- C408, Portland Square, Drake Circus, Plymouth, PL4 8AA
- +44 1752 586775
- iain.robinson@plymouth.ac.uk
Profiles
Dr Iain Robinson
Associate Professor (Reader) in Neurosciences
Peninsula Medical School (Faculty of Health)
Biography
Biography
Iain Robinson did his PhD in the University of Liverpool looking at calcium signalling in adrenal chromaffin cells. He then did a post doc in the Mayo Clinic where he used pulsed laser imaging, capacitance and amperometry to study calcium signalling and exocytosis in mast cells and adrenal chromaffin cells. He then moved to Stanford University and started to work with Drosophila to study the molecular basis of exocytosis. He started his own research lab in the University of Cambridge using Drosophila to study synaptic vesicle endocytosis and t-tubule development. His lab moved to Case Western Reserve University before joining Peninsula. Current research looks at the role of membrane trafficking in regulating synaptic form and function.
Current teaching roles include:
Neuroscience Lead for PUPSMD
BMBS Year 2 Lead
Qualifications
BSc (Jt) Hons University of Wales, College Cardiff.
PhD University of Liverpool.
PG Cert (Clin Ed) Peninsula College of Medicine and Dentistry.
Key publications
(2002) 'Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain' Nature 418, (6895) 336-340 , DOI
(2001) 'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila' Genes & Development 15, (22) 2967-2979
(1996) 'Specialized release zones in chromaffin cells examined with pulsed-laser imaging' Cell Calcium 20, (2) 181-201 , DOI
(1995) 'Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells' Proc Natl Acad Sci U S A 92, (7) 2474-2478 , DOI
(1994) 'Pulsed laser imaging of rapid Ca2+ gradients in excitable cells' Biophys J 67, (2) 505-514 , DOI
(1994) 'The fusion pore interface: a new biological frontier' Curr Opin Neurobiol 4, (3) 330-336 , DOI
Publications
Publications
Key publications
(2002) 'Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain' Nature 418, (6895) 336-340 , DOI
(2001) 'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila' Genes & Development 15, (22) 2967-2979
(1996) 'Specialized release zones in chromaffin cells examined with pulsed-laser imaging' Cell Calcium 20, (2) 181-201 , DOI
(1995) 'Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells' Proc Natl Acad Sci U S A 92, (7) 2474-2478 , DOI
(1994) 'Pulsed laser imaging of rapid Ca2+ gradients in excitable cells' Biophys J 67, (2) 505-514 , DOI
(1994) 'The fusion pore interface: a new biological frontier' Curr Opin Neurobiol 4, (3) 330-336 , DOI
Key publications are highlighted
Journals
Articles
(2021) 'Standard setting anchor statements: a double cross-over trial of two different methods' MedEdPublish 10, (1:32) 1-13 Publisher Site , DOI Open access
(2017) 'Angoff anchor statements: setting a flawed gold standard?' MedEdPublish 6, (3:53) 1-7 , DOI Open access
(2016) 'Rigour in moderation processes is more important than the choice of method' Assessment & Evaluation in Higher Education 1-9 , DOI Open access
(2016) 'Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling' Nature Neuroscience 19, (10) 1311-1320 , DOI
(2014) 'Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy' J Clin Invest 124, (4) 1821-1834 , DOI
(2013) 'Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis' Open Biol 3, (8) , DOI
(2013) 'Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes' HUMAN MOLECULAR GENETICS 22, (8) 1539-1557 , DOI
(2013) 'Neuron-type specific functions of DNT1, DNT2 and Spz at the Drosophila neuromuscular junction' PLoS One 8, (10) , DOI
(2012) 'Barfly: Sculpting membranes at the Drosophila neuromuscular junction' DEVELOPMENTAL NEUROBIOLOGY 72, (1) 33-56 , DOI
(2011) 'Oxidative stress induces overgrowth of the Drosophila neuromuscular junction' Proceedings of the National Academy of Sciences of the United States of America 108, (42) 17521-17526 , DOI
(2011) 'Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies' Neuromolecular Med 13, (1) 77-87 , DOI
(2010) 'Oxidative stress induces overgrowth of the Drosophila neuromuscular junction' JOURNAL OF NEUROGENETICS 24, 8-9
(2010) 'Syndapin's role in synaptic form and function' JOURNAL OF NEUROGENETICS 24, 48-48
