Dr Iain Robinson
Profiles

Dr Iain Robinson

Associate Professor (Reader) in Neurosciences

Peninsula Medical School (Faculty of Health)

Iain Robinson did his PhD in the University of Liverpool looking at calcium signalling in adrenal chromaffin cells. He then did a post doc in the Mayo Clinic where he used pulsed laser imaging, capacitance and amperometry to study calcium signalling and exocytosis in mast cells and adrenal chromaffin cells. He then moved to Stanford University and started to work with Drosophila to study the molecular basis of exocytosis. He started his own research lab in the University of Cambridge using Drosophila to study synaptic vesicle endocytosis and t-tubule development. His lab moved to Case Western Reserve University before joining Peninsula. Current research looks at the role of membrane trafficking in regulating synaptic form and function.

Current teaching roles include:
SSC Lead for PCMD
SSC Lead for PUPSMD
ARG Chair for PUPSMD
Neuroscience Lead for PUPSMD
Neuroscience co-Lead for PCMD

Qualifications

BSc (Jt) Hons University of Wales, College Cardiff.
PhD University of Liverpool.
PG Cert (Clin Ed) Peninsula College of Medicine and Dentistry.

Key publications

Morse R, Todd AG, Shaw DJ, McConville AL, Robinson IM & Young PJ 2011 'Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies' Neuromolecular Med 13, (1) 77-87 Author Site , DOI
View all publications

Key publications

Morse R, Todd AG, Shaw DJ, McConville AL, Robinson IM & Young PJ 2011 'Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies' Neuromolecular Med 13, (1) 77-87 Author Site , DOI

