Dr Craig Donaldson
Profiles

Dr Craig Donaldson

Head of School

School of Biomedical & Healthcare Sciences (Plymouth University Peninsula Schools of Medicine and Dentistry)

Role

School of Biomedical & Healthcare Sciences

Qualifications

2004     PGCert in Teaching and Learning in Higher Education. University of the West of England
2003     CSci: Chartered Scientist
2003     PhD, Faculty of Medicine and Dentistry, University of Bristol
1987     Certificate in Health Service Management from Institute of Health Service Managers.
1985     M.Sc. Biochemical Immunology from CNAA, North East London Polytechnic
1982     FIBMS: Fellow of the Institute of Biomedical Sciences - Immunology
1980     HND in Medical Laboratory Sciences. Bristol Polytechnic

Previous Appointments

2013    Deputy Head of School, School of Biomedical & Healthcare Sciences, Plymouth University

2010    Associate Head of Department for Human & Biomedical Sciences

            Associate Professor in Healthcare Science. University of the West of England, Bristol
2008    Subject Group Leader, Human & Biomedical Sciences. University of the West of England, Bristol
2002    Senior Lecturer in Biomedical Sciences (Haematology and Immunology).
            University of the West of England, Bristol
1994    Research Fellow, Cord Blood Research Programme
            Division of Transplantation Sciences, University of Bristol.
1984    Senior MLSO. Section Head of Immunology, Department of Haematology,
            Southmead Hospital, Bristol
1983    Senior MLSO.  United Kingdom Transplant Service, Bristol
1980    Medical Laboratory Scientific Officer, South West Regional Blood Transfusion Centre, Bristol.

Professional membership

Fellow of the Institute of Biomedical Science.
Registered with Health & Care Professions Council as a Biomedical Scientist.
Chartered Scientist.
Member of the British Society of Immunology

Roles on external bodies

Member of the QAA Benchmarking Review Group for Biomedical Science, 2014 - 15
Member of the National School of Healthcare Science's Practitioner Training Programme Review Implementation Group: Lead for Delivery Framework Working Group and member of the Quality Management Working Group 2014 - 15
Chair of the Council for Healthcare Science Practitioner Training Programme Special Interest Group, March 2014 - date
Council of Healthcare Science representative on Health Education England Healthcare Science Advisory Group, November 2013 - date
Member of the Council for Healthcare Science in Higher Education, 2013 to date
Member of the Executive Committe of the Heads of University Centres for Biomedical Science, 2013 - 2016
Institute of Biomedical Science, South-West Regional Education Officer, 2010 to date.
Member South-West Region Modernising Scientific Careers Implementation Board.
IBMS Bristol Region Education Officer 2007 to 2013.
Member Heads of University Centres for Biomedical Science 2004 to date.

Teaching interests

DegreeProgrammes:

MSc Biomedical Science, BSc Biomedical Sciences, BSc Healthcare Sciences (Life Science), BSc Healthcare Sciences(Physiological Science)

Modules:

Master’s Level (Level 7)

·         BIOM5002 Current Applications of Cell Biology (Module Lead), BIOM5009 Haematology and Transfusion (ML), BIOM5010 Medical Genomics and Personalised Medicine

Stage 4 (Level 6)

·         BHCS3005 Transfusion and Transplantation Science (ML),BHCS3010 Haematology and Transfusion Medicine (ML), BHCS3001 Personal Research Project, BHCS3021 Research Project in Healthcare Science

Stage 2 (Level 5)

·         BHCS2001 Biology of Disease, BHCS2005 Clinical Haematology and Biochemistry, BHCS2007 Diagnostic and Clinical Biomedicine

Stage 1(Level 4)

