Dr Roy Moate
Associate Professor Manager of Electron Microscopy Centre
School of Biological & Marine Sciences (Faculty of Science & Engineering)
As Manager of Plymouth Electron Microscopy Centre I am responsible for the day to day running of the Centre which is a core University resource providing support for both teaching and research in a wide range of disciplines. The EMC is a well equipped microscopy and analysis centre housing a range of modern electron and light microscopes together with ancillary analytical equipment and image analysis facilities (http://www.plymouth.ac.uk/emc). As well as the research carried out by members of the University, within the Centre and from various other departments, particularly the Peninsula Medical School, strong links are maintained with colleagues in the Marine Biological Association of the UK, Derriford Hospital NHS Trust, the National Marine Aquarium and The EDEN project.
Apart from its academic functions, the EMC also has strong commercial links and provides essential consultancy services, both in terms of advice and practical help to local and regional manufacturing businesses. Through such work, there is, therefore, a significant contribution to the local economy and this is enhanced through programmes such as DTI Knowledge Transfer Partnerships.
The EMC is also actively involved in education at the secondary school level through the now well-established and highly regarded annual EM for Schools workshops. These workshops are held over a two-week period and attract up to 1,000 Sixth Form students (Years 12 &13) from state and independent schools across the South-West region.
BSc (Hons)2(i) Zoology , University of London (1976)
MSc Applied Fish Biology, CNAA Plymouth Polytechnic (1977)
PhD Biology, Plymouth Polytechnic,(1985)
Biomedical Scientist (Health Professions Council)
Fellow, Royal Microscopical Society
Member, Association of Clinical Electron Microscopy
I teach on a range of courses (undergraduate and postgraduate) mainly involved with the application of advanced optical and electron microscopy techniques to biological materials.
BIOM 2007 Techniques in Microscopy & Cellular Biology
BIO 5102 Applications in Electron Microscopy
My main interest is as part of the Plymouth Ciliary Research Group (collaboration between the Academic Dept Anaesthesia Derriford Hospital, Peninsula Medical School and Electron Microscope Centre, UoP) investigating the ultrastructure and function of respiratory tract cilia in critically ill patients. Current work in this area centres on a combined laboratory and clinical study to investigate the mechanistic basis of oxygen induced cell death associated with ciliary loss and ultrastructural abnormalities and their relationship to muco-ciliary dysfunction in long stay ICU patients.
Research degrees awarded to supervised students
SUCESSFULLY COMPLETED PhD’s:
- Hanady Al- Shmgani: (2013): Mechanisms of oxidative stress in respiratory epithelium (2nd supervisor).
- David Sanders (MD) (2012): Prosthetic mesh and wound infection rates following incisional hernia repair. (2nd supervisor).Yuqing Du (2012): Film deposition and Microfabrication of magnetic tunenle Junctions with an MgO barrier. (2nd Supervisor).
- Paul Waines (2011) : Biofilm Formation and Control in a Novel Warm Water Distribution System’ (2nd Supervisor).
- Arkadios Dimitroglou (2010) : Effects of dietary mannan oligosaccharide (MOS) supplementation in relation to intestinal integrity, microbiota, health & production of cultured fish species. (2nd Supervisor).
- Jonathan Lovell (2005): Development of a non-invasive electrophysiological system for measuring the auditory capability of marine animals (2nd Supervisor)
- Joanne Kirby, (2004) : Ultrastructure and function of respiratory cilia in the critically ill. (Director of Studies).
- Ross Kay (2004) : Risk factors associated with the muco-ciliary apparatus in intensive care patients (2nd Supervisor).
- Dagmar Hebel (1996) The effect of sub-lethal copper exposure on the gills of Carcinus maenus and the adaptive physiological response. (2nd Supervisor).
