Articles
Coady K, Browne P, Embry M, Hill T, Leinala E, Steeger T, Maslankiewicz L & Hutchinson T
2019
'When Are Adverse Outcome Pathways and Associated Assays “Fit for Purpose” for Regulatory Decision‐Making and Management of Chemicals?'
Integrated Environmental Assessment and Management
15,
(4)
633-647
, DOI
Parsons A, Lange A, Hutchinson TH, Miyagawa S, Iguchi T, Kudoh T & Tyler CR
2019
'Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio)'
Aquatic Toxicology
209,
99-112
Author Site
, DOI
PEARL
Eagles EJ, Benstead R, MacDonald S, Handy R & Hutchinson TH
2018
'Impacts of the mycotoxin zearalenone on growth and photosynthetic responses in laboratory populations of freshwater macrophytes (Lemna minor) and microalgae (Pseudokirchneriella subcapitata)'
Ecotoxicology and Environmental Safety
169,
225-231
Author Site
, DOI
PEARL
Tatsi K, Shaw BJ, Hutchinson TH & Handy RD
2018
'Copper accumulation and toxicity in earthworms exposed to CuO nanomaterials: Effects of particle coating and soil ageing'
Ecotoxicology and Environmental Safety
166,
462-473
Author Site
, DOI
PEARL
Van den Brink PJ, Boxall ABA, Maltby L, Brooks BW, Rudd MA, Backhaus T, Spurgeon D, Verougstraete V, Ajao C & Ankley GT
2018
'Toward sustainable environmental quality: Priority research questions for Europe'
Environmental Toxicology and Chemistry
, DOI
PEARL
Sewell F, Gellatly N, Beaumont M, Burden N, Currie R, de Haan L, Hutchinson TH, Jacobs M, Mahony C & Malcomber I
2018
'The future trajectory of adverse outcome pathways: a commentary'
Archives of Toxicology
92,
(4)
1657-1661
Author Site
, DOI
PEARL
Burden N, Gellatly N, Benstead R, Benyon K, Blickley TM, Clook M, Doyle I, Edwards P, Handley J & Katsiadaki I
2017
'Reducing repetition of regulatory vertebrate ecotoxicology studies'
Integrated Environmental Assessment and Management
13,
(5)
955-957
, DOI
Brockmeier EK, Hodges G, Hutchinson TH, Butler E, Hecker M, Tollefsen KE, Garcia-Reyero N, Kille P, Becker D & Chipman K
2017
'The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment'
Toxicological Sciences
158,
(2)
252-262
, DOI
PEARL
Ruppert K, Geiß C, Askem C, Benstead R, Brown R, Coke M, Ducrot V, Egeler P, Holbech H & Hutchinson TH
2017
'Development and validation of an OECD reproductive toxicity test guideline with the mudsnail Potamopyrgus antipodarum (Mollusca, Gastropoda)'
Chemosphere
181,
589-599
, DOI
PEARL
Geiß C, Ruppert K, Askem C, Barroso C, Faber D, Ducrot V, Holbech H, Hutchinson TH, Kajankari P & Kinnberg KL
2017
'Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz'
Ecotoxicology
26,
(3)
370-382
, DOI
PEARL
Kumar A, Batley GE & Hutchinson TH
2016
'The authors’ reply'
Environmental Toxicology and Chemistry
35,
(10)
2395-2396
, DOI
Charles S, Ducrot V, Azam D, Benstead R, Brettschneider D, De Schamphelaere K, Filipe Goncalves S, Green JW, Holbech H & Hutchinson TH
2016
'Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis'
Regulatory toxicology and pharmacology : RTP
PEARL
Burden N, Benstead R, Clook M, Doyle I, Edwards P, Maynard SK, Ryder K, Sheahan D, Whale G & van Egmond R
2016
'Advancing the 3Rs in regulatory ecotoxicology: A pragmatic cross-sector approach'
Integrated Environmental Assessment and Management
12,
(3)
417-421
, DOI
PEARL
Comber SDW, Rowett C & Hutchinson T
2016
'The impact of natural and anthropogenic Dissolved Organic Carbon (DOC), and pH on the toxicity of triclosan to the crustacean Gammarus pulex (L.)'
