- Deans Office, John Bull Building, Research Way, Plymouth Science Park, Plymouth, PL6 8BU
- robert.sneyd@pms.ac.uk
Profiles
Professor Robert Sneyd
Emeritus Professor
Faculty of Health
Robert can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
- Pharmacology
- Clinical trials
- Medicine
- Anaesthesia
- Acute pain management
- Drug development
- Sedation
- Medical education leadership
Email publicrelations@plymouth.ac.uk to enquire.
Qualifications
Qualifications: MD MA MB BChir FRCA SFHEAProfessor Sneyd was brought up in Cornwall and one of his first jobs (1975) was as a Nursing Auxiliary in Devonport Hospital, Plymouth - now long since demolished! He graduated from Cambridge University in 1981 and continued his medical training in London. Halfway through he undertook a research degree and then spent a period working full time in the pharmaceutical industry before returning to work in the NHS.
After completing his UK anaesthetic training, he worked at the University of Michigan Medical School at Ann Arbor, USA. In 1993, he returned to the South West as a Consultant Anaesthetist and after a few years moved to the University as Reader in Anaesthesia and then Professor. In 1998 he took over the running of the Plymouth Postgraduate Medical School, first as Acting Dean and then as Dean. He led the Plymouth team in the successful bid for a new Peninsula Medical School and served as Vice-Dean of the Peninsula College of Medicine and Dentistry. The first medical graduates have been working as NHS doctors since 1st August 2007 and the dental graduates have been doing so since 2011. He worked as a Consultant Anaesthetist at Derriford Hospital, mostly in neuro-anaesthesia and is very familiar with the interface between universities and the NHS. Until retiring in late 2018 he served as Executive Dean of the Faculty of Medicine and Dentistry in Plymouth, leading schools of medicine, dentistry and biomedical science.
In anaesthesia he has engaged nationally through the Association of Anaesthetists of Great Britain and Ireland as Council Member and Vice-President (2006-2011), the Royal College of Anaesthetists, UK as Council Member and Vice-President (2008-2018) and internationally with the European Society of Anaesthesiology, ESA as Council member and Director (2006-2012). For the NHS he has served on the Board of University Hospitals Plymouth (2013-2018), Peninsula Dental Social Enterprise (2013-2018) and Cornwall Partnership NHS Foundation Trust (2017-2019). Also Chair of the Intensive Care National Audit and Research Centre (2019-2020). In each case he has tried to represent the interests of patients and clinicians with an emphasis on sound strategy and common sense.
Professor Sneyd's research interests focus on drugs, pharmacology and pharmacokinetics with related projects based on signal processing. Having worked in the pharmaceutical industry he has a special interest in drug development, especially in intravenous anaesthesia. He led the 2013 UK national sedation review for the Academy of Medical Royal Colleges. He is a regular scientific reviewer, mostly for the British Journal of Anaesthesia but also for Anesthesiology, Anaesthesia, Anesthesia and Analgesia, the European Journal of Anaesthesiology and various other journals.
As Emeritus Professor he remains research active and works internationally to support the development of new medicines.
Roles on external bodies
Key publications
2008 'Novel lipid and preservative-free propofol formulation: properties and pharmacodynamics' Pharm Res 25, (2) 313-319 , DOI
2005 'Population pharmacokinetics of remifentanil in critically ill post cardiac neonates, infants and children' BRITISH JOURNAL OF ANAESTHESIA 95, (4) 578P-579P
2008 'Anaesthetic effects of propofol polymeric micelle: a novel water soluble propofol formulation' Br J Anaesth 101, (2) 186-193 , DOI
2008 'Assessing fitness for surgery: a comparison of questionnaire, incremental shuttle walk, and cardiopulmonary exercise testing in general surgical patients' Br J Anaesth 101, (6) 774-780 , DOI Open access
2005 'Mild intraoperative hypothermia during surgery for intracranial aneurysm' NEW ENGLAND JOURNAL OF MEDICINE 352, (2) 135-145 , DOI
1996 'Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination' Br J Anaesth 77, (4) 445-447 , DOI
Key publications
2008 'Novel lipid and preservative-free propofol formulation: properties and pharmacodynamics' Pharm Res 25, (2) 313-319 , DOI
2005 'Population pharmacokinetics of remifentanil in critically ill post cardiac neonates, infants and children' BRITISH JOURNAL OF ANAESTHESIA 95, (4) 578P-579P
2008 'Anaesthetic effects of propofol polymeric micelle: a novel water soluble propofol formulation' Br J Anaesth 101, (2) 186-193 , DOI
2008 'Assessing fitness for surgery: a comparison of questionnaire, incremental shuttle walk, and cardiopulmonary exercise testing in general surgical patients' Br J Anaesth 101, (6) 774-780 , DOI Open access
2005 'Mild intraoperative hypothermia during surgery for intracranial aneurysm' NEW ENGLAND JOURNAL OF MEDICINE 352, (2) 135-145 , DOI
1996 'Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination' Br J Anaesth 77, (4) 445-447 , DOI
Key publications are highlighted
Journals
