Professor Roman Borisyuk
Profiles

Professor Roman Borisyuk

Professor of Computational Neuroscience

School of Computing, Electronics and Mathematics (Faculty of Science and Engineering)

  • A 224, Portland Sq, Drake Circus, Plymouth, Devon, PL4 8AA
  • +44 1752 584949

Role

Professor of Computational Neuroscience
School of Computing and Mathematics
Centre for Robotics and Neural Systems

Qualifications

Diploma of Higher Education in Mathematics (equivalent to MSc) from Moscow State University, USSR, 1973

Candidate of Physical and Mathematical Sciences in Biophysics and Mathematical Biology (equivalent to PhD) from the Institute of Biological Physics of the USSR Academy of Sciences, 1984

Doctor of Physical and Mathematical Sciences in Biophysics and Mathematical Biology (equivalent to DSc) from the Institute of Experimental and Theoretical Biophysics of the Russian Academy of Sciences, 1996.

BACKGROUND

I have been working in the field of neural networks, mathematical and computational neuroscience since 1973. The main direction of my research has been related to modelling the functional behaviour of structures in the central nervous system. I was among the first in the world to apply new mathematical tools – multidimensional interacting Markovian processes and fields - to the analysis of dynamical regimes in stochastic neural networks.

I was engaged at Moscow in pioneer research concerned with developing numerical algorithms to investigate the bifurcations of steady states and limit cycles in nonlinear dynamical systems under parameter variation. These investigations showed that cooperative effects like physical phase-transitions and synchronisation phenomena occur normally in biological neural networks despite a very chaotic spike activity of single neurons. In addition, metastable states of neural networks were proved to be useful to model short-term memory in a series of theoretical and simulation works.

RESEARCH GOALS

I am currently study neurodynamics and synchronisation in neural networks with various types of elements and architectures. The rhythm and waves in the brain are of special interest. The fulfilment of this program will form a unified approach to the modelling of various cognitive functions such as attention, memory, and decision making.

Another important direction of my research relates to the “structure – function” problem. In collaboration with neurobiologists from Universities of Bristol and St Andrews we are developing biologically realistic detailed anatomical and physiological models of the tadpole nervous system which are able to execute information processing and control swimming behaviour.

Professional membership

1990-2000 Member of International Neural Network Society
2000-date Member of Society for Industrial and Applied Mathematics (SIAM)
1990-date Member of the Russian Neural Network Society
2003-date Memeber of Theoretical (Mathematical) Neuroscience Network (supported by Leverhulme Trust, EPSRC)

Roles on external bodies

1990-date Member of Editorial Board of "Neural Networks" - the official Journal of International Neural Network Society (Elsevier) 
2005-date Member of Editorial Board of  "Cognitive Neurodynamics" journal (Springer)
2002-2012 Member of Editorial Board of International Journal of Integrative Neuroscience (Imperial College Press)
2006-date Member of Scientific Council, European Complex Systems Society
1990-2010 Member of Executive Board of the Russian Neural Network Society
2003-date Member of Scientific Panels, European Commission, Brussels
2010-date Member of EPSRC college
1985-96 Member of Scientific Council of Institute of Mathematical Problems of Biology of the Russian Academy of Sciences
Scholarship from NSF, Invited Visiting Professor, Mathematical Biosciences Institute, Ohio State University, Columbus, Ohio, USA, April-June 2003

Teaching interests

Mathematical and Computational Neuroscience
Mathematical Modelling
Dynamical Systems
Bifurcation Theory

Research interests

CURRENT PROJECTS 

Study of tadpole nervous system
In collaboration with University of Bristol and University of St Andrews. Supported by BBSRC grants 2009,-2012, 2014-2017.

Borisyuk R.
, Al Azad A.K., Conte D., Roberts A., Soffe S.R. (2011) Modeling the connectome of a simple spinal cord. Front Neuroinform. 2011;5:20
Li W.-C., Cooke T., Sautois B., Soffe S., Borisyuk R., Roberts A. (2007) Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network. Neural Development, 2:17
Roberts A., Conte D., Hull M., Merrison R., Al Azad A.K., Buhl E., Borisyuk R., Soffe S.R. (2014) Building the early nervous system: simple rules control development of a vertebrate connectome generating behaviour. Journal of Neuroscience

Mathematical and computational modelling of the Basal Ganglia in norm and Parkinson disease including models of Deep Brain Stimulation
In collaboration with Imperial College London; Freiburg University; Toronto University; and Institute of Mathematics of the Ukrainian Academy of Sciences. Supported by the Faculty of Science and Technology studentship (2011-2014).

