- PU PSMD, John Bull Building, 16 Research Way, Plymouth, Devon, PL6 8BU
- +44 1752 586775
- iain.robinson@plymouth.ac.uk
Profiles
Dr Iain Robinson
Associate Professor (Reader) in Neurosciences
Peninsula Medical School (Faculty of Medicine and Dentistry)
Role
Iain Robinson did his PhD in the University of Liverpool looking at calcium signalling in adrenal chromaffin cells. He then did a post doc in the Mayo Clinic where he used pulsed laser imaging, capacitance and amperometry to study calcium signalling and exocytosis in mast cells and adrenal chromaffin cells. He then moved to Stanford University and started to work with Drosophila to study the molecular basis of exocytosis. He started his own research lab in the University of Cambridge using Drosophila to study synaptic vesicle endocytosis and t-tubule development. His lab moved to Case Western Reserve University before joining Peninsula. Current research looks at the role of membrane trafficking in regulating synaptic form and function.
Current teaching roles include:
SSC Lead for PCMD
SSC Lead for PUPSMD
ARG Chair for PUPSMD
Neuroscience Lead for PUPSMD
Neuroscience co-Lead for PCMD
Qualifications
BSc (Jt) Hons University of Wales, College Cardiff.
PhD University of Liverpool.
PG Cert (Clin Ed) Peninsula College of Medicine and Dentistry.
Key publications are highlighted
Journals
Articles
2016
'Rigour in moderation processes is more important than the choice of method'
Assessment & Evaluation in Higher Education
1-9
, DOI
PEARL
2016
'Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling'
Nature Neuroscience
19,
(10)
1311-1320
, DOI
2014
'Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy'
J Clin Invest
124,
(4)
1821-1834
, DOI
2013
'Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis'
Open Biol
3,
(8)
, DOI
2013
'Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes'
HUMAN MOLECULAR GENETICS
22,
(8)
1539-1557
, DOI
2013
'Neuron-type specific functions of DNT1, DNT2 and Spz at the Drosophila neuromuscular junction'
PLoS One
8,
(10)
, DOI
2012
'Barfly: Sculpting membranes at the Drosophila neuromuscular junction'
DEVELOPMENTAL NEUROBIOLOGY
72,
(1)
33-56
, DOI
2011
'Oxidative stress induces overgrowth of the Drosophila neuromuscular junction'
Proceedings of the National Academy of Sciences of the United States of America
108,
(42)
17521-17526
, DOI
2011
'Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies'
Neuromolecular Med
13,
(1)
77-87
, DOI
2010
'Oxidative stress induces overgrowth of the Drosophila neuromuscular junction'
JOURNAL OF NEUROGENETICS
24,
8-9
2010
'Syndapin's role in synaptic form and function'
JOURNAL OF NEUROGENETICS
24,
48-48
2007
'Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation'
J Cell Sci
120,
(Pt 24)
4367-4376
, DOI
2007
'Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development'
Journal of Cell Biology
178,
(2)
309-322
, DOI
2007
'A novel function for syndapin at Drosophila neuromuscular junctions'
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
146,
(4)
S103-S103
, DOI
2007
'Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation'
Journal of Cell Science
120,
(24)
4367-4376
2007
'Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development'
Journal of Cell Biology
178,
(2)
309-322
2004
'Independent regulation of synaptic size and activity by the anaphase-promoting complex'
Cell
119,
(5)
707-718
, DOI
2004
'Independent regulation of synaptic size and activity by the anaphase-promoting complex'
Cell
119 (5),
707-18
, DOI
2002
