Professor Jonathan Pinkney
Profiles

Professor Jonathan Pinkney

Professor of Endocrinology and Diabetes

Peninsula Medical School (Faculty of Health)

Biography

Biography

Jon Pinkney is Professor of Endocrinology and Diabetes at Peninsula Schools of Medicine and Dentisty, University of Plymouth, and Honorary Consultant Physician in Endocrinology, Diabetes and Weight Management at University Hospitals Plymouth NHS Trust. He undertook speciality training at University College London and the University of Bristol, and was Wellcome Travelling Fellow at Pennington Research Centre, Louisiana State University. He held Senior Lecturerships at the University of Liverpool and Peninsula College of Medicine and Dentisty before taking up his present post in 2010.

His clinical interests include all general adult endocrinology and diabetes, within which he has special interests in hypothalamic and pituitary endocrinology, obesity and bariatric surgery, reproductive endocrinology transitional care of children, and inherited endocrine tumour syndromes such as MEN. His outreach activities have included work for the Pituitary Foundation, and support of pituitary and endocrine patients. He has longstandng interests in the treatment of obesity and has been at the forefront of effort to improve the recognition of obesity as an important and treatable clinical problem. 

His portfolio of research interests include both biomedical and health services research on aspects of obesity, its environmental and molecular origins, its metabolic and social complications, the impact of obesity on people with diabetes and other endocrine conditions, and developing new approaches to treatment. He writes and speaks widely on these subjects. Current research activities include leading an NIHR programme grant investigating group-based behavioural treatment for severe obesity (Progroup), and Earlybird Study which is a longstanding cohort study of children designed to identify early predictors of obesity and metabolic disease in adults.

Qualifications

BSc (hons) 2:1 University of London King's College, 1982.
MB BS University of London, 1985.
MRCP 1988.
MD University College London, 1997.
FRCP 2003.

Professional membership

Royal College of Physicians (Fellow)
Endocrine Society
Association for the Study of Obesity

Roles on external bodies

Association for the Study of Obesity (Trustee)
Pituitary Foundation (Medical Committee Member)

Key publications

Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LMS & Randeva HS (2009) 'Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose' United States 1780-1788 , DOI Open access
Kos K, Wong SPY, Huda MSB, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JPH & Pinkney JH (2010) 'In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1' Diabetes Obes Metab 12, (4) 360-363 Author Site , DOI
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, LMS C & Randeva H (2009) 'Regularion of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin , insulin and glucose' Diabetes 8, (58) 1780-1780
Huda MSB, Dovey T, Wong SP, English PJ, Halford J, McCulloch P, Cleator J, Martin B, Cashen J & Hayden K (2009) 'Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects' Int J Obes (Lond) 33, (3) 317-325 Author Site , DOI
Huda MSB, Durham BH, Wong SP, Deepak D, Kerrigan D, McCulloch P, Ranganath L, Pinkney J & Wilding JPH (2008) 'Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal' Int J Obes (Lond) 32, (1) 129-135 Author Site , DOI
View all publications
Research

Research

Research interests

Medical and behavioural interventions for severe obesity in Tier 3 weight management services:

I am co-PI, together with Dr Mark Tarrant, for an NIHR funded programme grant "How are treatment outcomes for people with severe obesity ImPROved by GROUP-based behavioural intervention? This major 5 year project examines how Tier 3 services can be optimised, and tests a new group based behavioural intervention. The programme grant is also supported by PenARC. 

Early life origins of obesity and metabolic disease:

The Earlybird study was originally developed by Professor Terry Wilkin and has been continued by Dr Joanne Hosking and myself The study has followed a cohort of Plymouth children through to adult life, in order to identify potential early predictors of adult health. This important cohort study continues to provide numerous insights into the origins of weight gain and obesity, and how factors such as puberty affect health risks. Recent findings show how weight gain and puberty interact with genetic predisposition to affect the long term risks of developing diabetes. We are currently investigating metabonomic biomarkers are potential early indicators of risk, and to investigate the mechanisms that give rise to long term risks of type 2 diabetes and heart disease.  

Other research

Other research interests:

Polycystic Ovary Syndrome

Antenatal and early life nutrition

Publications

Publications

Key publications

Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LMS & Randeva HS (2009) 'Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose' United States 1780-1788 , DOI Open access
Kos K, Wong SPY, Huda MSB, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JPH & Pinkney JH (2010) 'In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1' Diabetes Obes Metab 12, (4) 360-363 Author Site , DOI
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, LMS C & Randeva H (2009) 'Regularion of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin , insulin and glucose' Diabetes 8, (58) 1780-1780
Huda MSB, Dovey T, Wong SP, English PJ, Halford J, McCulloch P, Cleator J, Martin B, Cashen J & Hayden K (2009) 'Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects' Int J Obes (Lond) 33, (3) 317-325 Author Site , DOI
Huda MSB, Durham BH, Wong SP, Deepak D, Kerrigan D, McCulloch P, Ranganath L, Pinkney J & Wilding JPH (2008) 'Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal' Int J Obes (Lond) 32, (1) 129-135 Author Site , DOI

