- Deans Office, John Bull Building, Research Way, Plymouth Science Park
- robert.sneyd@pms.ac.uk
Profiles
Professor Robert Sneyd
Emeritus Professor
Faculty of Health
Robert can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
- Pharmacology
- Clinical trials
- Medicine
- Anaesthesia
- Acute pain management
- Drug development
- Sedation
- Medical education leadership
Email publicrelations@plymouth.ac.uk to enquire.
Qualifications
Qualifications: MD MA MB BChir FRCA SFHEA
Professor Sneyd was brought up in Cornwall and one of his first jobs was as a Nursing Auxiliary in Devonport Hospital, Plymouth - now long since demolished! He graduated from Cambridge University in 1981 and continued his medical training in London. Half way through he undertook a research degree and then spent a period working full time in the pharmaceutical industry before returning to work in the NHS.
After completing his UK anaesthetic training he worked at the University of Michigan Medical School at Ann Arbor, USA. In 1993, he returned to the South West as a Consultant Anaesthetist and after a few years moved to the University as Reader in Anaesthesia and then Professor. In 1998 he took over the running of the Plymouth Postgraduate Medical School, first as Acting Dean and then as Dean. He led the Plymouth team in the successful bid for a new Peninsula Medical School and served as Vice-Dean of the Peninsula College of Medicine and Dentistry. The first medical graduates have been working as NHS doctors since 1st August 2007 and the dental graduates have been doing so since 2011. He does his clinical work as a Consultant Anaesthetist at Derriford Hospital, mostly in neuro-anaesthesia and is very familiar with the interface between universities and the NHS.
Professor Sneyd's research interests focus on drugs, pharmacology and pharmacokinetics with related projects based on signal processing. Having worked in the pharmaceutical industry he has a special interest in drug development, especially in Intravenous Anaesthesia. He now works as Dean of the Plymouth University Peninsula Schools of Medicine and Dentistry in Plymouth, UK and lead programmes in medicine and dentistry.
In anaesthesia he has engaged nationally through AAGBI (Council 2006-9, Vice-President 2009-11) and the Royal College of Anaesthetists, UK where he was Vice-President (2011-2012) and internationally with the European Society of Anaesthesiology, ESA as a Director. In each case he has tried to represent the interests of patients and clinicians with an emphasis on sound strategy and common sense.
Roles on external bodies
Council Member, Royal College of Anaesthetists
Scientific reviewer, mostly for British Journal of Anaesthesia but also for Anesthesiology, Anaesthesia, Anesthesia and Analgesia, European Journal of Anaesthesiology and various other journals.
I led the 2013 national sedation review for the Academy of Medical Royal Colleges
Key publications are highlighted
Journals
Articles
2020
'Remimazolam for anaesthesia or sedation'
Current opinion in anaesthesiology
33,
(4)
506-511
, DOI
PEARL
2020
'The impact of the COVID-19 pandemic on anaesthesia trainees and their training'
British Journal of Anaesthesia
PEARL
2019
'Deploying accelerometers for assessing recovery after day surgery'
British Journal of Anaesthesia
123,
(4)
e498-e498
, DOI
2019
'The US’s decision to resume the death penalty puts the wider public at risk'
British medical journal
Publisher Site
PEARL
2019
'Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: clinical indicators'
British Journal of Anaesthesia
, DOI
2019
'Capital punishment, my sixth great grandfather, and me—an essay by J Robert Sneyd'
BMJ
365,
, DOI
PEARL
2019
'Postoperative critical care and high-acuity care provision in the United Kingdom, Australia, and New Zealand'
British Journal of Anaesthesia
122,
(4)
460-469
, DOI
2019
'Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis'
British Journal of Anaesthesia
122,
(4)
500-508
, DOI
2019
'Who watches the watchmen and the problem of recursive flea bites'
British Journal of Anaesthesia
122,
(4)
407-408
, DOI
PEARL
2018
'Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals'
British Journal of Anaesthesia
121,
(4)
730-738
, DOI
2018
'A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications'
British Journal of Anaesthesia
, DOI
PEARL
2018
'Attempting tracheal intubation without paralysis'
British Journal of Anaesthesia
120,
(6)
1429-1430
, DOI
PEARL
2018
'Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial'
Anesth Analg
, DOI
PEARL
2018
'Quest for new drugs: a way to solve anaesthesia neurotoxicity?'
British Journal of Anaesthesia
120,
(4)
619-621
, DOI
PEARL
2018
'Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes'
British Journal of Anaesthesia
, DOI
2017
'A modified supraglottic airway for gastroscopy – an advance in patient safety?'
British Journal of Anaesthesia
120,
(2)
209-211
, DOI
PEARL
2017
'Thiopental to desflurane - an anaesthetic journey. Where are we going next?'