·         BHCS1001

Staff serving as external examiners

  •         

  • Chair of National School of Healthcare Science Reaccreditation panel for Southampton University’s Healthcare Science (Audiology) programme, April 2016
  • Chair of National School of Healthcare Science Reaccreditation panel for Leeds University’s Healthcare Science (Cardiac Physiology) and Healthcare Science (Audiology)  programmes, February 2016 
  • Chair of National School of Healthcare Science Reaccreditation panel for De Montfort University’s Healthcare Science (Audiology) programme, January 2016
  • Chair of National School of Healthcare Science Reaccreditation panel for Portsmouth University’s Healthcare Science (Life Science) programme, June 2015
  • External Examiner for University of Ulster Master of Research (MRes) programme 2015 – 2019
  • Chair of National School of Healthcare Science Reaccreditation panel for Leeds University’s Healthcare Science (Cardiac Physiology) and Healthcare Science (Audiology)  programmes, February 2016
  • Subject Specialist panel member Cardiff MetropolitanUniversity's periodic review of MSc Biomedical Science, February 2015
  • Panel Member for the IBMS re-accreditation of the MScBiomedical Science degree at Manchester Metropolitan University, January 2015
  • HEI Panel Member for the IBMS accreditation of the BSc BiomedicalScience degree Universiti Putra Malaysia, November 2014
  • External Examiner for University of Ulster for the MSc Biomedical Science programme, 2013 – 2017
  • Panel Member for the IBMS re-accreditation of the BSc andMSc Biomedical Science degree at University of Bradford, June 2013
  • Panel Member for the IBMS accreditation/HCPC approval ofthe Healthcare Science (Life Science) degree at University of Sunderland,December 2012
  • External Advisor: Periodic Course Review for Biosciencesprogrammes at University of Central Lancaster, May 2012
  • External examiner for Sheffield Hallam University for theBSc Biomedical Science degree 2011 - 2015
  • External examiner for Queens University, Belfast for theBSc Biomedical Science degree 2009 - 2013
  • External Advisor for Human Biology degree at Queens University,BelfastFebruary 2009
  • External examiner for the University of Wolverhampton for the MSc Award Board for the Schoolof Applied Sciences and the Biomedical Science Subject Board 2006-2010
  • External Panel Member for the joint IBMS accreditation/HPC approval of the Biomedical Science degree at Coventry University, November 2007
  • External Panel Member for the Life Sciences SubjectReview at Nottingham Trent University.November 2006

Research interests

My research expertise encompasses several aspect of stem cell transplantation. My current research focuses on chemotherapeutic damage to the marrow microenvironment /mesenchymal stem cells.

At the University of Bristol I worked as a Research Fellow on the Cord Blood Research Programme which was set up to investigate the feasibility of collecting cord blood donations to extend the pool of donors available to patients requiring a haemopoietic stem cell  (HSC) transplant. I gained extensive experience in managing a research programme having set up the techniques and procedures for the Bristol Cord Blood Bank. Subsequent research into expanding HSC in culture, to increase the stem dose available for transplant, thereby enhancing engraftment, gave me extensive experience of cell culture techniques.

 

Research degrees awarded to supervised students

PhD Completions
Lisa Spary (2007)  UWE, Bristol (Second Supervisor)
Kevin Kemp (2007), UWE Bristol (Director of Studies)
Alistair Kerr (2011) UWE, Bristol (Director of Studies)
Jennifer May (2011) UWE, Bristol (Director of Studies)
Kris Jeremy (2012) UWE, Bristol (Second Supervisor)

Professional Doctorate in Biomedical Science
David Jackson (2012) UWE, Bristol (Director of Studies)
Aaron Maramba (2013) UWE, Bristol (Director of Studies)
Lisa Wakeman (2013) UWE, Bristol (Director of Studies)

Grants & contracts

Higher Apprenticeship Fund. (£1,113,000) ‘West of England Higher Apprenticeships: Responding to Local Skills Demands.’ Stephen Batty, Vanessa Knight, Ron Ritchie, John Lanham, Terry Winnington, Kath Ross, Craig Donaldson. (Project Manager for Healthcare Science strand £142,500). 2012 – 2015

