Nicholas Osborne

Research interests
Epidemiology, toxicology, allergy, cyanobacteria, haemochromatosis, cancer
 

Research degrees awarded to supervised students
Co-supervision PhD student, Department of Paediatrics, University of Melbourne
Honours student, School of Biomedical and Health Sciences, Victoria University
Masters Biomedical Sciences internship (5 months) Radboud University, Nijmegen, the Netherlands
Two internships visiting 3rd year Nutrition students, Victoria University  

Grants & contracts

1. Association of pollution and atopy/autoimmune disease using GIS and pollution modelling methods
2. The genetics of food allergy – a population based study 
3. Vitamin D as a risk factor for paediatric food allergy and eczema
4. Tolerance in raw egg allergy on consumption of cooked egg

 

Publications

1.       Osborne NJ Koplin J, Martin P, Gurrin L, Lowe A, Matheson M, Ponsonby A-L, Wake M, Tang M, Dhamage S, Allen K, for the HealthNuts Study Investigators (2011) Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants (accepted Journal of Allergy and Clinical Immunology)

2.       Martin PE, Matheson MC, Gurrin L, Burgess JA, Osborne NJ, Lowe AJ, Morrison S, Mészáros D, Giles GG, Abramson MJ, Walters EH, Allen KJ & Dharmage SC (2011) Childhood eczema and rhinitis predict atopic but not non-atopic adult asthma: A prospective cohort study over four decades. Journal of Allergy and Clinical Immunology. (accepted to Journal of Allergy and Clinical Immunology)

3.       Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Thiele L, Tang ML, Ponsonby A-L, Dharmage SC, Allen KJ for the HealthNuts Study Investigators (2010) The HealthNuts population-based study of food allergy: Feasibility, Safety and Acceptability Clin Ex Allergy 2010; 40:1516–22

4.       Myers JH, Allinson M, Allen D, Allinson G, Osborne NJ and Nugegoda D (2010) A health risk assessment for cyanobacterial toxins in seafood from the Gippsland Lakes. A report to the Department of Health, Victoria. RMIT University and Future Farming Systems Research Division, Department of Primary Industries.

5.      Koplin JJ, Osborne NJ, Allen KJ. Prevalence of Allergen Avoidance Advisory Statements on Packaged Processed Goods in a Supermarket. (2010) Medical Journal of Australia; 193(7):426-7

6.      Koplin JJ, Osborne NJ, Wake M, Martin PE, Gurrin LC, Robinson MN, Slaa M, Thiele L, Miles L, Anderson D, Tan T, Dang T, Hill DJ, Lowe AJ, Matheson MC, Ponsonby A-L, Tang MLK, Dharmage SC, Allen KJ. (2010) Can early introduction of egg prevent egg allergy in infants? -  A population-based study J Allergy Clin Immunol. 126:807-13

7.       Allen, K, Bertalli, N, Osborne, NJ, Constantine, C, Delatycki, M, Nisselle, A, Nicoll, A, Gertig, D, McLaren, C, Giles, G, English, D, Hopper, J, Anderson, G, Olynyk, J, Powell, L, Gurrin, L, Investigators., for the HealthIron Study Investigators (2010) HFE-C282Y homozygotes with elevated SF less than 1000 µg/L are not at increased risk of iron overload-associated clinical features Hepatology 52(3): 925-33

8.       Osborne NJ, Gurrin LC, Allen KJ, Constantine CC, Delatycki MB, Nisselle AE, McLaren CE, Bahlo, M, Vulpe, CD, Anderson G, Southey MC, English DR, Hopper JL, Giles GG, Olynyk J, Nicoll A, Powell LW, Gertig DM (2010) HFE C282Y homozygotes are at increased risk of breast and colorectal cancer Hepatology 51(4):1311-8.

9.       Constantine, CC, Anderson, GJ, Vulpe, CD, McLaren, CE, Bahlo, M, Yeap, HL, Gertig, DM, Allen, KJ, Osborne, NJ, Bertalli, NA, Beckman, K, Chen, V, Matak, P, McKie, AT, Delatycki, MB, Olynyk, JK, English, DR, Southey, MC, Hopper, JL, Giles, GG, Gurrin, LC (2009). A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE Hereditary Haemochromatosis.  Br J Haem 147(1):140-

10.    Tang M, Osborne NJ and Katrina Allen (2009) Epidemiology of anaphylaxis. Current Opinions Allergy Immunol 9(4):351–356

11.    Allen, KJ Koplin, JJ Gould, C and Osborne NJ (2009) Prevalence of self-reported allergies to food in Australia using web-based questionnaires Med J Aust 190(1):46-47

12.    Gurrin LC, Bertalli NA, Dalton GW, Osborne NJ, Constantine CC, McLaren CE, English DR, Gertig DM, Delatycki MB, Nicoll AJ, Southey MC, Hopper JL, Giles GG,, Anderson G,  Olynyk J,  Powell LW, Allen KJ for the HealthIron Study Investigators (2009) HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity. Hepatology 50(1):94-101.

13.    Osborne NJ and Shaw GR (2008) Dermatitis associated with exposure to toxic cyanobacterium during recreational water exposure BMC Dermatol 8:5

14.    Gurrin LC, Osborne NJ, Constantine CC, McLaren CE, English DR, Gertig DM, Delatycki MB, Anderson GJ, Olynyk JK, Powell LW and Allen KJ for the HealthIron Investigators (2008) The Natural History of Serum Iron Indices for HFE C282Y Homozygosity Associated With Hereditary Hemochromatosis Gastroenterology 135(6):1945-52

15.    Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, McLaren CE, Bahlo M, Nisselle AE, Forrest SM, Vulpe CD, Anderson GJ, Giles GG, English DR, Hopper JL, Olynyk JK, Powell LW, and Gertig DM (2008) Iron-overload-related disease in HFE hereditary hemochromatosis New England Journal of Medicine 358(3):1-10

16.    Constantine CC, Gurrin LC, McLaren CE, Bahlo M, Anderson GJ, Vulpe CD, Forrest SM, Allen KJ, Gertig DM and HealthIron Investigators (2008) SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis BMC Medical Genetics 9:18

17.    Koplin JK, Dharmage, S Gurrin L, Osborne NJ, Tang, MLK, Lowe A, Hosking C, Hill D, Allen KJ (2008)  Soy consumption is not a risk factor for peanut sensitization. J Allergy Clin Immunol. 121(6):1455-9

18.    Osborne NJ, Seawright AA and Shaw, GR Dermal Toxicology of Lyngbya majuscula, from Moreton Bay, Queensland, Australia (2008) Harmful Algae 7(5):584-589

19.    Koplin J, Allen KJ, Gurrin LC, Osborne NJ, Tang MLK and Dharmage S (2008) Is caesarean delivery associated with sensitisation to food allergens and IgE-mediated food allergy: A systematic review.  Ped Allergy and Immunol 19(8):682-7.

20.    Osborne NJ, Shaw, GR and Webb, PM (2007) Health effects of recreational exposure to Moreton Bay, Australia waters during a Lyngbya majuscula bloom Environ International 33(3): 309-314

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Reports & invited lectures
Invited Lecture:

1. Australian Centre for Excellence in Risk Assessment (Department of Botany, University of Melbourne)
2. Bachelor of Science (Nutrition and Food Sciences), School of Biomedical and Health Sciences, Victoria University
3. University of Portsmouth