Peninsula Clinical Trials Unit: Publications

The FLYBITE Study - Wellcome Open Research - June 2021

A clinical study to optimise a sand fly biting protocol for use in a controlled human infection model of cutaneous leishmaniasis

Ferric Derisomaltose (FDI) - BMC Nephrology - March 2021

A multicentre prospective double blinded randomised controlled trial of intravenous iron (ferric Derisomaltose (FDI)) in Iron deficient but not anaemic patients with chronic kidney disease on functional status

The ADOS-2 Study - Journal of Autism and Developmental Disorders - March 2021

Adapting and validating the Autism Diagnostic Observation Schedule Version 2 for use with deaf children and young people

The CANDO Study - Brain, Behaviour, & Immunity - Health - February 2021

Assessment of Cytokines, microRNA and patient related outcome measures in Conversion Disorder/Functional Neurological Disorder (CD/FND): the CANDO clinical feasibility study

The MP Rapid 2019-NCOV Study - Sage Journals - February 2021

Evaluation of the MP Rapid 2019-NCOV IgM/IgG combo POCT test vs. an established platform-based method

The NoPAC Study - Annals of Emergency Medicine - February 2021

The Use of Tranexamic Acid to Reduce the Need for Nasal Packing in Epistaxis (NoPAC): Randomized Controlled Trial

The REACH-HF Study - NIHR Journals - February 2021

A facilitated home-based cardiac rehabilitation intervention for people with heart failure and their caregivers: a research programme including the REACH-HF RCT

The EXPRESS Study - Annals of Clinical Biochemistry - February 2021

Evaluation of the MP Rapid 2019-NCOV IgM/IgG Combo POCT test vs an established platform-based method

The PINS Study - The Bone & Joint Journal - February 2021

A prospective randomised clinical trial comparing a traditional versus an emollient skincare regimen for the care of pin-sites in patients with circular frames

The NAT-C Study - January 2021

A cluster randomised trial of a Needs Assessment Tool for adult Cancer patients and their carers (NAT-C) in primary care: A feasibility study

The SARS-CoV-2 Study - Clinical Medicine Journal - January 2021

Review of hygiene adaptations among UK doctors in controlling the spread of SARS-CoV-2 infection

The BRiMS Study - BMC - January 2021

Balance Right in Multiple Sclerosis (BRiMS): a feasibility randomised controlled trial of a falls prevention programme

The STEPS Study - Clinical Rehabilitation - December 2020

The effectiveness of peroneal nerve functional electrical simulation for the reduction of bradykinesia in Parkinson’s disease: A feasibility study for a randomised control trial

The SAFE Study - BMJ Open - December 2020

SAFE, a new therapeutic intervention for families of children with autism: a randomised controlled feasibility trial

The e-coachER Study - NIHR Journals - November 2020

Adding web-based behavioural support to exercise referral schemes for inactive adults with chronic health conditions: the e-coachER RCT

The e-coachER Study - British Journals of Sports Medicine - November 2020

Randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support for inactive adults with chronic
health conditions: the e-coachER trial

The SUMS Study - BMJ Open - October 2020

“I’m in a very good frame of mind”: a qualitative exploration of the experience of standing frame use in people with progressive multiple sclerosis

The LoDED Study - Heart - March 2020

Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial

The TACIT Study - Clinical Interventions in Aging - November 2019

Randomised Controlled Trial Of The Effect Of Tai Chi On Postural Balance Of People With Dementia

The SUMS Study - The Lancet Neurology - July 2019

Assessment of a home-based standing frame programme in people with progressive multiple sclerosis (SUMS): a pragmatic, multi-centre, randomised, controlled trial and cost-effectiveness analysis

The BRiMS Study - NIHR Journals Library - June 2019

A self-management programme to reduce falls and improve safe mobility in people with secondary progressive MS: the BRiMS feasibility RCT

The REACH-HF Study - European Journal of Preventive Cardiology - March 2019

The cost effectiveness of REACH-HF and home-based cardiac rehabilitation compared with the usual medical care for heart failure with reduced ejection fraction: A decision model-based analysis

The Heart of Stroke Study - BMJ Open - March 2019

HeART of Stroke: randomised controlled, parallel-arm, feasibility study of a community-based arts and health intervention plus usual care
compared with usual care to increase psychological well-being in people following a stroke

The Sorafenib Study - Journal of Neurology, Neurosurgery & Psychiatry - February 2019

