- DRF122, Derriford Research Faci;lity, Drake Circus, Plymouth, PL4 8AA
- +44 1752 584898
- vikram.sharma@plymouth.ac.uk
Profiles
Dr Vikram Sharma
Associate Professor in Biomedical Sciences
School of Biomedical Sciences (Faculty of Health)
Biography
Biography
Associate Professor in Biomedical Sciences & Head of Proteomics Core Laboratory
Qualifications
BSc (Hons) Biochemistry, 2001
MSc (Hons) Biochemistry (Research Masters), 2003
PhD (CSIR Fellow), Pharmacology and Toxicology, 2008
PgCert in Academic Practice, 2016
MSc (Hons) Biochemistry (Research Masters), 2003
PhD (CSIR Fellow), Pharmacology and Toxicology, 2008
PgCert in Academic Practice, 2016
Professional membership
BMSS
BBTS Red Cell SIG
Fellow of the HigherEducation Academy, UK
BBTS Red Cell SIG
Fellow of the HigherEducation Academy, UK
Roles on external bodies
I regularly review research articles from PLOS ONE, Proteomics-Clinical Applications (Wiley), Canadian Journal of Physiology and Pharmacology, Drug Design, Development and Therapy, Current Biomarkers Findings, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Journal of Blood Medicine (Dovepress). Besides this, I review/assess fellowship applications for The Royal College of Surgeons of England.
I am also an Editorial Board Member in Journal of Natural Science, Biology and Medicine, BEMS Reports and EC Pharmacology & Toxicology Journal.
I am also an Editorial Board Member in Journal of Natural Science, Biology and Medicine, BEMS Reports and EC Pharmacology & Toxicology Journal.
Key publications
'Abstract 36: Application of “Omics” to Assess the Inter Passage Variability in the Immunoprivilege of Mesenchymal Stem Cells' , DOI
(2020) 'Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences' Proteomes 8, (2) 6-6 , DOI Open access
(2020) 'Purification and characterization of nisin P produced by a strain of Streptococcus gallolyticus' Journal of Medical Microbiology , DOI Open access
(2020) 'NAD
(P) transhydrogenase has vital non‐mitochondrial functions in malaria parasite transmission' EMBO reports 21, (3) , DOI Open access
(2018) 'Early passaging of mesenchymal stem cells does not instigate significant modifications in their immunological behavior' Stem Cells Research and Therapy , DOI Open access
(2017) 'CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis' Kidney International 93, (3) 626-642 , DOI Open access
Teaching
Teaching
Teaching interests
Seminars on Proteomics and Bioinformatics based Data Analysis. Teaching and training sessions in Mass Spectrometry based Proteomics for undergraduates and postgraduates. Lecturing in the following modules:
BIOM3008
BIOM3026
BIOM5006
BIOM5001
BIOM5010
BHCS1004PP
Foundation Year
BHCS2007
BHCS2019
BHCS2002
BHCS3001
Personal tutor: BHCS1001, BHCS1002
BHCS2027
Module Lead : BHCS2020 (Human Metabolism) ,
Module Lead: BIOM5001: Molecular Biology: Genomics, Transcriptomics and Proteomics (Core module in MSc Biomedical Sciences)
Module Lead: BHCS3001 ( Project Module, Stage 4)
BIOM3008
BIOM3026
BIOM5006
BIOM5001
BIOM5010
BHCS1004PP
Foundation Year
BHCS2007
BHCS2019
BHCS2002
BHCS3001
Personal tutor: BHCS1001, BHCS1002
BHCS2027
Module Lead : BHCS2020 (Human Metabolism) ,
Module Lead: BIOM5001: Molecular Biology: Genomics, Transcriptomics and Proteomics (Core module in MSc Biomedical Sciences)
Module Lead: BHCS3001 ( Project Module, Stage 4)
Staff serving as external examiners
External reviewer for PhD thesis.
Research
Research
Research interests
I am running the Proteomics Core Laboratory located within the Derriford Research Facility. We collaborate on various projects employing LC-MS based Proteomics and Bioinformatic workflows to address challenging research questions. Besides this, I also provide specialist advice on experimental designs for a wide range of research projects.
