Peninsula Clinical Trials Unit: Non-CTIMPs

The following trials are fully managed


Title: Dementia - Person Aligned Care Team

Chief investigator: Professor Richard Byng, Faculty of Health, University of Plymouth



Title: A multi-centred RCT of an augmented exercise referral scheme using web-based behavioural support in individuals with metabolic, musculo-skeletal and mental health conditions.

Chief investigator: Professor Adrian Taylor, Faculty of Health, University of Plymouth


Title: Randomised controlled trial of the LoDED (Limit of Detection of Troponin and ECG Discharge) strategy versus usual care in adult chest pain patients attending the Emergency Department.

Chief investigator: Dr Edward Carlton, North Bristol NHS Trust.


MCL Biobank

Title: Establishing a biobank and database as a national resource for characterising indolent and aggressive forms of mantle cell lymphoma.

Chief investigator: Professor Simon Rule, University Hospitals Plymouth NHS Trust



Title: Rehabilitation enablement in chronic heart failure – A programme of research to develop and evaluate a home-based intervention for patients with heart failure.

Chief investigator: Dr Hasnain Dalal, Royal Cornwall Hospitals NHS Trust

ISRCTN78539530       Results Paper Protocol paper


Title: A study to establish the feasibility of a definitive randomised controlled trial evaluating SAFE, an intervention for families of children with autism.

Chief investigator: Dr Rebecca Stancer (previously McKenzie), Faculty of Arts, Humanities and Business, University of Plymouth



Title: The South West impact of multiple sclerosis project – a patient-orientated  longitudinal study of the impact of multiple sclerosis in South West England.

Chief investigator: Professor Jeremy Hobart, University of Plymouth


Title: A multi-centre randomised controlled trial to assess the effectiveness and cost effectiveness of a home-based self-management standing frame programme in people with progressive MS.

Chief investigator: Professor Jenny Freeman, University of Plymouth

Study website       ISRCTN69614598


Title: Trial of Physical Activity and Reduction of Smoking.

Chief investigator: Professor Adrian Taylor, University of Plymouth

Study website      ISRCTN47776579


Title: Trial of Intraoperative Cell salvage vs Transfusion in Ovarian Cancer – a feasibility study.

Chief investigator: Miss Khadra Galaal, Royal Cornwall Hospitals NHS Trust

CRUK    ISRCTN19517317

The following trials are supported through the provision of senior trial management oversight and/or data services


Title: A novel interactive training device to improve walking Ability and quality of life for Children with CErebral Palsy Trial. A multi-centred feasibility RCT with an embedded qualitative study.

Chief investigator: Rachel Rapson, Torbay and South Devon NHS Foundation Trust


Title: Improving depression treatment outcomes by better repairing positivity deficits: Development and pilot randomised controlled trial evaluation of a novel psychosocial therapy.

Chief investigator: Dr Barnaby Dunn, University of Exeter

Study website


Title: Does early mobilisation after ankle fracture surgery enhance Recovery? A pragmatic multi-centre randomised controlled trial with qualitative component and health economic analysis comparing the use of plaster versus support boot.

Chief investigator: Mr Anuraag Sangar, Poole Hospital NHS Foundation Trust


Title: A feasibility study and pilot study to establish methods for assessing the acceptability, and clinical and cost-effectiveness of enhanced psychological care in cardiac rehabilitation services for patients with new onset depression compared with usual care.

Chief investigator: Professor John Campbell, University of Exeter


Title: Community-based Prevention of Diabetes (ComPoD): A randomised trial with a waiting list control group to evaluate the effectiveness and cost-effectiveness of a third sector led, community-based diabetes prevention programme.

Chief investigators: Dr Colin Greaves and Dr Jane Smith, University of Exeter

Engager II

Title: Developing and evaluating a collaborative care intervention for prisoners, with common mental health problems, near to and after release.

Chief investigator: Dr Richard Byng, Faculty of Health, University of Plymouth


Title: A cluster randomised, controlled feasibility study of a nurse-led, holistic assessment and care planning intervention for older people living with frailty in primary care.

Chief investigator: Helen Lyndon, University of Plymouth

Study website          ISRCTN74345449

Improve II

Title: Integrating multifactorial psychotherapy research in an NHS Setting: A fractional factorial randomised trial delivering internet psychotherapy for depression.

Chief investigator: Professor Edward Watkins, University of Exeter


Title: Reducing Foot Plantar Pressure in people with diabetes using an instant insole solution: a mixed methods pilot study.

Chief investigator: Richard Collings, Faculty of Health, University of Plymouth

Study website


Title: Promoting mental health and building resilience in adolescence: Investigating mindfulness and attentional control.

Chief investigator: Professor Mark Williams, University of Oxford

Study website    ISRCTN86619085


Title: A randomised controlled trial and economic evaluation of a community-based physical activity intervention to prevent mobility-related disability for retired older people. The REACT (REtirement in ACTion) study.

Chief investigator: Dr Afroditi Stathi, University of Bath

Study website    ISRCTN45627165


Title: The effectiveness and cost effectiveness of the incredible years teacher classroom management programme in primary school children: a cluster RCT with parallel economic and process evaluations.

Chief Investigator: Professor Tamsin Ford, University of Exeter

Study website    ISRCTN84130388


Title: The effectiveness of peroneal nerve functional electrical stimulation (FES) for improving mobility in Parkinson’s disease: A pragmatic two site feasibility study for an assessor blinded randomised control trial (STEPS).

Chief investigator: Dr Paul Taylor, Salisbury NHS Foundation Trust


Title: Improving health, under community supervision, with the support of a Health Trainer: Developing and evaluating a pilot randomised controlled trial.

Chief investigator: Professor Adrian Taylor, Faculty of Health, University of Plymouth

Study website       ISRCTN80475744