Key publications are highlighted

Journals
Articles
Burr SA, Zahra D, Cookson J, Salih VM, Gabe-Thomas E & Robinson IM 2017 'Angoff anchor statements: setting a flawed gold standard?' MedEdPublish 6, (3:53) 1-7 , DOI PEARL
Zahra D, Robinson I, Roberts M, Coombes L, Cockerill J & Burr S 2016 'Rigour in moderation processes is more important than the choice of method' Assessment & Evaluation in Higher Education 1-9 Author Site , DOI PEARL
Böhme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lützkendorf J, Bergeron DD, Driller JH & Babikir H 2016 'Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling' Nature Neuroscience 19, (10) 1311-1320 , DOI
Wishart TM, Mutsaers CA, Riessland M, Reimer MM, Hunter G, Hannam ML, Eaton SL, Fuller HR, Roche SL & Somers E 2014 'Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy' J Clin Invest 124, (4) 1821-1834 Author Site , DOI
Takeda T, Robinson IM, Savoian MM, Griffiths JR, Whetton AD, McMahon HT & Glover DM 2013 'Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis' Open Biol 3, (8) Author Site , DOI
Diaper DC, Adachi Y, Sutcliffe B, Humphrey DM, Elliott CJH, Stepto A, Ludlow ZN, Vanden Broeck L, Callaerts P & Dermaut B 2013 'Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes' HUMAN MOLECULAR GENETICS 22, (8) 1539-1557 Author Site , DOI
Sutcliffe B, Forero MG, Zhu B, Robinson IM & Hidalgo A 2013 'Neuron-type specific functions of DNT1, DNT2 and Spz at the Drosophila neuromuscular junction' PLoS One 8, (10) Author Site , DOI
Oh E & Robinson I 2012 'Barfly: Sculpting membranes at the Drosophila neuromuscular junction' DEVELOPMENTAL NEUROBIOLOGY 72, (1) 33-56 Author Site , DOI
Milton VJ, Jarrett HE, Gowers K, Chalak S, Briggs L, Robinson IM & Sweeney ST 2011 'Oxidative stress induces overgrowth of the Drosophila neuromuscular junction' Proceedings of the National Academy of Sciences of the United States of America 108, (42) 17521-17526 , DOI
Rocha JJE, Korolchuk VI, Robinson IM & O'Kane CJ 2011 'A phagocytic route for uptake of double-stranded RNA in RNAi' PLoS One 6, (4) Author Site , DOI
Morse R, Todd AG, Shaw DJ, McConville AL, Robinson IM & Young PJ 2011 'Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies' Neuromolecular Med 13, (1) 77-87 Author Site , DOI
Milton VJ, Jarrett HE, Robinson IM, Gowers K, Briggs L & Sweeney ST 2010 'Oxidative stress induces overgrowth of the Drosophila neuromuscular junction' JOURNAL OF NEUROGENETICS 24, 8-9 Author Site
Robinson I, Oh E, Rogers C, Drummond J & Sharma A 2010 'Syndapin's role in synaptic form and function' JOURNAL OF NEUROGENETICS 24, 48-48 Author Site
Korolchuk VI, Schütz MM, Gómez-Llorente C, Rocha J, Lansu NR, Collins SM, Wairkar YP, Robinson IM & O'Kane CJ 2007 'Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation' J Cell Sci 120, (Pt 24) 4367-4376 Author Site , DOI
Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJT, Shupliakov O & Robinson IM 2007 'Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development' Journal of Cell Biology 178, (2) 309-322 , DOI
Robinson I, Oh E, Drummond J & Sharma A 2007 'A novel function for syndapin at Drosophila neuromuscular junctions' COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 146, (4) S103-S103 Author Site , DOI
Korolchuk VI, Schutz MM, Gomez-Llorente C, Rocha J, Lansu NR, Collins SM, Wairkar YP, Robinson IM & O'Kane CJ 2007 'Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation' Journal of Cell Science 120, (24) 4367-4376
Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan HL, Zhou Y, Venken KJT, Shupliakov O & Robinson IM 2007 'Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development' Journal of Cell Biology 178, (2) 309-322
Robinson I, Elliott D, Prokop A & van Roessel P 2004 'Independent regulation of synaptic size and activity by the anaphase-promoting complex' Cell 119, (5) 707-718 , DOI
Robinson 2004 'Independent regulation of synaptic size and activity by the anaphase-promoting complex' Cell 119 (5), 707-18 , DOI
Vilinsky I, Stewart BA, Drummond J, Robinson I & Deitcher DL 2002 'A Drosophila SNAP-25 null mutant reveals context-dependent redundancy with SNAP-24 in neurotransmission' GENETICS 162, (1) 259-271 Author Site
Robinson I, Ranjan R & Schwarz T 2002 'Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain' Nature 418, (6895) 336-340 , DOI
Robinson I, Drummond J, Loewen & Mackler J 2002 'The C(2)B Ca(2+)-binding motif of symaptotagimin is required for synaptic transmission in vivo' Nature 418, (6895) 340-344 , DOI
Robinson IM, Ranjan R & Schwarz TL 2002 'Synaptotagmins I and IV promote transmitter release independently of Ca2+ binding in the C(2)A domain' Nature 418, (6895) 336-340