Articles
2021 'Covid-19 vaccine rollout is missing any real sense of urgency' BMJ: British Medical Journal Open access
2020 'The value of anaesthesiologists in the COVID-19 pandemic: a model for our future practice?' British Journal of Anaesthesia 125, (5) 652-655 , DOI Open access
2020 'Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes' British Journal of Anaesthesia , DOI
2020 'Patient‐centred measurement of recovery from day‐case surgery using wrist worn accelerometers: a pilot and feasibility study' Anaesthesia , DOI Open access
2020 'Impact of Closed-loop Anesthesia on Cognitive Function: Comment' Anesthesiology 133, (4) 945-946 , DOI Open access
2020 'Impact of the COVID-19 pandemic on anaesthesia trainees and their training' British Journal of Anaesthesia 125, (4) 450-455 , DOI Open access
2020 'Remimazolam for anaesthesia or sedation' Current opinion in anaesthesiology 33, (4) 506-511 , DOI Open access
2019 'Deploying accelerometers for assessing recovery after day surgery' British Journal of Anaesthesia 123, (4) e498-e498 , DOI
2019 'The US’s decision to resume the death penalty puts the wider public at risk' BMJ: British Medical Journal Publisher Site Open access
2019 'Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: clinical indicators' British Journal of Anaesthesia , DOI
2019 'Capital punishment, my sixth great grandfather, and me—an essay by J Robert Sneyd' BMJ l1512-l1512 , DOI Open access
2019 'Postoperative critical care and high-acuity care provision in the United Kingdom, Australia, and New Zealand' British Journal of Anaesthesia 122, (4) 460-469 , DOI
2019 'Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis' British Journal of Anaesthesia 122, (4) 500-508 , DOI
2019 'Who watches the watchmen and the problem of recursive flea bites' British Journal of Anaesthesia 122, (4) 407-408 , DOI Open access
2018 'Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals' British Journal of Anaesthesia 121, (4) 730-738 , DOI
2018 'A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications' British Journal of Anaesthesia , DOI Open access
2018 'Attempting tracheal intubation without paralysis' British Journal of Anaesthesia 120, (6) 1429-1430 , DOI Open access
2018 'Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial' Anesth Analg , DOI Open access
2018 'Quest for new drugs: a way to solve anaesthesia neurotoxicity?' British Journal of Anaesthesia 120, (4) 619-621 , DOI Open access
2018 'Response to Serrao and Goodchild' British Journal of Anaesthesia 120, (4) 878-879 , DOI Open access
2018 'Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes' British Journal of Anaesthesia , DOI
2017 'A modified supraglottic airway for gastroscopy – an advance in patient safety?' British Journal of Anaesthesia 120, (2) 209-211 , DOI Open access
2017 'Thiopental to desflurane - an anaesthetic journey. Where are we going next?' British journal of anaesthesia 119, (suppl_1) i44-i52 , DOI Open access
2017 'Perioperative statins surgery and postoperative pain' Br J Anaesth 119, (4) 712-715 , DOI Open access
2017 'Comprehensive moUth care and Postoperative PneumoniA (CUPPA) - a traineeled randomised controlled trial' ANAESTHESIA 72, 36-36
2017 'Intraoperative dexamethasone does not increase the risk of postoperative wound infection: a propensity score-matched post hoc analysis of the ENIGMA-II trial (EnDEX)' British Journal of Anaesthesia 118, (2) 190-199 , DOI
2017 'Making sense of propofol sedation for endoscopy' British Journal of Anaesthesia 118, (1) 6-7 , DOI Open access
2016 'Time to move the goalposts? Do we need new targets for developing i.v. anaesthetics?' British Journal of Anaesthesia 117, (6) 684-687 , DOI Open access
2016 'Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial' British Journal of Anaesthesia 117, (6) 801-811 , DOI
2016 'Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness' Crit Care Med 44, (8) e614-e624 , DOI Open access
2016 'CUMSUM cannot define competency' British Journal of Anaesthesia 117, (1) 139-140 , DOI Open access
2016 'Severe Nausea and Vomiting in the Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia II Trial' Anesthesiology 124, (5) 1032-1040 , DOI Open access
2016 'Standardizing end points in perioperative trials: towards a core and extended outcome set' British Journal of Anaesthesia 116, (5) 586-589 , DOI Open access
2016 'Validation of preoperative cardiopulmonary exercise testing-derived variables to predict in-hospital morbidity after major colorectal surgery' British Journal of Surgery 103, (6) 744-752 , DOI
2016 'Endocrine disruptors in paediatric patients & in-vitro sealant weight variability' Dental Materials 32, , DOI
2015 'UK academic general practice and primary care - Plymouth medical school is committed to producing GPs of the future' BMJ 351, h4218-h4218 , DOI
2015 'NAP5 and the isolated forearm technique' British Journal of Anaesthesia 115, (1) 138-139 , DOI Open access
2015 'The NIAA Perioperative Clinical Trials Group: New horizons for UK perioperative medicine research' Bulletin of the Royal College of Anaesthetists 92, 17-17 Publisher Site Open access
2015 'A comparison of linear and logarithmic auditory tones in pulse oximeters' Applied Ergonomics 51, 350-357 , DOI Open access
