Jonathan Marsden

Teaching interests
I currently teach on the MSc in Neurological Rehabilitation at the Schools of Health Professions. I am the lead for the  "Cognition, perception and behaviour" module  and contribute to the "functional neuroanatomy modules"; "Pathomechanics of balance and walking" and "Research Methods"  

Research interests
  

My research interests and experience are in the field of neurorehabilitation and human motor physiology.  I am currently investigating the pathophysiology and rehabilitation of balance and gait disorders after central and peripheral neurological lesions. The primary aim of my current research is to identify the cause of balance and gait impairments after neurological dysfunction and to evaluate the efficacy of therapeutic interventions that aim to ameliorate these impairments.

Research degrees awarded to supervised students
2008 PhD Thesis G Ramdharry Compensatory strategies while walking in Charcot-Marie-Tooth Disease: impact and intervention  

Grants & contracts
2008-2011 Stroke Association: Determining the factors that limit functional movements in people with an upper motor neuron lesion: Towards targeted focal therapy with Botulinum Toxin £98,000 Co-applicant

 2000-2010 Reilly MM, Ramdharry GM, Marsden JF Strengthening Hip Flexors to improve walking distance in people with Charcot-Marie-Tooth Disease £117,802

2008-2010 Knowledge Transfer Partnership with DM Orthotics Development of orthotic lycra garments to reduce lumbo-pelvic pain and accelerate functional recovery in sportspeople and in women following childbirth £81,621

2008-2009 Vice Chancellor’s Community Research Awards University of Plymouth Current service delivery for people with Familial Spastic Paraparesis in the South West £10,000

2007-2008 Ipsen Education grant. :Factors that limit functional movements in the hand £10,000

2006-2009 Ataxia UK: Disruption of balance in spinocerebellar ataxia: Developing targeted therapies; co-applicant £77,000

2005-2008 MRC pathfinder: Modulation of post-stroke use-dependent plasticity with theta burst stimulation Co-applicant £214,607

2003-2007 MRC: Clinician Scientist Fellowship (£500,000) Personal award

1996-1997 The Sir Richard Stapley Educational Trust (£1,500) Personal award

Publications

RECENT CONFERENCE PROCEEDINGS

Marsden JF,  Hough A,  Shaw, Bakheit M, Freeman J (2009) Movement-related activation patterns in deep abdominal muscles following acute stroke Stroke  Research Network and Clinical Network Conference UK

Hough A, Marsden JF , Shaw, Bakheit M, Freeman J (2009) Exploring the validity of ultrasound as a measure of trunk muscle activity Stroke  Research Network and Clinical Network Conference UK

Ramdharry GM  ,Reilly M and Marsden JF (2009) Exploring the experience of living with fatigue in people with Charcot-Marie-Tooth disease CMTA conference proceeding

Bunn, LM, Marsden, JF, Giunti, P, Day, BL (2008) Vestibular processing for balance control in cerebellar disease 5^th International posture symposium Slovakia

Day BL, Marsden JF, Ramsay E & Fitzpatrick RF (2008) Uniting the left and right vestibular signals for human balance 5^th International posture symposium Slovakia

 
Marsden JJF (2008) Evidence based physiotherapy in movement disorders- a fruitful area for Tourette Syndrome? The way forward for Tourette Syndrome Research in the UK Oxford  UK

 
Marsden JF (2007) Factors affecting stiff-legged gait in Hereditary Spastic Paraparesis  Meeting for Clinician scientist in training.  Royal College of Physicians. London.uk

 
Ramdharry GM, Marsden JF, Day BL, Reilly M (2007) Walking endurance and proximal compensation for distal weakness in Charcot Marie Tooth Disease. World Physical Therapy Conference Vancouver Canada

 Marsden JF, Ramdharry GM, Wood N, Thompson AJ (2007) Factors affecting stiff-legged gait in hereditary and spontaneous spastic paraparesis World Physical Therapy Conference Vancouver Canada

ARTICLES 

Wallace A, Talell P,Dileone M, Oliver R, Ward N, Di Lazzero V, Rothwell JC,Greenwood R, Marsden JF (2009) Standardising treatment intensity for upper limb rehabilitation following a stroke:  a pilot study In submission

 
Day, BL, Marsden, JF, Ramsay, E, Fitzpatrick, R, (2009) Uniting the left and right vestibular signals for human balance In submission

 
Ramdharry GM, Day BL, Reilly MM, Marsden JF (2009) Hip flexor fatigue limits walking in Charcot –Marie Tooth Disease Muscle and Nerve (In Press)

Ramdharry GM, Marsden JF, Day BL, Thompson AJ (2006) De-stabilizing and training effects of foot orthoses in multiple sclerosis. Multiple Sclerosis 12(2):219-26.

Ciccarelli O, Toosy AT, Marsden JF, Wheeler-Kingshott CM, Miller DH, Matthews PM, Thompson AJ. Functional response to active and passive ankle movements with clinicalcorrelations in patients with 
primary progressive multiple sclerosis. J Neurology 2006 Jul;253(7):882-91. 