Mackler JM, Drummond JA, Loewen CA, Robinson IM & Reist NE 2002 'The C2BCa2+-binding motif of synaptotagmin is required for synaptic transmission in vivo' Nature 418, (6895) 340-344
Robinson I, McMahon H, Razzaq A & Robinson I 2001 'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophilia' Genes & Development 15, (22) 2967-2979 , DOI
Razzaq A, Robinson IM, McMahon HT, Skepper JN, Su Y, Zelhof AC, Jackson AP, Gay NJ & O'Kane CJ 2001 'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila' Genes & Development 15, (22) 2967-2979
Oberhauser AF, Robinson IM & Fernandez JM 1996 'Simultaneous capacitance and amperometric measurements of exocytosis: a comparison' Biophys J 71, (2) 1131-1139 Author Site , DOI
Robinson IM, Yamada M, Carrion-Vazquez M, Lennon VA & Fernandez JM 1996 'Specialized release zones in chromaffin cells examined with pulsed-laser imaging' Cell Calcium 20, (2) 181-201 Author Site , DOI
Robinson IM, Kinnick RR, Greenleaf JF & Fernandez JM 1996 'Stimulation of secretion from bovine adrenal chromaffin cells by microsecond bursts of therapeutic levels of ultrasound' J Physiol 492 ( Pt 1), 257-263 Author Site , DOI
Robinson IM, Kinnick RR, Greenleaf JF & Fernandez JM 1996 'Stimulation of secretion from chromaffin cells by microsecond tonebursts of ultrasound' BIOPHYSICAL JOURNAL 70, (2) MPME2-MPME2 Author Site
Robinson IM, Oberhauser AF & Fernandez JM 1995 'Pulsed-laser Ca2+ imaging and micro-amperometry: New tools to study exocytosis in excitable cells' JOURNAL OF GENERAL PHYSIOLOGY 106, (6) 16-16 Author Site
Robinson IM, Finnegan JM, Monck JR, Wightman RM & Fernandez JM 1995 'Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells' Proc Natl Acad Sci U S A 92, (7) 2474-2478 Author Site , DOI
Monck JR, Robinson IM, Escobar AL, Vergara JL & Fernandez JM 1994 'Pulsed laser imaging of rapid Ca2+ gradients in excitable cells' Biophys J 67, (2) 505-514 Author Site , DOI
Monck JR, Oberhauser AF, Robinson IM & Fernandez JM 1994 'Neurotransmitter release through the exocytotic fusion pore' Seminars in Neuroscience 6, (3) 177-185 , DOI
Robinson IM & Fernandez JM 1994 'The fusion pore interface: a new biological frontier' Curr Opin Neurobiol 4, (3) 330-336 Author Site , DOI
ROBINSON IM, OBERHAUSER AF, OKANO K & FERNANDEZ JM 1994 'HYDROLYSIS RESISTANT GTP ANALOGS STIMULATE EXOCYTOSIS IN BOVINE ADRENAL CHROMAFFIN CELLS' BIOPHYSICAL JOURNAL 66, (2) A352-A352 Author Site
MONCK J, ESCOBAR A, ROBINSON I, VERGARA J & FERNANDEZ J 1994 'PULSED-LASER IMAGING OF RAPID CA2+ SIGNALING IN EXCITABLE CELLS' BIOPHYSICAL JOURNAL 66, (2) A351-A351 Author Site
OBERHAUSER AF, ROBINSON IM, BALAN V & FERNANDEZ JM 1994 'REGULATION OF THE EXOCYTOTIC FUSION SCAFFOLD BY GTP AND CA2+ BINDING-PROTEINS' BIOPHYSICAL JOURNAL 66, (2) A352-A352 Author Site
MATHIASEN D, ROSSUM LM, ROBINSON IM, BURGOYNE RD, EAST JM, MOLLER M, RASMUSSEN HN & TREIMAN M 1993 'ISOLATION OF CHROMAFFIN CELL THAPSIGARGIN-SENSITIVE CA2+ STORE IN LIGHT MICROSOMES FROM BOVINE ADRENAL-MEDULLA' INTERNATIONAL JOURNAL OF BIOCHEMISTRY 25, (5) 641-652 Author Site , DOI
Robinson IM, Cheek TR & Burgoyne RD 1992 'Ca2+ influx induced by the Ca(2+)-ATPase inhibitors 2,5-di-(t-butyl)-1,4-benzohydroquinone and thapsigargin in bovine adrenal chromaffin cells' Biochemical Journal 288,
Robinson IM, Cheek TR & Burgoyne RD 1992 'Ca2+ influx induced by the Ca(2+)-ATPase inhibitors 2,5-di-(t-butyl)-1,4-benzohydroquinone and thapsigargin in bovine adrenal chromaffin cells' Biochem J 288 ( Pt 2), 457-463 Author Site , DOI
Watkinson A & Robinson I 1992 'Reserpine-induced processing of chromogranin A in cultured bovine adrenal chromaffin cells' J Neurochem 58, (3) 877-883 Author Site , DOI
Robinson IM & Burgoyne RD 1991 'A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells' FEBS Lett 289, (2) 151-154 Author Site , DOI
Robinson IM & Burgoyne RD 1991 'Characterisation of distinct inositol 1,4,5-trisphosphate-sensitive and caffeine-sensitive calcium stores in digitonin-permeabilised adrenal chromaffin cells' J Neurochem 56, (5) 1587-1593 Author Site , DOI
Conference Papers
Oberhauser AF, Robinson IM & Fernandez JM 1995 'Do caged-Ca2+ compounds mimic the physiological stimulus for secretion?' France 1-/-0/19001-/-0/190071-75 , DOI
Robinson IM, Oberhauser AF & Fernandez JM 1994 'Is the activity of the fusion pore scaffold regulated by a coincidence detector?' United States 1-/-0/19001-/-0/1900168-178 , DOI
Burgoyne RD, Morgan A, Robinson I, Pender N & Cheek TR 1993 'Exocytosis in adrenal chromaffin cells' England 1-/-0/19001-/-0/1900309-314