2015 'Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis' Open Heart 2, , DOI Open access
2015 'Defining competence in obstetric epidural anaesthesia for inexperienced trainees' British journal of anaesthesia 114, (6) 951-957 , DOI Open access
2015 'Randomised controlled trial of stroke volume optimisation during elective major abdominal surgery in patients stratified by aerobic fitness' British Journal of Anaesthesia 115, 578-589 , DOI Open access
2015 'Sedation practice in six acute hospitals - a snapshot survey' Anaesthesia 70, (4) 407-415 , DOI Open access
2015 'Predictors of Cognitive Status in Post-Aneurysm Surgery Patients' STROKE 46,
2014 'The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial' The Lancet 384, (9952) 1446-1454 , DOI
2014 'Investigation of the mechanism(s) of oxygen-induced ciliated epithelial loss in bovine bronchus tissue' EUROPEAN RESPIRATORY JOURNAL 44,
2014 'Randomized controlled trial of intraoperative goal-directed fluid therapy using LiDCO and microcirculatory changes in patients having major abdominal surgery' BRITISH JOURNAL OF ANAESTHESIA 113, (2) 330-330
2014 'Cardiopulmonary exercise capacity and preoperative markers of inflammation' Mediators Inflamm 2014, , DOI Open access
2014 'Systemic concentrations of levobupivacaine administered by rectus sheath catheter' BRITISH JOURNAL OF ANAESTHESIA 112, (1) 188P-188P
2013 'Nitrous oxide: are we still in equipoise? A qualitative review of current controversies' Br J Anaesth 111, (6) 877-885 , DOI
2013 'A survey of trainee research experience within the south west peninsula deanery prior to the establishment of a trainee research collaborative' ANAESTHESIA 68, 101-101
2013 'Patients' inability to perform a preoperative cardiopulmonary exercise test or demonstrate an anaerobic threshold is associated with inferior outcomes after major colorectal surgery' Br J Anaesth 111, (4) 607-611 , DOI Open access
2013 'Utility of an anaesthetic trainee led research network to contribute to multicentre studies' ANAESTHESIA 68, 44-44
2013 'Effects of hyperoxia on the permeability of 16HBE14o- cell monolayers--the protective role of antioxidant vitamins E and C' FEBS J 280, (18) 4512-4521 , DOI
2013 'Comparison of three advanced haemodynamic monitors to measure circulating volume status during major rectal surgery' BRITISH JOURNAL OF ANAESTHESIA 110, (5) 873-873
2013 'Proportion of patients undergoing emergency surgery at risk of postoperative pulmonary and cardiac complications South West Anaesthetic Research Matrix ('SWARM')' BRITISH JOURNAL OF ANAESTHESIA 110, (5) 863-864
2013 'Bayesian methods to determine performance differences and to quantify variability among centers in multi-center trials: the IHAST trial' BMC Medical Research Methodology 13, (1) , DOI Open access
2012 'Is postoperative cognitive dysfunction a risk factor for dementia? A cohort follow-up study' British Journal of Anaesthesia 110, (suppl 1) i92-i97 , DOI
2012 'Hyperoxia-induced ciliary loss and oxidative damage in an in vitro bovine model: the protective role of antioxidant vitamins E and C' Biochem Biophys Res Commun 429, (3-4) 191-196 , DOI
2012 'Hyperoxia mediates barrier permeability dysfunction in 16HBE140-cells' EUROPEAN RESPIRATORY JOURNAL 40,
2012 'Remimazolam: new beginnings or just a me-too?' Anesth Analg 115, (2) 217-219 , DOI Open access
2012 'Acute postoperative neurological deterioration associated with surgery for ruptured intracranial aneurysm: incidence, predictors, and outcomes' Journal of Neurosurgery 116, (6) 1267-1278 , DOI
2012 'The effect of temperature on di(2-ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions' Anaesthesia 67, (5) 514-520 , DOI
2012 'A national survey of anaesthetists (NAP5 baseline) to estimate an annual incidence of accidental awareness during general anaesthesia in the UK' Br J Anaesth 110, 501-509 , DOI
2012 'Effects of goal-directed fluid therapy during colorectal surgery on the sublingual microcirculation' BRITISH JOURNAL OF ANAESTHESIA 108, (4) 719-720
2012 'Inability to perform a pre-operative cardiopulmonary exercise test as a predictor of worse outcomes after major colorectal surgery' ANAESTHESIA 67, (4) 445-445
2012 'Patients' inability to perform a preoperative cardiopulmonary exercise test risk predicts inferior medium-term mortality after major colorectal surgery' BRITISH JOURNAL OF ANAESTHESIA 108, (4) 716-717
2012 'Cytochrome P450 polymorphism and postoperative cognitive dysfunction' Minerva Anestesiol 78, (3) 303-309
2012 'First human administration of MR04A3: a novel water-soluble nonbenzodiazepine sedative' Anesthesiology 116, (2) 385-395 , DOI Open access
2012 'Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery' Br J Anaesth 108, (1) 53-62 , DOI Open access
2012 'The role of routine pre-operative bedside echocardiography in detecting aortic stenosis in patients with a hip fracture' Anaesthesia 67, (1) 51-54 , DOI
2011 'Europe is mostly united but lacks a common support of young investigators' Anesthesiology 115, (4) 674-676 , DOI
2011 'Mechanical bowel preparation and fasting may influence aerobic capacity in cardiopulmonary exercise testing' BRITISH JOURNAL OF SURGERY 98, 177-178