British journal of anaesthesia
119,
(suppl_1)
i44-i52
, DOI
PEARL
2017
'Perioperative statins surgery and postoperative pain'
Br J Anaesth
119,
(4)
712-715
, DOI
PEARL
2017
'Comprehensive moUth care and Postoperative PneumoniA (CUPPA) - a traineeled randomised controlled trial'
ANAESTHESIA
72,
36-36
2017
'Intraoperative dexamethasone does not increase the risk of postoperative wound infection: a propensity score-matched post hoc analysis of the ENIGMA-II trial (EnDEX)'
British Journal of Anaesthesia
118,
(2)
190-199
, DOI
2017
'Making sense of propofol sedation for endoscopy'
British Journal of Anaesthesia
118,
(1)
6-7
, DOI
PEARL
2016
'Time to move the goalposts? Do we need new targets for developing i.v. anaesthetics?'
British Journal of Anaesthesia
117,
(6)
684-687
, DOI
PEARL
2016
'Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial'
British Journal of Anaesthesia
117,
(6)
801-811
, DOI
2016
'Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness'
Crit Care Med
44,
(8)
e614-e624
, DOI
PEARL
2016
'Severe Nausea and Vomiting in the Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia II Trial'
Anesthesiology
124,
(5)
1032-1040
, DOI
PEARL
2016
'Standardizing end points in perioperative trials: towards a core and extended outcome set'
British Journal of Anaesthesia
116,
(5)
586-589
, DOI
PEARL
2016
'Validation of preoperative cardiopulmonary exercise testing-derived variables to predict in-hospital morbidity after major colorectal surgery'
British Journal of Surgery
103,
(6)
744-752
, DOI
2015
'UK academic general practice and primary care - Plymouth medical school is committed to producing GPs of the future'
BMJ
351,
h4218-h4218
, DOI
2015
'NAP5 and the isolated forearm technique'
British Journal of Anaesthesia
115,
(1)
138-139
, DOI
PEARL
2015
'The NIAA Perioperative Clinical Trials Group: New horizons for UK perioperative medicine research'
Bulletin of the Royal College of Anaesthetists
92,
17-17
Publisher Site
PEARL
2015
'A comparison of linear and logarithmic auditory tones in pulse oximeters'
Applied Ergonomics
51,
350-357
, DOI
PEARL
2015
'Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis'
Open Heart
2,
, DOI
PEARL
2015
'Defining competence in obstetric epidural anaesthesia for inexperienced trainees'
British journal of anaesthesia
114,
(6)
951-957
, DOI
PEARL
2015
'Randomised controlled trial of stroke volume optimisation during elective major abdominal surgery in patients stratified by aerobic fitness'
British Journal of Anaesthesia
115,
578-589
, DOI
PEARL
2015
'Sedation practice in six acute hospitals - a snapshot survey'
Anaesthesia
70,
(4)
407-415
, DOI
PEARL
2015
'Predictors of Cognitive Status in Post-Aneurysm Surgery Patients'
STROKE
46,
2014
'The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial'
The Lancet
384,
(9952)
1446-1454
, DOI
2014
'Investigation of the mechanism(s) of oxygen-induced ciliated epithelial loss in bovine bronchus tissue'
EUROPEAN RESPIRATORY JOURNAL
44,
2014
'Randomized controlled trial of intraoperative goal-directed fluid therapy using LiDCO and microcirculatory changes in patients having major abdominal surgery'
BRITISH JOURNAL OF ANAESTHESIA
113,
(2)
330-330
2014
'Cardiopulmonary exercise capacity and preoperative markers of inflammation'
Mediators Inflamm
2014,
, DOI
PEARL
2014
'Systemic concentrations of levobupivacaine administered by rectus sheath catheter'
BRITISH JOURNAL OF ANAESTHESIA
112,
(1)
188P-188P
2013
'Nitrous oxide: are we still in equipoise? A qualitative review of current controversies'
Br J Anaesth
111,
(6)
877-885
, DOI
2013
'A survey of trainee research experience within the south west peninsula deanery prior to the establishment of a trainee research collaborative'
ANAESTHESIA
68,
101-101
2013
'Patients' inability to perform a preoperative cardiopulmonary exercise test or demonstrate an anaerobic threshold is associated with inferior outcomes after major colorectal surgery'
Br J Anaesth
111,
(4)
607-611
, DOI
PEARL
2013
'Utility of an anaesthetic trainee led research network to contribute to multicentre studies'
ANAESTHESIA
68,
44-44
2013
'Effects of hyperoxia on the permeability of 16HBE14o- cell monolayers--the protective role of antioxidant vitamins E and C'
FEBS J
280,
(18)
4512-4521
, DOI
2013
'Comparison of three advanced haemodynamic monitors to measure circulating volume status during major rectal surgery'
BRITISH JOURNAL OF ANAESTHESIA
110,
(5)
873-873
2013