Merrison-Hort RJ, Yousif N, Njap F, Hofmann UG, Burylko O, Borisyuk R. (2013) An interactive channel model of the Basal Ganglia: Bifurcation analysis under healthy and Parkinsonian conditions. J Math Neurosci. 3(1):14
Yousif N, Borisyuk R., Pavese N, Nandi D, Bain P. (2012) Spatiotemporal visualization of deep brain stimulation-induced effects in the subthalamic nucleus. Eur J Neurosci., 36(2):2252-9

Synchronization based modelling of cognitive functions
In collaboration with Institute of Mathematical Problems in Biology, Russian Academy of Science, Frankfurt Institute for Advanced Studies, Max-Plank-Institute for Brain Research, Humboldt University. Supported by the University of Plymouth studentship, EU CogNovo project, 2014-2018 (Project Leader – Prof. Sue Denham)

Borisyuk R., Chik D., Kazanovich Y., da Silva Gomes J. (2013) Spiking neural network model for memorizing sequences with forward and backward recall. Bio Systems; 112(3):214-23.
Chik D, Borisyuk R, Kazanovich Y. (2009) Selective attention model with spiking elements. Neural Networks, 22:890-900
Borisyuk R., Kazanovich Y., Chik D., Tikhanoff V. and Cangelosi A. (2009). A neural model of selective attention and object segmentation in the visual scene: An approach based on partial synchronization and star-like architecture of connections. Neural Networks, 22(5-6):707-19
Borisyuk R., Chik D, Kazanovich Y. (2009). Visual perception of ambiguous figures: synchronization based neural models. Biological Cybernetics,100(6):491- 504

Development of new methods for spike train analysis
In collaboration with SoC&M (Dr Liz Stuart) and University of Newcastle. Supported by EPSRC CARMEN grant

Masud MS, Borisyuk R. (2011) Statistical technique for analysing functional connectivity of multiple spike trains. J Neurosci Methods. 196(1):201-19.
Somerville J, Stuart L, Sernagor E, Borisyuk R. (2010) iRaster: a novel information visualization tool to explore spatiotemporal patterns in multiple spike trains. J Neurosci Methods. 194(1):158-71

Complex nonlinear dynamics and bifurcations of coupled oscillators
In collaboration with Institute of Mathematical Problems in Biology, Russian Academy of Science and Institute of Mathematics, Ukrainian Academy of Science; Supported by the Travel grants from the Royal Society (2010) and Plymouth University (2012).

Kazanovich Y, Burylko O., Borisyuk R. (2013) Competition for synchronization in a phase oscillator system. PhysicaD, 261, 114-124.
Burylko O., Kazanovich Y., Borisyuk R. (2012) Bifurcations in phase oscillator networks with a central element. PhysicaD, 241 (12), 1072-1089.  