2011 'Does a preoperative cardiopulmonary exercise test identify a subgroup of patients who benefit from intraoperative goal directed therapy during elective colorectal surgery?' BRITISH JOURNAL OF SURGERY 98, 38-38
2011 'Inhalational or total intravenous anaesthesia: is total intravenous anaesthesia useful and are there economic benefits?' Curr Opin Anaesthesiol 24, (2) 182-187 , DOI Open access
2011 'Variation of patient characteristics, management, and outcome with timing of surgery for aneurysmal subarachnoid hemorrhage' Journal of Neurosurgery 114, (4) 1045-1053 , DOI
2011 'Is the impact of intraoperative goal-directed fluid therapy on length of stay after major elective colorectal surgery related to patients' aerobic fitness?' BRITISH JOURNAL OF ANAESTHESIA 106, (3) 440P-440P
2011 'Propofol and children--what we know and what we do not know' Paediatr Anaesth 21, (3) 247-254 , DOI Open access
2010 'The incidence and severity of aortic stenosis in an unselected patient population admitted with a hip fracture - the role of routine pre-operative bedside echocardiography' ANAESTHESIA 65, (12) 1249-1249
2010 'New drugs and technologies, intravenous anaesthesia is on the move (again)' Br J Anaesth 105, (3) 246-254 , DOI Open access
2010 'Perioperative Hypothermia (33°C) Does Not Increase the Occurrence of Cardiovascular Events in Patients Undergoing Cerebral Aneurysm Surgery' Anesthesiology 113, (2) 327-342 , DOI
2010 'First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial' BMC Anesthesiol 10, , DOI Open access
2010 'Tracheal intubation without neuromuscular blocking agents: is there any point?' Br J Anaesth 104, (5) 535-537 , DOI Open access
2010 'Does preoperative cardiopulmonary exercise test predict hospital stay after major elective colorectal surgery?' BRITISH JOURNAL OF ANAESTHESIA 104, (4) 519-520
2010 'Interobserver variability in determination of anaerobic threshold by cardiopulmonary exercise testing' ANAESTHESIA 65, (1) 109-110 , DOI
2010 'No Association between Intraoperative Hypothermia or Supplemental Protective Drug and Neurologic Outcomes in Patients Undergoing Temporary Clipping during Cerebral Aneurysm Surgery' Anesthesiology 112, (1) 86-101 , DOI
2009 'Routine use of nasogastric tubes does not reduce postoperative nausea and vomiting' Anesth Analg 109, 768-773 , DOI
2009 'Off-label use of medicines is bad medicine flying the flag of clinical freedom' Int J Obstet Anesth 18, (3) 249-250 , DOI Open access
2009 'PERIOPERATIVE FEVER AND OUTCOME IN SURGICAL PATIENTS WITH ANEURYSMAL SUBARACHNOID HEMORRHAGE' Neurosurgery 64, (5) 897-909 , DOI
2009 'Effect of temperature on plasticizer release [di(2-ethylhexyl)phthalate] from TIVA infusion sets' BRITISH JOURNAL OF ANAESTHESIA 102, (4) 581-582
2009 'Effect of Nitrous Oxide Use on Long-term Neurologic and Neuropsychological Outcome in Patients Who Received Temporary Proximal Artery Occlusion during Cerebral Aneurysm Clipping Surgery' Anesthesiology 110, (3) 563-573 , DOI
2009 'Long-term Consequences of Postoperative Cognitive Dysfunction' Anesthesiology 110, (3) 548-555 , DOI
2008 'Independent Associations Between Electrocardiographic Abnormalities and Outcomes in Patients With Aneurysmal Subarachnoid Hemorrhage: Findings From the Intraoperative Hypothermia Aneurysm Surgery Trial' Stroke 40, (2) 412-418 , DOI
2008 'Assessing fitness for surgery: a comparison of questionnaire, incremental shuttle walk, and cardiopulmonary exercise testing in general surgical patients' Br J Anaesth 101, (6) 774-780 , DOI Open access
2008 'Pharmacokinetics and anaesthetic effects of propofol-PM: a novel water soluble propofol formulation' ANAESTHESIA 63, (12) 1392-1393 , DOI
2008 'Memory and awareness during anaesthesia' BRITISH JOURNAL OF ANAESTHESIA 101, (5) 739-740
2008 'Anaesthetic effects of propofol polymeric micelle: a novel water soluble propofol formulation' Br J Anaesth 101, (2) 186-193 , DOI
2008 'Effect of Nitrous Oxide on Neurologic and Neuropsychological Function after Intracranial Aneurysm Surgery' Anesthesiology 108, (4) 568-579 , DOI
2008 'Hyperglycemia in Patients Undergoing Cerebral Aneurysm Surgery: Its Association With Long-term Gross Neurologic and Neuropsychological Function' Mayo Clinic Proceedings 83, (4) 406-417 , DOI
2008 'Novel lipid and preservative-free propofol formulation: properties and pharmacodynamics' Pharm Res 25, (2) 313-319 , DOI
2007 'A comparison of questionnaire, shuttle walk and cardiopulmonary exercise testing in preoperative assessment of high-risk general surgical patients' BRITISH JOURNAL OF ANAESTHESIA 99, (5) 764P-764P
2007 'Choice reaction time in patients with post-operative cognitive dysfunction*' Acta Anaesthesiologica Scandinavica 52, (1) 95-98 , DOI
2007 'Plasticizer release (DEHP) from TIVA infusion sets' BRITISH JOURNAL OF ANAESTHESIA 99, (5) 765P-765P
2007 'Elevated oxygen fraction reduces cilial abundance in explanted human bronchial tissue' Ultrastruct Pathol 31, (5) 339-346 , DOI
2007 'Improving prediction of outcome in "good grade" subarachnoid hemorrhage' NEUROSURGERY 61, (3) 470-473 , DOI
2007 'IMPROVING PREDICTION OF OUTCOME IN “GOOD GRADE” SUBARACHNOID HEMORRHAGE' Neurosurgery 61, (3) 470-474 , DOI
2007 'Recovery of Cognitive Function After Surgery for Aneurysmal Subarachnoid Hemorrhage' Stroke 38, (6) 1864-1872 , DOI