(2007) 'Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation' J Cell Sci 120, (Pt 24) 4367-4376 , DOI
(2007) 'Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development' Journal of Cell Biology 178, (2) 309-322 , DOI
(2007) 'A novel function for syndapin at Drosophila neuromuscular junctions' COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 146, (4) S103-S103 , DOI
(2007) 'Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation' Journal of Cell Science 120, (24) 4367-4376
(2007) 'Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development' Journal of Cell Biology 178, (2) 309-322
(2004) 'Independent regulation of synaptic size and activity by the anaphase-promoting complex' Cell 119, (5) 707-718 , DOI
(2004) 'Independent regulation of synaptic size and activity by the anaphase-promoting complex' Cell 119 (5), 707-18 , DOI
(2002) 'A Drosophila SNAP-25 null mutant reveals context-dependent redundancy with SNAP-24 in neurotransmission' GENETICS 162, (1) 259-271
(2002) 'Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain' Nature 418, (6895) 336-340 , DOI
(2002) 'The C(2)B Ca(2+)-binding motif of symaptotagimin is required for synaptic transmission in vivo' Nature 418, (6895) 340-344 , DOI
(2002) 'Synaptotagmins I and IV promote transmitter release independently of Ca2+ binding in the C(2)A domain' Nature 418, (6895) 336-340
(2002) 'The C2BCa2+-binding motif of synaptotagmin is required for synaptic transmission in vivo' Nature 418, (6895) 340-344
(2001) 'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophilia' Genes & Development 15, (22) 2967-2979 , DOI
(2001) 'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila' Genes & Development 15, (22) 2967-2979
(1996) 'Simultaneous capacitance and amperometric measurements of exocytosis: a comparison' Biophys J 71, (2) 1131-1139 , DOI
(1996) 'Specialized release zones in chromaffin cells examined with pulsed-laser imaging' Cell Calcium 20, (2) 181-201 , DOI
(1996) 'Stimulation of secretion from bovine adrenal chromaffin cells by microsecond bursts of therapeutic levels of ultrasound' J Physiol 492 ( Pt 1), 257-263 , DOI
(1996) 'Stimulation of secretion from chromaffin cells by microsecond tonebursts of ultrasound' BIOPHYSICAL JOURNAL 70, (2) MPME2-MPME2
(1995) 'Pulsed-laser Ca2+ imaging and micro-amperometry: New tools to study exocytosis in excitable cells' JOURNAL OF GENERAL PHYSIOLOGY 106, (6) 16-16
(1995) 'Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells' Proc Natl Acad Sci U S A 92, (7) 2474-2478 , DOI
(1994) 'Pulsed laser imaging of rapid Ca2+ gradients in excitable cells' Biophys J 67, (2) 505-514 , DOI
(1994) 'The fusion pore interface: a new biological frontier' Curr Opin Neurobiol 4, (3) 330-336 , DOI
(1994) 'Neurotransmitter release through the exocytotic fusion pore' Seminars in Neuroscience 6, (3) 177-185 , DOI
(1994) 'HYDROLYSIS RESISTANT GTP ANALOGS STIMULATE EXOCYTOSIS IN BOVINE ADRENAL CHROMAFFIN CELLS' BIOPHYSICAL JOURNAL 66, (2) A352-A352
(1994) 'PULSED-LASER IMAGING OF RAPID CA2+ SIGNALING IN EXCITABLE CELLS' BIOPHYSICAL JOURNAL 66, (2) A351-A351
(1994) 'REGULATION OF THE EXOCYTOTIC FUSION SCAFFOLD BY GTP AND CA2+ BINDING-PROTEINS' BIOPHYSICAL JOURNAL 66, (2) A352-A352
(1993) 'ISOLATION OF CHROMAFFIN CELL THAPSIGARGIN-SENSITIVE CA2+ STORE IN LIGHT MICROSOMES FROM BOVINE ADRENAL-MEDULLA' INTERNATIONAL JOURNAL OF BIOCHEMISTRY 25, (5) 641-652 , DOI
(1992) 'Ca2+ influx induced by the Ca(2+)-ATPase inhibitors 2,5-di-(t-butyl)-1,4-benzohydroquinone and thapsigargin in bovine adrenal chromaffin cells' Biochem J 288 ( Pt 2), 457-463 , DOI
(1992) 'Ca2+ influx induced by the Ca(2+)-ATPase inhibitors 2,5-di-(t-butyl)-1,4-benzohydroquinone and thapsigargin in bovine adrenal chromaffin cells' Biochemical Journal 288,
(1992) 'Reserpine-induced processing of chromogranin A in cultured bovine adrenal chromaffin cells' J Neurochem 58, (3) 877-883 , DOI
(1991) 'A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells' FEBS Lett 289, (2) 151-154 , DOI
(1991) 'Characterisation of distinct inositol 1,4,5-trisphosphate-sensitive and caffeine-sensitive calcium stores in digitonin-permeabilised adrenal chromaffin cells' J Neurochem 56, (5) 1587-1593 , DOI