Ciccarelli O, Toosy AT, Marsden JF, Wheeler-Kingshott CM, Sahyoun C,Matthews PM, Miller DH, Thompson AJ. Identifying brain regions for integrative sensorimotor processing with ankle movements. Exp Brain Res. 2005 Sep;166(1):31-42. 

Marsden JF & Greenwood Physiotherapy after stroke: define, divide and conquer.J Neurology Neurosurgery and Psychiatry. 2005 Apr;76(4):465-6.

O. Ciccarelli, A. T. Toosy, J. F. Marsden, G. T. Ingle, C. A. Wheeler-Kingshott, D. H. Miller, A. J.Thompson (2004) Cortical motor reorganisation in primary progressive multiple sclerosis Journal of Neurology, Neurosurgery and Psychiatry 75 pp 803 (Proceedings of the Association of British Neurologists )

Marsden JF, Blakey G & Day BL (2003) Modulation of human vestibular-evoked postural responses by
alterations in load Journal of Physiology 548.3 pp 949-955

Sharrot A, Marsden J & Brown P (2003) Primary orthostatic tremor is an exaggeration of a physiological response to instability. Movement Disorders 18,2 pp 195-199

Norton J, Wood D, Day BL & Marsden J (2002) Spinally Generated EMG Oscillations and Spasms in a Low Thoracic Complete Paraplegic.Movement Disorders 18,1 pp101-106

Fitzpatrick RC, Marsden J, Lord SR & Day BL (2002) Galvanic vestibular stimulation evokes sensations of body rotation Neuroreport 13, 18 pp 2379-2383

Marsden JF,Castellote J & Day BL (2002). Bipedal distribution of human vestibular-evoked postural responses during asymmetrical standing .Journal of Physiology 542,1 pp 323-331

Barnes G & Marsden J (2002) Anticipatory control of hand and eye movements in humans during oculo-manual tracking Journal of Physiology 539 pp 317-330

Brown P & Marsden J (2001) Cortical network resonance and motor activities in humans Neuroscientist 7 pp 518-527

Marsden J, Limousin-Dowsey P, Ashby P, Pollak P & Brown P (2001) Subthalamic nucleus, sensorimotor cortex and muscle inter-relationships in Parkinson’s disease Brain 124 pp 378-388

Brown P, Marsden J, Defebvre L, Cassiml F, Mazzone P, Oliviero A, Altibrandi M.G, Di Lazzaro V, Limousin-Dowsey P, Fraix V, Odin P & Pollak P (2001) Intermuscular coherence in Parkinson’s disease: relationship to bradykinesia Neuroreport 12 pp 2577-2581

Marsden J, Limousin-Dowsey P, Fraix V, Pollak P, Odin P & Brown P (2001) Intermuscular coherence in Parkinson’s disease: effects of subthalamic nucleus stimulation Neuroreport 12 pp 1113-1117

Marsden J, Brown P & Salenius S (2001) Involvement of the sensorimotor cortex in physiological force and action tremor. Neuroreport 12 pp 1937-1941

Marsden J, Ashby P, Limousin-Dowsey P, Rothwell JC & Brown P(2000) Coherence cerebellar thalamus, cortex and muscle in man Brain 123 pp 1459-70

Tijssen MAJ, Marsden J & Brown P (2000) Frequency analysis of EMG activity in patients with idiopathic torticollis Brain. 123 pp 677-686

Marsden J, Werhahn K, Ashby P, Rothwell JC, Noachtar S & Brown P (2000) Organisation of cortical activities related to movement in humans Journal of Neuroscience. 20 pp 2307-2314

Marsden J, Ashby P, Rothwell JC & Brown P (2000) Phase relationships between cortical and muscle oscillatons in cortical myoclonus: electroencephalographic assessment in a single case Clinical Neurophysiology 111 pp 2170-2174

Marsden J, Farmer SF, Halliday D, Rosenberg J & Brown P (1999) The unilateral and bilateral control of motor unit pairs in the first dorsal interosseous and paraspinal muscles Journal of Physiology. 521.2 pp 553-564

Brown P, Farmer SF, Halliday D, Marsden J & Rosenberg J (1999) Coherent cortical and muscle discharge in cortical myoclonus Brain. 122,pp 461-472

Spauschus A, Marsden J, Halliday D, Rosenberg J & Brown P (1999) The origin of ocular microtremor in man Experimental Brain research 126 pp 556-562

BOOK CHAPTERS

Stephenson, V & Marsden, JF (2006) What is Spasticity? In Stephenson & Jarrett (Eds) Spasticity Management Routledge, London

“Physical exercise regimes” Foord G & Marsden J (1996) IN Luxon LM & Davies R (Eds). Handbook of Vestibular Rehabilitation. Whurr Publishers.

Reports & invited lectures
 

Marsden JF (2008) Evidence based physiotherapy in movement disorders- a fruitful area for Tourette Syndrome? The way forward for Tourette Syndrome Research in the UK Oxford  UK