Professor Kim Tieu

Professor Kim Tieu

Professor in Neurodegenerative Diseases

Biomedical Research - Translational & Stratified Medicine (Peninsula Schools of Medicine and Dentistry)


2016-present ║ Professor ║ Plymouth University Peninsula Schools of Medicine and   Dentistry.

2013-2015 ║ Associate Professor (Reader) ║ Plymouth University Peninsula Schools of Medicine and Dentistry.

2013-present ║ Adjunct Faculty ║ University of Rochester(Rochester, New York). 

2015-present ║ Visiting Professor ║ Department o fNeurology, Huashan Hospital, Fudan University (Shanghai, China).


2004-2012 ║ Assistant Professor ║ Depts. of Environmental Medicine and Neurology, University of Rochester (Rochester, New York).

2000-2004 ║ Post-doctoral fellow ║ Dept. of Neurology, Columbia University, New York.

1995-2000 ║ Ph.D ║ Neuroscience, University of Saskatchewan, Canada.

1993-2000 ║ Pharmacist ║ Saskatoon, Canada

1988-1993 ║ BSP ║ Pharmacy, University of Saskatchewan, Canada.

Professional membership

Fellow of the Higher Education Academy, UK
Society for Neuroscience
Society of Toxicology
Biochemical Society

Roles on external bodies

Invited Scientific Review

A) Journals:  Annalsof Neurology, Brain, Cell Biology and Toxicology, Cell Death and Disease,European Journal of Pharmacology, Experimental Neurology, Journal of AppliedToxicology, Journal of Neurochemistry, Journal of Neuroscience, Journal ofParkinson’s disease, Mitochondrion, Movement Disorders, Nanomedicine, NatureCommunications, Nature Chemical Biology, Naunyn-Schmiedeberg Archives ofPharmacology, Neurobiology of Disease, Neurochemical Research,Neuropharmacology, Neuroscience, Neurotherapeutics, Neurotoxicology,Pharmacology and Therapeutics, PlosOne, Scientific Reports, ToxicologicalSciences, Toxicology.

B) Grants:  The National Institutes of Health(USA), Medical Research Council (UK), Parkinson’s UK, The French NationalResearch Agency, The Research Grants Council (RGC) of Hong Kong.


Research interests

My research interest has always been to study mechanisms of neuronal dysfunction and degeneration as seen in Parkinson’s disease (PD), with the ultimate goal of developing effective therapies for this devastating neurological disorder.  The research projects in my lab focus on the following fundamental questions: 1) Is mitochondrial dysfunction pathogenic in PD?  If so, can mitochondrial dynamics be targeted for PD treatment?  2) The role of genetic and environmental factors in the development and progression of PD?  To address these questions, we perform rigorous biochemical, histological, functional and genetic analyses in experimental models of PD.  When applicable, post-mortem human samples are also used.

Grants & contracts

1) MRC ║ £511 K (2014 - 2017) ║ PI: Kim Tieu
2) NIH ║ $740 K (2014 - 2018) ║ PI: Kim Tieu

1) NIH ║ ~ $1,6 M (2006 – 2012) ║ PI: Kim Tieu
2) NIH ║ ~ 422 K (2009 – 2012) ║ PI: Kim Tieu
3) Environmental Protection Agency (EPA) ║ ~ $8 M (2005 – 2010) ║ PI: Gunter Oberdoerster, Kim Tieu: 5% effort
4) NIH ║ $25 K (2005 – 2006) ║ PI: Kim Tieu