Key publications are highlighted

Journals
Articles
Pinkney J & Tarrant M (2023) 'Time for a new agenda for behavioural treatment of overweight and obesity' Clinical Obesity , DOI Open access
Watkins R, Swancutt D, Alexander M, Moghadam S, Perry S, Dean S, Sheaff R, Pinkney J, Tarrant M & Lloyd J (2023) 'A Qualitative Exploration of Patient and Staff Experiences of the Receipt and Delivery of Specialist Weight Management Services in the UK' The Patient - Patient-Centered Outcomes Research , DOI Open access
Redfern K, Hollands HJ, Welch CR, Pinkney JH & Rees GA (2022) 'Dietary Intakes of Folate, Vitamin D and Iodine during the First Trimester of Pregnancy and the Association between Supplement Use and Demographic Characteristics amongst White Caucasian Women Living with Obesity in the UK' Nutrients 14, (23) 5135-5135 Publisher Site , DOI Open access
Swancutt D, Tarrant M, Ingram W, Baldrey S, Burns L, Byng R, Calitri R, Creanor S, Dean S & Evans L (2022) 'A group-based behavioural intervention for weight management (PROGROUP) versus usual care in adults with severe obesity: a feasibility randomised controlled trial protocol' Pilot and Feasibility Studies 8, (1) , DOI Open access
Martin F-P, Pinkney J & Saavedra JM (2022) 'Editorial: Nutrition and Metabolism in School-Age Children' Frontiers in Nutrition 9, , DOI Open access
Milne-Ives M, Swancutt D, Burns L, Pinkney J, Tarrant M, Calitri R, Chatterjee A & Meinert E (2021) 'The effectiveness and usability of online, group-based interventions for people with severe obesity: Systematic review protocol' JMIR Research Protocols , DOI Open access
Redfern KM, Hollands HJ, Hosking J, Welch CR, Pinkney JH & Rees GA (2021) 'The relationship between gestational weight gain, maternal upper-body subcutaneous fat changes and infant birth size: a pilot observational study amongst women with obesity' Early Human Development 154, (0) 105307-105307 , DOI Open access
Tomlinson J, Mari A, Tura A, Bond K, Stenhouse E, Dew T, Vincent RP & Pinkney J (2020) 'β-Cell Glucose Sensitivity determines hyperglycaemia in Polycystic Ovary Syndrome' Translational Metabolic Syndrome Research 3, 35-41 , DOI Open access
Cominetti O, Hosking J, Jeffery A, Pinkney J & Martin F-P (2020) 'Contributions of Fat and Carbohydrate Metabolism to Glucose Homeostasis in Childhood Change With Age and Puberty: A 12-Years Cohort Study (EARLYBIRD 77)' Frontiers in Nutrition 7, 0-0 , DOI Open access
O'Kane M, Parretti HM, Pinkney J, Welbourn R, Hughes CA, Mok J, Walker N, Thomas D, Devin J & Coulman KD (2020) 'British Obesity and Metabolic Surgery Society Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery—2020 update' Obesity Reviews 21, (11) , DOI Open access
Chynoweth J, Hosking J, Jeffery A & Pinkney J (2020) 'Contrasting impact of androgens on male and female adiposity, fat distribution and insulin resistance in childhood and adolescence (EarlyBird 75)' Pediatric Obesity 15, (12) 0-0 , DOI Open access
Rance S, Westlake D, Brant H, Holme I, Endacott R, Pinkney J & Byng R (2020) 'Admission Decision-Making in Hospital Emergency Departments: The Role of the Accompanying Person' Global Qualitative Nursing Research 7, 233339362093002-233339362093002 , DOI Open access
Carayol J, Hosking J, Pinkney J, Marquis J, Charpagne A, Metairon S, Jeffery A, Hager J & Martin F-P (2020) 'Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76)' Diabetes Care 43, (3) 653-660 , DOI Open access
Hosking J, Pinkney J, Jeffery A, Cominetti O, Da Silva L, Collino S, Kussmann M, Hager J & Martin F (2019) 'Insulin Resistance during normal child growth and development is associated with a distinct blood metabolic phenotype (Earlybird 72)' Pediatric Diabetes 20, (7) 832-841 , DOI Open access
Swancutt D, Tarrant M & Pinkney J (2019) 'How Group-Based Interventions Can Improve Services for People with Severe Obesity' Current Obesity Reports 8, (3) 333-339 , DOI Open access
Wong SPY, Huda M, English P, Bargiota A, Wilding JPH, Johnson A, Corrall R & Pinkney JH (2019) 'Correction to: Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C' Diabetologia 62, (4) 732-732 , DOI
Redfern KM, Hine R, Hollands H, Welch CR, Pinkney J & Rees G (2019) 'Objectively measured sleep duration and plasma glucose values following an oral glucose tolerance test amongst pregnant women with obesity in the UK' Sleep Medicine , DOI Open access
