- DCL level 7, Derriford Hospital, Derriford Rd, Plymouth, PL6 8DH
- adrian.copplestone@plymouth.ac.uk
Profiles
Professor Adrian Copplestone
Emeritus Professor
Peninsula Medical School (Faculty of Health)
Biography
Biography
Associate Dean (Plymouth Locality) Peninsula College of Medicine and Dentistry
Honorary Professor in Haematology
Consultant Haematologist, Derriford Hospital
Publications
Publications
Key publications
Key publications are highlighted
Journals
Articles
(2016) 'Type C <scp>TP</scp>53‐<scp>CDKN</scp>1A pathway dysfunction occurs independently of <i><scp>CDKN</scp>1A</i> gene polymorphisms in chronic lymphocytic leukaemia and is associated with <i><scp>TP</scp>53</i> abnormalities' British Journal of Haematology 178, (5) 824-826 Publisher Site , DOI
(2013) 'The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units' Blood Transfus 12, (2) 210-219 , DOI
(2013) 'The implementation of NICE guidance on venous thromboembolism risk
assessment and prophylaxis: A before- after observational study to assess the
impact on patient safety across four hospitals in England' BMC Health Services Research 1-18 Publisher Site Open access
(2013) 'A No-Prophylaxis Platelet-Transfusion Strategy for Hematologic Cancers' New England Journal of Medicine 368, (19) 1771-1780 Publisher Site , DOI
(2012) 'Results of a Randomized Trial of Chlorambucil Versus Fludarabine for Patients With Untreated Waldenström Macroglobulinemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma' Journal of Clinical Oncology 31, (3) 301-307 Publisher Site , DOI
(2012) 'The effect of maximum storage on iron status, oxidative stress and antioxidant protection in paediatric packed cell units' Blood Transfus N/a, 1-9 , DOI
(2010) 'Do All Patients With Hematologic Malignancies and Severe Thrombocytopenia Need Prophylactic Platelet Transfusions?' Transfusion Medicine Reviews 24, (3) 163-171 Publisher Site , DOI
(2008) 'Generation<i>in vitro</i>of B-cell chronic lymphocytic leukaemia-proliferative and specific HLA class-II-restricted cytotoxic T-cell responses using autologous dendritic cells pulsed with tumour cell lysate' Clinical and Experimental Immunology 126, (1) 16-28 Publisher Site , DOI
(2008) 'Teaching transfusion in UK medical schools: a survey by the National Blood Transfusion Committee' Medical Education 42, (4) 439-439 Publisher Site , DOI
(2005) 'ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)' Blood 107, (9) 3584-3592 Publisher Site , DOI
(2005) 'Changes in blood supplies, regulations, and transfusion practice' BMJ 330, (7486) 268-269 Publisher Site , DOI
(2004) 'Prospective randomized controlled trial of acute normovolaemic haemodilution in major gastrointestinal surgery' British Journal of Anaesthesia 93, (6) 775-781 Publisher Site , DOI
(2004) 'Activation of coagulation occurs after electrical cardioversion in patients with chronic atrial fibrillation despite optimal anticoagulation with warfarin' International Journal of Cardiology 95, (1) 83-88 Publisher Site , DOI
(2003) 'Anticoagulation in pregnancy: a survey of current practice' British Journal of Haematology 124, (1) 124-125 Publisher Site , DOI
(2003) 'Ethics of large clinical trials in rapidly lethal diseases' The Lancet 361, (9365) 1297-1297 Publisher Site , DOI
(2003) 'Ethics of large clinical trials in rapidly lethal diseases' The Lancet 361, (9365) 1296-1296 Publisher Site , DOI
(2003) '<i>In vitro</i>dendritic cell-induced T cell responses to B cell chronic lymphocytic leukaemia enhanced by IL-15 and dendritic cell–B-CLL electrofusion hybrids' Clinical and Experimental Immunology 131, (1) 82-89 Publisher Site , DOI
(2003) 'Long-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation' HAEMATOLOGICA 88, (11) 1272-1278
(2003) 'A study of the proteins responsible for stimulating B-CLL-specific T-cell responses by autologous dendritic cells pulsed with tumour cell lysate' The Hematology Journal 4, (4) 271-276 Publisher Site , DOI
(2002) 'Allelic Discrimination of Factor V Leiden Using the GeneAmp® 5700 Sequence Detection System' Thrombosis and Haemostasis 88, (12) 1071-1072 Publisher Site , DOI
(2001) 'Thymic Enlargement in an Adult Following a Severe Infection' Clinical Radiology 56, (4) 331-333 Publisher Site , DOI
(2001) 'Vigam‐S, a solvent/detergent‐treated intravenous immunoglobulin, in idiopathic thrombocytopenic purpura' Transfusion Medicine 11, (1) 37-44 Publisher Site , DOI
(2001) 'Nomograms for the Administration of Unfractionated Heparin' Thrombosis and Haemostasis 85, (03) 565-565 Publisher Site , DOI
(2000) 'An external quality assurance scheme for haematological cell morphology - A pilot cpa scheme which assesses individual performance' Blood 96, (11 PART II)
(2000) 'Composition of b cell lysates from patients with b cell chronic lymphocytic leukaemia which when pulsed onto autologous dendritic cells have stimulated autologous and allogeneic t cell responses' Blood 96, (11 PART II)
(1999) 'Response to cladribine in previously treated patients with chronic lymphocytic leukaemia identified by <i>ex vivo</i> assessment of drug sensitivity by DiSC assay' British Journal of Haematology 106, (2) 474-476 Publisher Site , DOI
