Roy Moate

Roy Moate

Job title: Associate Professor (Senior Lecturer) Manager of Electron Microscopy Centre, School of Biomedical and Biological Sciences (Faculty of Science and Technology)
Telephone: +44 (0)1752 584535
Email: R.Moate@plymouth.ac.uk

Role

I am responsible for the day to day management of the Plymouth Electron Microscopy Centre which is a core University resource providing support for both teaching and research in a wide range of disciplines. The EMC is a well equipped microscopy and analysis centre housing a range of modern electron and light microscopes together with ancillary analytical equipment and image analysis facilities (http://www.plymouth.ac.uk/emc). As well as the research carried out by members of the University, within the Centre and from various other departments, particularly the Peninsula Medical School, strong links are maintained with colleagues in the Marine Biological Association of the UK, Derriford Hospital NHS Trust, the National Marine Aquarium and The EDEN project.

Apart from its academic functions, the EMC also has strong commercial links and provides essential consultancy services, both in terms of advice and practical help to local and regional manufacturing businesses. Through such work, there is, therefore, a significant contribution to the local economy and this is enhanced through programmes such as DTI Knowledge Transfer Partnerships.

The EMC is also actively involved in education at the secondary school level through the now well-established and highly regarded annual EM for Schools workshops. These workshops are held over a two-week period and attract up to 1,000 Sixth Form students (Years 12 &13) from state and independent schools across the South-West region.

Qualifications & background

BSc (Hons)2(i) Zoology , University of London (1976)

MSc Applied Fish Biology, CNAA Plymouth Polytechnic (1977)

PhD Biology, Plymouth Polytechnic,(1985)

Professional membership

Biomedical Scientist (Health Professions Council)
Fellow, Royal Microscopical Society

Member, Association of Clinical Electron Microscopy

Teaching interests

I teach on a range of courses (undergraduate and postgraduate) mainly involved with the application of advanced optical and electron microscopy techniques to biological materials.

Module Leader:

BIOL 3002 Biological Electron Microscopy

BIO 5102 Applications in Electron Microscopy

Research interests

My main current interest is as part of the Plymouth Ciliary Research Group (collaboration between the Academic Dept Anaesthesia Derriford Hospital, Peninsula Medical School and Electron Microscope Centre, UoP) investigating the ultrastructure and function of respiratory tract cilia in critically ill patients. These studies have revealed a high incidence of ultrastructural abnormalities together with significant loss of cilia coverage in ICU patients and we have established, using cultured tissue, that exposure to high oxygen concentrations leads to a decrease in cilia abundance (Kay et al., 2002). Further, we have obtained confirmatory results using human tracheal biopsy samples from ICU patients (Kay, R.: presentation at annual ESICM meeting, Barcelona, September 2002). Current research in this area centers on a combined laboratory and clinical study to investigate the mechanistic basis of oxygen induced cell death associated with ciliary loss and ultrastructural abnormalities and their relationship to muco-ciliary dysfunction in long stay ICU patients.

Research degrees awarded to supervised students

SUCESSFULLY COMPLETED PhD’s:

Lovell, J.M. 2005 Development of a non-invasive electrophysiological system for measuring the auditory capability of marine animals (2^nd Supervisor)
Kirby, J(2004) : Ultrastructure and function of respiratory cilia in the critically ill. (Director of Studies).
Ross Kay (2004) Risk factors associated with the muco-ciliary apparatus in intensive care patients (2nd Supervisor).
Dagmar Hebel (1996) The effect of sub-lethal copper exposure on the gills of Carcinus maenus and the adaptive physiological response. (2nd Supervisor).
Penny Sargeant (1995) An ultrastructural investigation of Vulval Vestibulitis Syndrome and associated inflammatory reponse in perineal skin. (Director of Studies)
Sarah Lawson (1994) Effect of copper exposure on the gill structure of an euryhaline crab Carcinus maenas (Crustacea Decapoda). (2nd Supervisor)
Edward Lavelle (1994) Gastrointestinal antigen processing and its relevance to enteric vaccine delivery in rainbow trout Onchorhynchus mykiss (Walbaum, 1792). (2nd Supervisor).