'Proportion of patients undergoing emergency surgery at risk of postoperative pulmonary and cardiac complications South West Anaesthetic Research Matrix ('SWARM')'
BRITISH JOURNAL OF ANAESTHESIA
110,
(5)
863-864
2013
'Bayesian methods to determine performance differences and to quantify variability among centers in multi-center trials: the IHAST trial'
BMC Medical Research Methodology
13,
(1)
, DOI
PEARL
2012
'Is postoperative cognitive dysfunction a risk factor for dementia? A cohort follow-up study'
British Journal of Anaesthesia
110,
(suppl 1)
i92-i97
, DOI
2012
'Hyperoxia-induced ciliary loss and oxidative damage in an in vitro bovine model: the protective role of antioxidant vitamins E and C'
Biochem Biophys Res Commun
429,
(3-4)
191-196
, DOI
2012
'Hyperoxia mediates barrier permeability dysfunction in 16HBE140-cells'
EUROPEAN RESPIRATORY JOURNAL
40,
2012
'Acute postoperative neurological deterioration associated with surgery for ruptured intracranial aneurysm: incidence, predictors, and outcomes'
Journal of Neurosurgery
116,
(6)
1267-1278
, DOI
2012
'The effect of temperature on di(2-ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions'
Anaesthesia
67,
(5)
514-520
, DOI
2012
'A national survey of anaesthetists (NAP5 baseline) to estimate an annual incidence of accidental awareness during general anaesthesia in the UK'
Br J Anaesth
110,
501-509
, DOI
2012
'Effects of goal-directed fluid therapy during colorectal surgery on the sublingual microcirculation'
BRITISH JOURNAL OF ANAESTHESIA
108,
(4)
719-720
2012
'Inability to perform a pre-operative cardiopulmonary exercise test as a predictor of worse outcomes after major colorectal surgery'
ANAESTHESIA
67,
(4)
445-445
2012
'Patients' inability to perform a preoperative cardiopulmonary exercise test risk predicts inferior medium-term mortality after major colorectal surgery'
BRITISH JOURNAL OF ANAESTHESIA
108,
(4)
716-717
2012
'Cytochrome P450 polymorphism and postoperative cognitive dysfunction'
Minerva Anestesiol
78,
(3)
303-309
2012
'First human administration of MR04A3: a novel water-soluble nonbenzodiazepine sedative'
Anesthesiology
116,
(2)
385-395
, DOI
PEARL
2012
'Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery'
Br J Anaesth
108,
(1)
53-62
, DOI
PEARL
2012
'The role of routine pre-operative bedside echocardiography in detecting aortic stenosis in patients with a hip fracture'
Anaesthesia
67,
(1)
51-54
, DOI
2011
'Europe is mostly united but lacks a common support of young investigators'
Anesthesiology
115,
(4)
674-676
, DOI
2011
'Mechanical bowel preparation and fasting may influence aerobic capacity in cardiopulmonary exercise testing'
BRITISH JOURNAL OF SURGERY
98,
177-178
2011
'Does a preoperative cardiopulmonary exercise test identify a subgroup of patients who benefit from intraoperative goal directed therapy during elective colorectal surgery?'
BRITISH JOURNAL OF SURGERY
98,
38-38
2011
'Inhalational or total intravenous anaesthesia: is total intravenous anaesthesia useful and are there economic benefits?'
Curr Opin Anaesthesiol
24,
(2)
182-187
, DOI
PEARL
2011
'Variation of patient characteristics, management, and outcome with timing of surgery for aneurysmal subarachnoid hemorrhage'
Journal of Neurosurgery
114,
(4)
1045-1053
, DOI
2011
'Is the impact of intraoperative goal-directed fluid therapy on length of stay after major elective colorectal surgery related to patients' aerobic fitness?'
BRITISH JOURNAL OF ANAESTHESIA
106,
(3)
440P-440P
2011
'Propofol and children--what we know and what we do not know'
Paediatr Anaesth
21,
(3)
247-254
, DOI
PEARL
2010
'The incidence and severity of aortic stenosis in an unselected patient population admitted with a hip fracture - the role of routine pre-operative bedside echocardiography'
ANAESTHESIA
65,
(12)
1249-1249
2010
'New drugs and technologies, intravenous anaesthesia is on the move (again)'
Br J Anaesth
105,
(3)
246-254
, DOI
PEARL
2010
'Perioperative Hypothermia (33°C) Does Not Increase the Occurrence of Cardiovascular Events in Patients Undergoing Cerebral Aneurysm Surgery'
Anesthesiology
113,
(2)
327-342
, DOI
2010
'First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial'
BMC Anesthesiol
10,
, DOI
PEARL
2010
'Tracheal intubation without neuromuscular blocking agents: is there any point?'
Br J Anaesth
104,
(5)
535-537
, DOI
PEARL
2010
'Does preoperative cardiopulmonary exercise test predict hospital stay after major elective colorectal surgery?'
