Dr Florie Desriac

Dr Florie Desriac

Florie Desriac

School of Biomedical Sciences (Faculty of Health: Medicine, Dentistry and Human Sciences)


I obtained my PhD at the Université de Bretagne Occidentale (France) in 2013. My doctoral thesis and postdoctoral fellows were dedicated to antibacterial and antibiofilm compounds. Currently, I am a research fellow at the University of Plymouth where I work on new antibacterial compounds to bridge the gap on antibiotics discovery pipeline.

Professional background

Since Sept 2017: Postdoc at University of Plymouth-ISTMed (UK). Mat Upton Group. A new pipeline of first in class antibiotics template on the bacteriocins.

Janv 2017: Postdoc at the Laboratory Microbiology,Signal and Microenvironment, Evreux (France). Impact of natriuretic factor on Pseudomonas aeruginosa biofilm and virulence.

Nov 2015- Nov2016-: Postdoc at the CharlesViollette Institut, Lille (France). Strategic alternatives to reduce the use of colistin in pig farming.

Jan 2015- Oct2015: Engineer for the “SATT Ouest Valorisation”, Rennes (France): Marine bacteria producing antibacterial compounds as probiotics for shrimps farming.

2013- 2014: ATER (non-tenure-trackassistant professor) at the University of South Brittany, Lorient (France). Impact of marine associated bacteriaon the sponge Suberites domuncula.

Educational Background

- PhD in microbiology at the University of Western Brittany (France) 

- Master’s degree “Valorisation desBio resources” at the University of South Brittany with honours.

Research interests

Antimicrobial resistance (AMR) threatens our modern medicine directly, resulting in non-effective treatments for an increasing number of microbial infections but also indirectly as antibiotics underpin most of our current medical procedures (hip replacement, chemotherapy, organ donation…). Among the priorities raised to fight AMR, the reinvestment into antibiotic research discovery is a well-recognized element. According to the Pew’s most recent analysis of the antibiotic pipeline (June-2018), within the 42 antibiotics in development, fewer than 1 in 4 compounds belongs to a new drug classes or present a new mechanism of action. Knowing that the FDA will approve approximately only one drugs out of five that reaches the initial phase of clinical testing, one can understand the requirement for new drugs in the pipeline. My research interests are on antibiotics from their discovery, their mechanism of action to their pre-clinical evaluation.

Key publications are highlighted

Lesouhaitier O, Clamens T, Rosay T, Desriac F, Louis M, Rodrigues S, Gannesen A, Plakunov VK, Bouffartigues E & Tahrioui A 2018 'Host Peptidic Hormones Affecting Bacterial Biofilm Formation and Virulence' Journal of Innate Immunity 11, (3) 227-241 , DOI
Desriac F, Clamens T, Rosay T, Rodrigues S, Tahrioui A, Enault J, Roquigny L, Racine P-J, Taupin L & Bazire A 2018 'Different Dose-Dependent Modes of Action of C-Type Natriuretic Peptide on Pseudomonas aeruginosa Biofilm Formation' Pathogens 7, (2) Author Site , DOI PEARL
Bouazizi N, Bargougui R, Thebault P, Clamens T, Desriac F, Fioresi F, Ladam G, Morin-Grognet S, Mofaddel N & Lesouhaitier O 2018 'Development of a novel functional core-shell-shell nanoparticles: From design to anti-bacterial applications' Journal of Colloid and Interface Science 513, 726-735 , DOI
Bouazizi N, Vieillard J, Thebault P, Desriac F, Clamens T, Bargougui R, Couvrat N, Thoumire O, Brun N & Ladam G 2018 'Silver nanoparticle embedded copper oxide as an efficient core–shell for the catalytic reduction of 4-nitrophenol and antibacterial activity improvement' Dalton Transactions 47, (27) 9143-9155 , DOI
Offret C, Desriac F, Le Chevalier P, Mounier J, Jégou C & Fleury Y 2016 'Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological Significance' Marine Drugs 14, (7) 129-129 , DOI
Gardères J, Bedoux G, Koutsouveli V, Crequer S, Desriac F & Pennec G 2015 'Lipopolysaccharides from Commensal and Opportunistic Bacteria: Characterization and Response of the Immune System of the Host Sponge Suberites domuncula' Marine Drugs 13, (8) 4985-5006 , DOI
Desriac F, Le Chevalier P, Brillet B, Leguerinel I, Thuillier B, Paillard C & Fleury Y 2013 'Exploring the hologenome concept in marine bivalvia: haemolymph microbiota as a pertinent source of probiotics for aquaculture' FEMS Microbiology Letters 350, (1) 107-116 , DOI
Desriac F, Jégou C, Balnois E, Brillet B, Chevalier P & Fleury Y 2013 'Antimicrobial Peptides from Marine Proteobacteria' Marine Drugs 11, (10) 3632-3660 , DOI
Defer D, Desriac F, Henry J, Bourgougnon N, Baudy-Floc'h M, Brillet B, Le Chevalier P & Fleury Y 2013 'Antimicrobial peptides in oyster hemolymph: The bacterial connection' Fish & Shellfish Immunology 34, (6) 1439-1447 , DOI
Desriac F, Defer D, Bourgougnon N, Brillet B, Le Chevalier P & Fleury Y 2010 'Bacteriocin as Weapons in the Marine Animal-Associated Bacteria Warfare: Inventory and Potential Applications as an Aquaculture Probiotic' Marine Drugs 8, (4) 1153-1177 , DOI
Desriac F, Rodrigues S, Doghri I, Sablé S, Lanneluc I, Fleury Y, Bazire A & Dufour A 2018 'Antimicrobial and Antibiofilm Molecules Produced by Marine Bacteria' Blue Biotechnology Wiley-VCH Verlag GmbH & Co. KGaA 789-819 , DOI