Science of the Total Environment
565,
222-231
, DOI
PEARL
Kumar A, Batley GE, Nidumolu B & Hutchinson TH
2016
'Derivation of water quality guidelines for priority pharmaceuticals'
Environmental Toxicology and Chemistry
35,
(7)
1815-1824
, DOI
PEARL
Hutchinson TH, Wheeler JR, Gourmelon A & Burden N
2016
'Promoting the 3Rs to enhance the OECD fish toxicity testing framework'
Regulatory toxicology and pharmacology : RTP
76,
231-233
, DOI
PEARL
Hallett KC, Atfield A, Comber S & Hutchinson TH
2016
'Developmental toxicity of metaldehyde in the embryos of Lymnaea stagnalis (Gastropoda: Pulmonata) co-exposed to the synergist piperonyl butoxide'
Science of The Total Environment
543,
37-43
, DOI
PEARL
Hutchinson TH & Burden N
2015
'In Response: Benefits of the ARRIVE guidelines for improving scientific reporting in ecotoxicology-An academic perspective'
Environmental Toxicology and Chemistry
34,
(11)
2446-2448
, DOI
Burden N, Sewell F, Andersen ME, Boobis A, Chipman JK, Cronin MTD, Hutchinson TH, Kimber I & Whelan M
2015
'Adverse Outcome Pathways can drive non-animal approaches for safety assessment'
Journal of Applied Toxicology
35,
(9)
971-975
, DOI
PEARL
Ellis RP, Widdicombe S, Parry H, Hutchinson TH & Spicer JI
2015
'Pathogenic challenge reveals immune trade-off in mussels exposed to reduced seawater pH and increased temperature'
JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
462,
83-89
Author Site
, DOI
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S & Nepelska M
2014
'Adverse outcome pathway (AOP) development I: strategies and principles'
Toxicol Sci
142,
(2)
312-320
Author Site
, DOI
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S & Nepelska M
2014
'Adverse outcome pathway development II: best practices'
Toxicol Sci
142,
(2)
321-330
Author Site
, DOI
Ducrot V, Askem C, Azam D, Brettschneider D, Brown R, Charles S, Coke M, Collinet M, Delignette-Muller M-L & Forfait-Dubuc C
2014
'Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)'
Regulatory Toxicology and Pharmacology
70,
(3)
605-614
, DOI
Hutchinson TH, Madden JC, Naidoo V & Walker CH
2014
'Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals'
Philos Trans R Soc Lond B Biol Sci
369,
(1656)
Author Site
, DOI
Gaw S, Thomas KV & Hutchinson TH
2014
'Sources, impacts and trends of pharmaceuticals in the marine and coastal environment'
Philos Trans R Soc Lond B Biol Sci
369,
(1656)
Author Site
, DOI
Sanders MB, Bean TP, Hutchinson TH & Le Quesne WJF
2013
'Juvenile King Scallop, Pecten maximus, Is Potentially Tolerant to Low Levels of Ocean Acidification When Food Is Unrestricted'
PLoS ONE
8,
(9)
e74118-e74118
, DOI
PEARL
Hutchinson TH, Lyons BP, Thain JE & Law RJ
2013
'Evaluating legacy contaminants and emerging chemicals in marine environments using adverse outcome pathways and biological effects-directed analysis'
Marine Pollution Bulletin
n/a,
(n/a)
, DOI
David RM, Jones HS, Panter GH, Winter MJ, Hutchinson TH & Kevin Chipman J
2012
'Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna'
Chemosphere
88,
(8)
912-917
, DOI
Malham SK, Hutchinson TH & Longshaw M
2012
'A review of the biology of European cockles (Cerastoderma spp.)'
Journal of the Marine Biological Association of the United Kingdom
92,
(7)
1563-1577
, DOI
Jones HS, Trollope HT, Hutchinson TH, Panter GH & Chipman JK
2012
'Metabolism of ibuprofen in zebrafish larvae'
Xenobiotica
42,
(11)
1069-1075
, DOI
Giltrow E, Eccles PD, Hutchinson TH, Sumpter JP & Rand-Weaver M
2011
'Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas)'
General and Comparative Endocrinology
173,
(3)
483-490
, DOI
Ellis RP, Parry H, Spicer JI, Hutchinson TH, Pipe RK & Widdicombe S
2011
'Immunological function in marine invertebrates: responses to environmental perturbation'
Fish Shellfish Immunol
30,
(6)
1209-1222
Author Site
, DOI
Bartram AE, Winter MJ, Huggett DB, McCormack P, Constantine LA, Hetheridge MJ, Hutchinson TH, Kinter LB, Ericson JF & Sumpter JP
2011
'In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol'
Environmental Toxicology
27,
(10)
573-582
, DOI
Pope ND, O'Hara SCM, Imamura M, Hutchinson TH & Langston WJ
2011
'Influence of a collapsed coastal landfill on metal levels in sediments and biota—a portent for the future?'
Journal of Environmental Monitoring
13,
(7)
1961-1961
, DOI
Creton S, Douglas M, Wheeler JR & Hutchinson TH
2010
'Challenging the requirement for chronic fish toxicity studies on formulated plant protection products'
Toxicology Letters
199,
(2)
111-114
, DOI
Celander MC, Goldstone JV, Denslow ND, Iguchi T, Kille P, Meyerhoff RD, Smith BA, Hutchinson TH & Wheeler JR
2010
'Species extrapolation for the 21st century'
Environmental Toxicology and Chemistry
30,
(1)
52-63
, DOI
Owen SF, Huggett DB, Hutchinson TH, Hetheridge MJ, McCormack P, Kinter LB, Ericson JF, Constantine LA & Sumpter JP
2010
'The value of repeating studies and multiple controls: replicated 28-day growth studies of rainbow trout exposed to clofibric acid'
Environmental Toxicology and Chemistry
29,
(12)
2831-2839
, DOI