BRITISH JOURNAL OF ANAESTHESIA
104,
(4)
519-520
2010
'Interobserver variability in determination of anaerobic threshold by cardiopulmonary exercise testing'
ANAESTHESIA
65,
(1)
109-110
, DOI
2010
'No Association between Intraoperative Hypothermia or Supplemental Protective Drug and Neurologic Outcomes in Patients Undergoing Temporary Clipping during Cerebral Aneurysm Surgery'
Anesthesiology
112,
(1)
86-101
, DOI
2009
'Routine use of nasogastric tubes does not reduce postoperative nausea and vomiting'
Anesth Analg
109,
768-773
, DOI
2009
'Off-label use of medicines is bad medicine flying the flag of clinical freedom'
Int J Obstet Anesth
18,
(3)
249-250
, DOI
PEARL
2009
'PERIOPERATIVE FEVER AND OUTCOME IN SURGICAL PATIENTS WITH ANEURYSMAL SUBARACHNOID HEMORRHAGE'
Neurosurgery
64,
(5)
897-909
, DOI
2009
'Effect of temperature on plasticizer release [di(2-ethylhexyl)phthalate] from TIVA infusion sets'
BRITISH JOURNAL OF ANAESTHESIA
102,
(4)
581-582
2009
'Effect of Nitrous Oxide Use on Long-term Neurologic and Neuropsychological Outcome in Patients Who Received Temporary Proximal Artery Occlusion during Cerebral Aneurysm Clipping Surgery'
Anesthesiology
110,
(3)
563-573
, DOI
2009
'Long-term Consequences of Postoperative Cognitive Dysfunction'
Anesthesiology
110,
(3)
548-555
, DOI
2008
'Independent Associations Between Electrocardiographic Abnormalities and Outcomes in Patients With Aneurysmal Subarachnoid Hemorrhage: Findings From the Intraoperative Hypothermia Aneurysm Surgery Trial'
Stroke
40,
(2)
412-418
, DOI
2008
'Assessing fitness for surgery: a comparison of questionnaire, incremental shuttle walk, and cardiopulmonary exercise testing in general surgical patients'
Br J Anaesth
101,
(6)
774-780
, DOI
PEARL
2008
'Pharmacokinetics and anaesthetic effects of propofol-PM: a novel water soluble propofol formulation'
ANAESTHESIA
63,
(12)
1392-1393
, DOI
2008
'Memory and awareness during anaesthesia'
BRITISH JOURNAL OF ANAESTHESIA
101,
(5)
739-740
2008
'Anaesthetic effects of propofol polymeric micelle: a novel water soluble propofol formulation'
Br J Anaesth
101,
(2)
186-193
, DOI
2008
'Effect of Nitrous Oxide on Neurologic and Neuropsychological Function after Intracranial Aneurysm Surgery'
Anesthesiology
108,
(4)
568-579
, DOI
2008
'Hyperglycemia in Patients Undergoing Cerebral Aneurysm Surgery: Its Association With Long-term Gross Neurologic and Neuropsychological Function'
Mayo Clinic Proceedings
83,
(4)
406-417
, DOI
2008
'Novel lipid and preservative-free propofol formulation: properties and pharmacodynamics'
Pharm Res
25,
(2)
313-319
, DOI
2007
'A comparison of questionnaire, shuttle walk and cardiopulmonary exercise testing in preoperative assessment of high-risk general surgical patients'
BRITISH JOURNAL OF ANAESTHESIA
99,
(5)
764P-764P
2007
'Choice reaction time in patients with post-operative cognitive dysfunction*'
Acta Anaesthesiologica Scandinavica
52,
(1)
95-98
, DOI
2007
'Plasticizer release (DEHP) from TIVA infusion sets'
BRITISH JOURNAL OF ANAESTHESIA
99,
(5)
765P-765P
2007
'Elevated oxygen fraction reduces cilial abundance in explanted human bronchial tissue'
Ultrastruct Pathol
31,
(5)
339-346
, DOI
2007
'Improving prediction of outcome in "good grade" subarachnoid hemorrhage'
NEUROSURGERY
61,
(3)
470-473
, DOI
2007
'IMPROVING PREDICTION OF OUTCOME IN “GOOD GRADE” SUBARACHNOID HEMORRHAGE'
Neurosurgery
61,
(3)
470-474
, DOI
2007
'Recovery of Cognitive Function After Surgery for Aneurysmal Subarachnoid Hemorrhage'
Stroke
38,
(6)
1864-1872
, DOI
2007
'Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain following third molar extraction'
British Journal of Anaesthesia
98,
(5)
672-676
, DOI
2007
'Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery'
British Journal of Anaesthesia
99,
(2)
252-261
, DOI
2007
'Acute hydrocephalus and clinical outcome in subarachnoid hemorrhage'
STROKE
38,
(2)
541-541
2007
'Brain swelling, surgical exposure, and outcome following subarachnoid hemorrhage'
STROKE
38,
(2)
542-542
2007
'Early postoperative neurological deficits and outcome after subarachnoid hemorrhage in good grade patients'
STROKE
38,
(2)
475-475
2007
'Use of MMSE as an outcome assessment in patients with subarachnoid hemorrhage'
STROKE
38,
(2)
541-541
2007
'A comparison of questionnaire, shuttle walk and cardiopulmonary exercise testing in preoperative assessment of high-risk general surgical patients'
British Journal of Anaesthesia
99,
(5)
764P-764P
2007
'Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction'
British Journal of Anaesthesia
98,
(5)
672-676
2007
'Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery'
British Journal of Anaesthesia
99,
(2)
252-261
2006
'Effects of intraoperative hypothermia on neuropsychological outcomes after intracranial aneurysm surgery'
Annals of Neurology
60,
(5)
518-527
, DOI
2006
'Depth of anaesthesia monitoring: what's available, what's validated and what's next?'
