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Kim Tieu

 

Personal photograph uploaded by Kim Tieu

Dr Kim Tieu - ()

  • Job title: Associate Professor (Reader) in Clinical Neurobiology, Centre for Biomedical Research - Translational & Stratified Medicine (Peninsula Schools of Medicine and Dentistry)
  • Address: R2RL25, The John Bull Building, Tamar Science Park, Research Way,
    Plymouth, Devon, PL6 8BU
  • Telephone: +441752432053
  • Email: kim.tieu@plymouth.ac.uk


Role

 

2013-present   Principal Investigator,  Associate Professor (Reader), Department of Clinical Neurobiology, Plymouth University Peninsula Schools of Medicine and Dentistry.

2013-present    Adjunct Faculty, University of Rochester (Rochester, New York).

 

Qualifications & background

2004-2012      Principal Investigator ( Assistant Professor)    Departments of Environmental Medicine and Neurology in the Center for Translational Neuromedicine, University of Rochester (Rochester, New York).

 

2000-2004       Post-doctoral fellow     Department of Neurology, Columbia University, New York, New York.

1995-2000       Ph.D                             Neuroscience, Department of Neuropsychiatry, University of Saskatchewan, Canada.

1993-2000       Pharmacist                  Saskatchewan, Canada

1988-1993       B.S.P.                          Pharmacy, College of Pharmacy,

                                                            University of Saskatchewan, Canada.

 



Research interests

My research interest has always been to study mechanisms of neuronal dysfunction and degeneration as seen in Parkinson’s disease (PD), with the ultimate goal of developing effective therapies for this devastating neurological disorder.  Our research projects address the following fundamental questions: 1) Is mitochondrial dysfunction pathogenic in PD?  If so, can mitochondrial dynamics be targeted for PD treatment?  2) Glial-neuronal interactions: How do glial cells contribute to the vulnerability of dopamine neurons (the primary cell type affected in PD)?  3) Gene-environment interactions: Do mutations linked to PD render dopamine neurons more susceptible to environmental insults?  To address these questions, we perform rigorous biochemical, histological, functional and genetic analyses in experimental models of PD.  When applicable, post-mortem human samples are also used.

 

UoP Research group membership

Clinical Neuroscience 

Journals
Articles
Tieu K & Xia XG  (2014)  'Cytosolic PINK1 escapes from mitochondria to promote dendritic outgrowth' J Neurochem  128  (6),  pp 787 - 789  Author Site , DOI 
Jin YN, Yu YV, Gundemir S, Jo C, Cui M, Tieu K & Johnson GV  (2013)  'Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin' PLoS One  (3),  p e57932  Author Site , DOI 
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K & Nedergaard M  (2012)  'Cultured astrocytes do not release adenosine during hypoxic conditions' J Cereb.Blood Flow Metab.  32  (1),  pp e1 - e7 , DOI 
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K & Nedergaard M  (2012)  'Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity' Proc.Natl.Acad.Sci U.S.A.  109  (16),  pp 6265 - 6270 , DOI 
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrane J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, Li C, Tieu K & Przedborski S  (2012)  'PINK1-dependent recruitment of Parkin to mitochondria in mitophagy' Proc.Natl.Acad.Sci.U.S.A.  107  (1),  pp 378 - 383 , DOI 
Tieu K  (2011)  'A Guide to Neurotoxic Animal Models of Parkinson's Disease' Cold Spring Harbor Perspective in Medicine  1,  p a009316  Author Site
Lim S, Chesser AS, Grima JC, Rappold PM, Blum D, Przedborski S & Tieu K  (2011)  'D-�-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease' PLoS ONE  6(9): e24620. doi:10.1371/journal.pone.0024620, 
Rappold PM, Cui M, Chesser AS, Tibbett J, Grima JC, Duan L, Sen N, Javitch JA & Tieu K  (2011)  'Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3' Proc.Natl.Acad.Sci U.S.A.  108  (51),  pp 20766 - 20771 , DOI 
Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K & Nedergaard M  (2010)  'Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture' Nat.Neurosci.  13  (7),  pp 883 - 888 , DOI 
Rappold PM & Tieu K  (2010)  'Astrocytes and therapeutics for Parkinson's disease' Neurotherapeutics.  (4),  pp 413 - 423
Cui M, Tang X, Christian WV, Yoon Y & Tieu K  (2010)  'Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1' J.Biol.Chem.  285  (15),  pp 11740 - 11752 , DOI 
Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N, Przedborski S & Tieu K  (2009)  'The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway' Proc.Natl.Acad.Sci.U.S.A.  106  (19),  pp 8043 - 8048 , DOI 
Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z & Xia XG  (2007)  'Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice' international journal of biological sciences  (4),  pp 242 - 50
Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP, Heinecke JW & Przedborski S  (2005)  'Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice' J.Neurosci.  25  (28),  pp 6594 - 6600  Author Site
Perier C, Tieu K, Guegan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S & Vila M  (2005)  'Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage' Proc.Natl.Acad.Sci.U.S.A.  102  (52),  pp 19126 - 19131
Tieu K, Perier C, Vila M, Caspersen C, Zhang HP, Teismann P, Jackson-Lewis V, Stern DM, Yan SD & Przedborski S  (2004)  'L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease' Ann.Neurol.  56  (1),  pp 51 - 60  Author Site
Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD, Naini A, Vila M, Jackson-Lewis V, Ramasamy R & Przedborski S  (2003)  'D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson's disease' J.Clin.Invest.  112,  pp 892 - 901
Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H & Przedborski S  (2002)  'Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease' J.Neurosci.  22  (5),  pp 1763 - 1771
Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, Rocha M, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, Burke R & Hen R  (2002)  'Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP' Proc.Natl.Acad.Sci.USA  99  (22),  pp 14524 - 14529  Author Site
Chapters
Tieu K  (2006)  'Mitochondrial dysfunction and neurodegenerative disorders in the basal ganglia' in Bezard E (ed.)  Recent Breakthroughs in Basal Ganglia Research  New York:  Nova Science Publishers