Kathryn Yuill

Teaching interests
Human physiology
Cardiovascular physiology
Pharmacology
Ion channel biophysics

Module leader for BIOM1011 Cardiovascular Physiology
Pathway lead for Physiological Sciences 

Research interests
My research interests centre on investigating changes in cardiovascular ion channel function induced by disease states, and by pharmacological modulation.  I am particularly interested in understanding the relationship between ion channel function and calcium release in sinoatrial and atrioventricular nodal myocytes, and how this is altered in diseases, like Type I and Type II Diabetes.  

Publications

Research papers:

K.H. Yuill, M.K. Convery, P.C. Dooley, S.A. Doggrell and J.C. Hancox. (2000). Effects of BDF 9198 on action potentials and ionic currents from guinea-pig isolated ventricular myocytes. Brit. J. Pharmacol. 130: 1753-66

 C.I Spencer, K.H. Yuill, J.J. Borg, J.C. Hancox and R.Z. Kozlowski. (2001). Actions of Pyrethroid insecticides on sodium currents, action potentials, and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts. J. Pharmacol. Exp. Ther. 298: 1067-1082

 J.J. Borg, K.H. Yuill, J.C. Hancox, C.I Spencer and R.Z. Kozlowski. (2002). Inhibitory effects of the antiestrogen agent clomiphene on cardiac sarcolemmal anionic and cationic current. J. Pharmacol. Exp. Ther. 303: 282-92

 K.H. Yuill and J.C. Hancox. (2002). Characteristics of single cells isolated from adult guinea-pig atrioventricular node. Pflügers Arch 445: 311-320

 K.H. Yuill, J.J. Borg, H.J Witchel, A.A. Paul, R.Z. Kozlowski and J.C. Hancox. (2004). Potent inhibition of cardiac human potassium (HERG) channels by the anti-oestrogen agent clomiphene in the absence of QT interval prolongation. Biochem. Biophys. Res. Commun. 318: 556-61.

 K.H. Yuill, I. Ashmole, and P.R. Stanfield. (2004). The selectivity filter of the tandem pore potassium channel TASK-1 and its pH sensitivity and ionic selectivity. Pflügers Arch. 448: 63-9.

 K.H. yuill, P.J. Stansfeld, I. Ashmole, M.J. Sutcliffe and P.R. Stanfield. (2007) The selectivity, voltage-dependence and acid sensitivity of the Tandem pore potassium channel TASK-1: contributions of the pore domains. Pflügers Arch. 455(2):333-48.

 A.L. Firth, K.H. Yuill  and S.V. Smirnov. (2008) Mitochondria Dependent Regulation of Kv Channel Currents in Rat Pulmonary Artery Smooth Muscle Cells. Am J Physiol Lung Cell Mol Physiol.295(1):L61-70.

 A. L. Firth, D.V. Gordienko, K.H. Yuill and S.V. Smirnov. (2008) Cellular Localization of Mitochondria Contributes to Kv Channel Mediated Regulation of Cellular Excitability in the Pulmonary but not Mesenteric Circulation. Am J Physiol Lung Cell Mol Physiol. 296(3):L347-60.

 S.J Potocnik, I. McSherry, H. Ding, T.V. Murphy, N. Kotecha, K.H.Yuill, K.A. Dora, C.R. Triggle and M. A. Hill.  (2009) Endothelium-dependent vasodilation in myogenically-active mouse skeletal muscle arterioles: role of EDH and K⁺ channels.  Microcirculation. 16(5):377-90.

 K.H. Yuill, A. J. McNeish, Y. Kansui, C.J. Garland and K.A Dora (2010).  Nitric oxide suppresses cerebral vasomotion by sGC-independent effects on RYRs and voltage gated calcium channels. J. Vasc Res. 47(2):93-107.

 K.H.Yuill*, D.Tosh, J.C. Hancox. (2010) Streptozotocin-induced Diabetes mellitus in rats modulates action potentials and ionic currents in the atrioventricular node. Exp Physiol. 95 (4): 508-517. * Corresponding author.