Br J Anaesth
97,
(1)
85-94
, DOI
2006
'A Bayesian network model to predict fever following aneurysmal subarachnoid hemorrhage'
STROKE
37,
(2)
726-726
2006
'A shortened baseline NIH stroke scale predicts 3-month outcome after subarachnoid hemorrhage'
STROKE
37,
(2)
640-640
2006
'Cerebral infarction by aneurysm location in neurosurgically treated patients: Analysis of the IHAST dataset'
STROKE
37,
(2)
725-725
2006
'Fever is associated with adverse outcomes following aneurysmal subarachnoid hemorrhage'
STROKE
37,
(2)
689-689
2006
'Intraoperative hyperglycemia is associated with increased long-term postoperative cognitive abnormalities in patients undergoing cerebral aneurysm clipping'
STROKE
37,
(2)
691-691
2006
'Organ culture of human bronchial explants'
BRITISH JOURNAL OF ANAESTHESIA
96,
(2)
281P-282P
2006
'The effects of hypothermia on neuropsychological outcomes after cerebral aneurysm surgery'
STROKE
37,
(2)
673-674
2006
'Uneven cilial distribution in rat trachea'
BRITISH JOURNAL OF ANAESTHESIA
96,
(2)
281P-281P
2005
'Is peri-operative cortisol secretion related to post-operative cognitive dysfunction?'
Acta Anaesthesiol Scand
49,
(9)
1225-1231
, DOI
2005
'Population pharmacokinetics of remifentanil in critically ill post cardiac neonates, infants and children'
BRITISH JOURNAL OF ANAESTHESIA
95,
(4)
578P-579P
2005
'Painless surgery'
NEW SCIENTIST
187,
(2515)
18-18
2005
'Intraoperative clonidine administration to neurosurgical patients'
Anesth Analg
101,
(3)
922-923
, DOI
2005
'Oxidative metabolism in platelets, platelet aggregation, and hematology in patients undergoing multiple hyperbaric oxygen exposures'
Undersea Hyperb Med
32,
(5)
327-340
2005
'A single exposure to hyperbaric oxygen does not cause oxidative stress in isolated platelets: no effect on superoxide dismutase, catalase, or cellular ATP'
Clin Biochem
38,
(8)
722-726
, DOI
2005
'Comparison of propofol/remifentanil and sevoflurane/remifentanil for maintenance of anaesthesia for elective intracranial surgery'
Br J Anaesth
94,
(6)
778-783
, DOI
2005
'Bispectral index and propofol induction: beware of inappropriate conclusions'
Anesth Analg
100,
(3)
904-905
, DOI
2005
'Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST)'
Neurosurgery
56,
(3)
N9-N10
, DOI
2005
'Recent advances in intravenous anaesthesia'
BRITISH JOURNAL OF ANAESTHESIA
94,
(3)
393-393
2005
'Mild intraoperative hypothermia during surgery for intracranial aneurysm'
NEW ENGLAND JOURNAL OF MEDICINE
352,
(2)
135-145
, DOI
2005
'Intraoperative clonidine administration to neurosurgical patients'
Anesthesia and Analgesia
101,
(3)
922-923
2004
'Postoperative cognitive dysfunction: true deterioration versus random variation'
Acta Anaesthesiologica Scandinavica
48,
(9)
1137-1143
, DOI
2004
'Carbon monoxide exposure in rat heart: evidence for two modes of toxicity'
Biochem Biophys Res Commun
321,
(1)
241-246
, DOI
2004
'A Factorial Trial of Six Interventions for the Prevention of Postoperative Nausea and Vomiting'
New England Journal of Medicine
350,
(24)
2441-2451
, DOI
2004
'Carbon monoxide exposure in rat heart: evidence for two modes of toxicity'
Biochemical and Biophysical Research Communications
321,
(1)
241-246
, DOI
2004
'Intraoperative hypothermia for intracranial aneurysm surgery (IHAST): Initial trial results'
STROKE
35,
(1)
250-250
2004
'Nonlinear methods for biopattern analysis: role and challenges'
Conf Proc IEEE Eng Med Biol Soc
2004,
5400-5406
, DOI
2004
'Safety and tolerability of volplex((r)) in elective surgery'
Clin Drug Investig
24,
73-79
2003
'Remifentanil manual versus target-controlled infusion [13] (multiple letters)'
Anesthesia and Analgesia
97,
(1)
2003
'Cognitive dysfunction after minor surgery in the elderly'
Acta Anaesthesiologica Scandinavica
47,
(10)
1204-1210
, DOI
2003
'Carbon monoxide exposure in rat heart: glutathione depletion is prevented by antioxidants'
Biochemical and Biophysical Research Communications
302,
(2)
392-396
, DOI
2003
'Cognitive dysfunction after minor surgery in the elderly'
Acta Anaesthesiologica Scandinavica
47,
(10)
1204-1210
2003
'Remifentanil manual versus target-controlled infusion'
Anesthesia and Analgesia
97,
(1)
300-300
2002
'Longterm functional recovery following day-case laparoscopic sterilisation: inhalational versus TIVA maintenance'
Jorunal of Ambulatory Surgery
10,
45-51
2002
