Profiles
Professor Daniel Martin
Professor of Perioperative and Intensive Care Medicine
Peninsula Medical School (Faculty of Health)
Biography
Biography
I am a Consultant in anaesthesia and intensive care medicine, working on the intensive care unit at Derriford hospital. My main research interest oxygen physiology; in particular how humans adapt to low levels of oxygen and the potential harm caused by excessive oxygen. This interest arose from my involvement in a series of research expeditions to high altitude with the Xtreme Everest team. In 2007, as part of my PhD, a group of us took arterial blood samples from one another near the summit of Mount Everest, which had some of the lowest oxygen levels ever reported in humans. In our hunt for key adaptive processes we have measured our mitochondrial function and compared it to that of high altitude Sherpas; we have investigated the function of the microcirculation and conducted a wide range of other studies at various altitudes over the last 15 years. We are continuing this area of research at sea level in partnership with colleagues at DDRC Healthcare.
I am currently the chief investigator for the NIHR funded UK-ROX trial and EXAKT study in the UK. In the UK-ROX trial we are evaluating whether giving a little less oxygen than usual to critically ill patients on a mechanical ventilator will improve their survival. The aim is to recruit 16,500 patients from 100 NHS intensive care units. In the EXAKT study we will be investigating the accuracy pulse oximeters in 900 critically ill patients with different skin tones, to answer a very important question about these essential oxygen monitoring devices.
I am also very interested in exercise and how it can be used to improve clinical outcomes. We have used a tailored exercise intervention to train patients waiting for liver transplantation and I am the co-chief investigator of the NIHR-funded EXALT trial in which we will further evaluate the effect of exercise around the time of liver transplantation. I am also invoked with a study to explore the benefits of exercise programmes in patients awaiting bariatric surgery.
I am the National Institute of Academic Anaesthesia academic training coordinator and Royal College of Anaesthetists Bernard Johnson advisor for academic training. I am passionate about promoting academic training for both doctors in training and allied health professionals. I supervise a number of higher degree students including scientists, medical doctors and allied health professionals.
I have been the Editor in Chief of the Journal of the Intensive Care Society for the last six years and sit on the Council of the Intensive Care Society.
In 2015 I was awarded Officer of the Order of the British Empire (OBE), for services to the prevention of infectious diseases. This was the result of our work at the Royal Free Hospital in London, caring for patients with Ebola virus disease.
I am a member of the Faculty of Health's Athena Swan Self-Assessment Team and am passionate about promoting equality in academic promotion.
My Orcid profile can be found here: https://orcid.org/0000-0001-6220-8235
Qualifications
BSc (1st class) University of Leicester 1994MB ChB University of Leicester 1997
FRCA 2004
FFICM 2011
PhD in applied physiology, University College London 2013
Professional membership
- Fellow of the Royal College of Anaesthetists
- Fellow of the Faculty of Intensive Care Medicine
- Fellow of the Royal Geographical Society
- Member of the Physiological Society
Roles on external bodies
- Council member, Intensive Care Society
- Editor in Chief, Journal of the Intensive Care
- Member of the Medicines and Healthcare products Regulatory Agency (MHRA) Interim Devices Working Group
- Bernard Johnson Adviser Academic Anaesthesia, Royal College of Anaesthetists
- Co-Director, Xtreme Everest Oxygen Research Consortium
Research
Research
Grants & contracts
I am the Chief Investigator of an NIHR HTA funded study to evaluate the clinical and cost-effectiveness of a conservative approach to oxygen therapy for mecnanically ventilated adults in intensive care units. This study will recruit 16,500 patients from 100 hospitals in the UK, to determine whether giving less oxygen than usual improves survival. This will be the largest study ever conducted in critically ill patients in the UK and will link to large related study being conducted in other countries around the world, to additionally answer this question globally.