2007 'Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain following third molar extraction' British Journal of Anaesthesia 98, (5) 672-676 , DOI
2007 'Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery' British Journal of Anaesthesia 99, (2) 252-261 , DOI
2007 'Acute hydrocephalus and clinical outcome in subarachnoid hemorrhage' STROKE 38, (2) 541-541
2007 'Brain swelling, surgical exposure, and outcome following subarachnoid hemorrhage' STROKE 38, (2) 542-542
2007 'Early postoperative neurological deficits and outcome after subarachnoid hemorrhage in good grade patients' STROKE 38, (2) 475-475
2007 'Use of MMSE as an outcome assessment in patients with subarachnoid hemorrhage' STROKE 38, (2) 541-541
2007 'A comparison of questionnaire, shuttle walk and cardiopulmonary exercise testing in preoperative assessment of high-risk general surgical patients' British Journal of Anaesthesia 99, (5) 764P-764P
2007 'Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction' British Journal of Anaesthesia 98, (5) 672-676
2007 'Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery' British Journal of Anaesthesia 99, (2) 252-261
2006 'Effects of intraoperative hypothermia on neuropsychological outcomes after intracranial aneurysm surgery' Annals of Neurology 60, (5) 518-527 , DOI
2006 'Depth of anaesthesia monitoring: what's available, what's validated and what's next?' Br J Anaesth 97, (1) 85-94 , DOI
2006 'A Bayesian network model to predict fever following aneurysmal subarachnoid hemorrhage' STROKE 37, (2) 726-726
2006 'A shortened baseline NIH stroke scale predicts 3-month outcome after subarachnoid hemorrhage' STROKE 37, (2) 640-640
2006 'Cerebral infarction by aneurysm location in neurosurgically treated patients: Analysis of the IHAST dataset' STROKE 37, (2) 725-725
2006 'Fever is associated with adverse outcomes following aneurysmal subarachnoid hemorrhage' STROKE 37, (2) 689-689
2006 'Intraoperative hyperglycemia is associated with increased long-term postoperative cognitive abnormalities in patients undergoing cerebral aneurysm clipping' STROKE 37, (2) 691-691
2006 'Organ culture of human bronchial explants' BRITISH JOURNAL OF ANAESTHESIA 96, (2) 281P-282P
2006 'The effects of hypothermia on neuropsychological outcomes after cerebral aneurysm surgery' STROKE 37, (2) 673-674
2006 'Uneven cilial distribution in rat trachea' BRITISH JOURNAL OF ANAESTHESIA 96, (2) 281P-281P
2005 'Is peri-operative cortisol secretion related to post-operative cognitive dysfunction?' Acta Anaesthesiol Scand 49, (9) 1225-1231 , DOI
2005 'Population pharmacokinetics of remifentanil in critically ill post cardiac neonates, infants and children' BRITISH JOURNAL OF ANAESTHESIA 95, (4) 578P-579P
2005 'Painless surgery' NEW SCIENTIST 187, (2515) 18-18
2005 'Intraoperative clonidine administration to neurosurgical patients' Anesth Analg 101, (3) 922-923 , DOI
2005 'Oxidative metabolism in platelets, platelet aggregation, and hematology in patients undergoing multiple hyperbaric oxygen exposures' Undersea Hyperb Med 32, (5) 327-340
2005 'A single exposure to hyperbaric oxygen does not cause oxidative stress in isolated platelets: no effect on superoxide dismutase, catalase, or cellular ATP' Clin Biochem 38, (8) 722-726 , DOI
2005 'Comparison of propofol/remifentanil and sevoflurane/remifentanil for maintenance of anaesthesia for elective intracranial surgery' Br J Anaesth 94, (6) 778-783 , DOI
2005 'Bispectral index and propofol induction: beware of inappropriate conclusions' Anesth Analg 100, (3) 904-905 , DOI
2005 'Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST)' Neurosurgery 56, (3) N9-N10 , DOI
2005 'Recent advances in intravenous anaesthesia' BRITISH JOURNAL OF ANAESTHESIA 94, (3) 393-393
2005 'Mild intraoperative hypothermia during surgery for intracranial aneurysm' NEW ENGLAND JOURNAL OF MEDICINE 352, (2) 135-145 , DOI
2005 'Intraoperative clonidine administration to neurosurgical patients' Anesthesia and Analgesia 101, (3) 922-923
2004 'Postoperative cognitive dysfunction: true deterioration versus random variation' Acta Anaesthesiologica Scandinavica 48, (9) 1137-1143 , DOI
2004 'Carbon monoxide exposure in rat heart: evidence for two modes of toxicity' Biochem Biophys Res Commun 321, (1) 241-246 , DOI
2004 'A Factorial Trial of Six Interventions for the Prevention of Postoperative Nausea and Vomiting' New England Journal of Medicine 350, (24) 2441-2451 , DOI
2004 'Carbon monoxide exposure in rat heart: evidence for two modes of toxicity' Biochemical and Biophysical Research Communications 321, (1) 241-246 , DOI
2004 'Intraoperative hypothermia for intracranial aneurysm surgery (IHAST): Initial trial results' STROKE 35, (1) 250-250
2004 'Nonlinear methods for biopattern analysis: role and challenges' Conf Proc IEEE Eng Med Biol Soc 2004, 5400-5406 , DOI
2004 'Safety and tolerability of volplex((r)) in elective surgery' Clin Drug Investig 24, 73-79
2003 'Remifentanil manual versus target-controlled infusion [13] (multiple letters)' Anesthesia and Analgesia 97, (1)
2003 'Cognitive dysfunction after minor surgery in the elderly' Acta Anaesthesiologica Scandinavica 47, (10) 1204-1210 , DOI
