Our research is driven by the desire to translate our findings into clinical practice.
We have developed blood group genotyping approaches that investigate the complete genes of the major blood group systems. In this we have identified multiple blood group alleles, critical for the development of software tools to genotype patients and donors using current next generation sequencing platforms.
We are also investigating novel approaches to non-invasive diagnosis of Down syndrome, and to understand the pathology of this condition.
Other projects include the development of recombinant Rh antigens and understanding the mechanisms of red cell turnover, especially involving red cell CD47.
The group utilises the genomic and proteomic analysis facilities and expertise of the University of Plymouth Systems Biology Centre.