Phase 0 trial investigating the intratumoural concentration and activity of sorafenib in neurofibromatosis type 2

The PASTIES (chronic pain follow-up study) - Anaesthesia - October 2018

The impact of emergency department patient-controlled analgesia (PCA) on the incidence of chronic pain following trauma and non-traumatic abdominal pain

The REACH-HF Study - European Journal of Preventive Cardiology - October 2018

The effects and costs of home-based rehabilitation for heart failure with reduced ejection fraction: The REACH-HF multicentre randomized controlled trial

The REACH-HFpEF Pilot Study - BMJ Open - March 2018

A randomised controlled trial of a facilitated home-based rehabilitation intervention in patients with heart failure with preserved ejection fraction and their caregivers

The HeLP Trial - Paediatric Exercise Science - March 2018

Children's compliance with wrist worn accelerometry within a cluster randomised controlled trial: Findings from The Healthy Lifestyles Programme (HeLP)

The HeLP Trial - NIHR Journals Library - January 2018

Cluster randomised controlled trial and economic and process evaluation to determine the effectiveness and cost effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children

The HeLP Trial - The Lancet Child & Adolescent Health - November 2017

Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial

The HeLP Trial - International Journal of Behavioral Nutrition and Physical Activity - November 2017

Intervention fidelity in the definitive cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP) trial: findings from the process evaluation

The STOPCUTS Trial - Pilot and Feasibility Studies - October 2017

Pilot parallel randomised controlled trial of protective socks against usual care to reduce skin tears in high risk people

Cost-effectiveness of screening for permanent hearing loss in children at school entry - BMJ Open - July 2017

A directly comparative two-gate case–control diagnostic accuracy study of the pure tone screen and HearCheck screener tests for identifying hearing impairment in school children

The DeCoDer Trial - NIHR Journals Library - June 2017

The data Debt Counselling for Depression in Primary Care: An Adaptive Randomised Controlled Pilot Trial

The PASTIES Trial - Association of Anaesthetists - May 2017

The cost‐effectiveness of patient‐controlled analgesia vs. standard care in patients presenting to the Emergency Department in pain, who are subsequently admitted to hospital

The HeLP Trial - BMC Public Health - April 2017

Trial baseline characteristics of a cluster randomised controlled trial of a school-located obesity prevention programme; the Healthy Lifestyles Programme (HeLP) trial

The DIAT Trial - BMJ Open - March 2017

A pre-consultation web-based tool to generate an agenda for discussion in diabetes outpatient clinics to improve patient outcomes (DIAT): a feasibility study

The HeLP Trial - BMC Public Health - December 2016

Detailed statistical analysis plan for a cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in school children

The SES Trial - NIHR Journals Library - May 2016

A programme of studies including assessment of diagnostic accuracy of school hearing screening tests and a cost-effectiveness model of school entry hearing screening programmes

The TWIST Trial - Clinical Rehabilitation - February 2016

Does the use of Nintendo Wii Sports TM improve arm function? Trial of Wii TM in Stroke: A randomised controlled trial and economics analysis

The Scrutiknee Trial - Pilot and Feasibility Studies - February 2016

Western medical acupuncture in a group setting for knee osteoarthritis: results of a pilot randomised controlled trial

The REACH-HF Trial - Chronic Illness - December 2015

Needs of caregivers in heart failure management: A qualitative study

The REVERT Trial - The Lancet - August 2015

Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial

The PASTIES Trial - British Medical Journal - May 2015

PAin SoluTions In the Emergency Setting (PASTIES) - patient controlled analgesia versus routine care in emergency department patients with pain from traumatic injuries: randomised trial

The PASTIES Trial - British Medical Journal - April 2015

PAin SoluTions In the Emergency Setting (PASTIES) - patient controlled analgesia versus routine care in emergency department patients with non-traumatic abdominal pain: randomised trial

The TWIST Trial - Clinical Rehabilitation - March 2015

Participant and caregiver experience of the Nintendo Wii Sports TM after stroke: qualitative study of the trial of Wii TM in stroke (TWIST)

The CUPID Trial - NIHR Journals Library - February 2015

The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis

The CUPID Trial - Lancet Neurology - September 2013

Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial

The South West Impact of Multiple Sclerosis (SWIMS) Trial - BMC Neurology - October 2010

Patient-orientated longitudinal study of multiple sclerosis in south west England (The South West Impact of Multiple Sclerosis Project, SWIMS) 1: protocol and baseline characteristics of cohort