Küster A, Alder AC, Escher BI, Duis K, Fenner K, Garric J, Hutchinson TH, Lapen DR, Péry A & Römbke J
2010
'Environmental risk assessment of human pharmaceuticals in the European Union: A case study with the β-blocker atenolol'
Integr Environ Assess Manag
6 Suppl,
514-523
Author Site
, DOI
Schmitt H, Boucard T, Garric J, Jensen J, Parrott J, Péry A, Römbke J, Straub JO, Hutchinson TH & Sánchez-Argüello P
2010
'Recommendations on the environmental risk assessment of pharmaceuticals: Effect characterization'
Integr Environ Assess Manag
6 Suppl,
588-602
Author Site
, DOI
Panter GH, Hutchinson TH, Hurd KS, Bamforth J, Stanley RD, Wheeler JR & Tyler CR
2010
'Effects of a weak oestrogenic active chemical (4-tert-pentylphenol) on pair-breeding and F1 development in the fathead minnow (Pimephales promelas)'
Aquatic Toxicology
97,
(4)
314-323
, DOI
Boxall A, Hardy A, Beulke S, Boucard T, Burgin L, Falloon P, Haygarth P, Hutchinson T, Kovats S & Leonardi G
2010
'Impacts of climate change on indirect human exposure to pathogens and chemicals from agriculture'
Ciência & Saúde Coletiva
15,
(3)
743-756
, DOI
Zhou J, Cai Z-H, Li L, Gao Y-F & Hutchinson TH
2010
'A proteomics based approach to assessing the toxicity of bisphenol A and diallyl phthalate to the abalone (Haliotis diversicolor supertexta)'
CHEMOSPHERE
79,
(5)
595-604
Author Site
, DOI
Jones HS, Panter GH, Hutchinson TH & Chipman JK
2010
'Oxidative and Conjugative Xenobiotic Metabolism in Zebrafish Larvae In Vivo'
Zebrafish
7,
(1)
23-30
, DOI
Craft JA, Gilbert JA, Temperton B, Dempsey KE, Ashelford K, Tiwari B, Hutchinson TH & Chipman JK
2010
'Pyrosequencing of Mytilus galloprovincialis cDNAs: Tissue-Specific Expression Patterns'
PLOS ONE
5,
(1)
Author Site
, DOI
PEARL
Kadar E, Dashfield S & Hutchinson TH
2010
'Developmental toxicity of benzotriazole in the protochordate Ciona intestinalis (Chordata, Ascidiae)'
Anal Bioanal Chem
396,
(2)
641-647
Author Site
, DOI
Tyler CR, van Aerle R, Nilsen MV, Blackwell R, Maddix S, Nilsen BM, Berg K, Hutchinson TH & Goksøyr A
2009
'Monoclonal antibody enzyme-linked immunosorbent assay to quantify vitellogenin for studies on environmental estrogens in the rainbow trout (Oncorhynchus mykiss)'
Environmental Toxicology and Chemistry
21,
(1)
47-54
, DOI
Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH & Sumpter JP
2009
'Chronic effects assessment and plasma concentrations of the β-blocker propranolol in fathead minnows (Pimephales promelas)'
Aquatic Toxicology
95,
(3)
195-202
, DOI
Solé M, Shaw JP, Frickers PE, Readman JW & Hutchinson TH
2009
'Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen'
Anal Bioanal Chem
396,
(2)
649-656
Author Site
, DOI
Kádár E, Lowe DM, Solé M, Fisher AS, Jha AN, Readman JW & Hutchinson TH
2009
'Uptake and biological responses to nano-Fe versus soluble FeCl3 in excised mussel gills'
Anal Bioanal Chem
396,
(2)
657-666
Author Site
, DOI
Canty MN, Hutchinson TH, Brown RJ, Jones MB & Jha AN
2009
'Linking genotoxic responses with cytotoxic and behavioural or physiological consequences: differential sensitivity of echinoderms (Asterias rubens) and marine molluscs (Mytilus edulis)'
Aquat Toxicol
94,
(1)
68-76
Author Site
, DOI
Hutchinson TH, Beesley A, Frickers PE, Readman JW, Shaw JP & Straub JO
2009
'Extending the environmental risk assessment for oseltamivir (Tamiflu®) under pandemic use conditions to the coastal marine compartment'
Environment International
35,
(6)
931-936
, DOI
Jones HS, Trollope HT, Hutchinson TH, Panter GH & Chipman JK
2009
'Assessment of an ibuprofen metabolism by zebrafish larvae, using liquid chromatography–mass spectrometry (LC–MS)'
Toxicology
262,
(1)
14-15
, DOI
Owen SF, Huggett DB, Hutchinson TH, Hetheridge MJ, Kinter LB, Ericson JF & Sumpter JP
2009
'Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry'
Aquatic Toxicology
93,
(4)
217-224
, DOI
Boxall ABA, Hardy A, Beulke S, Boucard T, Burgin L, Falloon PD, Haygarth PM, Hutchinson T, Kovats RS & Leonardi G
2009
'Impacts of Climate Change on Indirect Human Exposure to Pathogens and Chemicals from Agriculture'
Environmental Health Perspectives
117,
(4)
508-514
, DOI
PEARL
Boxall ABA, Hardy A, Beulke S, Boucard T, Burgin L, Falloon PD, Haygarth PM, Hutchinson TH, Kovats RS & Leonardi G
2009
'Impacts of Climate Change on Indirect Human Exposure to Pathogens and Chemicals from Agriculture'
Envionmental Health Perspectives
117,
(4)
508-514
, DOI
Hutchinson TH, Bögi C, Winter MJ & Owens JW
2009
'Benefits of the maximum tolerated dose (MTD) and maximum tolerated concentration (MTC) concept in aquatic toxicology'
Aquat Toxicol
91,
(3)
197-202
Author Site
, DOI
Singer AC, Howard BM, Johnson AC, Knowles CJ, Jackman S, Accinelli C, Caracciolo AB, Bernard I, Bird S & Boucard T
2008
'Meeting Report: Risk Assessment of Tamiflu Use Under Pandemic Conditions'
Environmental Health Perspectives
116,
(11)
1563-1567
, DOI
PEARL
Caldwell DJ, Mastrocco F, Hutchinson TH, La¨nge R, Heijerick D, Janssen C, Anderson PD & Sumpter JP
2008