'Cultured rat trachea as a model for the study of ciliary abundance: the effect of oxygen'
Anesthesiology
97,
(1)
275-277
, DOI
2002
'Critically ischaemic feet harbour an endothelium mediated but nitric oxide independent pathway that shunts blood away from the nutritional microcirculation'
BRITISH JOURNAL OF SURGERY
89,
100-100
2002
'Pharmacokinetics of propofol infusions in critically ill neonates, infants and children in intensive care'
Anesthesiology
97,
(6)
1393-1400
, DOI
2002
'Pharmacokinetics of propofol infusions in critically ill neonates, infants, and children in an intensive care unit'
Anesthesiology
97,
(6)
1393-1400
2001
'Drug development in the 21st century'
Current Anaesthesia & Critical Care
12,
(6)
329-334
, DOI
2001
'Erratum for :Remifentanil and fentanyl during anaesthesia for major abdominal and gynaecological surgery. An open, comparative study of safety and efficacy'
European Journal of Anaesthesiology
18,
(12)
839-839
, DOI
2001
'Remifentanil and fentanyl during anaesthesia for major abdominal and gynaecological surgery. An open, comparative study of safety and efficacy (vol 18, pg 605, 2001)'
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
18,
(12)
839-839
2001
'Remifentanil and fentanyl during anaesthesia for major abdominal and gynaecological surgery. An open, comparative study of safety and efficacy'
Eur J Anaesthesiol
18,
(9)
605-614
, DOI
2001
'Using Simulations in the Design of an Anesthesia System'
Simulation & Gaming
32,
(2)
205-214
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2001
'The assessment of postoperative cognitive function'
Acta Anaesthesiologica Scandinavica
45,
(3)
275-289
, DOI
2001
'Abnormalities of respiratory cilia in non-symptomatic smokers and non-smokers'
BRITISH JOURNAL OF ANAESTHESIA
86,
(2)
326P-326P
2001
'Ciliary abundance and abnormalities in critical illness'
BRITISH JOURNAL OF ANAESTHESIA
86,
(2)
321P-322P
2001
'Abnormalities of respiratory cilia in non-symptomatic smokers and non-smokers'
British Journal of Anaesthesia
86,
(2)
326P-326P
2001
'Carbon monoxide toxicity in the heart: evidence for ischaemia/reperfusion like injury. Joint meeting of the Biochemical Society and Physiological Society'
Biochemical Society Transactions
30,
2001
'Ciliary abundance and abnormalities in critical illness'
British Journal of Anaesthesia
86,
(2)
321P-322P
2001
'Lessons from Stafford'
British Journal of Anaesthesia
86,
(4)
469-473
2001
'The effect of multiple hyperbaric oxygen treatments on blood function and redox status. Joint meeting of the Biochemical Society and Physiological Society'
Biochemical Society Transactions
30,
2000
'Conflicts of interest: are they a problem for anaesthesia journals? What should we do about them?'
Br J Anaesth
85,
(6)
811-814
, DOI
2000
'Cognitive dysfunction 1-2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction'
Acta Anaesthesiol Scand
44,
(10)
1246-1251
2000
'Propofol/remifentanil vs sevoflurane/remifentanil for maintenance of anaesthesia during craniotomy'
ANESTHESIOLOGY
93,
(3A)
U152-U152
2000
'Does wound irrigation with triamcinolone reduce pain after surgery to the lumbar spine?'
Br J Anaesth
84,
(6)
731-734
, DOI
2000
'Incidence of hospital admission does not equal incidence of disease (multiple letters)'
British Medical Journal
320,
(7244)
2000
'Incidence of hospital admission does not equal incidence of disease. Conclusions drawn from data are incorrect'
BMJ
320,
(7244)
2000
'Do blood concentrations of neurone specific enolase and S-100 beta protein reflect cognitive dysfunction after abdominal surgery?ISPOCD Group'
British Journal of Anaesthesia
84,
(2)
242-244
, DOI
2000
'Wound infiltration with bupivacaine after surgery to the cervical spine using a posterior approach'
Br J Anaesth
84,
(1)
87-88
, DOI
1999
'Oxygen administration and explicit memory: no improvement found in healthy volunteers'
Br J Anaesth
83,
(5)
801-804
, DOI
1999
'Benzodiazepines and postoperative cognitive dysfunction in the elderly. ISPOCD Group. International Study of Postoperative Cognitive Dysfunction'
British Journal of Anaesthesia
83,
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585-589
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1999
'Closed-loop sedation during knee surgery under epidural anaesthesia'
BRITISH JOURNAL OF ANAESTHESIA
83,
(3)
516P-517P
1999
'Does nitrous oxide affect closed-loop anaesthetic propofol?'
