Research within the Plymouth Light Microscopy Service

Brain cancer (origin and therapy) 

• Stepanova,D. S. et al. An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis. Cancer Res 77, 5026-5038, (2017). DOI
  
• Provenzano,L. et al. Cellular prion protein(PrP(C)) in the development of Merlin-deficient tumours. Oncogene 36, 6132-6142,(2017). DOI
  
• Zhou,L. et al. The scaffold protein KSR1,a novel therapeutic target for the treatment of Merlin-deficient tumors. Oncogene 35, 3443-3453, (2016). DOI
  
• Hilton,D. A. et al. Activation of multiplegrowth factor signalling pathways is frequent in meningiomas. Neuropathology 36, 250-261, (2016). DOI
  
• Ammoun,S. et al. Axl/Gas6/NFkappaBsignalling in schwannoma pathological proliferation, adhesion and survival. Oncogene 33, 336-346, (2014). DOI

Disease models (Alzheimer disease, autophagy, Huntington, dental tissues) 

• Sealey, M. A. et al. Distinctphenotypes of three-repeat and four-repeat human tau in a transgenic model oftauopathy. Neurobiol Dis 105, 74-83, (2017). DOI
  
• Button, R. W., Roberts, S. L., Willis,T. L., Hanemann, C. O. & Luo, S. Accumulation of autophagosomes conferscytotoxicity. J Biol Chem 292, 13599-13614, (2017). DOI
  
• Button, R. W. & Luo, S. Theformation of autophagosomes during lysosomal defect: A new source ofcytotoxicity. Autophagy 13, 1797-1798, (2017). DOI
  
• Zhuang, H., Ali, K., Ardu, S.,Tredwin, C. & Hu, B. Autophagy in dental tissues: a double-edged sword.Cell Death Dis 7, e2192, (2016). DOI
  
• Zhuang, H. et al. Local anestheticsinduce autophagy in young permanent tooth pulp cells. Cell Death Discov 1,15024, (2015). DOI
  
• Liu, B., Campo, E. M. & Bossing,T. Drosophila embryos as model to assess cellular and developmental toxicity ofmulti-walled carbon nanotubes (MWCNT) in living organisms. PLoS One 9, e88681,(2014). DOI

Neurobiology (ischemia, peripheral nerveregeneration, neural stem cell reactivation, neural network formation) 

• Xu, J. et al. Inhibition of STEP61ameliorates deficits in mouse and hiPSC-based schizophrenia models. MolPsychiatry 23, 271-281, (2018). DOI
  
• Jackson, J. et al. White mattertauopathy: Transient functional loss and novel myelin remodeling. Glia 66,813-827, (2018). DOI
  
• Dun, X. P. & Parkinson, D. B.Whole Mount Immunostaining on Mouse Sciatic Nerves to Visualize Events ofPeripheral Nerve Regeneration. Methods Mol Biol 1739, 339-348, (2018). DOI
  
• Doyle, S. et al. Vesicular glutamaterelease from central axons contributes to myelin damage. Nat Commun 9, 1032,(2018). DOI
  
• Roberts, S. L. et al. Sox2 expressionin Schwann cells inhibits myelination in vivo and induces influx of macrophagesto the nerve. Development 144, 3114-3125, (2017). DOI
  
• Roberts, S. L. et al. The role ofp38alpha in Schwann cells in regulating peripheral nerve myelination andrepair. J Neurochem 141, 37-47, (2017). DOI
  
• Mindos, T. et al. Merlin controls therepair capacity of Schwann cells after injury by regulating Hippo/YAP activity.J Cell Biol 216, 495-510, (2017). DOI
  
• Fern, R. Astrocytes snipH out bicarbonateto regulate acid-base. J Physiol 595, 2417, (2017). DOI
  
• Dun, X. P. & Parkinson, D. B. Roleof Netrin-1 Signaling in Nerve Regeneration. Int J Mol Sci 18, (2017). DOI
  
• Carr, L., Parkinson, D. B. & Dun, X.P. Expression patterns of Slit and Robo family members in adult mouse spinalcord and peripheral nervous system. PLoS One 12, e0172736, (2017). DOI
  
• Quraishe, S. et al. Selective andcompartmentalized myelin expression of HspB5. Neuroscience 316, 130-142,(2016). DOI
  
• Parpura, V., Sekler, I. & Fern, R. Plasmalemmaland mitochondrial Na(+) -Ca(2+) exchange in neuroglia. Glia 64, 1646-1654,(2016). DOI
  
• Liu, B. & Bossing, T. Single neurontranscriptomics identify SRSF/SR protein B52 as a regulator of axon growth andCholine acetyltransferase splicing. Sci Rep 6, 34952, (2016). DOI
  
• Ding, R., Weynans, K., Bossing, T.,Barros, C. S. & Berger, C. The Hippo signalling pathway maintainsquiescence in Drosophila neural stem cells. Nat Commun 7, 10510, (2016). DOI
  
• Huria, T., Beeraka, N. M., Al-Ghamdi, B.& Fern, R. Premyelinated central axons express neurotoxic NMDA receptors:relevance to early developing white-matter injury. J Cereb Blood Flow Metab 35,543-553, (2015). DOI
  
• Hansen, D. B., Garrido-Comas, N.,Salter, M. & Fern, R. HCO3(-)-independent pH regulation in astrocytes insitu is dominated by V-ATPase. J Biol Chem 290, 8039-8047, (2015). DOI
  
• Alghamdi, B. & Fern, R. Phenotypeoverlap in glial cell populations: astroglia, oligodendroglia and NG-2(+)cells. Front Neuroanat 9, 49, (2015). DOI
  
• Button, R. W. et al. Artesunate inducesnecrotic cell death in schwannoma cells. Cell Death Dis 5, e1466, (2014). DOI
  
• Butt, A. M., Fern, R. F. & Matute,C. Neurotransmitter signaling in white matter. Glia 62, 1762-1779, (2014). DOI