- C513, Portland Square, Drake Circus, Plymouth, PL4 8AA
- nick.toms@plymouth.ac.uk
Profiles
Dr Nick Toms
Associate Professor in Clinical Education & Pharmacology (Education)
Peninsula Medical School (Faculty of Health)
Biography
Biography
BMBS Director of Medical Science Learning
Professional membership
Senior Fellow HEA
Association for the Study of Medical Education (ASME)
Teaching
Teaching
Teaching interests
My key areas of medical educational interest include:
- Pharmacology & therapeutics
- Physiology
- Neuroscience
- Medical biochemistry
- Technology-enhanced learning
- Small group learning (Team-Based Learning)
- Optimising student academic support
Staff serving as external examiners
University of Cardiff: Award and Subject External Examiner
University of Surrey: Curriculum Design Review (Biosciences pathway)
Publications
Publications
Key publications
Key publications are highlighted
Journals
Articles
(2021) 'Standard setting anchor statements: a double cross-over trial of two different methods' MedEdPublish 10, (1:32) 1-13 Publisher Site , DOI Open access
(2019) 'OncoSim and OncoWiki: an authentic learning approach to teaching cancer genomics' BMC Medical Education 19, (1) , DOI Open access
(2018) 'A holistic remediation intervention for struggling undergraduate medical students affords sustained Progress Test performance recovery' MedEdPublish , DOI Open access
(2009) 'The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1' Toxicol Appl Pharmacol 235, (1) 124-134 , DOI
(2008) 'Opposing roles for caspase and calpain death proteases in L-glutamate-induced oxidative neurotoxicity' Toxicol Appl Pharmacol 232, (2) 258-267 , DOI
(2007) 'Paracetamol inhibits nitric oxide synthesis in murine spinal cord slices' Eur J Pharmacol 562, (1-2) 68-71 , DOI
(2006) 'Pyruvate and oxaloacetate limit zinc-induced oxidative HT-22 neuronal cell injury' Neurotoxicology 27, (6) 1043-1051 , DOI
(2006) 'Live cell detection of caspase-3 activation by a Discosoma-red-fluorescent-protein-based fluorescence resonance energy transfer construct' Anal Biochem 349, (1) 148-155 , DOI
(2004) 'Novel metabotropic glutamate receptor negatively coupled to adenylyl cyclase in cultured rat cerebellar astrocytes' Glia 46, (1) 1-7 , DOI
(2004) 'Pyruvate limits zinc‐induced rat oligodendrocyte progenitor cell death' European Journal of Neuroscience 19, (2) 287-294 , DOI
(2003) 'Characterisation of zinc uptake into rat cultured cerebrocortical oligodendrocyte progenitor cells' Neuroscience Letters 352, (2) 113-116 , DOI
(2003) 'Characterisation of zinc uptake into rat cultured cerebrocortical oligodendrocyte progenitor cells' Neuroscience Letters , DOI
(2002) 'Sodium nitroprusside-induced rat fundus relaxation is ryanodine-sensitive and involves L-type Ca2+ channel and small conductance Ca(2+)-sensitive K+ channel components' Auton Autacoid Pharmacol 22, (5-6) 297-301 , DOI
(2002) 'Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells: involvement of extracellular Ca2+, protein kinase C, tyrosine kinase and Rho-A' Neuropharmacology 42, (1) 1-8 , DOI
(2001) 'Regional mapping of low-affinity kainate receptors in mouse brain using [3H](2S,4R)-4-methylglutamate autoradiography' European Journal of Pharmacology 431, (3) 305-310 , DOI
(2001) 'Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death' European Journal of Pharmacology 424, (3) R3-R4 , DOI
(1999) 'Group 1 mGlu receptors elevate [Ca2+]i in rat cultured cortical type 2 astrocytes: [Ca2+]i synergy with adenosine A1 receptors' Neuropharmacology 38, (10) 1511-1517 , DOI
(1999) 'Group I mGlu receptors potentiate synaptosomal [3H]glutamate release independently of exogenously applied arachidonic acid' Neuropharmacology 38, (4) 477-485 , DOI