Maghsoodi N, Shaw N, Cross GF, Alaghband-Zadeh J, Wierzbicki AS, Pinkney J, Millward A & Vincent RP (2018) 'Bile acid metabolism is altered in those with insulin resistance after gestational diabetes mellitus' Clinical Biochemistry 64, 12-17 , DOI Open access
Lauria M, Persico M, Dordevic N, Cominetti O, Matone A, Hosking J, Jeffery A, Pinkney J, Da Silva L & Priami C (2018) 'Consensus Clustering of temporal profiles for the identification of metabolic markers of pre-diabetes in childhood (EarlyBird 73)' Scientific Reports 8, 0-0 Author Site , DOI Open access
Jeffery SC, Hosking J, Jeffery AN, Murphy MJ, Voss LD, Wilkin TJ & Pinkney J (2017) 'Insulin resistance is higher in prepubertal girls but switches to become higher in boys at age 16: A Cohort Study (EarlyBird 57)' Pediatric Diabetes , DOI Open access
Swancutt D, Joel-Edgar S, Allen M, Thomas D, Brant H, Benger J, Byng R & Pinkney J (2017) 'Not all waits are equal: an exploratory investigation of emergency care patient pathways' BMC Health Services Research 17, (1) 0-0 , DOI Open access
Tomlinson J, Pinkney J, Adams L, Stenhouse E, Bendall A, Corrigan O & Letherby G (2017) 'The diagnosis and lived experience of polycystic ovary syndrome: A qualitative study' Journal of Advanced Nursing , DOI Open access
Ukoumunne OC, Vaidya B, Frost J, Anderson R, Argyle C, Daly M, Harris-Golesworthy F, Harris J, Gibson A & Ingram W (2017) 'A preconsultation web-based tool to generate an agenda for discussion in diabetes outpatient clinics to improve patient outcomes (DIAT): a feasibility study' BMJ Open 7, (3) , DOI Open access
Redfern KM, Rees GA & Pinkney JH (2016) 'Maternal Lifestyle Factors and Fetal Macrosomia Risk: A Review' EMJ Reproductive Health Publisher Site Open access
Pinkney J, Rance S, Benger J, Brant H, Joel-Edgar S, Swancutt D, Westlake D, Pearson M, Thomas D & Holme I (2016) 'How can frontline expertise and new models of care best contribute to safely reducing avoidable acute admissions? A mixed-methods study of four acute hospitals' Health Services Delivery Research 4, (3) 1-1 Publisher Site , DOI Open access
Cooper R, Pinkney J & Ayling RM (2015) 'Appropriateness of prescribing thyroxine in primary care' Ann Clin Biochem 52, (Pt 4) 497-501 Author Site , DOI
Aljwaid H, White DL, Collard KJ, Moody AJ & Pinkney JH (2015) 'Non-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetes' Journal of Diabetes and its Complications 29, (7) 943-949 , DOI Open access
(2015) 'Corrigenda' The Journal of Clinical Endocrinology & Metabolism 100, (2) 763-763 , DOI
Ashurst EJ, Jones RB, Abraham C, Jenner M, Boddy K, Besser REJ, Hammersley S & Pinkney J (2014) 'The Diabetes App Challenge: User-Led Development and Piloting of Internet Applications Enabling Young People With Diabetes to Set the Focus for Their Diabetes Consultations' JOURNAL OF MEDICAL INTERNET RESEARCH 16, (11) Author Site , DOI
Pinkney J (2014) 'The role of ghrelin in metabolic regulation' Curr Opin Clin Nutr Metab Care 17, (6) 497-502 Author Site , DOI
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T (2014) 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Clarke-Harris R, Wilkin TJ, Hosking J, Pinkney J, Jeffery AN, Metcalf BS, Godfrey KM, Voss LD, Lillycrop KA & Burdge GC (2014) 'PGC1α promoter methylation in blood at 5-7 years predicts adiposity from 9 to 14 years (EarlyBird 50)' Diabetes 63, (7) 2528-2537 Author Site , DOI
Pinkney JH, Streeter A, Hosking J, Mohammod M, Jeffery AN & Wilkin TJ (2014) 'Adiposity, Chronic Inflammation and the Prepubertal Decline of Sex Hormone Binding Globulin in Children: Evidence for Associations with the Timing of Puberty (EarlyBird 58)' Journal of Clinical Endocrinology and Metabolism
Ibanichuka J, Vincent RP, Ghataore L, Taylor NF, Millward A, Pinkney JH & Stenhouse E (2014) 'Changes in serum steroid concentrations in relation to fat distribution and insulin resistance in women with polycystic ovarian syndrome' Endocrine Abstracts , DOI
Frost J, Anderson R, Argyle C, Daly M, Harris-Golesworthy F, Harris J, Gibson A, Ingram W, Pinkney J & Ukoumunne OC (2013) 'A pilot randomised controlled trial of a preconsultation web-based intervention to improve the care quality and clinical outcomes of diabetes outpatients (DIAT)' BMJ Open 3, (7) Author Site , DOI Open access
