Professor Kim Tieu
Profiles

Professor Kim Tieu

Professor in Neurodegenerative Diseases

Biomedical Research - Translational & Stratified Medicine (Peninsula Schools of Medicine and Dentistry)

Role

2016-present ║ Professor ║ Plymouth University Peninsula Schools of Medicine and   Dentistry.

2013-2015 ║ Associate Professor (Reader) ║ Plymouth University Peninsula Schools of Medicine and Dentistry.

2013-present ║ Adjunct Faculty ║ University of Rochester(Rochester, New York). 

2015-present ║ Visiting Professor ║ Department o fNeurology, Huashan Hospital, Fudan University (Shanghai, China).

Qualifications

2004-2012 ║ Assistant Professor ║ Depts. of Environmental Medicine and Neurology, University of Rochester (Rochester, New York).

2000-2004 ║ Post-doctoral fellow ║ Dept. of Neurology, Columbia University, New York.

1995-2000 ║ Ph.D ║ Neuroscience, University of Saskatchewan, Canada.

1993-2000 ║ Pharmacist ║ Saskatoon, Canada

1988-1993 ║ BSP ║ Pharmacy, University of Saskatchewan, Canada.

Professional membership

Fellow of the Higher Education Academy, UK
Society for Neuroscience
Society of Toxicology
Biochemical Society

Roles on external bodies

Invited Scientific Review

A) Journals:  Annals of Neurology, Brain, Cell Biology and Toxicology, Cell Death and Disease, European Journal of Pharmacology, Experimental Neurology, Journal of Applied Toxicology, Journal of Neurochemistry, Journal of Neuroscience, Journal of Parkinson’s disease, Mitochondrion, Movement Disorders, Nanomedicine, Nature Communications, Nature Chemical Biology, Naunyn-Schmiedeberg Archives of Pharmacology, Neurobiology of Disease, Neurochemical Research, Neuropharmacology, Neuroscience, Neurotherapeutics, Neurotoxicology, Pharmacology and Therapeutics, PlosOne, Scientific Reports, Toxicological Sciences, Toxicology.

B) Grants:  The National Institutes of Health(USA), Medical Research Council (UK), European Union, Parkinson’s UK, The French National Research Agency, The Research Grants Council (RGC) of Hong Kong.

 

Research interests

My research interest has always been to study mechanisms of neuronal dysfunction and degeneration as seen in Parkinson’s disease (PD), with the ultimate goal of developing effective therapies for this devastating neurological disorder.  The research projects in my lab focus on the following fundamental questions: 1) Is mitochondrial dysfunction pathogenic in PD?  If so, can mitochondrial dynamics be targeted for PD treatment?  2) The role of genetic and environmental factors in the development and progression of PD?  To address these questions, we perform rigorous biochemical, histological, functional and genetic analyses in experimental models of PD.  When applicable, post-mortem human samples are also used.

Grants & contracts

Active
1) MRC ║ £511 K (2014 - 2017) ║ PI: Kim Tieu
2) NIH ║ $740 K (2014 - 2018) ║ PI: Kim Tieu

Completed
1) NIH ║ ~ $1,6 M (2006 – 2012) ║ PI: Kim Tieu
2) NIH ║ ~ 422 K (2009 – 2012) ║ PI: Kim Tieu
3) Environmental Protection Agency (EPA) ║ ~ $8 M (2005 – 2010) ║ PI: Gunter Oberdoerster, Kim Tieu: 5% effort
4) NIH ║ $25 K (2005 – 2006) ║ PI: Kim Tieu