My research primarily focusses on development of customised LC-MS based Proteomic Workflows for a wide range of applications. I have keen interest in epigenetic post translational modifications and their role in disease pathology, cancer and toxic responses.
Proteomics Team:
Mr. George Mawson ( Technical Support)
Miss Millie Lewis ( Placement Student)
My research primarily focusses on development of customised LC-MS based Proteomic Workflows for a wide range of applications. I have keen interest in epigenetic post translational modifications and their role in disease pathology, cancer and toxic responses.
Proteomics Team:
Mr. George Mawson ( Technical Support)
Miss Millie Lewis ( Placement Student)
Mr Daniel Busby ( Placement Student)
PhD Students:
Andrew Irvine: Integrative omics approaches in NSCLC
ResM Students:
Mr. Arran Brooks: Immunomodulation in NSCLC
Previous UK and EU Research exchange trainees:
Research Assistant: Ms Avinisha Lal (Role of New generation of Epi-Drugs in Cancer)
Erasmus Exchange Student: Ms Aurore Hebras (University of Poitiers, France)
Potential new positions:
PhD/ResM applicants are encouraged to apply.
Research groups
Grants & contracts
Projects running in the facility:
RCUK-CONICYT ( Co-Investigator)
EU-FP7 Nanosolutions
EU-FP7-SysVasc
EU-H2020 Transat ( Co-Investigator)
Royal Society International Exchange Award (Principal Investigator: 2018-2020)
EDRF projects with Commercial Partners
Wolfson Foundation Grant
RCUK-CONICYT ( Co-Investigator)
EU-FP7 Nanosolutions
EU-FP7-SysVasc
EU-H2020 Transat ( Co-Investigator)
Royal Society International Exchange Award (Principal Investigator: 2018-2020)
EDRF projects with Commercial Partners
Wolfson Foundation Grant
Publications
Publications
Key publications
'Abstract 36: Application of “Omics” to Assess the Inter Passage Variability in the Immunoprivilege of Mesenchymal Stem Cells' , DOI
(2020) 'Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences' Proteomes 8, (2) 6-6 , DOI Open access
(2020) 'Purification and characterization of nisin P produced by a strain of Streptococcus gallolyticus' Journal of Medical Microbiology , DOI Open access
(2020) 'NAD
(P) transhydrogenase has vital non‐mitochondrial functions in malaria parasite transmission' EMBO reports 21, (3) , DOI Open access
(2018) 'Early passaging of mesenchymal stem cells does not instigate significant modifications in their immunological behavior' Stem Cells Research and Therapy , DOI Open access
(2017) 'CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis' Kidney International 93, (3) 626-642 , DOI Open access
Key publications are highlighted
Journals
Articles
(2024) 'Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome' Cell Reports 43, (3) Publisher Site , DOI Open access
(2023) 'SARS-CoV-2 infection causes periodontal fibrotic pathogenesis through deregulating mitochondrial beta-oxidation' Cell Death Discovery 9, (1) , DOI Open access
(2022) 'How, where and when is SPINK3 bound and removed from mouse sperm?' Reproduction 163, (5) 251-266 , DOI
(2021) 'The caspase-6–p62 axis modulates p62 droplets based autophagy in a dominant-negative manner' Cell Death & Differentiation , DOI Open access
(2020) 'Plasmodium berghei LAPs form an extended protein complex that facilitates crystalloid targeting and biogenesis' Journal of Proteomics 227, 103925-103925 , DOI Open access
(2020) 'Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development' PLOS Pathogens 16, (6) , DOI Open access
(2020) 'Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences' Proteomes 8, (2) 6-6 , DOI Open access
(2020) 'Purification and characterization of nisin P produced by a strain of Streptococcus gallolyticus' Journal of Medical Microbiology , DOI Open access
(2020) 'NAD
(P) transhydrogenase has vital non‐mitochondrial functions in malaria parasite transmission' EMBO reports 21, (3) , DOI Open access
(2019) 'Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C60) in Toxicological Response of Marine Mussels' Nanomaterials 9, (7) 0-0 , DOI Open access
(2018) 'Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism' EBioMedicine , DOI Open access