Key publications are highlighted

Journals
Articles
Borisyuk R, Al Azad AK, Conte D, Roberts A & Soffe SR 2014 'A developmental approach to predicting neuronal connectivity from small biological datasets: a gradient-based neuron growth model' PLoS One 9, (2) Author Site , DOI PEARL
Burylko O, Kazanovich Y & Borisyuk R 2014 'Bifurcation study of phase oscillator systems with attractive and repulsive interaction' Phys Rev E Stat Nonlin Soft Matter Phys 90, (2) Author Site , DOI PEARL
Burylko O, Kazanovich Y & Borisyuk R 2014 'Bifurcation study of phase oscillator systems with attractive and repulsive interaction' PHYSICAL REVIEW E 90, (2) Author Site , DOI
Roberts A, Conte D, Hull M, Merrison-Hort R, al Azad AK, Buhl E, Borisyuk R & Soffe SR 2014 'Can simple rules control development of a pioneer vertebrate neuronal network generating behavior?' J Neurosci 34, (2) 608-621 Author Site , DOI
Li WC, Merrison-Hort R, Zhang HY & Borisyuk R 2014 'The generation of antiphase oscillations and synchrony by a rebound-based vertebrate central pattern generator' J Neurosci 34, (17) 6065-6077 Author Site , DOI
Merrison-Hort R, Yousif N, Njap F, Hofmann UG, Burylko O & Borisyuk R 2013 'An interactive channel model of the Basal Ganglia: bifurcation analysis under healthy and parkinsonian conditions' J Math Neurosci 3, (1) Author Site , DOI
Kazanovich Y, Burylko O & Borisyuk R 2013 'Competition for synchronization in a phase oscillator system' PHYSICA D-NONLINEAR PHENOMENA 261, 114-124 Author Site , DOI
Borisyuk R, Chik D, Kazanovich Y & da Silva Gomes J 2013 'Spiking neural network model for memorizing sequences with forward and backward recall' Biosystems 112, (3) 214-223 Author Site , DOI
Merrison-Hort R & Borisyuk R 2013 'The emergence of two anti-phase oscillatory neural populations in a computational model of the Parkinsonian globus pallidus' FRONTIERS IN COMPUTATIONAL NEUROSCIENCE 7, Author Site , DOI
Burylko O, Kazanovich Y & Borisyuk R 2012 'Bifurcations in phase oscillator networks with a central element' PHYSICA D-NONLINEAR PHENOMENA 241, (12) 1072-1089 Author Site , DOI
Yousif N, Borisyuk R, Pavese N, Nandi D & Bain P 2012 'Spatiotemporal visualization of deep brain stimulation-induced effects in the subthalamic nucleus' Eur J Neurosci 36, (2) 2252-2259 Author Site , DOI
Borisyuk R, Al Azad AK, Conte D, Roberts A & Soffe SR 2011 'Modeling the connectome of a simple spinal cord' Front Neuroinform 5, Author Site , DOI
Borisyuk R, Azad AKA, Conte D, Roberts A & Soffe SR 2011 'Modelling the connectome of a simple spinal cord' Frontiers in Neuroinformatics 5, Publisher Site , DOI
Masud MS & Borisyuk R 2011 'Statistical technique for analysing functional connectivity of multiple spike trains' J Neurosci Methods 196, (1) 201-219 Author Site , DOI
Somerville J, Stuart L, Sernagor E & Borisyuk R 2010 'iRaster: a novel information visualization tool to explore spatiotemporal patterns in multiple spike trains' J Neurosci Methods 194, (1) 158-171 Author Site , DOI
Borisyuk R, Kazanovich Y, Chik D, Tikhanoff V & Cangelosi A 2009 'A neural model of selective attention and object segmentation in the visual scene: an approach based on partial synchronization and star-like architecture of connections' Neural Netw 22, (5-6) 707-719 Author Site , DOI
Borisyuk R, Chik D & Kazanovich Y 2009 'SELECTIVE ATTENTION MODEL OF MOVING OBJECTS' NEURAL NETWORK WORLD 19, (5) 429-445 Author Site
Chik D, Borisyuk R & Kazanovich Y 2009 'Selective attention model with spiking elements' Neural Netw 22, (7) 890-900 Author Site , DOI
Borisyuk R, Chik D & Kazanovich Y 2009 'Visual perception of ambiguous figures: synchronization based neural models' Biol Cybern 100, (6) 491-504 Author Site , DOI
Borisyuk R, Cooke T & Roberts A 2008 'Stochasticity and functionality of neural systems: mathematical modelling of axon growth in the spinal cord of tadpole' Biosystems 93, (1-2) 101-114 Author Site , DOI