K.H. Yuill, P. Iarova, B, Kemp-Harper, C.J. Garland and K.A Dora.  A novel role for HNO in local and spreading vasodilatation in rat mesenteric resistance arteries. (In press, Antioxidant and redox signalling, doi:10.1089/ars.2010.3279).

T.Z. Beleznai,  P. Yarova, K.H. Yuill, K.A.Dora. Smooth muscle cell K+ channels modulate spreading dilatation in rat isolated small mesenteric arteries.  (In press, Microcirculation, May 2011)

Review Papers:

J.C. Hancox, K.H. Yuill, J.S. Mitcheson and M.K. Convery. (2003). Progress and gaps in understanding the electrophysiological properties of morphologically normal cells from the cardiac atrioventricular node. International Journal of Bifurcation and Chaos. 13: 3675-3691

 Editorial:

K.H Yuill & S.V Smirnov (2010) Calcium-dependent regulation of voltage-gated sodium channel in cardiac myocytes: Just the beginning?  Cardiovascular Research 85 (3) 411-12.

Conference abstracts

K.H. Yuill, M.K. Convery, S.A. Doggrell and J.C. Hancox. (1998). BDF-9198, a putative novel inotrope, prolongs the action potential in guinea-pig isolated ventricular myocytes. J. Physiol., 513: 163P.

 K.H. Yuill, P.C. Dooley, S.A. Doggrell and J.C. Hancox. (2000). Cardiac sodium current prolongation by BDF 9198 in guinea-pig ventricular myocytes. Proc. ASCEPT. 7: 98P

 K.H. Yuill, P.C. Dooley, S.A. Doggrell and J.C. Hancox. (2000). Effects of BDF 9198 on action potentials and ionic currents from guinea-pig isolated ventricular myocytes. Young Physiologists Symposium, Reading.

 K.H. Yuill, J.S. Mitcheson, and J.C. Hancox. (2000). Effect of isoprenaline on I_Ca,L in isolated rabbit atrioventricular nodal myocytes. Working Group on Cardiac Cellular Electrophysiology, Bern Meeting.

 K.H. Yuill, C.I. Spencer, J.J. Borg, R.Z. Kozlowski and J.C. Hancox. (2001). Modification of fast sodium current from guinea-pig ventricular myocytes by pyrethroid insecticides. J. Physiol, 531: 185P

 K.H. Yuill and J.C. Hancox. (2001). Isolation of calcium-tolerant myocytes from the guinea-pig atrioventricular node. J. Physiol, 536: S125 

J.C. Hancox and K.H. Yuill. (2002). Comparison of the single-cell properties of the guinea-pig and rabbit AV node. J. Physiol, 544: 4P

 K.H. Yuill, I. Ashmole and P.R. Stanfield. (2003). The acid-sensitive K⁺ channel TASK-1: the implications of twofold symmetry for pH dependence and ionic selectivity. J.Physiol. 551P: C24

 K.H. Yuill, I. Ashmole and P.R. Stanfield. (2004).  The tandem pore K⁺ channel TASK-1: mutations of GYG in P1 and GFG in P2 alter ionic selectivity.  Proc. Biophysical Soc. 86: 2847-P

 K.H. Yuill, I. Ashmole and P. R. Stanfield. (2003). Mutations of the selectivity filter  of the tandem pore K⁺ channel TASK-1 that affect  ionic selectivity. J. Physiol.  555P: C7

 K.H. Yuill, I. Ashmole and P.R. Stanfield. (2004). Mutations of isoleucine residues (194 and 1200) in the K⁺ channel consensus sequence alter the ionic selectivity of the tandem pore channel TASK-1. J. Physiol   557P: PC83

 Ashmole, I,  K.H. Yuill and P.R. Stanfield. (2004). The residue D204 is required for pH sensitivity and ionic selectivity in the tandem pore K⁺ channel TASK-1. J. Physiol.  557P: PC84