Publications
Publications
Key publications
Key publications are highlighted
Journals
Articles
(2024) 'Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care: Protocol for the UK-ROX trial' Journal of the Intensive Care Society Publisher Site , DOI Open access
(2024) 'The effect of skin tone on the ability of pulse oximetry to accurately estimate arterial oxygen saturation: a systematic review' British Journal of Anaesthesia , DOI Open access
(2024) 'Preoperative aerobic fitness and perioperative outcomes in patients undergoing cystectomy before and after implementation of a national lockdown' BJA Open 9, , DOI Open access
(2024) 'The barriers to and facilitators of implementing early mobilisation for patients with delirium on intensive care units: A systematic review' JOURNAL OF THE INTENSIVE CARE SOCIETY , DOI Open access
(2023) 'Is there clarity on the horizon for peri‐operative oxygen therapy?' Anaesthesia , DOI Open access
(2023) 'The effect of conservative oxygen therapy on mortality in adult critically ill patients: A systematic review and meta-analysis of randomised controlled trials' Journal of the Intensive Care Society 24, (4) 399-408 , DOI Open access
(2023) 'Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery' Perioperative Medicine 12, (1) , DOI Open access
(2023) 'Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure' Journal of Hepatology , DOI Open access
(2023) 'Is the U-shaped curve still of relevance to oxygenation of critically ill patients?' Intensive Care Medicine , DOI Open access
(2023) 'Critical illness aspects of heatstroke: A hot topic' Journal of the Intensive Care Society 24, (2) 206-214 , DOI Open access
(2022) 'Exploring incidence and risk factors for persistent postoperative opioid use in adult surgical patients: a systematic review protocol' JBI Evidence Synthesis 21, (4) 805-811 , DOI Open access
(2022) 'What matters most to adults with a tracheostomy in ICU and the implications for clinical practice: a qualitative systematic review and metasynthesis' Journal of Critical Care 72, , DOI Open access
(2022) 'Colorectal Endoscopic Stenting Trial (CReST) for obstructing left-sided colorectal cancer: randomized clinical trial' British Journal of Surgery 109, (11) 1073-1080 , DOI
(2022) 'Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis' Critical Care Explorations 4, (4) e0652-e0652 , DOI Open access
(2022) 'Past, present and future of conservative oxygen therapy in critical care' Thorax 77, (5) 431-432 , DOI Open access
(2022) 'Dietary Nitrate Supplementation Does Not Alter Exercise Efficiency at High Altitude – Further Results From the Xtreme Alps Study' Frontiers in Physiology 13, , DOI Open access
(2022) 'Effect of post-operative goal-directed fluid therapy (GDFT) on organ function after orthotopic liver transplantation: Secondary outcome analysis of the COLT randomised control trial' International Journal of Surgery 99, , DOI Open access
(2022) 'Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study' Thorax 77, (12) 1220-1228 , DOI
(2022) 'Barriers and facilitators of early mobilisation for intensive care unit delirium: perspectives from patients, family members and carers. A qualitative study protocol' International Journal of Therapy and Rehabilitation 29, (1) 1-9 , DOI Open access
(2021) 'Protocol for a prospective double-blind, randomised, placebo-controlled feasibility trial of octreotide infusion during liver transplantation' BMJ Open 11, (12) , DOI Open access
(2021) 'The Effect of Pre-operative Exercise Intervention on Patient Outcomes Following Bariatric Surgery: a Systematic Review and Meta-analysis' Obesity Surgery , DOI Open access
(2021) 'Lifting the lid on perioperative goal-directed therapy' British Journal of Anaesthesia 127, (4) 508-510 , DOI Open access
(2021) 'Treatment threshold for intra‐operative hypotension in clinical practice—a prospective cohort study in older patients in the UK' Anaesthesia , DOI Open access