Children with Leukaemia. (£23,327) ‘Comparison of phenotype and function of cord blood NKT-cells with adult NKT-cells in-vitro: relevance to graft versus leukaemia' Additional funding to allow collaborative research on Graft-versus-Host skin explant model with Prof. Anne Dickinson, Newcastle University. Dr Craig Donaldson, Dr Ruth Morse, Dr Roger Evely and Professor Jill Hows., 2009 - 2010

Children with Leukaemia. (£99,473) ‘Comparison of phenotype and function of cord blood NKT-cells with adult NKT-cells in-vitro: relevance to graft versus leukaemia' Dr Craig Donaldson, Dr Ruth Morse, Dr Roger Evely and Professor Jill Hows., 2008 - 2010

Bursary studentship – School of Life Sciences, University of the West of England (£53,945). ‘Investigation of Mesenchymal Stem Cell Response to Chemotherapeutic Injury’. 2007 – 2010

Children with Leukaemia. (£94,140) 'A study of human NKT cells in stem cell transplant recipients' Dr Craig Donaldson, Dr Ruth Morse, Dr Stephen Robinson, and Professor Jill Hows. Two year continuation, 2006 - 2008

Children with Leukaemia. (£39,500) 'A study of human NKT cells in stem cell transplant recipients' Dr Craig Donaldson, Dr Ruth Morse, Dr Stephen Robinson, and Professor Jill Hows. One year preliminary study, 2005 - 2006

Bursary studentship – Faculty of Applied Sciences, University of the West of England (£57,000). ‘The role of mesenchymal cells in stem cell transplantation for haematological malignancies’. 2004 – 2007

 