(2018) 'High throughput screening reveals no significant changes in protein synthesis, processing, and degradation machinery during passaging of mesenchymal stem cells' Canadian Journal of Physiology and Pharmacology 97, (6) 536-543 , DOI
(2018) 'Early passaging of mesenchymal stem cells does not instigate significant modifications in their immunological behavior' Stem Cells Research and Therapy , DOI Open access
(2017) 'CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis' Kidney International 93, (3) 626-642 , DOI Open access
(2017) 'Algal polysaccharide utilisation by saprotrophic planktonic marine fungi' Fungal Ecology 30, 135-138 , DOI Open access
(2017) 'LCCL protein complex formation in Plasmodium is critically dependent on LAP1' Mol Biochem Parasitol , DOI Open access
(2017) 'Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target' EBioMedicine , DOI Open access
(2016) 'Comparative proteomics and functional analysis reveal a role of plasmodium falciparum osmiophilic bodies in malaria parasite transmission' Molecular and Cellular Proteomics , DOI Open access
(2016) 'Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome' Blood cells, molecules & diseases 58, 35-44 Open access
(2015) 'The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors' Oncogene 35, (26) 3443-3453 , DOI Open access
(2014) 'Stage-specific quantitative changes in renal and urinary proteome during the progression and development of streptozotocin-induced diabetic nephropathy in rats' Mol Cell Biochem 388, (1-2) 95-111 Publisher Site
(2012) 'The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME' Plos One
(2012) 'SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes' Plos One
(2010) 'Evidence for a dynamic role of the linker histone variant H1x during retinoic acid-induced differentiation of NT2 cells' FEBS Letters 4661-4664
(2008) 'Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy' Free Radical Research 397-404
(2007) 'Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats' FEBS Letters 2027-2035
(2007) 'Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53' FEBS Letters 1071-1078
(2006) 'Bronchiolitis Obliterans with Organising Pneumonia presenting as Non Resolving Pneumonia' Medical Journal Armed Forces India 62, (4) 378-380 , DOI
Conference Papers
(2015) 'Abstract 704: Scaffold protein KSR1 is negatively regulated by merlin and promotes tumor development in merlin deficient tumors' American Association for Cancer Research (AACR) 704-704 , DOI
(2013) 'Quantitative mass spectrometric analysis reveals the target acetylome of epigenetic inhibitor UVI5008' British Society for Proteome Research 2-/-1/20132-/-1/2013
Presentations and posters
'Proteomic Approach to Identify Stage Specific Biomarkers in Streptozotocin Induced Diabetic Nephropathy'
'Abstract 36: Application of “Omics” to Assess the Inter Passage Variability in the Immunoprivilege of Mesenchymal Stem Cells' , DOI
'CSIG-27. PROTEOMIC ANALYSIS OF GENETICALLY STRATIFIED MENINGIOMA' , DOI
'OPTC-1. Proteomic analysis of genetically stratified low-grade meningioma' , DOI
'OS08.5.A Proteomic analysis of meningioma' , DOI
'P09.07 Constitutive activation of the EGFR-STAT1 axis increases proliferation of meningioma tumour cells' , DOI
'PO-522 Global proteome and phosphoprotein profiling of meningiomas reveals novel potential therapeutic targets and biomarkers' , DOI
'Proteomic analysis of genetically stratified low-grade meningioma' , DOI
'Proteomic analysis of genetically stratified meningioma' , DOI
'Understanding the pathogenic process of uropathogenic Escherichia coli ST127 using proteomics on uroepithelial co-culture samples' , DOI
'PROTEOMIC ANALYSIS OF MENINGIOMA DISCOVERS NEW PATHWAYS AND THEIR ACTIVATION INCLUDING NEK9 AND AKT' , DOI
'TARGETING CONSTITUTIVE ACTIVATION OF THE EGFR-STAT1 AXIS DECREASES PROLIFERATION OF MENINGIOMA TUMOUR CELLS' , DOI
'INTEGRATIVE ANALYSIS OF DIFFERENTIALLY REGULATED PROTEINS IN MENINGIOMA' , DOI
Personal
Personal
Conferences organised
IBMS accredited CPD event: Workshop on "Hands On Proteomics and Data Analysis" (2014)
Other academic activities
Supervision of undergraduate, postgraduate and PhD students. I also offer summer placement, masters and undergraduate research projects. External reviewer for PhD dissertations.