(2021) 'The coagulopathy of liver disease: a shift in thinking' British Journal of Hospital Medicine 82, (6) 1-9 , DOI Open access
(2021) 'A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients' Journal of the Intensive Care Society 22, (4) 280-287 , DOI Open access
(2021) 'Physiological responses during ascent to high altitude and the incidence of acute mountain sickness' Physiological Reports 9, (7) , DOI Open access
(2021) 'Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness' Redox Biology 41, 101907-101907 , DOI Open access
(2021) 'Incidence of accidental awareness during general anaesthesia in obstetrics: a multi-centre, prospective cohort study' Anaesthesia Publisher Site , DOI Open access
(2020) 'Clinical characteristics and outcomes of critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective observational cohort study' PLOS ONE 15, (12) e0243710-e0243710 , DOI Open access
(2020) 'Effects of perioperative oxygen concentration on oxidative stress in adult surgical patients: a systematic review' British Journal of Anaesthesia 126, (3) 622-632 , DOI Open access
(2020) 'Conservative or liberal oxygen therapy in adults after cardiac arrest' Resuscitation 157, 15-22 , DOI Open access
(2020) 'General anaesthetic and airway management practice for obstetric surgery in England: a prospective, multi-centre observational study' Anaesthesia , DOI Open access
(2020) 'An anaesthetic and intensive care perspective on infection control measures for the prevention of airborne transmission of SARS-CoV-2' British Journal of Hospital Medicine 81, (9) 1-9 , DOI Open access
(2020) 'Oxygen targets in the intensive care unit during mechanical ventilation for acute respiratory distress syndrome: a rapid review' Cochrane Database of Systematic Reviews , DOI Open access
(2020) 'Human adaptation to hypoxia in critical illness' Journal of Applied Physiology 129, (4) 656-663 , DOI Open access
(2020) 'Cardiopulmonary exercise testing and cardiopulmonary morbidity in patients undergoing major head and neck surgery' British Journal of Oral and Maxillofacial Surgery 59, (3) 297-302 , DOI Open access
(2020) 'A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study' British Journal of Anaesthesia 126, (1) 181-190 , DOI
(2020) 'Oxygenation of the critically ill in selected intensive care units in the UK: are we usual?' British Journal of Anaesthesia 125, (3) e277-e279 , DOI Open access
(2020) 'After the fire: Post-pandemic reflections' Journal of the Intensive Care Society 21, (3) 195-197 , DOI Open access
(2020) 'COVID-19: UK frontline intensivists' emerging learning' Journal of the Intensive Care Society 22, (3) 211-213 , DOI Open access
(2020) 'A comparison of the quality of image acquisition between two different sidestream dark field video-microscopes' Journal of clinical monitoring and computing 35, (3) 577-583 , DOI Open access
(2020) 'Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance' Perioperative Medicine 9, (1) , DOI Open access
(2020) 'COVID-19: An update from England’s high consequence infectious diseases intensive care unit leads' Journal of the Intensive Care Society 21, (2) 99-101 , DOI Open access
(2020) 'Reply to Tasker and to Lellouche and L’Her' American Journal of Respiratory and Critical Care Medicine 201, (4) 499-499 , DOI Open access
(2020) 'Management of hypoxaemia in the critically ill patient' British Journal of Hospital Medicine 81, (1) 1-10 , DOI Open access
(2020) 'An Outpatient Hospital-based Exercise Training Program for Patients With Cirrhotic Liver Disease Awaiting Transplantation: A Feasibility Trial' Transplantation 104, (1) 97-103 , DOI
(2019) 'The cardiac output optimisation following liver transplant (COLT) trial: a feasibility randomised controlled trial' HPB 22, (8) 1112-1120 , DOI Open access
