Dr Christian Gray
Profiles

Dr Christian Gray

Peninsula Medical School (Plymouth University Peninsula Schools of Medicine and Dentistry)

Role

Lecturer in Infection & Immunity (Immunology Lead)

Academic Lead for Intercalated Degree Programme

BMBS Prizes Coordinator/Advisor

Disability Champion

Qualifications

Background

Dr Christian Gray joined Plymouth School of Medicine and Dentistry in 2013 where he is the discipline lead for Immunology, Academic lead for Intercalated Degree Programme and Disability Champion.  Prior to this he was employed as aPostdoc in a variety of areas of immunological research including therapies for rheumatoid arthritis, pneumococcal vaccines, mastitis resistance in dairycattle, and vaccines for R. microplus. He obtained his PhD from the University of Newcastle, Australia in 2002. He was the first to identify a link between activation of regulatory T cells and suppression of the immune system in patients with melanoma. Within his current role he have transferred his skills from biomedical research into pedagogy of teaching and learning. He is actively developing a research portfolio within medical research focusing on the enhancement of student performance through intervention and supporting students with specific learning difficulties.

Education

Bachelor of Biotechnology, Flinders University, SA, Aus.

PhD (Immunology), Facultyof Medicine, University of Newcastle, NSW, Aus.

AFHEA (Teaching for Researchers) Centre for Lifelong Learning,University of Liverpool, UK.

PostgraduateCertificate in Academic Practice, PlymouthUniversity, UK.


Professional membership

BritishSociety of Immunology
The Higher Education Academy
The Association for Medical Education inEurope (AMEE)