BRITISH JOURNAL OF ANAESTHESIA
83,
(3)
516P-516P
1999
'Effect of midazolam on cilia survival'
BRITISH JOURNAL OF ANAESTHESIA
83,
(3)
527P-527P
1999
'Profiling novel i.v. anaesthetic agents with a rat EEG model'
BRITISH JOURNAL OF ANAESTHESIA
83,
(3)
514P-514P
1999
'Recovery profiles after day-case diagnostic gynaecological laparoscopy: comparison of two anaesthetic techniques over 1 week follow-up'
BRITISH JOURNAL OF ANAESTHESIA
83,
(3)
523P-524P
1999
'Towards a 'mixifusor'? Simulating the addition of remifentanil to a target-controlled infusion of propofol'
BRITISH JOURNAL OF ANAESTHESIA
83,
(3)
522P-522P
1999
'Long-term use of rocuronium in ICU patients with or without multi organ failure'
BRITISH JOURNAL OF ANAESTHESIA
82,
164-164
1999
'Propofol and epilepsy'
BRITISH JOURNAL OF ANAESTHESIA
82,
(6)
952-953
1999
'Electron microscopy of respiratory ciliated epithelium'
BRITISH JOURNAL OF ANAESTHESIA
82,
(3)
464P-465P
1999
'The role of bupivacaine in early postoperative pain control after lumbar decompression'
J Neurosurg
90,
(1 Suppl)
67-72
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1999
'The safety and effectiveness of remifentanil as an adjunct sedative for regional anesthesia'
Anesth Analg
88,
(1)
134-140
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1999
'The Safety and Effectiveness of Remifentanil as an Adjunct Sedative for Regional Anesthesia'
Anesthesia & Analgesia
88,
(1)
134-140
, DOI
1998
'An open, randomized comparison of alfentanil, remifentanil and alfentanil followed by remifentanil in anaesthesia for craniotomy'
Br J Anaesth
81,
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361-364
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1998
'Catecholamine-resistant cardiovascular collapse after propofol, atracurium and gentamicin'
Eur J Anaesthesiol
15,
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600-602
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1998
'I.v. anaesthesia and EEG burst suppression in rats: bolus injections and closed-loop infusions'
Br J Anaesth
81,
(3)
415-421
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1998
'A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents'
Eur J Anaesthesiol
15,
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433-445
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1998
'A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents'
European Journal of Anaesthesiology
15,
(4)
433-445
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1998
'Comparison of remifentanil in combination with isoflurane or propofol for short-stay surgical procedures'
Br J Anaesth
80,
(6)
752-755
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1998
'Cushing's disease treated by trans-sphenoidal selective adenomectomy in mid-pregnancy'
Br J Anaesth
80,
(6)
850-852
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1998
'An open randomized comparison of alfentanil, remifentanil, and alfentanil followed by remifentanil in anaesthesia for craniotomy'
British Journal of Anaesthesia
80,
(4)
555-556
1998
'Oxygen and explicit semantic memory'
British Journal of Anaesthesia
80,
(4)
1998
'Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study'
The Lancet
351,
(9106)
857-861
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1998
'Psychological evaluation of intensive care unit survivors'
British Journal of Anaesthesia
80,
(4)
544-545
1997
'Remifentanil in the critically ill (multiple letters) [1]'
Anaesthesia
52,
(12)
1230-1232
1997
'Administration to humans of ORG 21465, a water soluble steroid i.v. anaesthetic agent'
Br J Anaesth
79,
(4)
427-432
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1997
'Computer simulations of combined alfentanil and remifentanil infusions'
Journal of Neurosurgical Anesthesiology
9,
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405-405
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1997
'Computer-controlled infusion of ORG 21465, a water soluble steroid i.v. anaesthetic agent, into human volunteers'
Br J Anaesth
79,
(4)
433-439
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1997
'A comparison of remifentanil/isoflurane and fentanyl/isoflurane for major abdominal surgery'
ANESTHESIOLOGY
87,
(3)
A975-A975
, DOI
1997
'Use the correct statistical test [1] (multiple letters)'
Anesthesia and Analgesia
84,
(2)
465-466
1997
'Opioid analgesics'
Br J Hosp Med
57,
(3)
105-106
1996
'Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination'
Br J Anaesth
77,
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445-447
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1996
'Extended neuromuscular blockade with mivacurium following pancuronium'
Eur J Anaesthesiol
13,
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483-484
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1996
'Infusions of subhypnotic doses of propofol for the prevention of postoperative nausea and vomiting'
Anaesthesia
51,
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554-557
, DOI
1996
'Magnetic resonance imaging of the superior vena cava during spontaneous respiration with continuous positive airway pressure via a facemask in normal subjects'
BRITISH JOURNAL OF ANAESTHESIA
76,
(4)
P578-P579
1996
'Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination'
BRITISH JOURNAL OF ANAESTHESIA
76,
(4)
P591-P592
1996
'Org 21465 a new iv anaesthetic agent'
BRITISH JOURNAL OF ANAESTHESIA
76,
(4)
P586-P587
1995
'Topographic electroencephalogram of propofol-induced conscious sedation'
Clin Pharmacol Ther
58,
(6)
666-674
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1995
'A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE SAFETY AND EFFICACY OF REMIFENTANIL USED AS AN ADJUNCT SEDATIVE IN PATIENTS RECEIVING REGIONAL ANESTHESIA'
ANESTHESIOLOGY
83,
(3A)
A847-A847
1995
'INFUSIONS OF SUB-HYPNOTIC DOSES OF PROPOFOL FOR THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING'
ANESTHESIOLOGY
83,
(3A)
A308-A308
1995