Key publications are highlighted

Journals
Articles
Rappold PM, Cui M, Grima JC, Fan RZ, de Mesy-Bentley KL, Chen L, Zhuang X, Bowers WJ & Tieu K 2014 'Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo' NATURE COMMUNICATIONS 5, Author Site , DOI
Jin YN, Yu YV, Gundemir S, Jo C, Cui M, Tieu K & Johnson GV 2013 'Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin' PLoS One 8, (3) , DOI
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K & Nedergaard M 2012 'Cultured astrocytes do not release adenosine during hypoxic conditions' Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 32, (1) e1-e7
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K & Nedergaard M 2012 'Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity' Proceedings of the National Academy of Sciences of the United States of America 109, (16) 6265-6270
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W & Ko HS 2012 'PINK1-dependent recruitment of Parkin to mitochondria in mitophagy' Proc.Natl.Acad.Sci.U.S.A. 107, (1) 378-383 , DOI
Lim S, Chesser AS, Grima JC, Rappold PM, Blum D, Przedborski S & Tieu K 2011 'D-β-hydroxybutyrate is protective in mouse models of Huntington's disease' PloS one 6, (9)
Rappold PM, Cui M, Chesser AS, Tibbett J, Grima JC, Duan L, Sen N, Javitch JA & Tieu K 2011 'Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3' Proceedings of the National Academy of Sciences of the United States of America 108, (51) 20766-20771
Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F & Han X 2010 'Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture' Nature neuroscience 13, (7) 883-888
Fang F, Christian WV, Gorman SG, Cui M, Huang J, Tieu K & Ballatori N 2010 'Neurosteroid transport by the organic solute transporter OSTα-OSTβ' J Neurochem 115, (1) 220-233 Author Site , DOI
Cui M, Tang X, Christian WV, Yoon Y & Tieu K 2010 'Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1' The Journal of biological chemistry 285, (15) 11740-11752
Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N & Przedborski S 2009 'The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway' Proceedings of the National Academy of Sciences of the United States of America 106, (19) 8043-8048
Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z & Xia XG 2007 'Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice' International journal of biological sciences 3, (4) 242-250
Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP & Heinecke JW 2005 'Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice' The Journal of neuroscience : the official journal of the Society for Neuroscience 25, (28) 6594-6600
Perier C, Tieu K, Guégan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S & Vila M 2005 'Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage' Proceedings of the National Academy of Sciences of the United States of America 102, (52) 19126-19131
Tieu K, Perier C, Vila M, Caspersen C, Zhang HP, Teismann P, Jackson-Lewis V, Stern DM, Yan SD & Przedborski S 2004 'L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease' Annals of neurology 56, (1) 51-60
Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V & Przedborski S 2003 'Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration' Proc.Natl.Acad.Sci.U.S.A 100, (9) 5473-5478 Author Site
Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD, Naini A, Vila M, Jackson-Lewis V & Ramasamy R 2003 'D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson's disease' J.Clin.Invest. 112, 892-901 , DOI
Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H & Przedborski S 2003 'NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease' Proceedings of the National Academy of Sciences of the United States of America 100, (10) 6145-6150
Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H & Przedborski S 2002 'Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease' The Journal of neuroscience : the official journal of the Society for Neuroscience 22, (5) 1763-1771
Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y & Yuan CA 2002 'Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP' Proceedings of the National Academy of Sciences of the United States of America 99, (22) 14524-14529