Teaching interests

Basic and Clinical Immunology

Medical Microbiology

Haematology

Molecular Biology

Parasitology

Research degrees awarded to supervised students

Doctor of Philosophy, School of Veterinary Science,University of Queensland

Honours, School of Veterinary Science, Universityof Queensland

Master of Biotechnology and Molecular Biology, GriffithUniversity

Key publications are highlighted

Journals
Articles
Nagel R, Gray C, Bielefeldt-Ohmann H & Traub RJ 2015 'Features of Blastocystis spp. in xenic culture revealed by deconvolutional microscopy' Parasitology Research 114, (9) 3237-3245 , DOI PEARL
Gray C, Ahmed MS, Mubarak A, Kasbekar AV, Derbyshire S, McCormick MS, Mughal MK, McNamara PS, Mitchell T & Zhang Q 2014 'Activation of memory Th17 cells by domain 4 pneumolysin in human nasopharynx-associated lymphoid tissue and its association with pneumococcal carriage' Mucosal Immunol 7, (3) 705-717 Author Site , DOI
Malagón D, Botterill B, Gray DJ, Lovas E, Duke M, Gray C, Kopp SR, Knott LM, McManus DP & Daly NL 2013 'Anthelminthic activity of the cyclotides (kalata B1 and B2) against schistosome parasites' Peptide Science 100, 461-470 Publisher Site , DOI
Cuttell L, Gomez-Morales MA, Cookson B, Adams PJ, Reid SA, Vanderlinde PB, Jackson LA, Gray C & Traub RJ 2013 'Evaluation of ELISA coupled with Western blot as a surveillance tool for Trichinella infection in wild boar (Sus scrofa)' Vet Parasitol 25, 00574-00578 , DOI
Cuttell L, Cookson B, Jackson LA, Gray C & Traub RJ 2012 'First report of a Trichinella papuae infection in a wild pig (Sus scrofa) from an Australian island in the Torres Strait region' Vet Parasitol 185, (2-4) 343-345 Author Site , DOI
Gray C, Kasnekar A, McNamara P, Beer H, McCormick M, Mitchell T & Zhang Q 2012 'Induction of pro-inflammatory cytokines in human NALT and peripheral blood by domain 4 pneumolysin' Immunology 137, 216-216
Cuttell L, Corley SW, Gray CP, Vanderlinde PB, Jackson LA & Traub RJ 2012 'Real-time PCR as a surveillance tool for the detection of Trichinella infection in muscle samples from wildlife' Vet Parasitol 188, (3-4) 285-293 Author Site , DOI
Jonsson NN, Piper EK, Gray CP, Deniz A & Constantinoiu CC 2011 'Efficacy of toltrazuril 5 % suspension against Eimeria bovis and Eimeria zuernii in calves and observations on the associated immunopathology' Parasitology research 109 Suppl 1, S113-S128 , DOI
Gray C, McNamara P, Loh C, Leong S, McCormick M, Mitchell T & Zhang Q 2011 'Investigation of D4Ply as a novel vaccine candidate against pneumococcal disease in humans' Immunology 135, 183-183
Sando L, Pearson R, Gray C, Parker P, Hawken R, Thomson PC, Meadows JRS, Kongsuwan K, Smith S & Tellam RL 2009 'Bovine Muc1 is a highly polymorphic gene encoding an extensively glycosylated mucin that binds bacteria' J Dairy Sci 92, (10) 5276-5291 Author Site , DOI
Lutzow YS, Gray C & Tellam R 2008 '15-Deoxy-Delta12,14-prostaglandin J2 induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells' J Dairy Res 75, (1) 55-63 Author Site , DOI
Lutzow YCS, Donaldson L, Gray CP, Vuocolo T, Pearson RD, Reverter A, Byrne KA, Sheehy PA, Windon R & Tellam RL 2008 'Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection' BMC veterinary research 4, 18-18 , DOI
Jonsson NN, Vankan D, Stear MJ, Waine D & Gray CP 2008 'Selecting cattle for host resistance to tick (rhipicephalus microplus) infestation - natural and human-directed selection' Proceedings of the 31st Internationl Conference on Animal Genetics
Johnson B, Vanags D, Dobbin C, Triantafilou K, Gray C & Flesch I 2007 'Chaperonin 10 regulates the innate immune response to toll-like receptor activation' Inflammation Research 56, S125-S125
Jonsson NN & Gray CP 2007 'Coccidiosis in cattle: The role of hygiene and herbicides in its control' Cattle Practice 15, 263-266
Gray CP, St George TD & Jonsson NN 2007 'Milk fever in dairy cattle: A novel hypothesis for an immune mediated aetiology' Cattle Practice 15, 277-282
Gray C, Strandberg Y, Donaldson L & Tellam RL 2005 'Bovine mammary epithelial cells, initiators of innate immune responses to mastitis' Australian Journal of Experimental Agriculture 45, 757-761 , DOI
Donaldson L, Vuocolo T, Gray C, Strandberg Y, Reverter A, McWilliam S, Wang Y, Byrne K & Tellam R 2005 'Construction and validation of a Bovine Innate Immune Microarray' BMC Genomics 6, Author Site , DOI
Dobbin C, Gray C, Naylor D, James A, Flores F, Flesch I, Tully N & Johnson B 2005 'Heat shock protein 10 modulates innate immunity through interaction with multiple toll-like receptor family members' Tissue Antigens 66, 433-434
Strandberg Y, Gray C, Vuocolo T, Donaldson L, Broadway M & Tellam R 2005 'Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells' Cytokine 31, (1) 72-86 Author Site , DOI
Gray CP, Arosio P & Hersey P 2003 'Association of increased levels of heavy-chain ferritin with increased CD4(+) CD25(+) regulatory T-Cell levels in patients with melanoma' Clinical Cancer Research 9, 2551-2559
Gray CP, Arosio P & Hersey P 2002 'Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells' Blood 99, 3326-3334 , DOI
Gray CP & Hersey P 2001 'Heavy chain ferritin activates immunoregulatory T cells by induction of changes in antigen presenting cells' Journal of immunotherapy 24, (5) S8-S8
Gray CP, Franco AV, Arosio P & Hersey P 2001 'Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 production' International Journal of Cancer 92, 843-850 , DOI
Zhang XD, Zhang XY, Gray CP, Nguyen T & Hersey P 2001 'TRAIL Induced Apoptosis of Human Melanoma is Regulated by Smac/DIABLO Release from Mitochondria' Journal of Immunotherapy 24, (5) S26-S26
Zhang XD, Zhang XY, Gray CP, Nguyen T & Hersey P 2001 'Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by Smac/DIABLO release from mitochondria' Cancer Research 61, 7339-7348
Zhang XD, Franco AV, Nguyen T, Gray CP & Hersey P 2000 'Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells' Journal of Immunology 164, 3961-3970
Nguyen T, Thomas W, Zhang XD, Gray C & Hersey P 2000 'Immunologically-mediated tumour cell apoptosis: the role of TRAIL in T cell and cytokine-mediated responses to melanoma' Forum (Genoa, Italy) 10, 243-252
Zhang XD, Franco A, Myers K, Gray C, Nguyen T & Hersey P 1999 'Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma' Cancer Res 59, (11) 2747-2753 Author Site
Nguyen DT, Bleijs R, Gray C & Hersey P 1998 'Characterization of immunosuppressive factor(s) produced by melanoma cell lines' Proceedings of the American Association for Cancer Research Annual Meeting 39, 614-614
Lobato ZI, Coupar BE, Gray CP, Lunt R & Andrew ME 1997 'Antibody responses and protective immunity to recombinant vaccinia virus-expressed bluetongue virus antigens' Vet Immunol Immunopathol 59, (3-4) 293-309 Author Site

Links

INTERCALATED DEGREE AT PLYMOUTH UNIVERSITY PENINSULA SCHOOL OF MEDICINEAND DENTISTRY

https://www.plymouth.ac.uk/schools/peninsula-school-of-medicine/intercalated-degree