Tomlinson J, Letherby G, Pinkney J, Millward A & Stenhouse E (2013) 'Raising awareness of polycystic ovary syndrome' Nurs Stand 27, (40) 35-39 Author Site , DOI
Huda MSB, Mani H, Durham BH, Dovey TM, Halford JCG, Aditya BS, Pinkney JH, Wilding JP & Hart IK (2013) 'Plasma obestatin and autonomic function are altered in orexin-deficient narcolepsy, but ghrelin is unchanged' Endocrine 43, (3) 696-704 Author Site , DOI
Daousi C, Pinkney JH, Cleator J, Wilding JP & Ranganath LR (2013) 'Acute peripheral administration of synthetic human GLP-1 (7-36 amide) decreases circulating IL-6 in obese patients with type 2 diabetes mellitus: a potential role for GLP-1 in modulation of the diabetic pro-inflammatory state?' Regul Pept 183, 54-61 Author Site , DOI
Tomlinson JA, Pinkney JH, Evans P, Millward A & Stenhouse E (2013) 'Screening for diabetes and cardiometabolic disease in women with polycystic ovary syndrome' The British Journal of Diabetes & Vascular Disease 13, (3) 115-123 , DOI
Ajala O, English P & Pinkney J (2013) 'Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes' Am J Clin Nutr 97, (3) 505-516 Author Site , DOI
Jones R, Cleverly L, Hammersley S, Ashurst E & Pinkney J (2013) 'Apps and online resources for young people with diabetes: The facts' Journal of Diabetes Nursing 17, 20-26
Thong KY, Ryder REJ, Cull ML & Walton C (2012) 'Insulin avoidance and treatment outcomes among patients with a professional driving licence starting glucagon‐like peptide 1 (GLP‐1) agonists in the Association of British Clinical Diabetologists (ABCD) nationwide exenatide and liraglutide audits' Diabetic Medicine 29, (5) 690-692 , DOI
Huda MSB, Dovey TM, Wong SP, English PJ, Halford JCG, McCulloch P, Cleator J, Martin B, Cashen J & Hayden K (2011) 'Ghrelin does not orchestrate the metabolic changes seen in fasting but has significant effects on lipid mobilisation and substrate utilisation' Eur J Endocrinol 165, (1) 45-55 Author Site , DOI
Thong KY, Jose B, Sukumar N, Cull ML, Mills AP, Sathyapalan T, Shafiq W, Rigby AS, Walton C & Ryder REJ (2011) 'Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit*' Diabetes, Obesity and Metabolism 13, (8) 703-710 , DOI
Pinkney J (2011) 'The surgical panacea for diabetes: time for diabetologists to discriminate facts from fiction and flights of fantasy' Practical Diabetes International 28, (2) 76-80 , DOI
Kos K, Wong S, Tan BK, Kerrigan D, Randeva HS, Pinkney JH & Wilding JPH (2011) 'Human RBP4 adipose tissue expression is gender specific and influenced by leptin' Clin Endocrinol (Oxf) 74, (2) 197-205 Author Site , DOI
Pinkney J (2011) 'Consensus at last? The International Diabetes Federation statement on bariatric surgery in the treatment of obese Type 2 diabetes' DIABETIC MEDICINE 28, (8) 884-885 , DOI
Huda MSB, Mani H, Dovey T, Halford JCG, Boyland E, Daousi C, Wilding JPH & Pinkney J (2010) 'Ghrelin inhibits autonomic function in healthy controls, but has no effect on obese and vagotomized subjects' Clin Endocrinol (Oxf) 73, (5) 678-685 Author Site , DOI
Pinkney J, Fox T & Ranganath L (2010) 'Selecting GLP-1 agonists in the management of type 2 diabetes: differential pharmacology and therapeutic benefits of liraglutide and exenatide' Ther Clin Risk Manag 6, 401-411 Author Site , DOI Open access
Pinkney JH, Johnson AB & Gale EAM (2010) 'The big fat bariatric bandwagon' Diabetologia 53, (9) 1815-1822 Author Site , DOI
Deepak D, Daousi C, Javadpour M, Clark D, Perry Y, Pinkney J & Macfarlane IA (2010) 'The influence of growth hormone replacement on peripheral inflammatory and cardiovascular risk markers in adults with severe growth hormone deficiency' Growth Horm IGF Res 20, (3) 220-225 Author Site , DOI
White HD, Blair J, Pinkney J, Cuthbertson DJ, Day R, Weber A & MacFarlane IA (2010) 'Improvement in the care of multiple endocrine neoplasia type 1 through a regional multidisciplinary clinic' QJM 103, (5) 337-345 Author Site , DOI
Tomlinson J, Millward A, Stenhouse E & Pinkney J (2010) 'Type 2 diabetes and cardiovascular disease in polycystic ovary syndrome: what are the risks and can they be reduced?' Diabet Med 27, (5) 498-515 Author Site , DOI
Pinkney J (2010) 'Bariatric surgery for diabetes: gastric banding is simple and safe' The British Journal of Diabetes & Vascular Disease 10, (3) 139-142 , DOI
Kos K, Wong SPY, Huda MSB, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JPH & Pinkney JH (2010) 'In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1' Diabetes Obes Metab 12, (4) 360-363 Author Site , DOI
Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, Wilding J, Trayhurn P & Bing C (2010) 'The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity' Clin Endocrinol (Oxf) 72, (3) 334-341 Author Site , DOI
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, LMS C & Randeva H (2009) 'Regularion of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin , insulin and glucose' Diabetes 8, (58) 1780-1780
Daousi C, Wilding JPH, Aditya S, Durham BH, Cleator J, Pinkney JH & Ranganath LR (2009) 'Effects of peripheral administration of synthetic human glucose-dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes' Clin Endocrinol (Oxf) 71, (2) 195-201 Author Site , DOI
Huda MSB, Dovey T, Wong SP, English PJ, Halford J, McCulloch P, Cleator J, Martin B, Cashen J & Hayden K (2009) 'Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects' Int J Obes (Lond) 33, (3) 317-325 Author Site , DOI
Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, Wilding J, Trayhurn P & Bing C (2009) 'The aipokine zinc-α2-glycoprotein is down regulated with fat mass expansion in obesity' Proceedings of the Nutrition Society 68, (OCE2) , DOI
Deepak D, Daousi C, Boyland E, Pinkney JH, Wilding JPH & MacFarlane IA (2008) 'Growth hormone and changes in energy balance in growth hormone deficient adults' Eur J Clin Invest 38, (9) 622-627 Author Site , DOI
Davies M, Lavalle-González F, Storms F & Gomis R (2008) 'Initiation of insulin glargine therapy in type 2 diabetes subjects suboptimally controlled on oral antidiabetic agents: results from the AT.LANTUS trial*' Diabetes, Obesity and Metabolism 10, (5) 387-399 , DOI
Harrold JA, Dovey T, Cai X-J, Halford JCG & Pinkney J (2008) 'Autoradiographic analysis of ghrelin receptors in the rat hypothalamus' Brain Res 1196, 59-64 Author Site , DOI
Kos K, Wong S, Kerrigan D, Wilding JPH & Pinkney JH (2008) 'Adipose tissue derived SPARC and obesity related inflammation in healthy' DIABETOLOGIA 51, S330-S331
Pinkney JH, Wong SPY, Kerrigan D, Kos K & Wilding JPH (2008) 'Distribution and characteristics of adiponectin R1 and R2 receptor in RNA gene expression in human visceral and subcutaneous adipose tissue' DIABETOLOGIA 51, S90-S90
Huda MSB, Durham BH, Wong SP, Deepak D, Kerrigan D, McCulloch P, Ranganath L, Pinkney J & Wilding JPH (2008) 'Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal' Int J Obes (Lond) 32, (1) 129-135 Author Site , DOI
Tomlinson J & Pinkney J (2007) 'Diabetes and polycystic ovary syndrome' Practice Nurse 34, (10)
Pinkney J & Kerrigan D (2007) 'When to consider antiobesity drugs or bariatric surgery' Diabetes and Primary Care 9, (2)
Huda MSB, Durham BH, Wong SP, Dovey TM, McCulloch P, Kerrigan D, Pinkney JH, Fraser WD & Wilding JPH (2007) 'Lack of an acute effect of ghrelin on markers of bone turnover in healthy controls and post-gastrectomy subjects' Bone 41, (3) 406-413 Author Site , DOI
Tomlinson J, Pinkney J & Hattersley A (2006) 'Screening for diabetes and hyperglycaemia: A retrospective study' Diabetes Primary Care 8, (2) 106-113
Huda MSB, Wilding JPH & Pinkney JH (2006) 'Gut peptides and the regulation of appetite' Obes Rev 7, (2) 163-182 Author Site , DOI
Daousi C, Casson IF, Gill GV, MacFarlane IA, Wilding JPH & Pinkney JH (2006) 'Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors' Postgrad Med J 82, (966) 280-284 Author Site , DOI
Wong SPY, Huda M, English P, Bargiota A, Wilding JPH, Johnson A, Corrall R & Pinkney JH (2005) 'Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C' Diabetologia 48, (12) 2641-2649 Author Site , DOI
Daousi C, MacFarlane IA, English PJ, Wilding JPH, Patterson M, Dovey TM, Halford JCG, Ghatei MA & Pinkney JH (2005) 'Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?' J Clin Endocrinol Metab 90, (9) 5025-5030 Author Site , DOI
Daousi C, Dunn AJ, Foy PM, MacFarlane IA & Pinkney JH (2005) 'Endocrine and neuroanatomic features associated with weight gain and obesity in adult patients with hypothalamic damage' Am J Med 118, (1) 45-50 Author Site , DOI
Wallymahmed ME, Pinkney J, Saunders S & MacFarlane IA (2005) 'Vascular risk factors in patients with type 1 diabetes' Practical Diabetes International 22, (3) 81-85 , DOI
Harrold J, Pinkney J & Williams G (2004) 'Control of obesity through the regulation of appetite' Drug Discovery Today: Therapeutic Strategies 1, (2) 219-225 , DOI