'Derivation of an Aquatic Predicted No-Effect Concentration for the Synthetic Hormone, 17α-Ethinyl Estradiol'
Environmental Science & Technology
42,
(19)
7046-7054
, DOI
Hutchinson TH, Mahshid Y, Jönsson R, Björklund C & Kenne K
2008
'Proteomic analysis of phospholipidosis in citalopram treated U937 cells – Support for the cholesterol biosynthesis hypothesis'
Toxicology in Vitro
22,
(5)
1198-1204
, DOI
Richards FM, Alderton WK, Kimber GM, Liu Z, Strang I, Redfern WS, Valentin J-P, Winter MJ & Hutchinson TH
2008
'Validation of the use of zebrafish larvae in visual safety assessment'
Journal of Pharmacological and Toxicological Methods
58,
(1)
50-58
, DOI
Pounds N, Maclean S, Webley M, Pascoe D & Hutchinson T
2008
'Acute and chronic effects of ibuprofen in the mollusc Planorbis carinatus (Gastropoda: Planorbidae)'
Ecotoxicology and Environmental Safety
70,
(1)
47-52
, DOI
Winter MJ, Redfern WS, Hayfield AJ, Owen SF, Valentin J-P & Hutchinson TH
2008
'Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs'
Journal of Pharmacological and Toxicological Methods
57,
(3)
176-187
, DOI
Hooper HL, Connon R, Callaghan A, Fryer G, Yarwood-Buchanan S, Biggs J, Maund SJ, Hutchinson TH & Sibly RM
2008
'THE ECOLOGICAL NICHE OFDAPHNIA MAGNACHARACTERIZED USING POPULATION GROWTH RATE'
Ecology
89,
(4)
1015-1022
, DOI
Connon R, Hooper HL, Sibly RM, Lim F-L, Heckmann L-H, Moore DJ, Watanabe H, Soetaert A, Cook K & Maund SJ
2008
'Linking Molecular and Population Stress Responses inDaphnia magnaexposed to cadmium'
Environmental Science & Technology
42,
(6)
2181-2188
, DOI
Winter MJ, Lillicrap AD, Caunter JE, Schaffner C, Alder AC, Ramil M, Ternes TA, Giltrow E, Sumpter JP & Hutchinson TH
2008
'Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas)'
Aquatic Toxicology
86,
(3)
361-369
, DOI
Heckmann L-H, Sibly RM, Connon R, Hooper HL, Hutchinson TH, Maund SJ, Hill CJ, Bouetard A & Callaghan A
2008
'Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna'
GENOME BIOLOGY
9,
(2)
Author Site
, DOI
PEARL
Thorpe KL, Benstead R, Hutchinson TH & Tyler CR
2007
'Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas)'
Aquatic Toxicology
85,
(3)
176-183
, DOI
HECKMANN L, CALLAGHAN A, HOOPER H, CONNON R, HUTCHINSON T, MAUND S & SIBLY R
2007
'Chronic toxicity of ibuprofen to Daphnia magna: Effects on life history traits and population dynamics'
Toxicology Letters
172,
(3)
137-145
, DOI
OWEN S, GILTROW E, HUGGETT D, HUTCHINSON T, SAYE J, WINTER M & SUMPTER J
2007
'Comparative physiology, pharmacology and toxicology of β-blockers: Mammals versus fish'
Aquatic Toxicology
82,
(3)
145-162
, DOI
Winter MJ, Ellis LCJ & Hutchinson TH
2007
'Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide'
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
629,
(2)
89-99
, DOI
Thorpe KL, Benstead R, Hutchinson TH & Tyler CR
2007
'An optimised experimental test procedure for measuring chemical effects on reproduction in the fathead minnow, Pimephales promelas'
Aquatic Toxicology
81,
(1)
90-98
, DOI
Hutchinson TH
2007
'Small is useful in endocrine disrupter assessment—four key recommendations for aquatic invertebrate research'
Ecotoxicology
16,
(1)
231-238
, DOI
Williams TD, Caunter JE, Lillicrap AD, Hutchinson TH, Gillings EG & Duffell S
2007
'EVALUATION OF THE REPRODUCTIVE EFFECTS OF TAMOXIFEN CITRATE IN PARTIAL AND FULL LIFE-CYCLE STUDIES USING FATHEAD MINNOWS (PIMEPHALES PROMELAS)'
Environmental Toxicology and Chemistry
26,
(4)
695-695
, DOI
Hooper HL, Connon R, Callaghan A, Maund SJ, Liess M, Duquesne S, Hutchinson TH, Moggs J & Sibly RM
2006
'The use of image analysis to estimate population growth rate in Daphnia magna'
JOURNAL OF APPLIED ECOLOGY
43,
(4)
828-834
Author Site
, DOI
Crane HM, Pickford DB, Hutchinson TH & Brown JA
2006
'The Effects of Methimazole on Development of the Fathead Minnow, Pimephales promelas, from Embryo to Adult'
Toxicological Sciences
93,
(2)
278-285
, DOI
Cunningham VL, Buzby M, Hutchinson T, Mastrocco F, Parke N & Roden N
2006
'Effects of Human Pharmaceuticals on Aquatic Life: Next Steps'
Environmental Science & Technology
40,
(11)
3456-3462
, DOI
HOOPER HL, CONNON R, CALLAGHAN A, MAUND SJ, LIESS M, DUQUESNE S, HUTCHINSON TH, MOGGS J & SIBLY RM
2006
'The use of image analysis to estimate population growth rate in Daphnia magna'
Journal of Applied Ecology
43,
(4)
828-834
, DOI
Noël HL, Hopkin SP, Hutchinson TH, Williams TD & Sibly RM
2006
'Population Growth Rate And Carrying Capacity For SpringtailsFolsomia CandidaExposed To Ivermectin'
Ecological Applications
16,
(2)
656-665
, DOI
Hutchinson TH, Ankley GT, Segner H & Tyler CR
2006
'Screening and Testing for Endocrine Disruption in Fish—Biomarkers As “Signposts,” Not “Traffic Lights,” in Risk Assessment'
Environmental Health Perspectives
114,
(Suppl 1)
106-114
, DOI
PEARL
NOËL HL, HOPKIN SP, HUTCHINSON TH, WILLIAMS TD & SIBLY RM
2006
'Towards a population ecology of stressed environments: the effects of zinc on the springtail Folsomia candida'
Journal of Applied Ecology
43,
(2)
325-332
, DOI
Hutchinson, T.H., Hurd, K.S., Bamforth & J.