(2019) 'Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study' British Journal of Anaesthesia 124, (3) 261-270 , DOI
(2019) 'Perioperative Oxidative Stress: The Unseen Enemy' Anesthesia & Analgesia 129, (6) 1749-1760 , DOI Open access
(2019) 'The effect of normobaric hypoxic exposure on coagulation as measured by thromboelastography' Thrombosis Research 184, 105-109 , DOI Open access
(2019) 'Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude – A randomised controlled trial (Xtreme Alps)' Nitric Oxide 94, 27-35 , DOI
(2019) 'Enhanced flow-motion complexity of skin microvascular perfusion in Sherpas and lowlanders during ascent to high altitude' Scientific Reports 9, (1) , DOI
(2019) 'Ward-based Goal-Directed Fluid Therapy (GDFT) in Acute Pancreatitis (GAP) trial: study protocol for a feasibility randomised controlled trial' BMJ Open 9, (10) e028783-e028783 , DOI Open access
(2019) 'The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study' American Journal of Respiratory and Critical Care Medicine 200, (11) 1373-1380 , DOI Open access
(2019) 'Data integrity issues: catalyst for a more robust approach to research on perioperative oxygen therapy?' Perioperative Medicine 8, (1) , DOI
(2019) 'Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study' British Journal of Anaesthesia 123, (2) 161-169 , DOI
(2019) 'Observational study of the microcirculation in patients with liver cirrhosis' JGH Open 3, (6) 518-524 , DOI
(2019) 'Perioperative oxygen therapy: meaningful outcomes and unintended consequences?' British Journal of Anaesthesia 123, (1) e6-e7 , DOI
(2019) 'Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp' Scientific Reports 9, (1) , DOI
(2019) 'Pushing arterial-venous plasma biomarkers to new heights: A model for personalised redox metabolomics?' Redox Biology 21, 101113-101113 , DOI
(2019) 'Protocol for a feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients' BMJ Open 9, (1) e021674-e021674 , DOI Open access
(2019) 'O<sub>2</sub>, do we know what to do?' CRITICAL CARE AND RESUSCITATION 21, (4) 230-232
(2018) 'Oxygenation targets in acutely ill patients: still a matter of debate' The Lancet 392, (10163) 2436-2436 , DOI
(2018) 'Perioperative antioxidants for adults undergoing elective non-cardiac surgery' Cochrane Database of Systematic Reviews , DOI
(2018) 'Correction to: Intraoperative oxygenation in adult patients undergoing surgery (iOPS): a retrospective observational study across 29 UK hospitals' Perioperative Medicine 7, (1) , DOI
(2018) 'Sustained vasomotor control of skin microcirculation in Sherpas <i>versus</i> altitude‐naive lowlanders: Experimental evidence from Xtreme Everest 2' Experimental Physiology 103, (11) 1494-1504 , DOI
(2018) 'Impact of postoperative intravenous fluid administration on complications following elective hepato-pancreato-biliary surgery' Hepatobiliary & Pancreatic Diseases International 17, (5) 402-407 , DOI
(2018) 'Might children rust? What are the risks of supplemental oxygen in acute illness' Archives of Disease in Childhood 104, (2) 106-107 , DOI Open access
(2018) 'The Smell of Hypoxia: using an electronic nose at altitude and proof of concept of its role in the prediction and diagnosis of acute mountain sickness' Physiological Reports 6, (17) e13854-e13854 , DOI
(2018) 'Variation in the perioperative care of women undergoing abdominal-based microvascular breast reconstruction in the United Kingdom (The optiFLAPP Study)' Journal of Plastic, Reconstructive & Aesthetic Surgery 72, (1) 35-42 , DOI
(2018) 'Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial' The Lancet Respiratory Medicine 6, (9) 691-698 , DOI
(2018) 'Effects of major hepato-pancreatico-biliary surgery and general anaesthesia on skeletal-muscle mitochondrial respiration: a pilot study' British Journal of Anaesthesia 121, (2) e18-e18 , DOI