(1998) 'Dyskeratosis Congenita (DC) Registry: identification of new features of DC' British Journal of Haematology 103, (4) 990-996 Publisher Site , DOI
(1998) 'Autoimmune Haemolysis in Patients with B-CLL Treated with Chlorodeoxyadenosine (CDA)' Leukemia & Lymphoma 29, (3-4) 391-398 Publisher Site , DOI
(1997) 'Atypical lymphocyte morphology: an adverse prognostic factor for disease progression in stage A CLL independent of trisomy 12' British Journal of Haematology 98, (4) 934-939 Publisher Site , DOI
(1997) 'A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions' Transfusion Medicine 7, (1) 33-39 Publisher Site , DOI
(1997) 'The distribution of leukaemia in association with domestic water quality in South West England' European Journal of Cancer Prevention 6, (1) 11-19 Publisher Site , DOI
(1997) 'Thromboprophylaxis with Low Molecular Weight Heparin (Fragmin) in High Risk Pregnancies' Thrombosis and Haemostasis 77, (01) 039-043 Publisher Site , DOI
(1996) 'A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe Francais des Myelodysplasies and European CMML Group' Blood 88, (7) 2480-2487 Publisher Site , DOI
(1996) 'Guidelines on gamma irradiation of blood components for the prevention of transfusion‐associated graft‐versus‐host disease' Transfusion Medicine 6, (3) 261-271 Publisher Site , DOI
(1996) 'Delayed reactivation of hepatitis B infection after cladribine' The Lancet 348, (9020) 129-129 Publisher Site , DOI
(1996) 'Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion' Immunohematology 12, (2) 80-83 Publisher Site , DOI
(1996) 'Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients' British Journal of Haematology 92, (2) 382-388 Publisher Site , DOI
(1995) 'Management of blood loss in Jehovah's Witnesses' BMJ 311, (7013) 1115-1116 Publisher Site , DOI
(1995) 'Wider benefits of leukodepletion of blood products [letter]' Blood 86, (1) 409-410 Publisher Site , DOI
(1995) 'Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells' Journal of Clinical Pathology 48, (5) 482-487 Publisher Site , DOI
(1995) 'A rapid and reliable PCR method for detecting clonal T cell populations' Molecular Pathology 48, (2) M101-M104 Publisher Site , DOI
(1995) 'Effect of anti-APO1 on Spontaneous Apotosis of B Cells in Chronic Lymphocytic Leukaemia: The Role of bel-2 and Interleukin 4' Leukemia & Lymphoma 19, (3-4) 301-308 Publisher Site , DOI
(1994) 'Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4' Blood 84, (7) 2297-2304 Publisher Site , DOI
(1994) 'Necrosis of the female breast: a complication of oral anticoagulation in patients with protein S deficiency' The Breast 3, (2) 116-118 Publisher Site , DOI
(1994) 'Bedside filtration of blood products in the prevention of HLA alloimmunization--a prospective randomized study. Alloimmunisation Study Group' Blood 83, (10) 3028-3035 Publisher Site , DOI
(1993) 'Acute non-lymphocytic leukemia with t(16;21)' Cancer Genetics and Cytogenetics 70, (2) 144-145 Publisher Site , DOI
(1992) 'Definition of relapse in acute myeloid leukaemia' Leukemia Research 16, (12) 1139-1140 Publisher Site , DOI
(1992) 'Acute myeloid leukemia with T-lymphoid expression and distinct chromosomal abnormalities [letter; comment]' Blood 80, (5) 1368-1369 Publisher Site , DOI
(1992) 'Acquired factor XI inhibitor in chronic lymphocytic leukaemia' Journal of Clinical Pathology 45, (4) 352-353 Publisher Site , DOI
(1991) 'The radiologist cries “HELLP”!' The British Journal of Radiology 64, (766) 964-966 Publisher Site , DOI
(1991) 'Haematological toxicity compromises MOPP/ABVD chemotherapy in Hodgkin's disease' Clinical Oncology 3, (3) 151-154 Publisher Site , DOI
(1990) 'Control of haemostasis' Br J Hosp Med 43, (5) 385-389
(1990) 'Radon and leukaemia (IV)' Lancet 335, (8701)
(1988) 'Acute myeloblastic leukaemia in the elderly' Leukemia Research 12, (8) 617-625 Publisher Site , DOI
(1987) 'An 8;14 translocation in a case of plasma cell leukemia' Leukemia Research 11, (7) 655-659 Publisher Site , DOI
(1985) 'Successful Treatment of Post‐Transfusion Purpura with High Dose Immunoglobulins after Lack of Response to Plasma Exchange' Vox Sanguinis 49, (2) 164-167 Publisher Site , DOI
(1984) 'Neutropenic typhlitis' Diseases of the Colon & Rectum 27, (4) 274-275 Publisher Site , DOI
(1984) 'Assessment of Therapeutic Control of Anticoagulation' Acta Haematologica 71, (6) 376-380 Publisher Site , DOI
(1983) 'FALSE NEGATIVE RESULTS WITH LATEX-BASED TEST FOR FIBRINOGEN DEGRADATION PRODUCTS' The Lancet 322, (8359) 1144-1144 Publisher Site , DOI
(1982) 'Neutropenic enterocolitis during mianserin-induced agranulocytosis' BMJ 285, (6348) 1117-1117 Publisher Site , DOI
Chapters
Conference Papers
(2024) 'Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin With Gemtuzumab Ozogamicin Improves Event-Free Survival in Younger Patients With Newly Diagnosed AML and Overall Survival in Patients With <i>NPM1</i> and <i>FLT3</i> Mutations' American Society of Clinical Oncology (ASCO) 1158-1168 Publisher Site , DOI