Key publications are highlighted

Journals
Articles
Andrews SW, Kabrah S, May JE, Donaldson C & Morse HR 2013 'Multiple myeloma: the bone marrow microenvironment and its relation to treatment' Br J Biomed Sci 70, (3) 110-120 Author Site
May JE, Morse HR, Xu J & Donaldson C 2012 'Development of a novel, physiologically relevant cytotoxicity model: application to the study of chemotherapeutic damage to mesenchymal stromal cells' Toxicol Appl Pharmacol 263, (3) 374-389 Author Site , DOI
Brincat P, Degaetano J & Donaldson C 2012 'Evaluation of a method allowing preservation of fresh lymph nodes for flow cytometric immunophenotyping' CYTOMETRY PART B-CLINICAL CYTOMETRY 82B, (4) 245-251 Author Site , DOI
Kemp K, Morse R, Sanders K, Hows J & Donaldson C 2011 'Alkylating chemotherapeutic agents cyclophosphamide and melphalan cause functional injury to human bone marrow-derived mesenchymal stem cells' Ann Hematol 90, (7) 777-789 Author Site , DOI
May JE, Morse R, Xu J, Avent ND, Cox C, Wexler SA & Donaldson C 2010 'An in vitro model of chemotherapeutic damage to mesenchymal stem cells' MUTAGENESIS 25, (6) 633-633 Author Site
Kemp K, Morse R, Wexler S, Cox C, Mallam E, Hows J & Donaldson C 2010 'Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy' Ann Hematol 89, (7) 701-713 Author Site , DOI
Rees B, Morse R, Robinson S, Hows J & Donaldson C 2009 'A preliminary study of human natural killer T-cell recovery post allogeneic stem cell transplantation' BONE MARROW TRANSPLANTATION 43, S368-S368 Author Site
May JE, Xu J, Morse HR, Avent ND & Donaldson C 2009 'Toxicity testing: the search for an in vitro alternative to animal testing' Br J Biomed Sci 66, (3) 160-165 Author Site
Gharehbaghian A, Donaldson C, Newman J, Bannister G & Bradley BA 2006 'The correlation between the percent of CD3- CD56+ cells and NK precursor function' Iran J Allergy Asthma Immunol 5, (4) 167-175 Author Site
Kemp KC, Hows J & Donaldson C 2005 'Bone marrow-derived mesenchymal stem cells' Leuk Lymphoma 46, (11) 1531-1544 Author Site , DOI
Wexler SA, Donaldson C, Denning-Kendall P, Rice C, Bradley B & Hows JM 2003 'Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not' Br J Haematol 121, (2) 368-374 Author Site
Mori H, Colman SM, Xiao ZJ, Ford AM, Healy LE, Donaldson C, Hows JM, Navarrete C & Greaves M 2002 'Chromosome translocations and covert leukemic clones are generated during normal fetal development' PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99, (12) 8242-8247 Author Site , DOI
Donaldson C, Truman C & Hows JM 2001 'A long-term stroma based hematopoietic cell assay to study the development and killing repertoire of natural killer cells' BLOOD 98, (11) 658A-659A Author Site
Haque KM, Truman CA, Gharehbaghian A, Laundy V, Donaldson C, Hows JM & Bradley BA 2001 'Cyclosporin resistant allo-activated natural killer cells: possible evidence of functional natural killer memory' Transplant Proc 33, (1-2) 331-332 Author Site
Donaldson C, Denning-Kendall P, Bradley B & Hows J 2001 'The CD34+CD38neg population is significantly increased in haemopoietic cell expansion cultures in serum-free compared to serum-replete conditions: dissociation of phenotype and function' Bone Marrow Transplantation 27, (4) 365-371 , DOI
Conference Papers
May J, Morse R, Xu J, Avent N, Febrey S, Cox C, Wexler S & Donaldson C 2011 'Chemotherapy-induced damage to mesenchymal stem cells: an in vitro model' S308-S308
Maramba A, North J, Lowdell MW & Donaldson C 2011 'IgM ligation triggers Zeta associated protein of 70 kDa (ZAP-70) tyrosine 292 and 319 phosphorylation in B-Chronic lymphocytic leukaemia (B-CLL)' 72-73
May E, Xu J, Morse R, Avent N, Cox C, Wexler S & Donaldson C 2010 'MODELING CHEMOTHERAPEUTIC DAMAGE TO MESENCHYMAL STEM CELLS' 664-664
Rees BM, Allen JE, Morse HR & Donaldson C 2010 'The effects of IL-2 and IL-15 on NKT-cell activation and cytotoxicity against leukaemic cell lines' 69-69
May J, Xu J, Morse R, Avent N, Cox C, Wexler S & Donaldson C 2009 'Mesenchymal stem cell response to chemotherapeutic damage' S163-S163
Kemp KC, Morse R, Wexler SA, Cox C, Hows JM & Donaldson C 2007 'Chemotherapy induced mesenchymal stem cell damage in patients with haematological malignancies' S121-S121
Kemp KC, Morse R, Sanders K, Hows JM & Donaldson C 2007 'Protection by keratinocyte growth factor against the altered expression of CD44 on mesenchymal stem cells after chemotherapeutic insult' S121-S122
Rees BM, Robinson S, Hows JM & Donaldson C 2006 'Natural killer T-cells express CD52: implications for allogeneic stem cell transplantation' 113-113
Kemp K, Morse R, Wexler S, Cox C, Hows J & Donaldson C 2006 'Reduced mesenchymal stem cell (MSC) proliferation and adhesion molecule expression in patients after chemotherapy for haernatological malignancies' 67-67 , DOI
Kemp K, Morse R, Wexler S, Cox C, Symes L, Meyrick S, Denning-Kendall P, Rees B, Hows J & Donaldson C 2005 'Chemotherapy induced mesenchymal stem cell damage in patients with haematological malignancy' S101-S101
Donaldson C & Hows J 2003 'Proliferative capacity of cord blood CD34 cells in NK culture is greater than that of BM CD34 cells' 208-209