(2018) 'Intraoperative oxygenation in adult patients undergoing surgery (iOPS): a retrospective observational study across 29 UK hospitals' Perioperative Medicine 7, (1) , DOI
(2018) 'Rhythm and cues: role of chronobiology in perioperative medicine' British Journal of Anaesthesia 121, (2) 344-349 , DOI
(2018) 'Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study' The Lancet 391, (10140) 2631-2640 , DOI
(2018) 'Clinical chronobiology: a timely consideration in critical care medicine' Critical Care 22, (1) , DOI Open access
(2018) 'Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery' New England Journal of Medicine 378, (24) 2263-2274 , DOI
(2018) 'Metabolic adjustment to high-altitude hypoxia: from genetic signals to physiological implications' Biochemical Society Transactions 46, (3) 599-607 , DOI
(2018) 'Correction to: American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery' Perioperative Medicine 7, (1) , DOI
(2018) 'Cardiac output Optimisation following Liver Transplant (COLT) trial: study protocol for a feasibility randomised controlled trial' Trials 19, (1) , DOI
(2018) 'Tackling delirium: a crucial target for improving clinical outcomes' British Journal of Hospital Medicine 79, (3) 132-135 , DOI
(2018) 'The 2018 Lake Louise Acute Mountain Sickness Score' High Altitude Medicine & Biology 19, (1) 4-6 , DOI Open access
(2018) 'Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine' Intensive Care Medicine 44, (3) 281-299 , DOI
(2018) 'Continuous renal replacement therapy for the critically ill patient' British Journal of Hospital Medicine 79, (1) C2-C7 , DOI
(2017) 'Oxygen therapy and the Goldilocks principle' Journal of the Intensive Care Society 18, (4) 279-281 , DOI
(2017) 'Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis' Critical Care 21, (1) , DOI Open access
(2017) 'Effects of dietary nitrate on respiratory physiology at high altitude - Results from the Xtreme Alps study' Nitric Oxide 71, 57-68 , DOI
(2017) 'Review article: the role of the microcirculation in liver cirrhosis' Alimentary Pharmacology & Therapeutics 46, (9) 825-835 , DOI
(2017) 'Metabolic basis to Sherpa altitude adaptation' Proceedings of the National Academy of Sciences 114, (24) 6382-6387 , DOI Open access
(2017) 'Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m)' Experimental Physiology 102, (6) 711-724 , DOI
(2017) 'Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition' Redox Biology 13, 60-68 , DOI
(2017) 'Immediate postoperative management and complications on the intensive care unit' British Journal of Hospital Medicine 78, (5) 273-277 , DOI
(2017) 'Should modulation of p50 be a therapeutic target in the critically ill?' Expert Review of Hematology 10, (5) 449-458 , DOI
(2017) 'Caudwell Xtreme Everest: A prospective study of the effects of environmental hypoxia on cognitive functioning' PLOS ONE 12, (3) e0174277-e0174277 , DOI
(2017) 'Pain Assessment in <scp>INT</scp>ensive care (<scp>PAINT</scp>): an observational study of physician‐documented pain assessment in 45 intensive care units in the United Kingdom' Anaesthesia 72, (6) 737-748 , DOI
(2017) 'The significance of circadian rhythms and dysrhythmias in critical illness' Journal of the Intensive Care Society 18, (2) 121-129 , DOI
(2017) 'Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude' Journal of Applied Physiology 122, (4) 1011-1018 , DOI
(2016) 'Surviving physiological stress: Can insights into human adaptation to austere environments be applied to the critical care unit?' Trends in Anaesthesia and Critical Care 11, 6-13 , DOI
(2016) 'The human physiological impact of global deoxygenation' The Journal of Physiological Sciences 67, (1) 97-106 , DOI
(2016) 'Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries' British Journal of Anaesthesia 117, (5) 601-609 , DOI Open access
(2016) 'American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery' Perioperative Medicine 5, (1) , DOI