 Ashmole, I  K.H. Yuill, P. Stansfeld, MJ Sutcliffe, and Peter R. Stanfield. (2004).  Mutations of the conserved glutamate residues E30 and E182 alter ionic selectivity and pH sensitivity in the tandem pore K⁺ channel TASK-1.  J. Physiol  560P: PC30

 N. Johnson, K.H Yuill, I. Ashmole, and P.R. Stanfield. (2004).  Mutation of the isoleucine residue, I94 in the K⁺ channel consensus sequence alters the ionic selectivity and pH-dependence of the tandem pore K⁺ channel TASK-3.  J. Physiol.  560P: PC31

 K.H. Yuill, I. Ashmole and P.R. Stanfield. (2005).  The acid sensitive K channel TASK-1: mutation of the residue A237, abolishes sensitivity to intracellular pH. Proc. Biophysical Soc.  88: 2320-P

 Ashmole, I.  K.H. Yuill and P.R. Stanfield. (2005).  Mutations of isoleucine in the K⁺ channel consensus sequence, alter pH-dependence and ionic selectivity in TASK-1. Proc. Biophysical Soc.  88: 2319-P

 A.L. Smith, K.H. Yuill, and S.V. Smirnov. (2005). Effect of extracellular Na⁺ removal and amiloride on voltage-gated K⁺ channel currents (I_Kv) in rat small (resistance) pulmonary arterial myocytes (PAMs). Proc. Biophysical Soc, 88: 305a, 1492-P

 A.L. Smith, K.H. Yuill,  and S.V. Smirnov. (2005). The effect of mitochondrial electron transport chain (ETC) inhibitors on voltage-dependent K⁺ (Kv) currents in rat small pulmonary arterial myocytes (PAMs). J Physiol. 567P: PC159

 A.L. Smith, K.H. Yuill  and S.V. Smirnov. (2005). Effects of hydrogen peroxide (H₂O₂) on voltage-dependent  K⁺ (Kv) currents in rat small pulmonary arterial myocytes (PAMs): the role of intracellular redox state. Proc. Brit. Pharmacological Soc. 3: 125P

 K.H. Yuill and S.V. Smirnov (2007). Biophysical and pharmacological characterisation of an extracellular calcium dependent, cation current in rat small pulmonary arterial myocytes. Proc. Biophysical Soc, 90: PC557

 K.H. Yuill and S.V. Smirnov (2007). Characterisation of an extracellular Ca²⁺-dependent, non-selective cation current in rat small pulmonary and mesenteric arterial myocytes. Proc Life Sciences, PC372

 C.J. Garland, P. Iarova, K.H. Yuill & K.A. Dora (2007). Smooth muscle hyperpolarisation and relaxation to catecholamines in the rat mesenteric artery Proc. Brit. Pharmacological Soc (Dec 2007)

 K.H. Yuill, K.A.Dora and C.J.Garland (2007). Electrophysiological characterisation of individual myocytes isolated from the rat atrioventricular node. Proc. Brit. Pharmacological Soc (Dec 2007)

 S.V.Smirnov, V.S. Telezhkin, A.L. Firth & K.H. Yuill.  (2008) Involvement of Na⁺-H⁺ exchanger in hypoxia mediated inhibition of voltage gated K channels in rat small pulmonary arterial myocytes.  Fundamental and Clinical Pharmacology 22 (Supp 2) PO31.

 A. L. Firth, D. V. Gordienko, K. H. Yuill, S. V. Smirnov. (2008) Cellular localization of mitochondria contributes to the regulation of voltage dependent potassium currents in the rat pulmonary, but not mesenteric arterial myocytes. Proc Physiol Soc 13, C4

 K.H. Yuill. (2010) Modulation of ion channel function by anandamide in rat atrioventricular nodal myocytes. Proc. Brit. Pharmacological Soc. 068P.