2006
' Development of chronic tests for endocrine active chemicals. Part I. An extended fish early- life stage test for oestrogen active chemicals in the fathead minnow <em>Pimephales promelas</em>'
Aquatic Toxicology
77,
279-290
Hutchinson TH, Shillabeer N, Winter MJ & Pickford DB
2006
'Acute and chronic effects of carrier solvents in aquatic organisms: A critical review'
Aquatic Toxicology
76,
(1)
69-92
, DOI
Iguchi T, Irie F, Urushitani H, Tooi O, Kawashima Y, Roberts M, Norrgren L & Hutchinson T
2006
'Availability of in vitro vitellogenin assay for screening of estrogenic and anti-estrogenic activities of environmental chemicals'
Environ Sci
13,
(3)
161-183
Author Site
Eidem, J.K., Kleivdal, H., Kroll, K., Denslow, N., van Aerle, R., Tyler, C., Panter, G., Hutchinson, T., Goksoyr & A
2006
'Development and validation of a direct homologous quantitative sandwich ELISA for fathead minnow (Pimephales promelas) vitellogenin'
Aquatic Toxicology
78,
(2)
202-206
Heckmann L-H, Connon R, Hutchinson TH, Maund SJ, Sibly RM & Callaghan A
2006
'Expression of target and reference genes in Daphnia magna exposed to ibuprofen'
BMC Genomics
7,
(1)
175-175
, DOI
PEARL
Jeram S, Sintes JMR, Halder M, Fentanes JB, Sokull-Klüttgen B & Hutchinson TH
2005
'A strategy to reduce the use of fish in acute ecotoxicity testing of new chemical substances notified in the European Union'
Regulatory Toxicology and Pharmacology
42,
(2)
218-224
, DOI
Crane HM, Pickford DB, Hutchinson TH & Brown JA
2005
'Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows,
Pimephales promelas'
Environmental Health Perspectives
113,
(4)
396-401
, DOI
PEARL
Knacker T, Duis K, Ternes T, Fenner K, Escher B, Schmitt H, Römbke J, Garric J, Hutchinson T & Boxall A
2005
'The EU-project ERAPharm - Incentives for the further development of guidance documents? (4 pages)'
Environmental Science and Pollution Research - International
12,
(2)
62-65
, DOI
Brown RJ, Rundle SD, Hutchinson TH, Williams TD & Jones MB
2005
'A microplate freshwater copepod bioassay for evaluating acute and chronic effects of chemicals'
Environmental Toxicology and Chemistry
24,
(6)
1528-1531
Hooper HL, Sibly RM, Hutchinson TH & Maund SJ
2005
'JOINT EFFECTS OF DENSITY AND A GROWTH INHIBITOR ON THE LIFE HISTORY AND POPULATION GROWTH RATE OF THE MIDGE CHIRONOMUS RIPARIUS'
Environmental Toxicology and Chemistry
24,
(5)
1140-1140
, DOI
Inudo M, Ishibashi H, Matsumura N, Matsuoka M, Mori T, Taniyama S, Kadokami K, Koga M, Shinohara R & Hutchinson TH
2004
'Effect of estrogenic activity, and phytoestrogen and organochlorine pesticide contents in an experimental fish diet on reproduction and hepatic vitellogenin production in medaka (Oryzias latipes)'
COMPARATIVE MEDICINE
54,
(6)
673-680
Author Site
Crane HM, Pickford DB, Hutchinson TH & Brown JA
2004
'Developmental changes of thyroid hormones in the fathead minnow, Pimephales promelas'
General and Comparative Endocrinology
139,
(1)
55-60
, DOI
Panter GH, Hutchinson TH, Hurd KS, Sherren A, Stanley RD & Tyler CR
2004
'Successful detection of (anti-)androgenic and aromatase inhibitors in pre-spawning adult fathead minnows (Pimephales promelas) using easily measured endpoints of sexual development'
Aquatic Toxicology
70,
(1)
11-21
, DOI
Snape JR, Maund SJ, Pickford DB & Hutchinson TH
2004
'Ecotoxicogenomics: the challenge of integrating genomics into aquatic and terrestrial ecotoxicology'
Aquatic Toxicology
67,
(2)
143-154
, DOI
Hooper HL, Sibly RM, Maund SJ & Hutchinson TH
2003
'The joint effects of larval density and 14C-cypermethrin on the life history and population growth rate of the midge Chironomus riparius'
Journal of Applied Ecology
40,
(6)
1049-1059
, DOI
Pickford DB, Hetheridge MJ, Caunter JE, Tilghman Hall A & Hutchinson TH
2003
'Assessing chronic toxicity of bisphenol A to larvae of the African clawed frog (Xenopus laevis) in a flow-through exposure system'
Chemosphere
53,
(3)
223-235
, DOI
Hooper HL, Sibly RM, Hutchinson TH & Maund SJ
2003
'The influence of larval density, food availability and habitat longevity on the life history and population growth rate of the midge Chironomus riparius'
Oikos
102,
(3)
515-524
, DOI
Brown AR, Riddle AM, Cunningham NL, Kedwards TJ, Shillabeer N & Hutchinson TH
2003
'Predicting the Effects of Endocrine Disrupting Chemicals on Fish Populations'
Human and Ecological Risk Assessment: An International Journal
9,
(3)
761-788
, DOI
Hutchinson TH, Field MDR & Manning MJ
2003
'Evaluation of non-specific immune functions in dab, Limanda limanda L., following short-term exposure to sediments contaminated with polyaromatic hydrocarbons and/or polychlorinated biphenyls'
MARINE ENVIRONMENTAL RESEARCH
55,
(3)
193-202
Author Site
, DOI