- Penny Sargeant (1995) An ultrastructural investigation of Vulval Vestibulitis Syndrome and associated inflammatory response in perineal skin. (Director of Studies)
- Sarah Lawson (1994) Effect of copper exposure on the gill structure of an euryhaline crab Carcinus maenas (Crustacea Decapoda). (2nd Supervisor)
- Edward Lavelle (1994) Gastrointestinal antigen processing and its relevance to enteric vaccine delivery in rainbow trout Onchorhynchus mykiss (Walbaum, 1792). (2nd Supervisor).
Grants & contracts
2013- 2014 Northcott Devon Medical Foundation: Identifying targets to boost repair in the peripheral nervous system. £8,350 (with D.B. Parkinson & XP Dun).
1997-2012 Consultancy Services (Materials testing, failure analysis, product development; NHS pathology services) total £695,000.
2011 EMC Investment project (European Regional Development Fund) : £770,450 (with R.Lorraine, R&E, UoP)
2008 Iraqi Government PhD Scholarship: £82,500 “Mechanisms of oxygen-induced loss of cilia in the human bronchus.” (Dr J Moody, PI)
2008 Experiential CETL Staff Award development project: £2,850 “Virtual EM_ an interactive learning resource for cell biology.” (with P. Bond & P. Smithers)
2007 Proof of Concept Funding (UoP) : £3,648 “Micro to macro; an interactive image based e-learning interface.” (with P. Bond).
2007 Science Learning Centre SW £16,450 “WebSEM, remote scanning electron microscopy for schools”.
2006 HEIF3 studentship with Dart Valley Systems Ltd , total £65,000 (DVS £30,000) : “Sub clinical biofilm development in novel no-touch tap systems”. (With Bradley, G., PI).
2004 Case student with PMS , total £65,000 (Derriford Intensive Care Unit, £30,000. “Oxygen induced cell death associated with mucociliary dysfunction in long stay ICU patients” (With Sneyd, JR (PI), McNaughton, P & AJ Moody.)
2002 Royal Society small equipment grant £9,850 “Opacification of hydrogel intraocular lenses following cataract surgery: a clinical and ultrastructural analysis” Grant No. RSRG23713 (With Nabil Habib, Plymouth NHS).
2001 SRIF equipment grant £36,540 “SIS digital camera and image analysis work station for Transmission Electron Microscope”
2000 Case student with PMS , total £65,000 (£30,000, Anaesthesia Research, Plymouth). “Risk factors associated with the muco-ciliary apparatus in intensive care patients” . (With Sneyd JR (PI) and J. Langton) .
1997 Case student with PMS total £65,000 (£30,000, Anaesthesia Research, Plymouth). “Ultrastructure and function of respiratory cilia in the critically ill” (With Sneyd, J.R, and J.L. Langton).
£28,000 Other small grants (Wellcome Trust Summer Scholarships/ British Council Travel Grants/ Public Engagement/ Royal Soc. Equipment grants)
Doddrell R, Xin-Peng Dun, Moate R, Jessen K. R. , Mirsky R and Parkinson D.B. (2012) Regulation of Schwann Cell Differentiation and Proliferation by the Pax-3 Transcription Factor : GLIA 60: 1269–1278
Sanders, D.L., Kingsnorth, A.N., Lambie, J., Bond, P., Moate, R., Steer J. (2012): An experimental study exploring the relationship between the size of bacterial inoculum and bacterial adherence to prosthetic mesh. Accepted: Surgical Endoscopy
Shivane, A., R. Moate, P. Bond, A. Endean and D. Hilton (2012): Macrophagic myofasciitis: a report of second case from UK. Accepted: Neuropathology and Applied Neurobiology
Waines PL, Moate R, Moody AJ, Allen M & Bradley G (2011) The effect of material choice on biofilm formation in a model warm water distribution system. Biofouling, 10, 1161-74
Dimitroglou, A., Merrifield, D. L., Spring, P., Sweetman, J., Moate, R. & Davies, S. J., (2010) Effects of dietary mannan oligosaccharides (MOS) and soybean meal on growth performance, feed utilisation, intestinal histology and gut microbiota of gilthead sea bream (Sparus aurata). Aquaculture, 300, 182-188
Dimitroglou, A., Merrifield, D. L., Moate, R., Davies, S.J., Spring, P., Sweetman, J., Bradley, G., (2009) Dietary mannan oligosaccharide supplementation modulates intestinal microbial ecology and improves gut morphology of rainbow trout, Oncorhynchus mykiss (Walbaum). Journal of Animal Science 87, 3226-3234
Rankin H.V., A.J. Moody, R.M. Moate, P. McNaughton, M.E.F. Smith & J.R.Sneyd (2007) Elevated oxygen fraction reduces cilial abundance in explanted human bronchial tissue. Ultrastructural Pathology 31 (5) 339-346.
