Mr James Conway
Profiles

Mr James Conway

Weekend Duty Technician (Derriford)

School of Biological and Marine Sciences (Faculty of Science and Engineering)

Biography

Biography

I am a PhD candidate in the Kramer lab at the University of Plymouth's Derriford Research Facility. My research is focused upon the role of the E3 ubiquitin protein ligases Nedd4-1 and Nedd4-2 in the mouse dopaminergic midbrain and their crosstalk with alpha-synuclein. I am also the Alzheimer's Research UK (ARUK) early career researcher (ECR) representative for the University of Plymouth.

Prior to this I completed an MSc in Molecular Neuroscience at the University of Bristol, where my Research project was titled: "Is microRNA-7 the answer to effective GDNF treatment in Parkinson's?".

Qualifications

PhD Medical Studies - University of Plymouth - 2019-present

MSc (Distinction) Molecular Neuroscience - University of Bristol - 2018-2019

BSc (Hons) Biological Sciences - University of the West of England, Bristol - 2015-2018

Professional membership

British Neuroscience Association (BNA) - 2018-present

Teaching

Teaching

Teaching interests

I supervise both undergraduate and postgraduate, as well as placement students in the laboratory. 

Research

Research

Research interests

My research is focused upon the role of the E3 ubiquitin protein ligases Nedd4-1 and Nedd4-2 in the mouse dopaminergic midbrain and their crosstalk with alpha-synuclein. In addition to this i am also interested in: Neurodegeneration, Parkinson's disease, Neurotrophic Signalling.

Grants & contracts

The influence of Nedd4 ligases on the dopaminergic midbrain and alpha synuclein in Parkinson’s Disease and Dementia with Lewy Bodies - Northcott Devon Medical Foundation (Exeter, Devon) - 2021-present - £5982

The function of E3 ubiquitin protein ligase Nedd4-1 in the brain and its crosstalk with dementia-related proteins in vivo - Alzheimer’s Research UK (Cambridge, Cambridgeshire) - 2021-present - £4988


Publications

Publications

Key publications

Key publications are highlighted

Journals

Conway JA, Kramer E. Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson’s disease? A discussion of data from the culture dish to the clinic Neural Regeneration Research 17(7):1462-1467 10 Dec 2021 (Journal article). DOI: 1https://doi.org/0.4103/1673-5374.327330   

Conway, J.A., Ince, S., Black, S. et al. GDNF/RET signaling in dopamine neurons in vivo. Cell Tissue Res 382, 135–146 (2020). https://doi.org/10.1007/s00441-020-03268-9

Articles
Conway JA, Kinsman G & Kramer ER (2022) 'The Role of NEDD4 E3 Ubiquitin–Protein Ligases in Parkinson’s Disease' Genes 13, (3) , DOI Open access
Conway JA & Kramer E (2021) 'Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson’s disease? A discussion of data from the culture dish to the clinic' Neural Regeneration Research 17, (7) 1462-1467 , DOI Open access
Conway JA, Ince S, Black S & Kramer ER (2020) 'GDNF/RET signaling in dopamine neurons in vivo' Cell and Tissue Research , DOI Open access
Personal

Personal

Other academic activities

I am the Alzheimer's Research UK (ARUK) early career research representative for the University of Plymouth as well as the Postgraduate Research (PGR) student representative for the schools of Medicine, Dentistry and Biomedical Sciences.

Colleagues:

  • Professor Edgar Kramer - Director of Studies
  • Dr Michele Kiernan - Research Technician