(2016) 'High altitude-related hypertensive crisis and acute kidney injury in an asymptomatic healthy individual' Extreme Physiology & Medicine 5, (1) , DOI
(2016) 'Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp' Nitric Oxide 60, 24-31 , DOI
(2016) 'Changes in labial capillary density on ascent to and descent from high altitude' F1000Research 5, 2107-2107 , DOI
(2016) 'Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns' Journal of Applied Physiology 121, (3) 709-715 , DOI
(2016) 'Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia' Nitric Oxide 58, 59-66 , DOI
(2016) 'Care of elderly patients: a prospective audit of the prevalence of hypotension and the use of BIS intraoperatively in 25 hospitals in London' Perioperative Medicine 5, (1) , DOI
(2016) 'Late Ebola virus relapse causing meningoencephalitis: a case report' The Lancet 388, (10043) 498-503 , DOI
(2016) 'Benefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: A prospective cohort study' Urologic Oncology: Seminars and Original Investigations 34, (9) 417.e17-417.e23 , DOI
(2016) 'Ebola virus disease: the UK critical care perspective' British Journal of Anaesthesia 116, (5) 590-596 , DOI
(2016) 'Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery' BMJ Open 6, (3) e010359-e010359 , DOI
(2016) 'Clinical Management of Ebola Virus Disease in the United States and Europe' New England Journal of Medicine 374, (7) 636-646 , DOI
(2016) '‘Too much of a coincidence’: identical twins with exertional heatstroke in the same race' BMJ Case Reports bcr2015212592-bcr2015212592 , DOI
(2016) 'Subclinical cardiopulmonary dysfunction in stage 3 chronic kidney disease' Open Heart 3, (1) e000370-e000370 , DOI
(2016) 'A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes' BMC Medical Imaging 16, (1) , DOI
(2015) 'Thromboelastography in the Management of Coagulopathy Associated With Ebola Virus Disease' Clinical Infectious Diseases 62, (5) 610-612 , DOI
(2015) 'Recommendations for perioperative oxygenation' British Journal of Anaesthesia 115, (5) 802-802 , DOI
(2015) 'Post-exposure prophylaxis against Ebola virus disease with experimental antiviral agents: a case-series of health-care workers' The Lancet Infectious Diseases 15, (11) 1300-1304 , DOI
(2015) 'Getting the most from venous occlusion plethysmography: proposed methods for the analysis of data with a rest/exercise protocol' Extreme Physiology & Medicine 4, (1) , DOI
(2015) 'Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis' Open Heart 2, , DOI Open access
(2015) 'Design and conduct of Xtreme Everest 2: An observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia' F1000Research 4, 90-90 , DOI
(2015) 'Oxygen therapy and anaesthesia: too much of a good thing?' Anaesthesia 70, (5) 522-527 , DOI
(2015) 'Cerebral Hemodynamics at Altitude: Effects of Hyperventilation and Acclimatization on Cerebral Blood Flow and Oxygenation' Wilderness & Environmental Medicine 26, (2) 133-141 , DOI
(2015) 'International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients*' Critical Care Medicine 43, (1) 48-56 , DOI
(2014) 'Systemic oxygen extraction during exercise at high altitude' British Journal of Anaesthesia 114, (4) 677-682 , DOI
(2014) 'Changes in muscle proteomics in the course of the Caudwell Research Expedition to Mt. Everest' PROTEOMICS 15, (1) 160-171 , DOI
(2014) 'Acute respiratory distress syndrome on the intensive care unit' British Journal of Hospital Medicine 75, (12) 672-677 , DOI
(2014) 'Oral Coenzyme Q10 Supplementation Does Not Prevent Cardiac Alterations During a High Altitude Trek to Everest Base Camp' High Altitude Medicine & Biology 15, (4) 459-467 , DOI
(2014) 'King of the Mountains: Tibetan and Sherpa Physiological Adaptations for Life at High Altitude' Physiology 29, (6) 388-402 , DOI
(2014) 'Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients' Cochrane Database of Systematic Reviews 2018, (12) , DOI