Pinkney J & Kerrigan D (2004) 'Review: When should bariatric surgery be used in the treatment of type 2 diabetes?' The British Journal of Diabetes & Vascular Disease 4, (4) 232-237 , DOI
Wong S & Pinkney J (2004) 'Role of cytokines in regulating feeding behaviour' Curr Drug Targets 5, (3) 251-263 Author Site , DOI
Pinkney J & Kerrigan D (2004) 'Current status of bariatric surgery in the treatment of type 2 diabetes' Obes Rev 5, (1) 69-78 Author Site , DOI
MacFarlane IA, Gill GV, Finnegan D & Pinkney J (2004) 'Diabetes in a high secure hospital' Postgrad Med J 80, (939) 35-37 Author Site , DOI
Flower L, Gray R, Pinkney J & Mohamed-Ali V (2003) 'Stimulation of interleukin-6 release by interleukin-1β from isolated human adipocytes' CYTOKINE 21, (1) 32-37 , DOI
Pinkney J & Williams G (2002) 'Ghrelin gets hungry' Lancet 359, (9315) 1360-1361 Author Site , DOI
Pinkney J, Wilding J, Williams G & MacFarlane I (2002) 'Hypothalamic obesity in humans: what do we know and what can be done?' Obes Rev 3, (1) 27-34 Author Site , DOI
Pinkney J (2002) 'Prevention and cure of type 2 diabetes - Weight loss is the key to controlling the diabetes epidemic' BMJ-BRITISH MEDICAL JOURNAL 325, (7358) 232-233 , DOI
Mohamed-Ali V & Pinkney J (2002) 'Therapeutic Potential of Insulin-Like Growth Factor-1 in Patients with Diabetes Mellitus' Treatments in Endocrinology 1, (6) 399-410 , DOI
Mohamed-Ali V, Flower L, Sethi J, Hotamisligil G, Gray R, Humphries SE, York DA & Pinkney J (2001) 'β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:<i>In Vivo</i>and<i>in Vitro</i>Studies' The Journal of Clinical Endocrinology &amp; Metabolism 86, (12) 5864-5869 Publisher Site , DOI
Pinkney JH, Vernon P, Carstensen E, Gillies S, Phillips DI & Yudkin JS (2001) 'Intracellular pH, intrauterine growth and the insulin resistance syndrome' Clin Physiol 21, (6) 640-647 Author Site , DOI
Pinkney J (2001) 'Review: Implications of obesity for diabetes and coronary heart disease in clinical practice' The British Journal of Diabetes &amp; Vascular Disease 1, (2) 103-106 , DOI
Bolton CH, Downs LG, Victory JGG, Dwight JF, Tomson CRV, Mackness MI & Pinkney JH (2001) 'Endothelial dysfunction in chronic renal failure: roles of lipoprotein oxidation and pro‐inflammatory cytokines' Nephrology Dialysis Transplantation 16, (6) 1189-1197 , DOI
Pinkney JH, Sjöström CD & Gale EA (2001) 'Should surgeons treat diabetes in severely obese people?' Lancet 357, (9265) 1357-1359 Author Site , DOI
Mohamed-Ali V, Flower L, Sethi J, Hotamisligil G, Gray R, Humphries SE, York DA & Pinkney J (2001) 'β-adrenergic regulation of IL-6 release from adipose tissue:: <i>In vivo</i> and <i>in vitro</i> studies' JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 86, (12) 5864-5869 , DOI
Mohamed-Ali V, Armstrong L, Clarke D, Bolton CH & Pinkney JH (2001) 'Evidence for the regulation of levels of plasma adhesion molecules by proinflammatory cytokines and their soluble receptors in type 1 diabetes' JOURNAL OF INTERNAL MEDICINE 250, (5) 415-421 , DOI
Pinkney JH, Boss O, Bray GA, Bulmer K, Coppack SW & Mohamed-Ali V (2000) 'Physiological Relationships of Uncoupling Protein-2 Gene Expression in Human Adipose Tissue in Vivo1' The Journal of Clinical Endocrinology &amp; Metabolism 85, (6) 2312-2317 Publisher Site , DOI
Pinkney JH, Goodrick SJ, Katz JR, Johnson AB, Lightman SL, Coppack SW, Medbak S & Mohamed-Ali V (2000) 'Thyroid and sympathetic influences on plasma leptin in hypothyroidism and hyperthyroidism' International Journal of Obesity 24, (S2) S165-S166 , DOI
Mohamed-Ali V, Bulmer K, Clarke D, Goodrick S, Coppack SW & Pinkney JH (2000) 'β-Adrenergic regulation of proinflammatory cytokines in humans' International Journal of Obesity 24, (S2) S154-S155 , DOI
Pinkney JH, Downs L, Hopton M, Mackness MI & Bolton CH (1999) 'Endothelial dysfunction in Type 1 diabetes mellitus: relationship with LDL oxidation and the effects of vitamin E' Diabetic Medicine 16, (12) 993-999 , DOI
Mohamed-Ali, Pinkney, Panahloo, Cwyfan-Hughes, Holly & Yudkin (1999) 'Insulin‐like growth factor binding protein‐1 in NIDDM: relationship with the insulin resistance syndrome' Clinical Endocrinology 50, (2) 221-228 , DOI
Mohamed-Ali V, Pinkney JH & Coppack SW (1998) 'Adipose tissue as an endocrine and paracrine organ' International Journal of Obesity 22, (12) 1145-1158 , DOI