(1997) 'Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival' Biochem J 324 ( Pt 2), (Pt 2) 365-369 , DOI
(1997) 'Inhibition of AMPA receptor-stimulated 57Co2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (D- and L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells' Neuropharmacology 36, (3) 335-343 , DOI
(1997) 'A novel kainate receptor ligand [3H]-(2S,4R)-4-methylglutamate: pharmacological characterization in rabbit brain membranes' Neuropharmacology 36, (11-12) 1483-1488 , DOI
(1996) 'Latest eruptions in metabotropic glutamate receptors' Trends Pharmacol Sci 17, (12) 429-435 , DOI
(1996) 'The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist' Br J Pharmacol 119, (5) 851-854 , DOI
(1996) 'Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors' Eur J Pharmacol 309, (1) 71-78 , DOI
(1995) 'Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells' Br J Pharmacol 116, (7) 2824-2827 , DOI
(1994) 'NMDA receptor-mediated stimulation of rat cerebellar nitric oxide formation is modulated by cyclic AMP' Eur J Pharmacol 266, (1) 63-66 , DOI
Conference Papers
(2016) 'Team-based learning as a formative assessment tool for consolidation week at Plymouth Peninsula School of Medicine' Ottawa 2016 Perth Western Australia 3-/-0/20163-/-0/2016Open access
(2007) 'Opposing roles for caspase and calpain death proteases in l-glutamate-induced oxidative neurotoxicity' Elsevier BV 182-183 , DOI
(2006) 'Modulation of Six1 expression by the anti-mania agents lithium chloride and sodium valproate' 70-71 , DOI
(2003) 'Caspases mediate the execution of apoptosis by paracetamol (acetaminophen) in human HUH7 hepatoblastoma cells'
(2003) 'Pyruvate affords protection from zinc toxic insults in the murine HT-22 hippocampal neuronal cell line'
(2003) 'Staurosporine and anti-FAS (CD95) antibody induce caspase activation in the HT-22 murine hippocampal cell line'
(2003) 'Pyruvate rescues oligodendrocyte progenitor cells from zinc toxic insults' U102-U102
(2002) 'Attenuation of excitotoxic oligodendrocyte progenitor cell degeneration by the caspase inhibitor, Z-VAD-fmk'
(2001) 'AMPA receptor-mediated excitotoxic cell death in rat cultured oligodendrocyte progenitor cells' U73-U73
(1999) 'Coupling of group 1 mGluRs to phospholipase D in cultured CHO-mGluR1 alpha cells and cortical type 1 astrocytes' A22-A22
(1999) 'Novel glutamate-mediated inhibition of forskolin-stimulated cyclic AMP accumulation in rat cultured cerebellar astrocytes'
(1998) 'Activation of group I mGluRs increases extracellular glycine levels in the nucleus accumbens and caudate-putamen of freely-moving rats' R138-R138
(1998) 'Adenosine A<sub>1</sub> receptor activation potentiates group I metabotropic glutamate receptor-stimulated [Ca<SUP>2+</SUP>]<sub>i</sub> in cultured cortical glia' R137-R137
(1998) 'The group I, II and III mGluR modulating glutamate release in nucleus accumben and caudate putamen of freely-moving rats in vivo' R138-R138
(1997) 'mGlu<sub>1α</sub> receptor undergoes rapid, PKC-independent desensitization when expressed in CHO cells' U104-U104
(1997) 'Effects of the mGlu receptor agonist (1S,3S)-ACPD on glutamate, aspartate and glycine release in the nucleus accumbens and striatum of the rat' P158-P158
(1995) 'CHARACTERIZATION OF METABOTROPIC GLUTAMATE-RECEPTOR COUPLED PHOSPHOINOSITIDE HYDROLYSIS IN CULTURED RAT CEREBELLAR GRANULE CELLS' P109-P109
(1995) 'LACK OF EVIDENCE FOR CYCLIC-AMP-DEPENDENT REGULATION OF NMDA RECEPTOR-STIMULATED NITRIC-OXIDE SYNTHESIS IN CULTURED RAT CEREBELLAR GRANULE CELLS' P277-P277
(1994) 'CYCLIC-AMP ENHANCES NMDA RECEPTOR-MEDIATED STIMULATION OF RAT CEREBELLAR NITRIC-OXIDE FORMATION' P57-P57
Presentations and posters
'Student Perceptions towards Responseware in a Team Based Learning setting'