Li W-C, Cooke T, Sautois B, Soffe SR, Borisyuk R & Roberts A 2007 'Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network' NEURAL DEVELOPMENT 2, Author Site , DOI
Borisyuk R & Yousif N 2007 'International symposium: theory and neuroinformatics in research related to deep brain stimulation' Expert Rev Med Devices 4, (5) 587-589 Author Site , DOI
Borisyuk R & Cooke T 2007 'Metastable states, phase transitions, and persistent neural activity' BIOSYSTEMS 89, (1-3) 30-37 Author Site , DOI
Kazanovich Y & Borisyuk R 2006 'An oscillatory neural model of multiple object tracking' NEURAL COMPUTATION 18, (6) 1413-1440 Author Site , DOI
Borisyuk R & Kazanovich Y 2006 'Oscillations and waves in the models of interactive neural populations' BIOSYSTEMS 86, (1-3) 53-62 Author Site , DOI
Borisyuk R, Borisyuk G, Rallings C & Thrasher M 2005 'Forecasting the 2005 General Election: A Neural Network Approach' British Journal of Politics and International Relations 7, 199-209 Author Site , DOI
Borisyuk R 2005 'Models of the hippocampal theta rhythm. , :' Journal of High Nervous Activity (Zhurnal visshei nervnoi deytel’nosti) (in Russian) 54, 83-98
Borisyuk R 2005 'Neural connectivity and dynamical regimes of neural activity in a network of interactive populations' BRAIN, VISION, AND ARTIFICIAL INTELLIGENCE, PROCEEDINGS 3704, 39-48 Author Site
Stuart L, Walter M & Borisyuk R 2005 'The correlation grid: analysis of synchronous spiking in multi-dimensional spike train data and identification of feasible connection architectures' Biosystems 79, (1-3) 223-233 Author Site , DOI
Stuart L, Walter M & Borisyuk R 2005 'The correlation grid: analysis of synchronous spiking in multi-dimensional spike train data and identification of feasible connection architectures' Biosystems 79, (1-3) 223-233
Borisyuk R & Hoppensteadt F 2004 'A theory of epineuronal memory' NEURAL NETWORKS 17, (10) 1427-1436 Author Site , DOI
Borisyuk RM & Kazanovich YB 2004 'Designing an oscillatory model of brain cognitive functions' Connectionist Models of Cognition and Perception Ii 15, 285-294
Borisyuk RM & Kazanovich YB 2004 'Oscillatory model of attention-guided object selection and novelty detection' Neural Networks 17, (7) 899-915 , DOI
Borisyuk RM 2004 'Simulation of the hippocampal theta rhythm' Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova 54, (1) 85-100
Borisyuk RM & Kazanovich YB 2003 'Oscillatory neural network model of attention focus formation and control' Biosystems 71, (1-2) 29-38 , DOI
Kazanovich Y & Borisyuk R 2003 'Synchronization in oscillator systems with a central element and phase shifts' PROGRESS OF THEORETICAL PHYSICS 110, (6) 1047-1057 Author Site , DOI
Borisyuk GN, Borisyuk RM, Kazanovich YB & Ivanitsky GR 2002 'Modelling the dynamics of neural activity and information processing in the brain: the results of the decade' Uspekhi fizicheskih nauk – Physica - Uspekhi 172, (10) 1189-1214
Borisyuk GN, Borisyuk RM, Kazanovich YB & Ivanitskii GR 2002 'Models of neural dynamics in brain information processing — the developments of 'the decade'' Physics-Uspekhi 45, (10) 1073-1095 , DOI
Kazanovich Y & Borisyuk R 2002 'Object selection by an oscillatory neural network' BIOSYSTEMS 67, (1-3) 103-111 Author Site , DOI
Borisyuk R 2002 'Oscillatory activity in the neural networks of spiking elements' BIOSYSTEMS 67, (1-3) 3-16 Author Site , DOI
Borisyuk R & Bugmann G 2002 'Special issue - Papers presented at the International Workshop on NEURONAL CODING '01 - Plymouth, UK 9-14 September, 2001 - Foreword' BIOSYSTEMS 67, (1-3) 1-2 Author Site , DOI
Stuart L, Walter M & Borisyuk R 2002 'Visualisation of synchronous firing in multi-dimensional spike trains' Biosystems 67, (1-3) 265-279 Author Site