Pinkney JH, Goodrick SJ, Katz J, Johnson AB, Lightman SL, Coppack SW & Mohamed-Ali V (1998) 'Leptin and the pituitary–thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects' Clinical Endocrinology 49, (5) 583-588 , DOI
Coppack SW, Pinkney JH & Mohamed-Ali V (1998) 'Leptin production in human adipose tissue' Proceedings of the Nutrition Society 57, (3) 461-470 , DOI
Jackson SNJ, Pinkney J, Bargiotta A, Veal CD, Howlett TA, McNally PG, Corral R, Johnson A & Trembath RC (1998) 'A Defect in the Regional Deposition of Adipose Tissue (Partial Lipodystrophy) Is Encoded by a Gene at Chromosome 1q' The American Journal of Human Genetics 63, (2) 534-540 , DOI
Pinkney JH, Coppack SW & Mohamed-Ali V (1998) 'Effect of isoprenaline on plasma leptin and lipolysis in humans' Clinical Endocrinology 48, (4) 407-411 , DOI
Mohamed-Ali V, Pinkney JH, Panahloo A, Goodrick S, Coppack SW & Yudkin JS (1997) 'Relationships Between Plasma Leptin and Insulin Concentrations, But Not Insulin Resistance, in Non-insulin-Dependent (Type 2) Diabetes Mellitus' Diabetic Medicine 14, (5) 376-380 , DOI
Pinkney JH, Vernon P, Gillies S, Phillips D & Yudkin JS (1997) 'Sodium-Hydrogen Exchange Kinetics in Cultured Human Skin Fibroblasts: An Investigation of the Relationship with Birthweight and the Insulin Resistance Syndrome' Clinical Science 92, (s36) 15P-16P , DOI
Foyle W-J, Fernandez M, Denver E, Sampson MJ, Pinkney J & Yudkin JS (1996) 'Cellular sodium membrane transport and cardiovascular risk factors in non—Insulin-dependent diabetes mellitus' Metabolism 45, (8) 961-965 , DOI
Pinkney JH, Vernon P & Yudkin JS (1996) 'Nutritional and Endocrine Factors Determine Subsequent cell Growth in Neonatal Rat Fibroblasts: An In-Vitro Model of Cell-Programming' Clinical Science 90, (s34) 19P-19P , DOI
Pinkney JH, Denver AE, Mohamed-Ali V, Foster C & Yudkin JS (1995) 'Insulin resistance in non-insulin-dependent diabetes mellitus is associated with microalbuminuria independently of ambulatory blood pressure' Journal of Diabetes and its Complications 9, (4) 230-233 , DOI
Sampson MJ, Denver E, Foyle WJ, Dawson D, Pinkney J & Yudkin JS (1995) 'Association between left ventricular hypertrophy and erythrocyte sodium-lithium exchange in normotensive subjects with and without NIDDM' Diabetologia 38, (4) 454-460 , DOI
O'Brien E (1995) 'Ambulatory blood pressure measurement and insulin resistance' Hypertension 25, (3) Author Site
Pinkney JH, Foyle W-J, Denver AE, Mohamed-Ali V, McKinlay S & Yudkin JS (1995) 'The relationship of urinary albumin excretion rate to ambulatory blood pressure and erythrocyte sodium-lithium countertransport in NIDDM' Diabetologia 38, (3) 356-362 , DOI
Pinkney JH, Mohamed-Ali V, Denver AE, Foster C, Sampson MJ & Yudkin JS (1994) 'Insulin resistance, insulin, proinsulin, and ambulatory blood pressure in type II diabetes' Hypertension 24, (3) 362-367 , DOI
Pinkney JH & Yudkin JS (1994) 'Antihypertensive drugs: Issues beyond blood pressure control' Progress in Cardiovascular Diseases 36, (5) 397-415 , DOI
Pinkney JH, Bingley PJ, Sawtell PA, Dunger DB & Gale EAM (1994) 'Presentation and progress of childhood diabetes mellitus: a prospective population-based study' Diabetologia 37, (1) 70-74 , DOI
Pinkney JH, Nagi DK & Yudkin JS (1993) 'From ‘Syndrome X’ to the Thrifty Phenotype: A Reappraisal of the Insulin Resistance Theory of Atherogenesis' Vascular Medicine Review vmr-4, (1) 19-47 , DOI
Pinkney J, Catnach S, Woods A & Fairclough P (1993) 'Coronary thrombolysis: still too little too late?' Health Trends 25, (4) 132-134 Author Site
Catnach S, Pinkney J, Woods A & Fairclough P (1992) '"Fast track" admission for acute myocardial infarction' BMJ 304, (6823) 380-381 , DOI
Pinkney JH, Clarke G & Fairclough PD (1991) 'Gastrointestinal involvement in Wegener’s granulomatosis' Gastrointestinal Endoscopy 37, (3) 411-412 , DOI
ISHIZUKA T (1988) 'Effect of circulation time on plasma high density lipoprotein cholesterol in rats' Cardiovascular Research 22, (5) 368-371 , DOI
Browett PJ, Pattinson J, Pinkney J, Hoffbrand AV & Norton JD (1988) 'Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia' European Journal of Haematology 40, (2) 181-184 , DOI
Letters
Ajala O, English P & Pinkney J (2013) 'Low-carbohydrate, high-protein diets for management of type 2 diabetes Reply' AMERICAN JOURNAL OF CLINICAL NUTRITION 98, (1) 248-248 , DOI