2003 'Carbon monoxide exposure in rat heart: glutathione depletion is prevented by antioxidants' Biochemical and Biophysical Research Communications 302, (2) 392-396 , DOI
2003 'Cognitive dysfunction after minor surgery in the elderly' Acta Anaesthesiologica Scandinavica 47, (10) 1204-1210
2003 'Remifentanil manual versus target-controlled infusion' Anesthesia and Analgesia 97, (1) 300-300
2002 'Longterm functional recovery following day-case laparoscopic sterilisation: inhalational versus TIVA maintenance' Jorunal of Ambulatory Surgery 10, 45-51
2002 'Cultured rat trachea as a model for the study of ciliary abundance: the effect of oxygen' Anesthesiology 97, (1) 275-277 , DOI
2002 'Critically ischaemic feet harbour an endothelium mediated but nitric oxide independent pathway that shunts blood away from the nutritional microcirculation' BRITISH JOURNAL OF SURGERY 89, 100-100
2002 'Pharmacokinetics of propofol infusions in critically ill neonates, infants and children in intensive care' Anesthesiology 97, (6) 1393-1400 , DOI
2002 'Pharmacokinetics of propofol infusions in critically ill neonates, infants, and children in an intensive care unit' Anesthesiology 97, (6) 1393-1400
2001 'Drug development in the 21st century' Current Anaesthesia & Critical Care 12, (6) 329-334 , DOI
2001 'Erratum for :Remifentanil and fentanyl during anaesthesia for major abdominal and gynaecological surgery. An open, comparative study of safety and efficacy' European Journal of Anaesthesiology 18, (12) 839-839 , DOI
2001 'Remifentanil and fentanyl during anaesthesia for major abdominal and gynaecological surgery. An open, comparative study of safety and efficacy (vol 18, pg 605, 2001)' EUROPEAN JOURNAL OF ANAESTHESIOLOGY 18, (12) 839-839
2001 'Remifentanil and fentanyl during anaesthesia for major abdominal and gynaecological surgery. An open, comparative study of safety and efficacy' Eur J Anaesthesiol 18, (9) 605-614 , DOI
2001 'Using Simulations in the Design of an Anesthesia System' Simulation & Gaming 32, (2) 205-214 , DOI
2001 'The assessment of postoperative cognitive function' Acta Anaesthesiologica Scandinavica 45, (3) 275-289 , DOI
2001 'Abnormalities of respiratory cilia in non-symptomatic smokers and non-smokers' BRITISH JOURNAL OF ANAESTHESIA 86, (2) 326P-326P
2001 'Ciliary abundance and abnormalities in critical illness' BRITISH JOURNAL OF ANAESTHESIA 86, (2) 321P-322P
2001 'Abnormalities of respiratory cilia in non-symptomatic smokers and non-smokers' British Journal of Anaesthesia 86, (2) 326P-326P
2001 'Carbon monoxide toxicity in the heart: evidence for ischaemia/reperfusion like injury. Joint meeting of the Biochemical Society and Physiological Society' Biochemical Society Transactions 30,
2001 'Ciliary abundance and abnormalities in critical illness' British Journal of Anaesthesia 86, (2) 321P-322P
2001 'Lessons from Stafford' British Journal of Anaesthesia 86, (4) 469-473
2001 'The effect of multiple hyperbaric oxygen treatments on blood function and redox status. Joint meeting of the Biochemical Society and Physiological Society' Biochemical Society Transactions 30,
2000 'Conflicts of interest: are they a problem for anaesthesia journals? What should we do about them?' Br J Anaesth 85, (6) 811-814 , DOI
2000 'Cognitive dysfunction 1-2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction' Acta Anaesthesiol Scand 44, (10) 1246-1251
2000 'Propofol/remifentanil vs sevoflurane/remifentanil for maintenance of anaesthesia during craniotomy' ANESTHESIOLOGY 93, (3A) U152-U152
2000 'Does wound irrigation with triamcinolone reduce pain after surgery to the lumbar spine?' Br J Anaesth 84, (6) 731-734 , DOI
2000 'Incidence of hospital admission does not equal incidence of disease (multiple letters)' British Medical Journal 320, (7244)
2000 'Incidence of hospital admission does not equal incidence of disease. Conclusions drawn from data are incorrect' BMJ 320, (7244)
2000 'Do blood concentrations of neurone specific enolase and S-100 beta protein reflect cognitive dysfunction after abdominal surgery?ISPOCD Group' British Journal of Anaesthesia 84, (2) 242-244 , DOI
2000 'Wound infiltration with bupivacaine after surgery to the cervical spine using a posterior approach' Br J Anaesth 84, (1) 87-88 , DOI
1999 'Oxygen administration and explicit memory: no improvement found in healthy volunteers' Br J Anaesth 83, (5) 801-804 , DOI
1999 'Benzodiazepines and postoperative cognitive dysfunction in the elderly. ISPOCD Group. International Study of Postoperative Cognitive Dysfunction' British Journal of Anaesthesia 83, (4) 585-589 , DOI
1999 'Closed-loop sedation during knee surgery under epidural anaesthesia' BRITISH JOURNAL OF ANAESTHESIA 83, (3) 516P-517P
1999 'Does nitrous oxide affect closed-loop anaesthetic propofol?' BRITISH JOURNAL OF ANAESTHESIA 83, (3) 516P-516P
1999 'Effect of midazolam on cilia survival' BRITISH JOURNAL OF ANAESTHESIA 83, (3) 527P-527P
1999 'Profiling novel i.v. anaesthetic agents with a rat EEG model' BRITISH JOURNAL OF ANAESTHESIA 83, (3) 514P-514P
1999 'Recovery profiles after day-case diagnostic gynaecological laparoscopy: comparison of two anaesthetic techniques over 1 week follow-up' BRITISH JOURNAL OF ANAESTHESIA 83, (3) 523P-524P
