juvenile fathead minnow. ToxicologyLetters 131:51-63

Panter G.H., HutchinsonT.H., Länge R., Lye C., Sumpter J.P., Zerulla M., Tyler C.R. 2002.  Utility of a juvenile fathead minnowscreening assay for detecting (anti-)estrogenic substances.  Environmental Toxicology and Chemistry 21: 319-326

HalmS., Pounds N.A., Maddix S., Rand-Weaver M., Sumpter J.P., Hutchinson T.H., Tyler C.R. 2002. Exposure to exogenous 17-oestradiol disrupts P450aromB mRNA expressionin the brain and gonad of adult fathead minnows. Aquatic Toxicology 60(3-4):285-299

TylerC.R., van Aerle R., Nilsen M.B., Blackwell R., Maddix S., Nilsen B.M., Berg K.,Hutchinson T.H., Goksoyr A. 2002. Development and validation of a monoclonal ELISA to quantifyvitellogenin in the rainbow trout and its application for studies onenvironmental oestrogens. EnvironmentalToxicology and Chemistry 21: 47-54

ThorpeK.L., Hutchinson T.H., Hetheridge M.J., Scholze M., Sumpter J.P., Tyler C.R. 2001.  Assessing the interactive effects of binarymixtures of environmental oestrogens in rainbow trout using vitellogenininduction. Environmental Science &Technology 35: 2476-2481

Dinan L., BourneP., Whiting P., Dhadialla T.S., Hutchinson T.H.  2001.  Screeningof environmental contaminants for ecdysteroid agonist and antagonist activityusing the Drosophila melanogaster BIIcell in vitro assay. EnvironmentalToxicology and Chemistry 20:2038-2046

Länge R., Hutchinson T.H.,Croudace C.P., Siegmund F., Schweinfurth H., Hampe P., Panter G.H., Sumpter J.P.2001.  Effects of the synthetic oestrogen17 a -ethinylestradiol over the life-cycle of the fathead minnow. EnvironmentalToxicology and Chemistry 20:1216 – 1227

Hutchinson T.H. , Brown R., Brugger K.E.,Campbell P.M., Holt M., Länge R., McCahon P., Tattersfield L.J., van Egmond R.2000. Ecological risk assessment of endocrine disruptors. Environmental Health Perspectives 108: 1007-1014

Thorpe K.L., Hetheridge M.J.,Hutchinson T.H., Tyler C.R. 2000. Development of an in vivoscreening assay for estrogenic chemicals using juvenile rainbow trout (Oncorhynchus mykiss). Environmental Toxicology and Chemistry 19: 2812-2820

Hutchinson T.H. , Matthiessen P. 1999.  Endocrine disruption and wildlife:identification and ecological relevance. Science of the Total Environment 233:1-3

Hutchinson T.H. , Pounds N.A., Hampel M.,Williams T.D. 1999.  Impact of naturaland synthetic steroids on the survival, developmental and reproduction ofmarine copepods Tisbe battagliai.  Science of the Total Environment 233:167-179

Hutchinson T.H. , Field M.D.R., Manning M.J.1999.  Evaluation of immune function injuvenile turbot (Scopthalmus maximusL.) exposed to sediments contaminated with polychlorinated biphenyls.  Fishand Shellfish Immunology 9: 457-472

Hutchinson T.H. , Pounds N.A., Hampel M.,Williams T.D. 1999.  Life-cycle studieswith marine copepods (Tisbe battagliai)exposed to 20-hydroxyecdysone and diethylstilbestrol. Environmental Toxicology and Chemistry 18: 2914-2920

Tyler C.R., van Aerle R., HutchinsonT.H., Maddix S., Trip H. 1999.  An in vivo testing system for endocrinedisruptors in fish early life-stages using induction of vitellogenin. Environmental Toxicology and Chemistry 18:337-347

Hutchinson T.H. , Jha A.N., Mackay J.M.,Elliott B.M., Dixon D.R. 1998.  Evaluationof the genotoxicity of disinfected sewage effluent using the marine worm Platynereis dumerilii (Polychaeta:Nereidae).  Mutation Research 399: 97-108

Campbell P.M., HutchinsonT.H. 1998.  Wildlife and endocrinedisrupters: requirements for hazard identification.  EnvironmentalToxicology and Chemistry 17: 127-135

Ankley G., Hutchinson T.H., … plus 28 workshop co-authors (1998)Overview of a workshop on screening methods for detecting potential (anti-)estrogenic/androgenic chemicals in wildlife. Environmental Toxicology andChemistry 17: 68 – 87

Solbé J.F., Mark U., BuyleB., Guhl W., Hutchinson T.H., Kloepper-Sams P.J., Länge R., Munk R.,Scholz N., Bontinck W., Niessen H. 1998. Analysis of the ECETOC Aquatic Toxicity (EAT) Database. I.  General Introduction.  Chemosphere36: 99-113

Länge R., Hutchinson T.H.,Scholz N., Solbé J.F. 1998.  Analysis ofthe ECETOC Aquatic Toxicity (EAT) Database. II. Comparison of acute to chronicratios for various aquatic organisms and chemical substances.  Chemosphere36: 115-127