Pinkney JH (2010) 'Obesity surgery Big questions remain unanswered' BRITISH MEDICAL JOURNAL 341, , DOI
Chapters
Pinkney J, Tomlinson J & Stenhouse E (2012) 'Overview of Type 2 Diabetes' Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome Elsevier 15-27 , DOI
Ranganath LR & Pinkney J (2011) 'The Paradoxical Role of Glucose-Dependent Insulinotropic Polypeptide (GIP) in Diet and Eating Behaviour in Health and Disease' Handbook of Behavior, Food and Nutrition Springer New York 241-257 , DOI
Kerrigan D & Pinkney J (2009) 'The Role of Metabolic Surgery in the Management of Type 2 Diabetes' Wiley 203-220 , DOI
Pinkney JH & Kopelman PG (2003) 'Endocrine determinants of obesity' Handbook of Obesity: Etiology and Pathophysiology, Second Edition 655-669
Conference Papers
Redfern K, Pinkney J & Rees G (2019) 'Mid-pregnancy changes in maternal upper body subcutaneous fat assessed using skinfold measurements and oral glucose tolerance test results amongst women with obesity in the UK' 26th European Congress on Obesity Karger Publishers Open Access 223-223 , DOI Open access
Redfern KM, Rees GA & Pinkney JH (2017) 'The effect of timing and composition of gestational weight gain in obese pregnant women on infant birth weight: A prospective cohort study' European Congress on Obesity 2017 Porto, Portugal 5-/-0/20175-/-0/2017Karger Publishers Open Access 147-148 Publisher Site , DOI Open access
Pinkney J, Mari A, Tura A, Bond K, Stenhouse E, Vincent RP & Tomlinson J (2015) 'Insulin sensitivity with reactive hypoglycaemia: a metabolic subtype of polycystic ovary syndrome with reduced risks of type 2 diabetes and cardiovascular disease' S302-S302
Tomlinson J, Mari A, Tura A, Bond K, Stenhouse E, Vincent RP & Pinkney J (2015) 'The beta cell and insulin resistance in polycystic ovary syndrome: new insights into the origins and prevention of type 2 diabetes' S190-S190
Ajala O, English P & Pinkney J (2013) 'A systematic review and meta-analysis of different dietary approaches to the management of Type 2 diabetes' 104-104
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LMS & Randeva HS (2009) 'Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose' United States 1780-1788 , DOI Open access
Kos KT, Wong S, Jernas M, Kerrigan D, Carlsson L, Wilding JPH & Pinkney JH (2009) 'The human adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1' S282-S282
Huda M, Dovey T, Wong S, English P, Halford J, McCulloch P, Cleator J, Martin B, Cashen J & Hayden K (2008) 'Endocrine adaptations to short term fasting are preserved after gastrectomy but impaired in morbid obesity' S74-S74
Kos K, Wong S, Kerrigan D, Wilding JPH & Pinkney JH (2008) 'Gender differences of RBP4 expression, relation of plasma, VAT and SCAT expression and its relation with insulin resistance and inflammation' S15-S15
Huda M, Mani H, Durham B, Dovey T, Halford J, Aditya S, Pinkney J, Wilding J & Hart I (2007) 'Changes in circulating plasma ghrelin and obestatin in narcolepsy-cataplexy' A218-A219
(2000) 'True' Springer Science and Business Media LLC S154-S155 , DOI
Pinkney JH, Stehouwer CDA, Coppack SW & Yudkin JS (1997) 'Endothelial Dysfunction: Cause of the Insulin Resistance Syndrome' American Diabetes Association S9-S13 , DOI
PINKNEY JH, DENVER AE, FOYLE WJ, FOSTER C & YUDKIN JS (1995) 'INSULIN-RESISTANCE AND NOT HYPERINSULINEMIA DETERMINES ERYTHROCYTE NA+/LI+ COUNTERTRANSPORT IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS' 685-686
Presentations and posters
Jeffery SC, Hosking J, Jeffery AN, Murphy MJ, Voss LD, Wilkin TJ & Pinkney J Jeffery SC, Hosking J, Jeffery AN, Murphy MJ, Voss LD, Wilkin TJ & Pinkney J 'Gender differences in insulin resistance during adolescence: a longitudinal study (EarlyBird)' Open access
Hosking J, Lauria M, Cominetti O, Jeffery A, Hager J, Pinkney J & Martin F-P Hosking J, Lauria M, Cominetti O, Jeffery A, Hager J, Pinkney J & Martin F-P 'Longitudinal analyses of serum metabolite phenotypes in the EarlyBird cohort identify metabolic readouts associated with childhood insulin resistance' Open access
Other Publications
Redfern K (2018) The Timing and Composition of Gestational Weight Gain and the Impact on Neonatal Anthropometry.
Personal

Personal

Conferences organised

Annual Plymouth Symposium on Obesity, Diabetes and the Metabolic Syndrome