Thorpe KL, Cummings RI, Hutchinson TH, Scholze M, Brighty G, Sumpter JP & Tyler CR
2003
'Relative Potencies and Combination Effects of Steroidal Estrogens in Fish'
Environmental Science & Technology
37,
(6)
1142-1149
, DOI
Halm S, Kwon JY, Rand-Weaver M, Sumpter JP, Pounds N, Hutchinson TH & Tyler CR
2003
'Cloning and gene expression of P450 17α-hydroxylase,17,20-lyase cDNA in the gonads and brain of the fathead minnow Pimephales promelas'
General and Comparative Endocrinology
130,
(3)
256-266
, DOI
Brown RJ, Rundle SD, Hutchinson TH, Williams TD & Jones MB
2003
'A copepod life-cycle test and growth model for interpreting the effects of lindane'
Aquatic Toxicology
63,
(1)
1-11
Hutchinson TH, Barrett S, Buzby M, Constable D, Hartmann A, Hayes E, Huggett D, Laenge R, Lillicrap AD & Straub JO
2003
'A STRATEGY TO REDUCE THE NUMBERS OF FISH USED IN ACUTE ECOTOXICITY TESTING OF PHARMACEUTICALS'
Environmental Toxicology and Chemistry
22,
(12)
3031-3031
, DOI
Thomas-Jones E, Thorpe K, Harrison N, Thomas G, Morris C, Hutchinson T, Woodhead S & Tyler C
2003
'DYNAMICS OF ESTROGEN BIOMARKER RESPONSES IN RAINBOW TROUT EXPOSED TO 17β-ESTRADIOL AND 17α-ETHINYLESTRADIOL'
Environmental Toxicology and Chemistry
22,
(12)
3001-3001
, DOI
Thorpe KL, Benstead R, Hutchinson TH, Cummings RI & Tyler CR
2003
'Reproductive effects of exposure to oestrone in the fathead minnow'
Fish Physiology and Biochemistry
28,
(1-4)
451-452
, DOI
Brown RJ, Rundle SD, Hutchinson TH, Williams TD & Jones MB
2003
'Small-scale detritus-invertebrate interactions: influence of detrital biofilm composition on development and reproduction in a meiofaunal copepod'
Archiv fur Hydrobiologie
157,
(1)
117-129
Hutchinson TH & Pickford DB
2002
'Ecological risk assessment and testing for endocrine disruption in the aquatic environment'
Toxicology
181-182,
383-387
, DOI
Halm S, Pounds N, Maddix S, Rand-Weaver M, Sumpter JP, Hutchinson TH & Tyler CR
2002
'Exposure to exogenous 17β-oestradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas)'
Aquatic Toxicology
60,
(3-4)
285-299
, DOI
Pounds NA, Hutchinson TH, Williams TD, Whiting P & Dinan L
2002
'Assessment of putative endocrine disrupters in an in vivo crustacean assay and an in vitro insect assay'
Marine Environmental Research
54,
(3-5)
709-713
, DOI
Zerulla M, Länge R, Steger-Hartmann T, Panter G, Hutchinson T & Dietrich DR
2002
'Morphological sex reversal upon short-term exposure to endocrine modulators in juvenile fathead minnow (Pimephales promelas)'
Toxicology Letters
131,
(1-2)
51-63
, DOI
Hutchinson TH
2002
'Reproductive and developmental effects of endocrine disrupters in invertebrates: in vitro and in vivo approaches'
Toxicology Letters
131,
(1-2)
75-81
, DOI
Panter GH, Hutchinson TH, Länge R, Lye CM, Sumpter JP, Zerulla M & Tyler CR
2002
'Utility of a juvenile fathead minnow screening assay for detecting (anti-)estrogenic substances'
Environmental Toxicology and Chemistry
21,
(2)
319-326
, DOI
Matthiessen P, Allen Y, Bamber S, Craft J, Hurst M, Hutchinson T, Feist S, Katsiadaki I, Kirby M & Robinson C
2002
'The impact of oestrogenic and androgenic contamination on marine organisms in the United Kingdom - summary of the EDMAR programme'
Marine Environmental Research
54,
(3-5)
645-649
van Aerle R, Pounds N, Hutchinson TH, Maddix S & Tyler CR
2002
'Windows of sensitivity for the oestrogenic effects of ethinylestradiol in early life stages of the fathead minnow'
Ecotoxicology
11,
(6)
423-434
, DOI
Dinan L, Bourne P, Whiting P, Dhadialla TS & Hutchinson TH
2001
'Screening of environmental contaminants for ecdysteroid agonist and antagonist activity using theDrosophila melanogasterBIIcell in vitro assay'
Environmental Toxicology and Chemistry
20,
(9)
2038-2046
, DOI
Thorpe KL, Hutchinson TH, Hetheridge MJ, Scholze M, Sumpter JP & Tyler CR
2001
'Assessing the Biological Potency of Binary Mixtures of Environmental Estrogens using Vitellogenin Induction in Juvenile Rainbow Trout (Oncorhynchus mykiss)'
Environmental Science & Technology
35,
(12)
2476-2481
, DOI
Länge R, Hutchinson TH, Croudace CP, Siegmund F, Schweinfurth H, Hampe P, Panter GH & Sumpter JP
2001
'Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)'
Environmental Toxicology and Chemistry
20,
(6)
1216-1227
, DOI
Dinan L, Bourne P, Whiting P, Dhadialla TS & Hutchinson TH
2001
'SCREENING OF ENVIRONMENTAL CONTAMINANTS FOR ECDYSTEROID AGONIST AND ANTAGONIST ACTIVITY USING THE DROSOPHILA MELANOGASTER BII CELL IN VITRO ASSAY'
Environmental Toxicology and Chemistry
20,
(9)
2038-2038
, DOI
Thorpe KI, Hutchinson TH, Hetheridge MJ, Sumpter JP & Tyler CR
2000
'Development of an in vivo screening assay for estrogenic chemicals using juvenile rainbow trout (Oncorhynchus mykiss)'
Environmental Toxicology and Chemistry
19,
(11)
2812-2820
, DOI