1999 'Towards a 'mixifusor'? Simulating the addition of remifentanil to a target-controlled infusion of propofol' BRITISH JOURNAL OF ANAESTHESIA 83, (3) 522P-522P
1999 'Long-term use of rocuronium in ICU patients with or without multi organ failure' BRITISH JOURNAL OF ANAESTHESIA 82, 164-164
1999 'Propofol and epilepsy' BRITISH JOURNAL OF ANAESTHESIA 82, (6) 952-953
1999 'Electron microscopy of respiratory ciliated epithelium' BRITISH JOURNAL OF ANAESTHESIA 82, (3) 464P-465P
1999 'The role of bupivacaine in early postoperative pain control after lumbar decompression' J Neurosurg 90, (1 Suppl) 67-72 , DOI
1999 'The safety and effectiveness of remifentanil as an adjunct sedative for regional anesthesia' Anesth Analg 88, (1) 134-140 , DOI
1999 'The Safety and Effectiveness of Remifentanil as an Adjunct Sedative for Regional Anesthesia' Anesthesia & Analgesia 88, (1) 134-140 , DOI
1998 'An open, randomized comparison of alfentanil, remifentanil and alfentanil followed by remifentanil in anaesthesia for craniotomy' Br J Anaesth 81, (3) 361-364 , DOI
1998 'Catecholamine-resistant cardiovascular collapse after propofol, atracurium and gentamicin' Eur J Anaesthesiol 15, (5) 600-602 , DOI
1998 'I.v. anaesthesia and EEG burst suppression in rats: bolus injections and closed-loop infusions' Br J Anaesth 81, (3) 415-421 , DOI
1998 'A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents' Eur J Anaesthesiol 15, (4) 433-445 , DOI
1998 'A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents' European Journal of Anaesthesiology 15, (4) 433-445 , DOI
1998 'Comparison of remifentanil in combination with isoflurane or propofol for short-stay surgical procedures' Br J Anaesth 80, (6) 752-755 , DOI
1998 'Cushing's disease treated by trans-sphenoidal selective adenomectomy in mid-pregnancy' Br J Anaesth 80, (6) 850-852 , DOI
1998 'An open randomized comparison of alfentanil, remifentanil, and alfentanil followed by remifentanil in anaesthesia for craniotomy' British Journal of Anaesthesia 80, (4) 555-556
1998 'Oxygen and explicit semantic memory' British Journal of Anaesthesia 80, (4)
1998 'Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study' The Lancet 351, (9106) 857-861 , DOI
1998 'Psychological evaluation of intensive care unit survivors' British Journal of Anaesthesia 80, (4) 544-545
1997 'Remifentanil in the critically ill (multiple letters) [1]' Anaesthesia 52, (12) 1230-1232
1997 'Administration to humans of ORG 21465, a water soluble steroid i.v. anaesthetic agent' Br J Anaesth 79, (4) 427-432 , DOI
1997 'Computer simulations of combined alfentanil and remifentanil infusions' Journal of Neurosurgical Anesthesiology 9, (4) 405-405 , DOI
1997 'Computer-controlled infusion of ORG 21465, a water soluble steroid i.v. anaesthetic agent, into human volunteers' Br J Anaesth 79, (4) 433-439 , DOI
1997 'A comparison of remifentanil/isoflurane and fentanyl/isoflurane for major abdominal surgery' ANESTHESIOLOGY 87, (3) A975-A975 , DOI
1997 'Opioid analgesics' Br J Hosp Med 57, (3) 105-106
1997 'Use the correct statistical test [1] (multiple letters)' Anesthesia and Analgesia 84, (2) 465-466 , DOI
1996 'Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination' Br J Anaesth 77, (4) 445-447 , DOI
1996 'Extended neuromuscular blockade with mivacurium following pancuronium' Eur J Anaesthesiol 13, (5) 483-484 , DOI
1996 'Infusions of subhypnotic doses of propofol for the prevention of postoperative nausea and vomiting' Anaesthesia 51, (6) 554-557 , DOI
1996 'Magnetic resonance imaging of the superior vena cava during spontaneous respiration with continuous positive airway pressure via a facemask in normal subjects' BRITISH JOURNAL OF ANAESTHESIA 76, (4) P578-P579
1996 'Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination' BRITISH JOURNAL OF ANAESTHESIA 76, (4) P591-P592
1996 'Org 21465 a new iv anaesthetic agent' BRITISH JOURNAL OF ANAESTHESIA 76, (4) P586-P587
1995 'Topographic electroencephalogram of propofol-induced conscious sedation' Clin Pharmacol Ther 58, (6) 666-674 , DOI
1995 'A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE SAFETY AND EFFICACY OF REMIFENTANIL USED AS AN ADJUNCT SEDATIVE IN PATIENTS RECEIVING REGIONAL ANESTHESIA' ANESTHESIOLOGY 83, (3A) A847-A847
1995 'INFUSIONS OF SUB-HYPNOTIC DOSES OF PROPOFOL FOR THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING' ANESTHESIOLOGY 83, (3A) A308-A308
1995 'Facilitation of laryngeal mask insertion. Effects of lignocaine given intravenously before induction with propofol' Anaesthesia 50, (5) 464-466 , DOI
1995 'Effects of propofol sedation on seizures and intracranially recorded epileptiform activity in patients with partial epilepsy' Anesthesiology 82, (4) 843-851 , DOI
1995 'Use of sufentanil and atracurium anesthesia in a patient with acute porphyria undergoing coronary artery bypass surgery' J Cardiothorac Vasc Anesth 9, (1) 75-78 , DOI
1994 'Use of proton nmr spectroscopy to measure propofol metabolites in the urine of the female Caucasian patient' Xenobiotica 24, (10) 1021-1028 , DOI
1994 'USING SEQUENTIAL TESTING TO ASSESS SKILL AT TRACHEAL INTUBATION' ANESTHESIOLOGY 81, (3A) A1242-A1242
1994 'Propofol at a subanesthetic dose may have abuse potential in healthy volunteers' Anesth Analg 78, (5) 1032-1033 , DOI