Key publications are highlighted

Rappold PM, Cui M, Grima JC, Fan RZ, de Mesy-Bentley KL, Chen L, Zhuang X, Bowers WJ & Tieu K 2014 'Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo' NATURE COMMUNICATIONS 5, Author Site , DOI
Jin YN, Yu YV, Gundemir S, Jo C, Cui M, Tieu K & Johnson GV 2013 'Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin' PLoS One 8, (3) , DOI
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K & Nedergaard M 2012 'Cultured astrocytes do not release adenosine during hypoxic conditions' J Cereb.Blood Flow Metab. 32, (1) e1-e7 , DOI
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K & Nedergaard M 2012 'Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity' Proc.Natl.Acad.Sci U.S.A. 109, (16) 6265-6270 , DOI
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W & Ko HS 2012 'PINK1-dependent recruitment of Parkin to mitochondria in mitophagy' Proc.Natl.Acad.Sci.U.S.A. 107, (1) 378-383 , DOI
Lim S, Chesser AS, Grima JC, Rappold PM, Blum D, Przedborski S & Tieu K 2011 'D-�-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease' PLoS ONE 6(9): e24620. doi:10.1371/journal.pone.0024620,
Rappold PM, Cui M, Chesser AS, Tibbett J, Grima JC, Duan L, Sen N, Javitch JA & Tieu K 2011 'Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3' Proc.Natl.Acad.Sci U.S.A. 108, (51) 20766-20771 , DOI
Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F & Han X 2010 'Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture' Nat.Neurosci. 13, (7) 883-888 , DOI
Fang F, Christian WV, Gorman SG, Cui M, Huang J, Tieu K & Ballatori N 2010 'Neurosteroid transport by the organic solute transporter OSTα-OSTβ' J Neurochem 115, (1) 220-233 Author Site , DOI
Cui M, Tang X, Christian WV, Yoon Y & Tieu K 2010 'Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1' J.Biol.Chem. 285, (15) 11740-11752 , DOI
Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N & Przedborski S 2009 'The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway' Proc.Natl.Acad.Sci.U.S.A. 106, (19) 8043-8048 , DOI
Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z & Xia XG 2007 'Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice' international journal of biological sciences 3, (4) 242-50 , DOI
Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP & Heinecke JW 2005 'Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice' J.Neurosci. 25, (28) 6594-6600 Author Site
Perier C, Tieu K, Guegan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S & Vila M 2005 'Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage' Proc.Natl.Acad.Sci.U.S.A. 102, (52) 19126-19131 , DOI
Tieu K, Perier C, Vila M, Caspersen C, Zhang HP, Teismann P, Jackson-Lewis V, Stern DM, Yan SD & Przedborski S 2004 'L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease' Ann.Neurol. 56, (1) 51-60 , DOI
Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V & Przedborski S 2003 'Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration' Proc.Natl.Acad.Sci.U.S.A 100, (9) 5473-5478 Author Site
Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD, Naini A, Vila M, Jackson-Lewis V & Ramasamy R 2003 'D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson's disease' J.Clin.Invest. 112, 892-901 , DOI
Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H & Przedborski S 2003 'NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease' Proc.Natl.Acad.Sci.USA 100, 6145-6150
Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H & Przedborski S 2002 'Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease' J.Neurosci. 22, (5) 1763-1771
Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y & Yuan CA 2002 'Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP' Proc.Natl.Acad.Sci.USA 99, (22) 14524-14529 , DOI
Tieu K, Ashe PC, Zuo DM & Yu PH 2001 'Inhibition of 6-hydroxydopamine-induced p53 expression and survival of neuroblastoma cells following interaction with astrocytes' Neuroscience. 103, (1) 125-132 Author Site
Vila M, Jackson-Lewis V, Guégan C, Wu DC, Teismann P, Choi DK, Tieu K & Przedborski S 2001 'The role of glial cells in Parkinson's disease' Curr Opin Neurol 14, (4) 483-489 Author Site
Tieu K, Zuo DM & Yu PH 1999 'Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: involvement of bcl-2 and p53 proteins' J.Neurosci.Res. 58, (3) 426-435 Author Site
Tieu K 2015 'Organic Cation Transporters as Modulators of Neurodegeneration and Neuroprotection in the Brain' Advances in Experimental Medicine and Biology (in press)
Tieu K & Imm J 2014 'Mitochondrial Dynamics as a Potential Therapeutic Target for Parkinson’s Disease?' ADVANCES IN CLINICAL NEUROSCIENCE & REHABILITATION 14, (1) 6-8 Author Site
Tieu K 2011 'A Guide to Neurotoxic Animal Models of Parkinson's Disease' Cold Spring Harbor Perspective in Medicine 1, , DOI
Rappold PM & Tieu K 2010 'Astrocytes and therapeutics for Parkinson's disease' Neurotherapeutics. 7, (4) 413-423 , DOI
Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K & Hammond CL 2009 'Glutathione dysregulation and the etiology and progression of human diseases' Biol.Chem. 390, (3) 191-214
Przedborski S, Tieu K, Perier C & Vila M 2004 'MPTP as a mitochondrial neurotoxic model of Parkinson's disease' J.Bioenerg.Biomembr. 36, (4) 375-379
Teismann P, Vila M, Choi DK, Tieu K, Wu DC, Jackson-Lewis V & Przedborski S 2003 'COX-2 and neurodegeneration in Parkinson's disease' Ann N Y Acad Sci 991, 272-277 Author Site
Przedborski S, Jackson-Lewis V, Vila M, Wu DC, Teismann P, Tieu K, Choi D-K & Cohen O 2003 'Free radical and nitric oxide toxicity in Parkinson's disease' Adv Neurol 91, 83-94
Tieu K, Ischiropoulos H & Przedborski S 2003 'Nitric oxide and reactive oxygen species in Parkinson's disease' IUBMB Life 55, (6) 329-335 Author Site , DOI
Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V & Przedborski S 2003 'Pathogenic role of glial cells in Parkinson's disease' Mov.Disord. 18, (2) 121-129
Wu DC, Tieu K, Cohen O, Choi DK, Vila M, Jackson-Lewis V, Teismann P & Przedborski S 2002 'Glial cell response: A pathogenic factor in Parkinson's disease' J Neurovirol 8, (6) 551-558 Author Site , DOI
Yu PH, Zhang X, Zuo DM, Lai CT, Tieu K, Davis BA & Boulton AA 1998 'Aliphatic N-methylpropargylamines as potential neurorescue agents' Restor Neurol Neurosci 12, (2-3) 113-118 Author Site
Editorial comments
Tieu K & Xia XG 2014 'Cytosolic PINK1 escapes from mitochondria to promote dendritic outgrowth' J Neurochem 128, (6) 787-789 , DOI
Tolkovsky AM & Tieu K 2014 'Principles of Mitophagy and Beyond' in Autophagy (Volume 4) Elsevier 65-83
Tieu K & Przedborski S 2006 'Mitochondrial dysfunction and neurodegenerative disorders' in DiMauro S; Hirano M; Schon E Mitochondrial Medicine Lancaster The Parthenon Publishing Group 279-307
Tieu K 2006 'Mitochondrial dysfunction and neurodegenerative disorders in the basal ganglia' in Bezard E Recent Breakthroughs in Basal Ganglia Research New York Nova Science Publishers
Przedborski S & Tieu K 2005 'Toxic animal models' in Beal MF; Lang AE; Ludolph AC Neurodegenerative Diseases Cambridge Cambridge University Press 196-221
Tieu K & Yu PH 1998 'Neural cell adhesion molecules' in Boulton AA; Baker GB;B Totowa, New Jersey Humana Press 103-130