Hutchinson TH, Brown R, Brugger KE, Campbell PM, Holt M, Länge R, McCahon P, Tattersfield LJ & van Egmond R
2000
'Ecological risk assessment of endocrine disruptors'
Environmental Health Perspectives
108,
(11)
1007-1014
, DOI
PEARL
Hutchinson TH, Brown R, Brugger KE, Campbell PM, Holt M, Lange R, McCahon P, Tattersfield LJ & van Egmond R
2000
'Ecological Risk Assessment of Endocrine Disruptors'
Environmental Health Perspectives
108,
(11)
1007-1007
, DOI
Thorpe KL, Hutchinson TH, Hetheridge MJ, Sumpter JP & Tyler CR
2000
'DEVELOPMENT OF AN IN VIVO SCREENING ASSAY FOR ESTROGENIC CHEMICALS USING JUVENILE RAINBOW TROUT (ONCORHYNCHUS MYKISS)'
Environmental Toxicology and Chemistry
19,
(11)
2812-2812
, DOI
Hutchinson TH, Pounds NA, Hampel M & Williams TD
1999
'Life-cycle studies with marine copepods (Tisbe battagliai) exposed to 20-hydroxyecdysone and diethylstilbestrol'
Environmental Toxicology and Chemistry
18,
(12)
2914-2920
, DOI
1999
'Editorial'
Science of The Total Environment
233,
(1-3)
1-3
, DOI
Hutchinson TH, Field MDR & Manning MJ
1999
'Evaluation of immune function in juvenile turbot Scophthalmus maximus (L.) exposed to sediments contaminated with polychlorinated biphenyls'
FISH & SHELLFISH IMMUNOLOGY
9,
(6)
457-472
Author Site
, DOI
Hutchinson TH, Pounds NA, Hampel M & Williams TD
1999
'Impact of natural and synthetic steroids on the survival, development and reproduction of marine copepods (Tisbe battagliai)'
Science of The Total Environment
233,
(1-3)
167-179
, DOI
Tyler CR, van Aerle R, Hutchinson TH, Maddix S & Trip H
1999
'An in vivo testing system for endocrine disruptors in fish early life stages using induction of vitellogenin'
Environmental Toxicology and Chemistry
18,
(2)
337-347
, DOI
Tyler CR, van Aerle R, Hutchinson TH, Maddix S & Trip H
1999
'AN IN VIVO TESTING SYSTEM FOR ENDOCRINE DISRUPTORS IN FISH EARLY LIFE STAGES USING INDUCTION OF VITELLOGENIN'
Environmental Toxicology and Chemistry
18,
(2)
337-337
, DOI
Hutchinson TH, Pounds NA, Hampel M & Williams TD
1999
'LIFE-CYCLE STUDIES WITH MARINE COPEPODS (TISBE BATTAGLIAI) EXPOSED TO 20-HYDROXYECDYSONE AND DIETHYLSTILBESTROL'
Environmental Toxicology and Chemistry
18,
(12)
2914-2914
, DOI
Palau-Casellas A & Hutchinson TH
1998
'Acute toxicity of chlorinated organic chemicals to the embryos and larvae of the marine worm Platynereis dumerilii (Polychaeta : Nereidae)'
ENVIRONMENTAL TOXICOLOGY AND WATER QUALITY
13,
(2)
149-155
Author Site
, DOI
Hutchinson TH, Jha AN, Mackay JM, Elliott BM & Dixon DR
1998
'Assessment of developmental effects, cytotoxicity and genotoxicity in the marine polychaete (Platynereis dumerilii) exposed to disinfected municipal sewage effluent'
Mutat Res
399,
(1)
97-108
Author Site
, DOI
Palau-Casellas A & Hutchinson TH
1998
'Acute toxicity of chlorinated organic chemicals to the embryos and larvae of the marine wormPlatynereis dumerilii (Polychaeta: Nereidae)'
Environmental Toxicology and Water Quality
13,
(2)
149-155
, DOI
Solbé J, Mark U, Buyle B, Guhl W, Hutchinson T, Kloepper-Sams P, Länge R, Munk R, Scholz N & Bontinck W
1998
'Analysis of the Ecetoc Aquatic Toxicity (EAT) database I — General introduction'
Chemosphere
36,
(1)
99-113
, DOI
Länge R, Hutchinson TH, Scholz N & SolbÉ J
1998
'Analysis of the ecetoc aquatic toxicity (EAT) database II — Comparison of acute to chronic ratios for various aquatic organisms and chemical substances'
Chemosphere
36,
(1)
115-127
, DOI
Hutchinson TH, Solbe J & Kloepper-Sams PJ
1998
'Analysis of the ecetoc aquatic toxicity (EAT) database III — Comparative toxicity of chemical substances to different life stages of aquatic organisms'
Chemosphere
36,
(1)
129-142
, DOI
Hutchinson TH, Scholz N & Guhl W
1998
'Analysis of the ecetoc aquatic toxicity (EAT) database IV — Comparative toxicity of chemical substances to freshwater versus saltwater organisms'
Chemosphere
36,
(1)
143-153
, DOI
Ankley G, Mihaich E, Stahl R, Tillitt D, Colborn T, McMaster S, Miller R, Bantle J, Campbell P & Denslow N
1998
'Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife'
Environmental Toxicology and Chemistry
17,
(1)
68-87
, DOI
Campbell PM & Hutchinson TH
1998
'Wildlife and endocrine disrupters: Requirements for hazard identification'
Environmental Toxicology and Chemistry
17,
(1)
127-135
, DOI
Campbell PM & Hutchinson TH
1998
'WILDLIFE AND ENDOCRINE DISRUPTERS: REQUIREMENTS FOR HAZARD IDENTIFICATION'
Environmental Toxicology and Chemistry
17,
(1)
127-127
, DOI
Hutchinson TH, Hutchings MJ & Moore KW
1997
'A Review of the Effects of Bromate on Aquatic Organisms and Toxicity of Bromate to Oyster (Crassostrea gigas) Embryos'
Ecotoxicology and Environmental Safety
38,
(3)
238-243
, DOI
Jha AN, Hutchinson TH, Mackay JM, Elliott BM & Dixons DR
1997
