- Room 2 floor research office, John Bull Building, Error retrieving address, Error retrieving address, Error retrieving address, Error retrieving address
Dr Thomas Mindos
Post-Doctoral Research Fellow
Plymouth University Peninsula Schools of Medicine and Dentistry
BSc in Molecular Cellular Biology (University of Essex)
Merlin acts as a tumour suppresor and hence is involved in a lot of cancers, primarily though in Schwannomas in type 2 neurofibromatosis. I am currently investigating the role of Merlin (NF2) in Schwann cell biology and peripheral nerve injury in mice. I research the co-operation of injury signals and loss of Merlin in the development of a proliferation-permissive environment that might lead to the formation of Schwannoma tumours.
I have investigated the molecular mechanisms that lead to prostate cancer progression and the contribution of CCN1 (Cyr61) matricellular protein during this progression to the highly aggressive, metastatic and androgen-independent stage.