Grants & contracts

£430,000 Consultancy Services 1997-2007 (Materials testing, failure analysis, product development; NHS pathology services).

£16,450 Science Learning Centre SW 2007 (WebSEM, remote scanning electron microscopy for schools)

£30,000 Dart Valley Systems Ltd ,2006 (Sub clinical biofilm development in novel no-touch tap systems) Bradley, G (PI) & RM Moate . HEIF3 studentship

£30,000 Derriford Intensive Care Unit, 2004 (Oxygen induced cell death associated with mucociliary dysfunction in long stay ICU patients) Sneyd, JR (PI), Moate RM, McNaughton, P & AJ Moody. Case student with PMS.
£9,850 Royal Society small equipment grant 2002 (Opacification of hydrogel intraocular lenses following cataract surgery: a clinical and ultrastructural analysis) Grant No. RSRG23713

£36,540 SRIF equipment grant 2001 (SIS digital camera and image analysis work station for Transmission Electron Microscope)

£30,000 Anaesthesia Research, Plymouth 2000 (Risk factors associated with the muco-ciliary apparatus in intensive care patients) Sneyd JR (PI) Moate RM, and J. Langton . Case student with Peninsula Medical School

£30,000 Anaesthesia Research, Plymouth, 1997 (Ultrastructure and function of respiratory cilia in the critically ill) Moate RM (PI) Sneyd, J.R, and J.L. Langton. Case student with Peninsula Medical School.
£28,000 Other small grants (Wellcome Trust Summer Scholarships/ British Council Travel Grants/ Public Engagement/ Royal Soc. Equipment grants)

Publications

Rankin H.V., A.J. Moody, R.M. Moate, P. McNaughton, M.E.F. Smith & J.R.Sneyd (2007) Elevated oxygen fraction reduces cilial abundance in explanted human bronchial tissue. Ultrastructural Pathology 31 (5) 339-346.

Lovell, J.M Findlay, M.M., Harper, G.M., Moate, R.M. & Harper, G.M. (2007). The polarisation of inner ear hair cells from the lesser spotted dogfish (Scyliorhinus canicula). J Fish Biology 70: 362 - 373

Lovell, J.M., Christiansen, L., Findlay, M.M. & Moate, R.M. (2006). The influence of body size on the form and function of the statocyst from the prawn Palaemon serratus. J Experimental Biology. 209: 2480-2485.

Lovell, J.M., Findlay, M.M., Harper, G.M., Moate, R.M. (2006). Morphology of the inner ear ultrastructure from the paddlefish (Polyodon spathula) using scanning and transmission electron microscopy. J. Microsc . 222(Pt 1): 36-41.

Lovell, J.M, Findlay, M.M, Moate, R.M & Pilgrim D.A. (2005). The polarization of inner ear ciliary bundles from a scorpaeniform fish. J. Fish Biology 66, pp 836–846.

Lovell, J.M, Findlay, M.M, Moate, R.M & Yan H.Y (2005). The hearing abilities of the prawn (Palaemon serratus). Comp. Biochem. Physiol. A Mol. Integr. Physiol. Vol 140/1 pp 89-100

Tsigkoros, D, E. Folland, R. Moate and C.S. Brennan (2003) Feta cheese texture: the effect of caprine and ovine milk concentration. Int J. Dairy Tech.: 36 (4): 233-236

Kay, R. R.Moate, J.R.Sneyd,-Bray.I., & Langton, J. (2002) Cultured Rat Trachea as a Model for the Study of Ciliary Abundance – the Effect of Oxygen. Anesthesiology, 97: 275 – 278

Habib, N., R. Moate, G.Gock, T. Freegard & P.Newman (2002) Late Surface Opacification of Hydroview Intraocular Lenses, Eye, 16: 69 - 74

Griffiths, G. L.Winder, .Bean, R.Preston, R.Moate, R.Neal, E.Williams, J.Holland & G. Thomas (2001) Laser marking the carabid Pterostichus melanarius for mark-release-recapture. Ecological Entomology 26, 662 - 663

El-Ghazaly, G. R.Moate, S. Huysmanns, & S. Rowley (2000) Selected stages in Pollen Wall Development in Echinodorus, Magnolia, Betula, Rondeletia, Borago and Matrricaria, In: M.Hartley, C.Morton & S. Blackmore (Eds) Pollen & Spores:Morphology & Biology, pp. 17 – 29 Royal Botanic Gardens, Kew/Linnean Society, London.

