Hana Lango Allen

Mrs Hana Lango Allen - (Hana Lango, Hana Lango Allen)

Institute of Biomedical & Clinical Science (Peninsula College of Medicine & Dentistry)
Address: Peninsula College of Medicine and Dentistry, Inst of Biomedical & Clinical Science, PMS Building (RD&E), Royal Devon & Exeter Hospital,
Wonford, Devon, EX2 5DW
Telephone: 01392 722967
Email: hana.langoallen@pms.ac.uk

Role
Research Fellow in Molecular Genetics
- Bioinformatics
- Next Generation Sequencing data analysis

Qualifications & background
BSc in Zoology (University of Bristol, 2004)
MSc in Bioinformatics (University of Leicester, 2005)
PhD "The role of common genetic variation in model polygenic and monogenic traits" (Peninsula Medical School, University of Exeter, 2010)

Professional membership
Genetics Society
American Society of Human Genetics

Teaching interests
BClinSci degree: Expanding Horizons 2 module, Small Structured Group Learning facilitation
Medical Degree: Statistics teaching, Problem Based Learning facilitation

Research interests
- Next Generation Sequencing - whole exome sequencing in patients with unidentified pathogenic mutations
- Genome-Wide Association Studies and fine-mapping of complex human diseases and traits (type 2 diabetes, adult height)

Publications

Hana Lango Allen et al. (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832

Hana Lango Allen et al. (2010) Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Diabetes 59:266

Hana Lango et al. (2008) Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 57:3129

Michael N Weedon, Hana Lango, et al. (2008) Genome-wide association analysis identifies 20 loci that influence adult height. Nature Genetics 40:575

Hana Lango & Michael N Weedon: What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice? (2008) Journal Of Internal Medicine 263: 16

Michael N Weedon, Guillaume Lettre, Rachel M Freathy, Cecilia M Lindgren, Benjamin F Voight, John RB Perry, Katherine S Elliott, Rachel Hackett, Candace Guiducci, Beverley Shields, Eleftheria Zeggini, Hana Lango, et al. (2007) A common variant of HMGA2 is associated with adult and childhood height in the general population. Nature Genetics 39:1245

Manjinder S Sandhu, Michael N Weedon, Katherine A Fawcett, Jon Wasson, Sally L Debenham, Allan Daly, Hana Lango, et al. (2007) Common variants in WFS1 confer risk of type 2 diabetes. Nature Genetics 39:951

Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (2007) Nature 447:661

Eleftheria Zeggini, Michael N Weedon, Cecilia M Lindgren, Timothy M Frayling, Katharine S Elliott, Hana Lango, et al. (2007) Replication of Genome-Wide Association Signals in U.K. Samples Reveals Risk Loci for Type 2 Diabetes. Science 317:1035

Timothy M Frayling, Nicholas J Timpson, Michael N. Weedon, Eleftheria Zeggini, Rachel M Freathy, Cecilia M Lindgren, John RB Perry, Katherine S Elliott, Hana Lango et al. (2007) A common variant in the FTO gene region is associated with body mass index in the general population and predisposes to adult and childhood obesity. Science 316:889

Links
http://www.diabetesgenes.org/