Tieu K, Ashe PC, Zuo DM & Yu PH 2001 'Inhibition of 6-hydroxydopamine-induced p53 expression and survival of neuroblastoma cells following interaction with astrocytes' Neuroscience 103, (1) 125-132
Vila M, Jackson-Lewis V, Guégan C, Wu DC, Teismann P, Choi DK, Tieu K & Przedborski S 2001 'The role of glial cells in Parkinson's disease' Curr Opin Neurol 14, (4) 483-489 Author Site
Tieu K, Zuo DM & Yu PH 1999 'Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: involvement of bcl-2 and p53 proteins' Journal of neuroscience research 58, (3) 426-435
Reviews
Tieu K & Imm J 2014 'Mitochondrial Dynamics as a Potential Therapeutic Target for Parkinson’s Disease?' ADVANCES IN CLINICAL NEUROSCIENCE & REHABILITATION 14, (1) 6-8 Author Site
Tieu K 2011 'A Guide to Neurotoxic Animal Models of Parkinson's Disease' Cold Spring Harbor Perspective in Medicine 1, , DOI
Rappold PM & Tieu K 2010 'Astrocytes and therapeutics for Parkinson's disease' Neurotherapeutics. 7, (4) 413-423 , DOI
Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K & Hammond CL 2009 'Glutathione dysregulation and the etiology and progression of human diseases' Biol.Chem. 390, (3) 191-214
Przedborski S, Tieu K, Perier C & Vila M 2004 'MPTP as a mitochondrial neurotoxic model of Parkinson's disease' J.Bioenerg.Biomembr. 36, (4) 375-379
Teismann P, Vila M, Choi DK, Tieu K, Wu DC, Jackson-Lewis V & Przedborski S 2003 'COX-2 and neurodegeneration in Parkinson's disease' Ann N Y Acad Sci 991, 272-277 Author Site
Przedborski S, Jackson-Lewis V, Vila M, Wu DC, Teismann P, Tieu K, Choi D-K & Cohen O 2003 'Free radical and nitric oxide toxicity in Parkinson's disease' Adv Neurol 91, 83-94
Tieu K, Ischiropoulos H & Przedborski S 2003 'Nitric oxide and reactive oxygen species in Parkinson's disease' IUBMB Life 55, (6) 329-335 Author Site , DOI
Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V & Przedborski S 2003 'Pathogenic role of glial cells in Parkinson's disease' Mov.Disord. 18, (2) 121-129
Wu DC, Tieu K, Cohen O, Choi DK, Vila M, Jackson-Lewis V, Teismann P & Przedborski S 2002 'Glial cell response: A pathogenic factor in Parkinson's disease' J Neurovirol 8, (6) 551-558 Author Site , DOI
Yu PH, Zhang X, Zuo DM, Lai CT, Tieu K, Davis BA & Boulton AA 1998 'Aliphatic N-methylpropargylamines as potential neurorescue agents' Restor Neurol Neurosci 12, (2-3) 113-118 Author Site
Editorial comments
Tieu K & Xia XG 2014 'Cytosolic PINK1 escapes from mitochondria to promote dendritic outgrowth' J Neurochem 128, (6) 787-789 , DOI
Chapters
Tieu K 2016 'Organic Cation Transporters as modulators of neurodegeneration and neuroprotection' in Ciarimboli G; Gautron S; Schlatter E Organic Cation Transporters (Integration of Physiology, Pathology, and Pharmacology) Springer
Tolkovsky AM & Tieu K 2014 'Principles of Mitophagy and Beyond' in Autophagy (Volume 4) Elsevier 65-83
Tieu K & Przedborski S 2006 'Mitochondrial dysfunction and neurodegenerative disorders' in DiMauro S; Hirano M; Schon E Mitochondrial Medicine Lancaster The Parthenon Publishing Group 279-307
Tieu K 2006 'Mitochondrial dysfunction and neurodegenerative disorders in the basal ganglia' in Bezard E Recent Breakthroughs in Basal Ganglia Research New York Nova Science Publishers
Przedborski S & Tieu K 2005 'Toxic animal models' in Beal MF; Lang AE; Ludolph AC Neurodegenerative Diseases Cambridge Cambridge University Press 196-221
Tieu K & Yu PH 1998 'Neural cell adhesion molecules' in Boulton AA; Baker GB;B Totowa, New Jersey Humana Press 103-130

Other academic activities

INVITED LECTURES (Past 5 years): 2016 The 5th Oriental Congress of Neurology, Shanghai ║ 2016 Society of Toxicology Annual Meeting, New Orleans ║ 2015 Northeast Ohio Medical University ║ 2015 University of Aberdeen ║ 2015 Universite de Lille, Lille ║ 2015 University of Exeter ║ 2014 Sheffield Institute for Translational Neuroscience, University of Sheffield ║ 2013 University of Oxford, MitOX conference ║ 2013 Cambridge University, John Van Geest Centre for Brain Repair ║ 2013 Vall d'Hebron Research Institute, Barcelona ║ 2013 ASPET Annual Meeting at Experimental Biology, Boston ║ 2012 University of Kansas, Lawrence, Kansas ║ 2011 The XIX World Congress on Parkinson's Disease and Related Disorders, Shanghai ║ 2011 Department of Neurology, Huashan hospital, Fudan University, Shanghai ║ 2011 University of Central Florida, Orlando, Florida ║