El-Ghazaly, G., R. Moate, M.Cresti, B. Walles , Y. Takahashi, F. Ferreira and G. Obermeyer. (1999). Localization and release of allergens from tapetum and pollen grains of Betula pendula. Protoplasm, 208; 37-46

Bond, P., Brown, M.T., Moate, R.M., Gledhill, M., Hill, S. & Nimmo, M. (1999) Arrested Development in Fucus spiralis germlings exposed to copper: A morphological and ultrastructural investigation. Eur. J. Phycol. ,34; 513-521.

Hebel, D., M.B. Jones; R.Moate and Depledge, M. (1999). Differing sensitivities of respiratory and osmoregulatory gill tissue of Carcinus maenas (Crustacea:Decapoda) to water-borne copper. Mar. Biol. 133:675-681.

Whitear, M. & R Moate. (1998) Cellular diversity in the epidermis of Raja clavata (Chondrichthyes). J. Zool. (Lond.); 246: 275-285.

Gledhill, M., M.T. Brown, M.Nimmo, R Moate and S.J. Hill. (1998) Comparison of techniques for the removal of particulate material from seaweed tissue. Mar. Env. Res; 45 (3): 295-307.

PUBLISHED ABSTRACTS & CONFERENCE CONTRIBUTIONS:

Rankin, H.V., Sneyd, J.R., Moody A.J., McNaughton, P., & R.M. Moate (2005) 'The impact of rat trachea cilial banding on experimental analysis and histological survey' presented at the 'Cilia, mucus and mucociliary interactions' Gordon Research Conference (GRC) in Buellton, California on 27th Feb - 4th March 2005

Tudorica, C.M., Kuri, V., Jones, T.E.R.., Moate, R. & Brennan, C.S. -glucanb(2003) Yoghurt rheology and microstructure as affected by barley inclusion. Poster presentation / paper in Proceedings of AACC / ICC International Dietary Fibre Conference 2003, May 2003, Noordwijkerhout, Netherlands).

Symons, L.J., Jones, T.E.R., Moate, R. & Brennan, C.S. (2003) Pasting -glucan / starch gels: the effect of barley beta-glucan extractsbbehaviour of on starch gelatinisation and degradation. (Invited oral presentation and paper in the Cereals 2003 Proceedings of The Royal Australian Chemical Institute September 2003 Adelaide).

Kay, R.J, McNaughton, P., Kirkby,J., Bailey, J.A., Moate, R.M. ,Langton, J.A & Sneyd, J.R. (2002): Ciliary Ultrastructure and Coverage of Bronchial Respiratory Epithelium in Intensive Care Patients. Intensive Care Med; 2002 [Suppl1] 28: S3-S4

Kay R.; Kirkby J.; Watson G.; Sneyd R.; Langton J.; Moate R.; MacNaughton P. (2001); Ciliary Abundance and Abnormalities in Critical Illness. British Journal of Anaesthesia; 2001, 86, 2. 321- 322P

Kirkby J.; Kay R.; Sneyd R.; Langton J.; Moate R.; Loxdale S. (2001); Ciliary Abnormalities In Non-Symptomatic Smokers and Non-Smokers. British Journal of Anaesthesia; 2001, 86, 2, 326P

Kirkby J, Russell P, Sneyd J R.; Moate R M, Langton J A,(2001) Electron microscopy of respiratory ciliated epithelium. British Journal of Anaesthesia, 1999, 82, (3) 464-465

Kirkby J, Sneyd J R, Langton J A, Moate R M. (1999). Effect of midazolam on cilia survival. British Journal of Anaesthesia, 1999, 83, 527P