1994 'Respiratory sinus arrhythmia: comparison with EEG indices during isoflurane anaesthesia at 0.65 and 1.2 MAC' Br J Anaesth 72, (4) 397-402 , DOI
1994 'Administration of O2 in patients with critical coronary artery disease' Anesth Analg 78, (1) 196-197 , DOI
1993 'Determination of plasma propofol levels using gas chromatography-mass spectrometry with selected-ion monitoring' J Chromatogr 620, (2) 260-267 , DOI
1993 'CNS EFFECTS OF PROPOFOL SEDATION IN HUMANS' ANESTHESIOLOGY 79, (3A) A207-A207
1993 'EFFECT OF PROPOFOL ON ELECTROENCEPHALOGRAM OF EPILEPTIC PATIENTS' ANESTHESIOLOGY 79, (3A) A172-A172
1993 'Forearm compartment syndrome following intravenous infusion with a manual "bulb" pump' Anesth Analg 76, (5) 1160-1161
1993 'ELIMINATION KINETICS OF CARBOXYHEMOGLOBIN FOLLOWING SMOKE INHALATION IN MAN' Critical Care Medicine 21, (Supplement) S138-S138 , DOI
1992 '"Futility" as a criterion in limiting treatment' N Engl J Med 327, (17) 1239-1240
1992 '“Futility” as a Criterion in Limiting Treatment' New England Journal of Medicine 327, (17) 1239-1241 , DOI
1992 'The effect of pre-induction glycopyrronium on the haemodynamic response of elderly patients to anaesthesia with propofol' Anaesthesia 47, (7) 620-621 , DOI
1992 'Excitatory events associated with propofol anaesthesia: a review' J R Soc Med 85, (5) 288-291
1992 'Intrathecal diamorphine (heroin) for obstetric analgesia' Int J Obstet Anesth 1, (3) 153-155 , DOI
1992 'Effect of physiotherapy on the auditory evoked response of paralysed, sedated patients in the intensive care unit' Br J Anaesth 68, (4) 349-351 , DOI
1992 'CONTINUOUS ACQUISITION AND REAL-TIME ANALYSIS OF EEG, ECG AND RESPIRATORY DATA IN THE ANESTHETIZED HUMAN' JOURNAL OF PHYSIOLOGY-LONDON 446, P76-P76
1992 'Effect of physiotherapy on EEG spectral derivatives in sedated patients in the intensive care unit' British Journal of Anaesthesia 69, (2)
1992 'Intensive care sedation: Progress towards decreasing the mortality rate' British Journal of Intensive Care 2, (7)
1992 'INTRAVENOUS-INFUSION OF ADRENALINE DURING EXERCISE IN MAN' JOURNAL OF PHYSIOLOGY-LONDON 446, P210-P210
1991 'Excitatory events associated with anaesthesia' Journal of Drug Development, Supplement 4, (3) 110-111
1991 'Effect of preinduction glycopyrrolate on the hemodynamic response to anesthesia with propofol' Anesth Analg 72, (6) 831-834 , DOI
1989 'THE RELATIONSHIP BETWEEN ARTERIAL POTASSIUM AND CARBON-DIOXIDE PRODUCTION-RATE DURING ROWING IN MAN' JOURNAL OF PHYSIOLOGY-LONDON 414, P27-P27
1988 'A VERSATILE, LOW-COST ANIMAL VENTILATOR' JOURNAL OF PHYSIOLOGY-LONDON 407, P2-P2
1988 'ARTERIAL AND VENOUS POTASSIUM CHANGES DURING SEPARATE AND COMBINED FOREARM AND LEG EXERCISE IN MAN' JOURNAL OF PHYSIOLOGY-LONDON 403, P40-P40
1988 'Ventilatory effects of potassium during hyperoxia, normoxia and hypoxia in anaesthetized cats' Respir Physiol 72, (1) 59-64 , DOI
1987 'VENTILATORY EFFECTS OF POTASSIUM IN HYPEROXIA, NORMOXIA AND HYPOXIA IN ANESTHETIZED CATS' JOURNAL OF PHYSIOLOGY-LONDON 394, P172-P172
1986 'A simple atracurium infusion regimen for intra-abdominal surgery' Br J Anaesth 58, (12) 1387-1389 , DOI
Reviews
2012 'Depth-of-anaesthesia monitoring' Southern Africa Journal of Anaesthesia and Analgesia 18, 27-29
Chapters
2017 'Teaching in Anaesthesia' Oxford Textbook of Anaesthesia Oxford University Press , DOI Open access
2011 'Depth of Anaesthesia Monitoring' in Allman KG; Wilson IH Oxford Handbook of Anaesthesia Oxford OUP 1050-1052
2008 'Drug Administration Techniques' in Struys MRF; Priebe H; Cook T; Hunter JM The Year in Anaesthesia and Critical Care Atlas Medical Publishing 155-164
2006 'Research study design' in Galley HF; Webster NR Anaesthesia Sicence Blackwell Publishing 441-450
2004 'Awareness Under Anaesthesia and Modern EEG Based Monitoring' in Jobert M; Ruight GSF Essentials and Applications of EEG Research in Preclinical and Clinical Pharmacology International Pharmaco-EEG Group
2003 'Clinical pharmacology and anesthetic techniques' Wylie and Churchill-Davidsons: A Practice of Anesthesia, Seventh Edition 365-582
2003 'Epidemiological Aspects of PONV and Assessment of Risk' in Myles A; Rowbotham D; Strunin L The Effective Management of Post-Operative Nausea and Vomiting, 2nd edition 29-44
2003 'Intravenous Anaesthetics in an International Practice of Anaesthesia' in Healy TEJ; Knight P Wylie and Churchill-Davidson’s A Practice of Anaesthesia Edward Arnold (Publishers) Limited: London 565-582
2000 'Remifentanil and Managed Anaesthesia Care' in Groen-Mulder S; Engbers FHM; Vuyk J The Study and Practice of Intravenous Anaesthesia Wolters Kluwer Academic Publishers: London
1999 'Epidemiological Aspects of PONV and Assessment of Risk' in Strunin L; Rowbotham D; Myles A The Effective Management of Post-Operative Nausea and Vomiting
1992 'Isocapnic clamping with feedback and feed-forward control' in Ikeda; Doi; Kazama Computing and Monitoring in Anesthesia and Intensive Care: Recent Technological Advances
Reports
2018 Patient and colleague feedback for anaesthetists. Royal College of Anaesthetists, UK www.rcoa.ac.uk
2013 Safe Sedation Practice for Healthcare Procedures - Standards and Guidance. Academy of Medical Royal Colleges Publisher Site