Lovell, J.M Findlay, M.M., Harper, G.M., Moate, R.M. & Harper, G.M. (2007). The polarisation of inner ear hair cells from the lesser spotted dogfish (Scyliorhinus canicula). J Fish Biology 70: 362 - 373
Lovell, J.M., Christiansen, L., Findlay, M.M. & Moate, R.M. (2006). The influence of body size on the form and function of the statocyst from the prawn Palaemon serratus. J Experimental Biology. 209: 2480-2485.
Lovell, J.M., Findlay, M.M., Harper, G.M., Moate, R.M. (2006). Morphology of the inner ear ultrastructure from the paddlefish (Polyodon spathula) using scanning and transmission electron microscopy. J. Microsc . 222(Pt 1): 36-41.
Lovell, J.M, Findlay, M.M, Moate, R.M & Pilgrim D.A. (2005). The polarization of inner ear ciliary bundles from a scorpaeniform fish. J. Fish Biology 66, pp 836–846.
Lovell, J.M, Findlay, M.M, Moate, R.M & Yan H.Y (2005). The hearing abilities of the prawn (Palaemon serratus). Comp. Biochem. Physiol. A Mol. Integr. Physiol. Vol 140/1 pp 89-100
Tsigkoros, D, E. Folland, R. Moate and C.S. Brennan (2003) Feta cheese texture: the effect of caprine and ovine milk concentration. Int J. Dairy Tech.: 36 (4): 233-236
Kay, R. R.Moate, J.R.Sneyd,-Bray.I., & Langton, J. (2002) Cultured Rat Trachea as a Model for the Study of Ciliary Abundance – the Effect of Oxygen. Anesthesiology, 97: 275 – 278
Habib, N., R. Moate, G.Gock, T. Freegard & P.Newman (2002) Late Surface Opacification of Hydroview Intraocular Lenses, Eye, 16: 69 - 74
Griffiths, G. L.Winder, .Bean, R.Preston, R.Moate, R.Neal, E.Williams, J.Holland & G. Thomas (2001) Laser marking the carabid Pterostichus melanarius for mark-release-recapture. Ecological Entomology 26, 662 - 663
El-Ghazaly, G. R.Moate, S. Huysmanns, & S. Rowley (2000) Selected stages in Pollen Wall Development in Echinodorus, Magnolia, Betula, Rondeletia, Borago and Matrricaria, In: M.Hartley, C.Morton & S. Blackmore (Eds) Pollen & Spores:Morphology & Biology, pp. 17 – 29 Royal Botanic Gardens, Kew/Linnean Society, London.
El-Ghazaly, G., R. Moate, M.Cresti, B. Walles , Y. Takahashi, F. Ferreira and G. Obermeyer. (1999). Localization and release of allergens from tapetum and pollen grains of Betula pendula. Protoplasm, 208; 37-46
Bond, P., Brown, M.T., Moate, R.M., Gledhill, M., Hill, S. & Nimmo, M. (1999) Arrested Development in Fucus spiralis germlings exposed to copper: A morphological and ultrastructural investigation. Eur. J. Phycol. ,34; 513-521.
Hebel, D., M.B. Jones; R.Moate and Depledge, M. (1999). Differing sensitivities of respiratory and osmoregulatory gill tissue of Carcinus maenas (Crustacea:Decapoda) to water-borne copper. Mar. Biol. 133:675-681.