Stuart L, Walter M & Borisyuk R 2002 'Visualisation of synchronous firing in multi-dimensional spike trains' Biosystems 67, (1-3) 265-279
Stuart L, Walter M & Borisyuk R 2002 'Visualization of Synchronous Firing in Multi-dimensional Spike Trains' BioSystems, 67, 265-279
Borisyuk R, Denham M, Hoppensteadt F, Kazanovich A & Vinogradova O 2001 'Oscillatory model of novelty detection' NETWORK-COMPUTATION IN NEURAL SYSTEMS 12, (1) 1-20 Author Site , DOI
Borisyuk R 2001 'Puzle of chaotic neurodynamics' Behaioral Brain Science 24, 812-813
Borisyuk R 2001 'The puzzle of chaotic neurodynamics' BEHAVIORAL AND BRAIN SCIENCES 24, (5) 812-+ Author Site
Denham MJ & Borisyuk R 2000 'A computational model of GABAergic mediated theta rhythm production in the septal-hippocampal system and its modulation by ascending brainstem pathways' EUROPEAN JOURNAL OF NEUROSCIENCE 12, 161-161 Author Site
Borisyuk R, Denham M, Hoppensteadt F, Kazanovich Y & Vinogradova O 2000 'An oscillatory neural network model of sparse distributed memory and novelty detection' Biosystems 58, (1-3) 265-272 Author Site
Borisyuk R 2000 'Encyclopedia of computational neuroscience: The end of the second millennium' BEHAVIORAL AND BRAIN SCIENCES 23, (4) 534-+ Author Site , DOI
Borisyuk R, Denham M, Denham S & Hoppensteadt F 1999 'Computational models of predictive and memory-related functions of the hippocampus' Rev Neurosci 10, (3-4) 213-232 Author Site
Borisyuk R & Hoppensteadt F 1999 'Oscillatory models of the hippocampus: a study of spatio-temporal patterns of neural activity' Biol Cybern 81, (4) 359-371 Author Site , DOI
Borisyuk R 1998 'Oscillatory neural network models of information processing in the brain' EUROPEAN JOURNAL OF NEUROSCIENCE 10, 268-268 Author Site
Borisyuk R, Borisyuk G & Kazanovich Y 1998 'Synchronization of neural activity and information processing' BEHAVIORAL AND BRAIN SCIENCES 21, (6) 833-+ Author Site , DOI
Borisyuk RM, Borisyuk GN & Kazanovich YB 1998 'The synchronization principle in modelling of binding and attention' Membr Cell Biol 11, (6) 753-761 Author Site
Borisyuk RM & Borisyuk GN 1997 'Information coding on the basis of synchronization of neuronal activity' Biosystems 40, (1-2) 3-10 Author Site
Borisyuk RM, Borisyuk GN & Kazanovich YB 1997 'Pre-attention and attention modelling based on synchronization of neural activity' Biologicheskie Membrany 14, 614-620
Borisyuk R, Casolino M, DePascale MP, Morselli A, Picozza P, Ogurtsov A, Ricci M & Sparvoli R 1996 'Gamma-ray energy determination using neural network algorithms for an imaging silicon calorimeter' NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 381, (2-3) 512-516 Author Site , DOI
Borisyuk GN, Borisyuk RM, Khibnik AI & Roose D 1995 'Dynamics and bifurcations of two coupled neural oscillators with different connection types' Bull Math Biol 57, (6) 809-840 Author Site
Godukhin OV, Borisyuk GN, Borisyuk RM, Kirillov AB, Kovalenko EI & Kryukov VI 1981 'TYPES OF SPIKE DISCHARGE AND CHARACTER OF CORRELATION BETWEEN NEURONS IN THE RAT NEOSTRIATUM' Neurophysiology 13, 406-413
Books
Cangelosi A, Bugmann G & Borisyuk R 2005 Modeling language, cognition and action. Singapore World Scientific
Chapters
Borisyuk R, Borisyuk G & Kazanovich Y 2001 'Temporal structure of neural activity and modelling of information processing in the brain' 237-254
Conference Papers
Borisyuk R, Chik D, Kazanovich Y & IEEE 2009 'Partial Synchronization of Neural Activity and Information Processing' //0 //0 3399-3406
Borisyuk R, Chik D & Kazanovich Y 2008 'Selective attention model of moving objects' //0 //0 358-367
Borisyuk R & ieee 2004 'Stochastic dynamics and partial synchronization of stimulus-driven neural activity' //0 //0 3035-3040
Walter MA, Stuart LJ & Borisyuk R 2003 'Spike train correlation visualization' //0 //0 555-560