(2014) 'Effects of Prolonged Exposure to Hypobaric Hypoxia on Oxidative Stress, Inflammation and Gluco-Insular Regulation: The Not-So-Sweet Price for Good Regulation' PLoS ONE 9, (4) e94915-e94915 , DOI
(2014) 'Intravenous fluids: the tale goes on' British Journal of Hospital Medicine 75, (1) 4-5 , DOI
(2013) 'III. Oxygen therapy in anaesthesia: the yin and yang of O2' British Journal of Anaesthesia 111, (6) 867-871 , DOI
(2013) 'Predictors of Outcome Post Cardiac Arrest' Journal of Intensive Care Medicine 33, (4) 248-255 , DOI
(2013) 'Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype?' Extreme Physiology & Medicine 2, (1) , DOI
(2013) 'Design and conduct of ‘Xtreme Alps’: A double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude' Contemporary Clinical Trials 36, (2) 450-459 , DOI
(2013) 'The Use of Skeletal Muscle Near Infrared Spectroscopy and a Vascular Occlusion Test at High Altitude' High Altitude Medicine & Biology 14, (3) 256-262 , DOI
(2013) 'The Young Everest Study: preliminary report of changes in sleep and cerebral blood flow velocity during slow ascent to altitude in unacclimatised children' Archives of Disease in Childhood 98, (5) 356-362 , DOI
(2012) 'A paradigm of fragile Earth in Priestley's bell jar' Extreme Physiology & Medicine 1, (1) , DOI
(2012) 'The Prognostic Value of Cardiopulmonary Exercise Testing in Vascular Surgery Patients' European Journal of Vascular and Endovascular Surgery 44, (4) 457-457 , DOI
(2012) 'Enhanced recovery pathways as a way to reduce surgical morbidity' Current Opinion in Critical Care 18, (4) 385-392 , DOI
(2012) 'Cerebral Hemodynamics at Altitude Using Diffuse Correlation Spectroscopy and Transcranial Doppler' Wilderness & Environmental Medicine 23, (2) 194-194 , DOI
(2012) 'Changes in Peripheral and Cerebral Oxygenation With Altitude and Acclimatization' Wilderness & Environmental Medicine 23, (2) 193-194 , DOI
(2012) 'Reduced coagulation at high altitude identified by thromboelastography' Thrombosis and Haemostasis 107, (06) 1066-1071 , DOI
(2011) 'Acclimatization of skeletal muscle mitochondria to high‐altitude hypoxia during an ascent of Everest' The FASEB Journal 26, (4) 1431-1441 , DOI
(2011) 'Research on Mount Everest: Exploring adaptation to hypoxia to benefit the critically III patient' Netherlands Journal of Critical Care 15, (5) 240-248
(2011) 'Cerebral Artery Dilatation Maintains Cerebral Oxygenation at Extreme Altitude and in Acute Hypoxia—An Ultrasound and MRI Study' Journal of Cerebral Blood Flow & Metabolism 31, (10) 2019-2029 , DOI
(2010) 'Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia' BMC Medical Research Methodology 10, (1) , DOI
(2010) 'Caudwell Xtreme Everest Expedition' High Altitude Medicine & Biology 11, (2) 133-137 , DOI
(2010) 'Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude' Experimental Physiology 95, (8) 880-891 , DOI
(2010) 'An audit of timing of tracheostomy formation in neurosurgical patients: how long should we wait?' Critical Care 14, (Suppl 1) P223-P223 , DOI
(2009) 'Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude' Critical Care 13, (S5) , DOI
(2009) 'Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge' Critical Care 13, (S5) , DOI
(2009) 'Variation in human performance in the hypoxic mountain environment' Experimental Physiology 95, (3) 463-470 , DOI
(2009) 'The authors reply' New England Journal of Medicine 360, (18)
(2009) 'The Young Everest Study: effects of hypoxia at high altitude on cardiorespiratory function and general well-being in healthy children' Archives of Disease in Childhood 94, (8) 621-626 , DOI
(2009) 'Abnormal blood flow in the sublingual microcirculation at high altitude' European Journal of Applied Physiology 106, (3) 473-478 , DOI
(2009) 'Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest' New England Journal of Medicine 360, (2) 140-149 , DOI