Whitear, M. & R Moate. (1998) Cellular diversity in the epidermis of Raja clavata (Chondrichthyes). J. Zool. (Lond.); 246: 275-285.
Gledhill, M., M.T. Brown, M.Nimmo, R Moate and S.J. Hill. (1998) Comparison of techniques for the removal of particulate material from seaweed tissue. Mar. Env. Res; 45 (3): 295-307.
PUBLISHED ABSTRACTS & CONFERENCE CONTRIBUTIONS:
Al-Shmgani H S, Moody A J, Moate R M, Sneyd J R, MacNaughton P D. Investigation of the mechanism(s) of oxygen-induced cilial epithelial loss in bovine bronchus tissue. Injury and Repair Mechanisms in Chronic Airway Disease Conference (April 7-8, 2011), London, UK. Poster 1.
Waines P., Moate, R.M. & Bradley G (2009) Differential effects of thermal flushing on bacterial culturability and viability in model warm water system biofilms. 1st European Congress on Microbial Biofilms, Rome 2-5 September 2009.
Waines P., Moate, R.M. & Bradley G (2008) Aspects of biofilm formation using a novel water distribution system. SfAM summer conference, Belfast 7-10 July 2008
Rankin, H.V., Moate, R.M., Moody, A.J., MacNaughton, P. & Sneyd, J.R. (2006) Uneven cilial distribution in rat trachea, British Journal of Anaesthesia 96, 281P
Rankin, H.V., Moate, R.M., moody, A.J., MacNaughton, P., Rahamim, J., Smith, M.E.F. & Sneyd, J.R. (2006) Organ culture of human bronchial explants, British Journal of Anaesthesia 96, 281P-282P
Rankin, H.V., Sneyd, J.R., Moody A.J., McNaughton, P., & R.M. Moate (2005) 'The impact of rat trachea cilial banding on experimental analysis and histological survey' presented at the 'Cilia, mucus and mucociliary interactions' Gordon Research Conference (GRC) in Buellton, California on 27th Feb - 4th March 2005
Tudorica, C.M., Kuri, V., Jones, T.E.R.., Moate, R. & Brennan, C.S. -glucanb(2003) Yoghurt rheology and microstructure as affected by barley inclusion. Poster presentation / paper in Proceedings of AACC / ICC International Dietary Fibre Conference 2003, May 2003, Noordwijkerhout, Netherlands).
Symons, L.J., Jones, T.E.R., Moate, R. & Brennan, C.S. (2003) Pasting -glucan / starch gels: the effect of barley beta-glucan extractsbbehaviour of on starch gelatinisation and degradation. (Invited oral presentation and paper in the Cereals 2003 Proceedings of The Royal Australian Chemical Institute September 2003 Adelaide).
Kay, R.J, McNaughton, P., Kirkby,J., Bailey, J.A., Moate, R.M. ,Langton, J.A & Sneyd, J.R. (2002): Ciliary Ultrastructure and Coverage of Bronchial Respiratory Epithelium in Intensive Care Patients. Intensive Care Med; 2002 [Suppl1] 28: S3-S4
Kay R.; Kirkby J.; Watson G.; Sneyd R.; Langton J.; Moate R.; MacNaughton P. (2001); Ciliary Abundance and Abnormalities in Critical Illness. British Journal of Anaesthesia; 2001, 86, 2. 321- 322P
Kirkby J.; Kay R.; Sneyd R.; Langton J.; Moate R.; Loxdale S. (2001); Ciliary Abnormalities In Non-Symptomatic Smokers and Non-Smokers. British Journal of Anaesthesia; 2001, 86, 2, 326P
Kirkby J, Russell P, Sneyd J R.; Moate R M, Langton J A,(2001) Electron microscopy of respiratory ciliated epithelium. British Journal of Anaesthesia, 1999, 82, (3) 464-465
Kirkby J, Sneyd J R, Langton J A, Moate R M. (1999). Effect of midazolam on cilia survival. British Journal of Anaesthesia, 1999, 83, 527P