'A Drosophila SNAP-25 null mutant reveals context-dependent redundancy with SNAP-24 in neurotransmission'
GENETICS
162,
(1)
259-271
2002
'Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain'
Nature
418,
(6895)
336-340
, DOI
2002
'The C(2)B Ca(2+)-binding motif of symaptotagimin is required for synaptic transmission in vivo'
Nature
418,
(6895)
340-344
, DOI
2002
'Synaptotagmins I and IV promote transmitter release independently of Ca2+ binding in the C(2)A domain'
Nature
418,
(6895)
336-340
2002
'The C2BCa2+-binding motif of synaptotagmin is required for synaptic transmission in vivo'
Nature
418,
(6895)
340-344
2001
'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophilia'
Genes & Development
15,
(22)
2967-2979
, DOI
2001
'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila'
Genes & Development
15,
(22)
2967-2979
1996
'Simultaneous capacitance and amperometric measurements of exocytosis: a comparison'
Biophys J
71,
(2)
1131-1139
, DOI
1996
'Specialized release zones in chromaffin cells examined with pulsed-laser imaging'
Cell Calcium
20,
(2)
181-201
1996
'Stimulation of secretion from bovine adrenal chromaffin cells by microsecond bursts of therapeutic levels of ultrasound'
J Physiol
492 ( Pt 1),
257-263
1996
'Stimulation of secretion from chromaffin cells by microsecond tonebursts of ultrasound'
BIOPHYSICAL JOURNAL
70,
(2)
MPME2-MPME2
1995
'Pulsed-laser Ca2+ imaging and micro-amperometry: New tools to study exocytosis in excitable cells'
JOURNAL OF GENERAL PHYSIOLOGY
106,
(6)
16-16
1995
'Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells'
Proc Natl Acad Sci U S A
92,
(7)
2474-2478
1994
'Pulsed laser imaging of rapid Ca2+ gradients in excitable cells'
Biophys J
67,
(2)
505-514
, DOI
1994
'Neurotransmitter release through the exocytotic fusion pore'
Seminars in Neuroscience
6,
(3)
177-185
, DOI
1994
'The fusion pore interface: a new biological frontier'
Curr Opin Neurobiol
4,
(3)
330-336
1994
'HYDROLYSIS RESISTANT GTP ANALOGS STIMULATE EXOCYTOSIS IN BOVINE ADRENAL CHROMAFFIN CELLS'
BIOPHYSICAL JOURNAL
66,
(2)
A352-A352
1994
'PULSED-LASER IMAGING OF RAPID CA2+ SIGNALING IN EXCITABLE CELLS'
BIOPHYSICAL JOURNAL
66,
(2)
A351-A351
1994
'REGULATION OF THE EXOCYTOTIC FUSION SCAFFOLD BY GTP AND CA2+ BINDING-PROTEINS'
BIOPHYSICAL JOURNAL
66,
(2)
A352-A352
1993
'ISOLATION OF CHROMAFFIN CELL THAPSIGARGIN-SENSITIVE CA2+ STORE IN LIGHT MICROSOMES FROM BOVINE ADRENAL-MEDULLA'
INTERNATIONAL JOURNAL OF BIOCHEMISTRY
25,
(5)
641-652
, DOI
1992
'Ca2+ influx induced by the Ca(2+)-ATPase inhibitors 2,5-di-(t-butyl)-1,4-benzohydroquinone and thapsigargin in bovine adrenal chromaffin cells'
Biochemical Journal
288,
1992
'Ca2+ influx induced by the Ca(2+)-ATPase inhibitors 2,5-di-(t-butyl)-1,4-benzohydroquinone and thapsigargin in bovine adrenal chromaffin cells'
Biochem J
288 ( Pt 2),
457-463
1992
'Reserpine-induced processing of chromogranin A in cultured bovine adrenal chromaffin cells'
J Neurochem
58,
(3)
877-883
1991
'A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells'
FEBS Lett
289,
(2)
151-154
1991
'Characterisation of distinct inositol 1,4,5-trisphosphate-sensitive and caffeine-sensitive calcium stores in digitonin-permeabilised adrenal chromaffin cells'
J Neurochem
56,
(5)
1587-1593
Conference Papers
1995
'Do caged-Ca2+ compounds mimic the physiological stimulus for secretion?'
France
71-75
1994
'Is the activity of the fusion pore scaffold regulated by a coincidence detector?'
United States
168-178
1993
'Exocytosis in adrenal chromaffin cells'
England
309-314