'Evaluation of the genotoxicity of municipal sewage effluent using the marine worm Platynereis dumerilii (Polychaeta: Nereidae)'
Mutat Res
391,
(3)
179-188
Author Site
, DOI
Hutchinson TH & Manning MJ
1996
'Effect of in vivo cadmium exposure on the respiratory burst of Marine Fish (Limanda limanda L.) phagocytes'
Marine Environmental Research
41,
(4)
327-342
, DOI
HUTCHINSON TH & MANNING MJ
1996
'Seasonal trends in serum lysozyme activity and total protein concentration in dab (Limanda limandaL.) sampled from Lyme Bay, U.K'
Fish & Shellfish Immunology
6,
(7)
473-482
, DOI
Jha AN, Hutchinson TH, Mackay JM, Elliott BM & Dixon DR
1996
'Development of an in vivo genotoxicity assay using the marine worm Platynereis dumerilii (Polychaeta: Nereidae)'
Mutat Res
359,
(2)
141-150
Author Site
, DOI
1996
'Erratum'
Ecotoxicology and Environmental Safety
33,
(1)
102-102
, DOI
Hutchinson TH, Jha AN & Dixon DR
1996
'The polychaete Platynereis dumerilii (Audouin and Milne-Edwards): A new species for assessing the hazardous potential of chemicals in the marine environment (vol 31, pg 271, 1995)'
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
33,
(1)
102-102
Author Site
Jha AN, Dominquez I, Balajee AS, Hutchinson TH, Dixon DR & Natarajan AT
1995
'Localization of a vertebrate telomeric sequence in the chromosomes of two marine worms (phylum Annelida: class polychaeta)'
Chromosome Res
3,
(8)
507-508
Author Site
, DOI
Vanwijk DJ & Hutchinson TH
1995
'The Ecotoxicity of Chlorate to Aquatic Organisms: A Critical Review'
Ecotoxicology and Environmental Safety
32,
(3)
244-253
, DOI
Field MDR, Hutchinson TH & Manning MJ
1995
'Development of adherence techniques for collecting kidney phagocytes from marine fish (Limanda limanda L.)'
Fish & Shellfish Immunology
5,
(7)
505-517
, DOI
Jha AN, Hutchinson TH, Mackay JM, Elliott BM, Pascoe PL & Dixon DR
1995
'The chromosomes Of Platynereis dumerilii (Polychaeta: Nereidae)'
Journal of the Marine Biological Association of the United Kingdom
75,
(3)
551-562
, DOI
JHA AN, HUTCHINSON TH, MACKAY JM, ELLIOTT BM, PASCOE PL & DIXON DR
1995
'THE CHROMOSOMES OF PLATYNEREIS-DUMERILII (POLYCHAETA, NEREIDAE)'
JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM
75,
(3)
551-562
Author Site
, DOI
Hutchinson TH, Jha AN & Dixon DR
1995
'The polychaete Platynereis dumerilii (Audouin and Milne-Edwards): a new species for assessing the hazardous potential of chemicals in the marine environment'
Ecotoxicol Environ Saf
31,
(3)
271-281
Author Site
, DOI
Hutchinson TH & Williams TD
1994
'Culturing of fathead minnow (Pimephales promelasL.) larvae for aquatic toxicity testing: An observational note'
Environmental Toxicology and Chemistry
13,
(4)
665-669
, DOI
Hutchinson TH & Williams TD
1994
'CULTURING OF FATHEAD MINNOW (PIMEPHALES PROMELAS L.) LARVAE FOR AQUATIC TOXICITY TESTING: AN OBSERVATIONAL NOTE'
Environmental Toxicology and Chemistry
13,
(4)
665-665
, DOI
Hutchinson TH & Williams TD
1994
'Erratum: Culturing of fathead minnow (Pimephales promelas L.) larvae for aquatic toxicity testing: An observational note (Environmental Toxicology and Chemistry (1994) 13 (665-669))'
Environmental Toxicology and Chemistry
13,
(7)
1994
'I.1 Evaluation of immunological methods to monitor environmental stress in marine flatfish'
Developmental & Comparative Immunology
18,
S144-S144
, DOI
Hutchinson TH, Williams TD & Eales GJ
1994
'Toxicity of cadmium, hexavalent chromium and copper to marine fish larvae (Cyprinodon variegatus) and copepods (Tisbe battagliai)'
Marine Environmental Research
38,
(4)
275-290
, DOI
Williams TD, Hutchinson TH, Roberts GC & Coleman CA
1993
'The assessment of industrial effluent toxicity using aquatic microorganisms, invertebrates and fish'
Science of the Total Environment
(SUPPL. Part 2)
1129-1142
de L.G. Solbé JF, Buyle B, Guhl W, Hutchinson T, Laenge R, Mark U, Munk R & Scholz N
1993
'Developing hazard identification for the aquatic environment'
Science of The Total Environment
134,
47-61
, DOI
Williams TD, Hutchinson TH, Roberts GC & Coleman CA
1993
'The assessment of industrial effluent toxicity using aquatic microorganisms, invertebrates and fish'
Science of The Total Environment
134,
1129-1141
, DOI
Hutchinson TH & Williams TD
1990
'The use of sheepshead minnow (Cyprinodon variegatus) and a benthic copepod (Tisbe battagliai) in short-term tests for estimating the chronic toxicity of industrial effluents'
Environmental bioassay techniques and their application. Proc. conference, Lancaster, 1988
567-572
Hutchinson TH & Williams TD
1989
'The use of sheepshead minnow (Cyprinodon variegatus) and a benthic copepod (Tisbe battagliai) in short-term tests for estimating the chronic toxicity of industrial effluents'
Hydrobiologia
188-189,
(1)
567-572
, DOI