Hutchinson T.H. , Solbé J.F.,Kloepper-Sams P.J. 1998.  Analysis of theECETOC Aquatic Toxicity (EAT) Database. III. Comparative toxicity of chemicalsubstances to different life stages of aquatic organisms.  Chemosphere36: 129-142

Hutchinson T.H. , Scholz N., Guhl W. 1998.  Analysis of the ECETOC Aquatic Toxicity (EAT)Database. IV. Comparative toxicity of chemical substances to freshwater versussaltwater organisms.  Chemosphere 36: 143-153

Palau-Casellas A., Hutchinson T.H. 1998.  Acute toxicity of chlorinated organicchemicals to the embryos and larvae of the marine worm Platynereis dumerilii (Polychaeta: Nereidae).  EnvironmentalToxicology and Water Quality 13: 149-155

Hutchinson T.H. , Hutchings M.J., Moore K.W.1997.  A review of the effects of bromateon aquatic organisms and toxicity of bromate to oyster embryos. Ecotoxicology and Environmental Safety 38: 238 – 243

Carissan F.M., HutchinsonT.H., Beaumont A.R., Pipe R.K. 1997. Investigation of the effects of sodium pentachlorophenol on the immunesystem of marine mussels. Developmentaland Comparative Immunology 21: 125-126

Jha A.N., Hutchinson T.H.,Mackay J.M., Elliott B.M., Dixon D.R. 1997. Evaluation of the genotoxicity of municipal sewage effluent using themarine worm Platynereis dumerilii(Polychaeta: Nereidae).  Mutation Research 391: 179-188

Hutchinson T.H. , Manning M.J. 1996.  Effects of cadmium on marine fish (Limanda limanda L.) kidney phagocytechemiluminescence.  Marine Environmental Research 41: 327-342

Hutchinson T.H. , Manning M.J. 1996.  Seasonal trends in serum total protein andlysozyme activity in marine fish (Limandalimanda L.) from Lyme Bay.  Fish and Shellfish Immunology 6: 473-482

Jha A.N., Hutchinson T.H.,Mackay J.M., Elliott B.M., Dixon D.R. 1996. Development of an in vivomarine genotoxicity test with Platynereisdumerilii (Polychaeta: Nereidae).  Mutation Research 359: 141-150

Hutchinson T.H. , Jha A.N., Dixon D.R.1995.  The polychaete Platynereis dumerilii: a new species forassessing the hazardous potential of chemicals in the marine environment.  Ecotoxicologyand Environmental  Safety  31: 271-281

Jha A.N., Hutchinson T.H.,Mackay J.M., Elliott B.M., Pascoe P., Dixon D.R. 1995.  The chromosomes of Platynereis dumerilii (Polychaeta: Nereidae).  Journalof the Marine Biological Association of the UK 75: 551-562

Jha A.N., Dominquez I.,  Balajee A.S., Hutchinson T.H., Dixon D.R.,Natarajan A.T. 1995.  Localization oftelomeric chromosome regions in two species of marine polychaete. Chromosome Research 3: 507-508

Field M.D.R., HutchinsonT.H., Manning M.J. 1995.  Developmentof adherence techniques for collecting kidney phagocytes from marine fish (Limanda limanda L.).  Fishand Shellfish Immunology 5: 505-517

Van Wijk D., Hutchinson T.H. 1995.  Theecotoxicity of chlorate to aquatic organisms: a critical review. Ecotoxicology and Environmental Safety32: 244-253

Hutchinson T.H. , Williams T.D. 1994.  Culturing of fathead minnow larvae foraquatic toxicity testing: an observational note.  EnvironmentalToxicology and Chemistry 13: 665‑669

Hutchinson T.H. , Williams T.D., Eales G.J.1994.  Toxicity of cadmium, hexavalentchromium and copper to marine fish larvae (Cyprinodonvariegatus) and copepods (Tisbebattagliai).  Marine Environmental Research 38: 275‑290

Williams T.D., HutchinsonT.H., Roberts G.C., Coleman C.A. 1993. The assessment of industrial effluent toxicity using aquaticmicroorganisms, invertebrates and fish.  Science of the Total Environment,supplement 1993 (part 2): 1129‑1141

Solbé J.F., Buyle B., GuhlW., Hutchinson T.H., Länge R., Mark U., Munk R., Scholz N. 1993.  Developing hazard identification for theaquatic environment.  Science of the Total Environment,supplement 1993 (part 1): 47-61

Simpson M.G., HutchinsonT.H. 1992.  Toxicological pathologyof dab Limanda limanda alongpollution gradients in the southern North Sea. Marine Ecology Progress Series 91:155-161

HutchinsonT.H. , Williams T.D. 1989. The use of sheepshead minnow (Cyprinodonvariegatus) larvae and a benthic marine copepod (Tisbe battagliai) in short-term tests for estimating the chronictoxicity of industrial effluents.  Hydrobiologia 188: 567-572