'Facilitation of laryngeal mask insertion. Effects of lignocaine given intravenously before induction with propofol'
Anaesthesia
50,
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464-466
, DOI
1995
'Effects of propofol sedation on seizures and intracranially recorded epileptiform activity in patients with partial epilepsy'
Anesthesiology
82,
(4)
843-851
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1995
'Use of sufentanil and atracurium anesthesia in a patient with acute porphyria undergoing coronary artery bypass surgery'
J Cardiothorac Vasc Anesth
9,
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75-78
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1994
'Use of proton nmr spectroscopy to measure propofol metabolites in the urine of the female Caucasian patient'
Xenobiotica
24,
(10)
1021-1028
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1994
'USING SEQUENTIAL TESTING TO ASSESS SKILL AT TRACHEAL INTUBATION'
ANESTHESIOLOGY
81,
(3A)
A1242-A1242
1994
'Propofol at a subanesthetic dose may have abuse potential in healthy volunteers'
Anesth Analg
78,
(5)
1032-1033
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1994
'Respiratory sinus arrhythmia: comparison with EEG indices during isoflurane anaesthesia at 0.65 and 1.2 MAC'
Br J Anaesth
72,
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397-402
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1994
'Administration of O2 in patients with critical coronary artery disease'
Anesth Analg
78,
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196-197
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1993
'Determination of plasma propofol levels using gas chromatography-mass spectrometry with selected-ion monitoring'
J Chromatogr
620,
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260-267
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1993
'CNS EFFECTS OF PROPOFOL SEDATION IN HUMANS'
ANESTHESIOLOGY
79,
(3A)
A207-A207
1993
'EFFECT OF PROPOFOL ON ELECTROENCEPHALOGRAM OF EPILEPTIC PATIENTS'
ANESTHESIOLOGY
79,
(3A)
A172-A172
1993
'Forearm compartment syndrome following intravenous infusion with a manual "bulb" pump'
Anesth Analg
76,
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1160-1161
1993
'ELIMINATION KINETICS OF CARBOXYHEMOGLOBIN FOLLOWING SMOKE INHALATION IN MAN'
Critical Care Medicine
21,
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1992
'"Futility" as a criterion in limiting treatment'
N Engl J Med
327,
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1239-1240
1992
'“Futility” as a Criterion in Limiting Treatment'
New England Journal of Medicine
327,
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1239-1241
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1992
'The effect of pre-induction glycopyrronium on the haemodynamic response of elderly patients to anaesthesia with propofol'
Anaesthesia
47,
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620-621
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1992
'Excitatory events associated with propofol anaesthesia: a review'
J R Soc Med
85,
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288-291
1992
'Intrathecal diamorphine (heroin) for obstetric analgesia'
Int J Obstet Anesth
1,
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153-155
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1992
'Effect of physiotherapy on the auditory evoked response of paralysed, sedated patients in the intensive care unit'
Br J Anaesth
68,
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349-351
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1992
'CONTINUOUS ACQUISITION AND REAL-TIME ANALYSIS OF EEG, ECG AND RESPIRATORY DATA IN THE ANESTHETIZED HUMAN'
JOURNAL OF PHYSIOLOGY-LONDON
446,
P76-P76
1992
'Effect of physiotherapy on EEG spectral derivatives in sedated patients in the intensive care unit'
British Journal of Anaesthesia
69,
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1992
'Intensive care sedation: Progress towards decreasing the mortality rate'
British Journal of Intensive Care
2,
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1992
'INTRAVENOUS-INFUSION OF ADRENALINE DURING EXERCISE IN MAN'
JOURNAL OF PHYSIOLOGY-LONDON
446,
P210-P210
1991
'Excitatory events associated with anaesthesia'
Journal of Drug Development, Supplement
4,
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110-111
1991
'Effect of preinduction glycopyrrolate on the hemodynamic response to anesthesia with propofol'
Anesth Analg
72,
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1989
'THE RELATIONSHIP BETWEEN ARTERIAL POTASSIUM AND CARBON-DIOXIDE PRODUCTION-RATE DURING ROWING IN MAN'
JOURNAL OF PHYSIOLOGY-LONDON
414,
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1988
'A VERSATILE, LOW-COST ANIMAL VENTILATOR'
JOURNAL OF PHYSIOLOGY-LONDON
407,
P2-P2
1988
'ARTERIAL AND VENOUS POTASSIUM CHANGES DURING SEPARATE AND COMBINED FOREARM AND LEG EXERCISE IN MAN'
JOURNAL OF PHYSIOLOGY-LONDON
403,
P40-P40
1988
'Ventilatory effects of potassium during hyperoxia, normoxia and hypoxia in anaesthetized cats'
Respir Physiol
72,
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59-64
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1987
'VENTILATORY EFFECTS OF POTASSIUM IN HYPEROXIA, NORMOXIA AND HYPOXIA IN ANESTHETIZED CATS'
JOURNAL OF PHYSIOLOGY-LONDON
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'A simple atracurium infusion regimen for intra-abdominal surgery'
Br J Anaesth
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'Awareness Under Anaesthesia and Modern EEG Based Monitoring'
in Jobert M; Ruight GSF
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International Pharmaco-EEG Group
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'Clinical pharmacology and anesthetic techniques'
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'Epidemiological Aspects of PONV and Assessment of Risk'
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