(2008) 'From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia' Postgraduate Medical Journal 84, (998) 622-627 , DOI
(2008) 'Changes in thenar eminence tissue oxygen saturation measured using near-infrared spectroscopy suggest ischaemic preconditioning in a repeated arterial occlusion forearm ischaemia model' Critical Care 12, (Suppl 2) P70-P70 , DOI
(2008) 'Tissue oxygen saturation during anaesthesia, cardiopulmonary bypass and intensive care stay for cardiac surgery' Critical Care 12, (Suppl 2) P71-P71 , DOI
(2007) 'Increased Gastric–End Tidal P<sub>CO<sub>2</sub></sub> Gap during Exercise at High Altitude Measured by Gastric Tonometry' High Altitude Medicine & Biology 8, (1) 50-55 , DOI
(2004) 'Medical management of severe traumatic brain injury' Hospital Medicine 65, (11) 674-680 , DOI
(2003) 'Active hypothermia in the management of head injuries' Hospital Medicine 64, (1) 61-61 , DOI
(2001) 'Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction' Atherosclerosis 154, (1) 123-128 , DOI
(2000) 'Analysis of the Postulated Interaction between the at II Sub-Type 1 Receptor Gene A1166-C Polymorphism and the ACE Gene I/D Polymorphism on Risk of MI' Clinical Science 99, (s43) 15P-15P , DOI
(1996) 'Helicobacter pylori seropositivity in subjects with acute myocardial infarction' Heart 76, (4) 308-311 , DOI
(1996) 'Apolipoprotein E polymorphism does not predict risk of restenosis after coronary angioplasty' Atherosclerosis 125, (2) 209-216 , DOI
(1996) 'Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of and prognosis after myocardial infarction' Journal of the American College of Cardiology 28, (2) 338-344 , DOI
(1996) 'Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction' QJM 89, (6) 437-444 , DOI
(1995) 'Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of restenosis after coronary angioplasty' The Lancet 345, (8956) 1013-1016 , DOI
(1994) 'Resistance to activated protein C and risk of premature myocardial infarction' The Lancet 344, (8938) 1709-1710 , DOI
Chapters
(2022) 'High Altitude Physiology and Medicine' Encyclopedia of Respiratory Medicine Elsevier 219-225 , DOI
(2012) 'Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients' John Wiley & Sons, Ltd , DOI
Conference Papers
(2023) 'Peri-operative opioid stewardship: a service evaluation of persistent postoperative opioid use at a tertiary healthcare institution' 12-12
(2023) 'Pathophysiological biomarkers associated with resolution of ACLF in patients treated with the liver dialysis device, DIALIVE' S220-S222
(2021) 'Ward based goal directed fluid therapy (GDFT) in acute pancreatitis (GAP) trial: a feasibility randomised controlled trial [ISRCTN 36077283]' Oxford University Press Open access
Presentations and posters
'A multi-centre, randomized controlled study, to evaluate the safety and performance of the DIALIVE Liver Dialysis Device in patients with Acute on Chronic Liver Failure (ACLF) versus standard of care (SOC)' , DOI
'P076 A multi-centre, randomized controlled study, to evaluate the safety and performance of the DIALIVE liver dialysis device in patients with acute on chronic liver failure (ACLF) versus standard of care (SOC) (ALIVER Consortium)' , DOI
'Pathophysiological basis of resolution of Acute-on-Chronic Liver Failure (ACLF) induced by the novel liver dialysis device, DIALIVE' , DOI
'P-P06 Ward based goal directed fluid therapy (GDFT) in acute pancreatitis (GAP) trial: a feasibility randomised controlled trial [ISRCTN 36077283]' , DOI Open access
'Perioperative Opioid Stewardship: A Service Evaluation of Persistent Postoperative Opioid Use at a Tertiary Healthcare Institution' , DOI
Other Publications
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Additional information
When not at work, you are most likely to find me scrambling up a Tor on the Moor or heading out to sea with a strong south westerly wind across the starboard bow.